WO2009012283A1 - Compounds and methods for kinase modulation, and indications therefor - Google Patents
Compounds and methods for kinase modulation, and indications therefor Download PDFInfo
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- WO2009012283A1 WO2009012283A1 PCT/US2008/070124 US2008070124W WO2009012283A1 WO 2009012283 A1 WO2009012283 A1 WO 2009012283A1 US 2008070124 W US2008070124 W US 2008070124W WO 2009012283 A1 WO2009012283 A1 WO 2009012283A1
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- 0 CC(CCC(C1)C1C1)(CC1c1c(*)ccc(N(*)S(*)(=O)=O)c1F)[Al] Chemical compound CC(CCC(C1)C1C1)(CC1c1c(*)ccc(N(*)S(*)(=O)=O)c1F)[Al] 0.000 description 2
- OTFGARFCEJZBON-CLTKARDFSA-N C/C(/C(N)=[IH])=N/C Chemical compound C/C(/C(N)=[IH])=N/C OTFGARFCEJZBON-CLTKARDFSA-N 0.000 description 1
- YFZDPIXYOILDMJ-UHFFFAOYSA-N CCCS(Nc(c(F)c1)ccc1F)(=O)=O Chemical compound CCCS(Nc(c(F)c1)ccc1F)(=O)=O YFZDPIXYOILDMJ-UHFFFAOYSA-N 0.000 description 1
- FNTLCAGZNVQXTA-UHFFFAOYSA-N CCCS(Nc(c(F)c1C(Nc(cc2)cnc2NC2CCCC2)=O)ccc1Cl)(=O)=O Chemical compound CCCS(Nc(c(F)c1C(Nc(cc2)cnc2NC2CCCC2)=O)ccc1Cl)(=O)=O FNTLCAGZNVQXTA-UHFFFAOYSA-N 0.000 description 1
- ONPHNVBFVXFPQU-UHFFFAOYSA-N CCCS(Nc(c(F)c1C(Nc(cc2)cnc2NCc2ccccc2)=O)ccc1Cl)(=O)=O Chemical compound CCCS(Nc(c(F)c1C(Nc(cc2)cnc2NCc2ccccc2)=O)ccc1Cl)(=O)=O ONPHNVBFVXFPQU-UHFFFAOYSA-N 0.000 description 1
- ICDIQGDNDNPGOE-UHFFFAOYSA-N CCCS(Nc(c(F)c1CNc2n[o]c(C)c2)ccc1F)(=O)=O Chemical compound CCCS(Nc(c(F)c1CNc2n[o]c(C)c2)ccc1F)(=O)=O ICDIQGDNDNPGOE-UHFFFAOYSA-N 0.000 description 1
- NZRAONTUJYLWKK-UHFFFAOYSA-N CCCS(Nc(ccc(Cl)c1C(Nc(cc2)cnc2NCc2ccc[s]2)=O)c1F)(=O)=O Chemical compound CCCS(Nc(ccc(Cl)c1C(Nc(cc2)cnc2NCc2ccc[s]2)=O)c1F)(=O)=O NZRAONTUJYLWKK-UHFFFAOYSA-N 0.000 description 1
- RWAQKKCELAQLHO-UHFFFAOYSA-N CCCS(Nc(ccc(F)c1C=O)c1F)(=O)=O Chemical compound CCCS(Nc(ccc(F)c1C=O)c1F)(=O)=O RWAQKKCELAQLHO-UHFFFAOYSA-N 0.000 description 1
- LWARYZZYJZIWEU-UHFFFAOYSA-N CNc1n[nH]c2ncccc12 Chemical compound CNc1n[nH]c2ncccc12 LWARYZZYJZIWEU-UHFFFAOYSA-N 0.000 description 1
- OWZYVAFVDAGFCG-UHFFFAOYSA-N Cc1c[nH]c2c1ccnn2 Chemical compound Cc1c[nH]c2c1ccnn2 OWZYVAFVDAGFCG-UHFFFAOYSA-N 0.000 description 1
- ZJOAOESGLMKKBV-UHFFFAOYSA-N Cc1c[nH]c2nccnc12 Chemical compound Cc1c[nH]c2nccnc12 ZJOAOESGLMKKBV-UHFFFAOYSA-N 0.000 description 1
- FKPXGNGUVSHWQQ-UHFFFAOYSA-N Cc1cc(N)n[o]1 Chemical compound Cc1cc(N)n[o]1 FKPXGNGUVSHWQQ-UHFFFAOYSA-N 0.000 description 1
- CEPCPXLLFXPZGW-UHFFFAOYSA-N Nc(ccc(F)c1)c1F Chemical compound Nc(ccc(F)c1)c1F CEPCPXLLFXPZGW-UHFFFAOYSA-N 0.000 description 1
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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BRPI0814423-0A BRPI0814423B1 (en) | 2007-07-17 | 2008-07-16 | Kinase modulating compounds and pharmaceutical composition comprising the same |
CN2008800249750A CN101808994B (en) | 2007-07-17 | 2008-07-16 | Compounds and methods for kinase modulation, and indications therefor |
CA2695004A CA2695004C (en) | 2007-07-17 | 2008-07-16 | Compounds and methods for kinase modulation, and indications therefor |
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US12/669,450 US20100190777A1 (en) | 2007-07-17 | 2008-07-16 | Compounds and methods for kinase modulation, and indications therefor |
EP08781880.3A EP2170830B1 (en) | 2007-07-17 | 2008-07-16 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS |
JP2010517126A JP2010533729A (en) | 2007-07-17 | 2008-07-16 | Compounds and methods for kinase regulation, and adaptations therefor |
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US13/866,353 US20130237531A1 (en) | 2007-07-17 | 2013-04-19 | Compounds and methods for kinase modulation, and indications therefor |
US13/926,959 US20140038948A1 (en) | 2007-07-17 | 2013-06-25 | Compounds and methods for kinase modulation, and indications therefor |
US14/245,770 US20140303187A1 (en) | 2007-07-17 | 2014-04-04 | Compounds and methods for kinase modulation, and indications therefor |
IL239959A IL239959A (en) | 2007-07-17 | 2015-07-15 | Compounds and methods for kinase modulation and indications therefor |
US15/048,851 US9469640B2 (en) | 2007-07-17 | 2016-02-19 | Compounds and methods for kinase modulation, and indications therefor |
US15/260,042 US9844539B2 (en) | 2007-07-17 | 2016-09-08 | Compounds and methods for kinase modulation, and indications therefor |
US15/656,990 US20170319559A1 (en) | 2007-07-17 | 2017-07-21 | Compounds and methods for kinase modulation, and indications therefor |
US16/058,945 US20190209536A1 (en) | 2007-07-17 | 2018-08-08 | Compounds and methods for kinase modulation, and indications therefor |
US16/109,199 US10426760B2 (en) | 2007-07-17 | 2018-08-22 | Compounds and methods for kinase modulation, and indications therefor |
US17/372,346 US20210353602A1 (en) | 2007-07-17 | 2021-07-09 | Compounds and methods for kinase modulation, and indications therefor |
US17/372,330 US20210346358A1 (en) | 2007-07-17 | 2021-07-09 | Compounds and methods for kinase modulation, and indications therefor |
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BR (1) | BRPI0814423B1 (en) |
CA (1) | CA2695004C (en) |
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