WO2009006492A3 - Stereoselective resolution of racemic amines - Google Patents

Stereoselective resolution of racemic amines Download PDF

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Publication number
WO2009006492A3
WO2009006492A3 PCT/US2008/068951 US2008068951W WO2009006492A3 WO 2009006492 A3 WO2009006492 A3 WO 2009006492A3 US 2008068951 W US2008068951 W US 2008068951W WO 2009006492 A3 WO2009006492 A3 WO 2009006492A3
Authority
WO
WIPO (PCT)
Prior art keywords
racemic amines
stereoselective
resolution
stereoselective resolution
amines
Prior art date
Application number
PCT/US2008/068951
Other languages
French (fr)
Other versions
WO2009006492A2 (en
Inventor
Ronald L Hanson
Animesh Goswami
Brian L Davis
William Lawrence Parker
Ramesh N Patel
Original Assignee
Bristol Myers Squibb Co
Ronald L Hanson
Animesh Goswami
Brian L Davis
William Lawrence Parker
Ramesh N Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Ronald L Hanson, Animesh Goswami, Brian L Davis, William Lawrence Parker, Ramesh N Patel filed Critical Bristol Myers Squibb Co
Publication of WO2009006492A2 publication Critical patent/WO2009006492A2/en
Publication of WO2009006492A3 publication Critical patent/WO2009006492A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Abstract

The invention relates to processes for the enzymatic, stereoselective resolution of racemic amines to provide chiral amines.
PCT/US2008/068951 2007-07-02 2008-07-02 Stereoselective resolution of racemic amines WO2009006492A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94749107P 2007-07-02 2007-07-02
US60/947,491 2007-07-02

Publications (2)

Publication Number Publication Date
WO2009006492A2 WO2009006492A2 (en) 2009-01-08
WO2009006492A3 true WO2009006492A3 (en) 2009-05-28

Family

ID=40226813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/068951 WO2009006492A2 (en) 2007-07-02 2008-07-02 Stereoselective resolution of racemic amines

Country Status (1)

Country Link
WO (1) WO2009006492A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107287255A (en) * 2016-03-31 2017-10-24 南京诺云生物科技有限公司 The new application of Pseudomonas veronii CIP104663 albumen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063336A2 (en) * 2004-12-10 2006-06-15 Cambrex North Brunswick, Inc. Thermostable omega-transaminases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063336A2 (en) * 2004-12-10 2006-06-15 Cambrex North Brunswick, Inc. Thermostable omega-transaminases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GASTALDI ET AL: "Dynamic kinetic resolution of amines involving biocatalysis and in situ free radical mediated racemization", ORGANIC LETTERS, vol. 9, March 2007 (2007-03-01), pages 837 - 839, XP002521885 *
GOSWAMI ET AL: "Enzymatic resolution of sec-butylamine", TETRAHEDRON: ASYMMETRY, vol. 16, 2005, pages 1715 - 1719, XP004861958 *
HANSON ET AL: "Preparation of (R)-amines from racemic amines with an (S)-amine transferase from Bacillus megaterium", ADVANCED SYNTHESIS & CATALYSIS, vol. 350, 9 May 2008 (2008-05-09), pages 1367 - 1375, XP002521356 *

Also Published As

Publication number Publication date
WO2009006492A2 (en) 2009-01-08

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