WO2009014160A1 - 膵癌の新規腫瘍マーカー - Google Patents

膵癌の新規腫瘍マーカー Download PDF

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Publication number
WO2009014160A1
WO2009014160A1 PCT/JP2008/063235 JP2008063235W WO2009014160A1 WO 2009014160 A1 WO2009014160 A1 WO 2009014160A1 JP 2008063235 W JP2008063235 W JP 2008063235W WO 2009014160 A1 WO2009014160 A1 WO 2009014160A1
Authority
WO
WIPO (PCT)
Prior art keywords
pancreatic cancer
amino acid
tumor marker
protein
acid residue
Prior art date
Application number
PCT/JP2008/063235
Other languages
English (en)
French (fr)
Inventor
Masaya Ono
Tesshi Yamada
Setsuo Hirohashi
Original Assignee
Japan Health Sciences Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Health Sciences Foundation filed Critical Japan Health Sciences Foundation
Priority to EP08791487A priority Critical patent/EP2182061B1/en
Priority to US12/452,824 priority patent/US8017732B2/en
Priority to AT08791487T priority patent/ATE536407T1/de
Publication of WO2009014160A1 publication Critical patent/WO2009014160A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen

Abstract

　膵癌の腫瘍マーカーとして有用な新規タンパク質およびその断片が開示される。このタンパク質またはその断片は、酸化されたアミノ酸残基を含む修飾α－フィブリノゲンタンパク質または同アミノ酸残基を含むその断片である。前記酸化されたアミノ酸残基は、（ａ）配列番号２中の５３０番目のプロリン残基に相当するプロリン残基、および（ｂ）配列番号２中の５６５番目のプロリン残基に相当するプロリン残基からなる群から選択される１以上のアミノ酸残基である。
PCT/JP2008/063235 2007-07-25 2008-07-24 膵癌の新規腫瘍マーカー WO2009014160A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08791487A EP2182061B1 (en) 2007-07-25 2008-07-24 Novel tumor marker for pancreatic cancer
US12/452,824 US8017732B2 (en) 2007-07-25 2008-07-24 Tumor marker for pancreatic cancer
AT08791487T ATE536407T1 (de) 2007-07-25 2008-07-24 Neuer tumormarker für pankreaskarzinom

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007193328A JP5140809B2 (ja) 2007-07-25 2007-07-25 修飾α−フィブリノゲンタンパク質またはその免疫原性断片
JP2007-193328 2007-07-25

Publications (1)

Publication Number Publication Date
WO2009014160A1 true WO2009014160A1 (ja) 2009-01-29

Family

ID=40281408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063235 WO2009014160A1 (ja) 2007-07-25 2008-07-24 膵癌の新規腫瘍マーカー

Country Status (5)

Country Link
US (1) US8017732B2 (ja)
EP (1) EP2182061B1 (ja)
JP (1) JP5140809B2 (ja)
AT (1) ATE536407T1 (ja)
WO (1) WO2009014160A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009088022A1 (ja) * 2008-01-07 2011-05-26 国立大学法人 鹿児島大学 新規癌マーカーおよびそれを用いた診断

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125021A2 (en) * 2005-05-16 2006-11-23 Dana Farber Cancer Institute, Inc. Fibrinogen alpha and hemoglobin polypeptides as cancer markers
JP2007193328A (ja) 2006-01-19 2007-08-02 Samsung Electronics Co Ltd フォトレジスト組成物及びこれを用いるフォトレジストパターンの形成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5200246B2 (ja) * 2005-03-14 2013-06-05 財団法人ヒューマンサイエンス振興財団 膵臓癌診断用マーカータンパク質

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125021A2 (en) * 2005-05-16 2006-11-23 Dana Farber Cancer Institute, Inc. Fibrinogen alpha and hemoglobin polypeptides as cancer markers
JP2007193328A (ja) 2006-01-19 2007-08-02 Samsung Electronics Co Ltd フォトレジスト組成物及びこれを用いるフォトレジストパターンの形成方法

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ABBASCIANO V. ET AL.: "Coagulation Disorders and Tumor Markers in the Diagnosis of Pancreatic Cancer", ONCOLOGY, vol. 48, 1991, pages 377 - 382, XP008130264 *
BLOOD, vol. 80, no. 8, 1992, pages 1972 - 1979
BLOOMSTON M. ET AL.: "Fibrinogen gamma Overexpression in Pancreatic Cancer Identified by Large-scale Proteomic Analysis of Serum Samples", CANCER RES., vol. 66, no. 5, 2006, pages 2592 - 2599, XP002484528 *
HONDA K. ET AL.: "'Suizo' Soki Hakken no Shin Gijutsu", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 64, no. 9, 2006, pages 1745 - 1755 *
I. THROMB, HAEMOST., vol. 4, no. 10, 2006, pages 2204 - 2209
MAEKAWA M.: "Shinki Shuyo Marker ni yoru Suigan Soki Shindan no Kanosei", IGAKU NO AYUMI, vol. 222, no. 1, 7 July 2007 (2007-07-07), pages 45 - 50 *
MAXWELL A.S. ET AL.: "Proline Oxidase Induces Apoptosis in Tumor cells, and Its Expression Is Frequently Absent or Reduced in Renal Carcinomas", J. BIOL. CHEM., vol. 278, no. 11, 2003, pages 9784 - 9789, XP008130139 *
PANDHARE J. ET AL.: "Proline Oxidase, a Proapoptotic Gene, Is Induced by Troglitazone", J. BIOL. CHEM., vol. 281, no. 4, 2006, pages 2044 - 2052, XP008130209 *
RADHI J.M. ET AL.: "Pancreatic Cancer and Fibrinogen Storage Disease", J. CLIN. PATHOL., vol. 51, 1998, pages 865 - 867, XP008130149 *
THROMB, HAEMOST, vol. 96, no. 2, 2006, pages 231 - 232

Also Published As

Publication number Publication date
JP2009029731A (ja) 2009-02-12
EP2182061A4 (en) 2010-09-01
EP2182061B1 (en) 2011-12-07
ATE536407T1 (de) 2011-12-15
EP2182061A1 (en) 2010-05-05
JP5140809B2 (ja) 2013-02-13
US8017732B2 (en) 2011-09-13
US20110112278A1 (en) 2011-05-12

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