WO2009005124A1 - Double-stranded rna originating in lactic acid bacterium - Google Patents
Double-stranded rna originating in lactic acid bacterium Download PDFInfo
- Publication number
- WO2009005124A1 WO2009005124A1 PCT/JP2008/062066 JP2008062066W WO2009005124A1 WO 2009005124 A1 WO2009005124 A1 WO 2009005124A1 JP 2008062066 W JP2008062066 W JP 2008062066W WO 2009005124 A1 WO2009005124 A1 WO 2009005124A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- double
- lactic acid
- stranded rna
- acid bacterium
- rna originating
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200880105541A CN101796187A (en) | 2007-07-04 | 2008-07-03 | Double-stranded RNA originating in lactic acid bacterium |
CA2694354A CA2694354C (en) | 2007-07-04 | 2008-07-03 | Lactic acid bacteria-derived double-stranded rna |
JP2009521668A JP5099649B2 (en) | 2007-07-04 | 2008-07-03 | Double-stranded RNA derived from lactic acid bacteria |
US12/452,405 US8334371B2 (en) | 2007-07-04 | 2008-07-03 | Lactic acid bacteria-derived double-stranded RNA |
EP08777818.9A EP2169057B1 (en) | 2007-07-04 | 2008-07-03 | Double-stranded rna originating in lactic acid bacterium |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007175694 | 2007-07-04 | ||
JP2007-175694 | 2007-07-04 | ||
JP2007-299243 | 2007-11-19 | ||
JP2007299243 | 2007-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009005124A1 true WO2009005124A1 (en) | 2009-01-08 |
Family
ID=40226165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/062066 WO2009005124A1 (en) | 2007-07-04 | 2008-07-03 | Double-stranded rna originating in lactic acid bacterium |
Country Status (6)
Country | Link |
---|---|
US (1) | US8334371B2 (en) |
EP (1) | EP2169057B1 (en) |
JP (1) | JP5099649B2 (en) |
CN (1) | CN101796187A (en) |
CA (1) | CA2694354C (en) |
WO (1) | WO2009005124A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011027829A1 (en) * | 2009-09-02 | 2011-03-10 | 京都府公立大学法人 | Composition containing rna derived from lactic acid bacterium as active ingredient |
WO2015004949A1 (en) | 2013-07-12 | 2015-01-15 | 森永乳業株式会社 | Novel lactobacillus and novel lactobacillus-containing medicine, food, beverage and feed |
US9549956B2 (en) | 2010-12-28 | 2017-01-24 | Kirin Holdings Kabushiki Kaisha | Agent for inducing interferon production containing lactic acid bacteria |
WO2017110421A1 (en) * | 2015-12-24 | 2017-06-29 | キッコーマン株式会社 | Method for producing macromolecular hyaluronic acid |
WO2017175774A1 (en) * | 2016-04-04 | 2017-10-12 | キッコーマン株式会社 | COMPOSITION FOR PROMOTING INTERFERON λ PRODUCTION AND METHOD FOR PRODUCING SAME |
JP2018016580A (en) * | 2016-07-27 | 2018-02-01 | 株式会社東洋発酵 | Immunostimulatory composition |
JP2018048087A (en) * | 2016-09-21 | 2018-03-29 | アダプトゲン製薬株式会社 | Body weight or visceral fat increase inhibitor, or food composition for inhibiting increase of body weight or visceral fat, or feed composition for inhibiting increase of body weight or visceral fat |
WO2018207924A1 (en) * | 2017-05-12 | 2018-11-15 | キッコーマン株式会社 | Method for producing double-stranded rna-rich lactic acid bacterium, and said lactic acid bacterium |
US11241463B2 (en) | 2013-07-12 | 2022-02-08 | Morinaga Milk Industry Co., Ltd. | Lactic acid bacterium, drug, food or drink, and feed which contain the lactic acid bacterium |
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EP2742127B1 (en) * | 2011-08-12 | 2019-10-09 | Mello Biotechnology, Inc. | Inducable expression from the eukaryotic pol-2 promoter in prokaryotes |
CN102935238A (en) * | 2012-07-27 | 2013-02-20 | 水爱生物科技(南通)有限公司 | Application of yeast M-dsRNA as TLR3 agonist, and yeast M-dsRNA preparation method |
US10196662B2 (en) * | 2012-08-10 | 2019-02-05 | Mello Biotechnology, Inc. | Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors |
CN105779442B (en) * | 2016-05-19 | 2019-05-28 | 清华大学 | A kind of native cellulose using the macro transcript profile RNA of flora extracting method |
WO2018047979A1 (en) | 2016-09-12 | 2018-03-15 | イチビキ株式会社 | Salt-tolerant lactobacillus, method of culturing salt-tolerant lactobacillus, and immunostimulant |
Citations (2)
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JP2006232790A (en) * | 2005-02-28 | 2006-09-07 | Meiji Milk Prod Co Ltd | Immune response-reinforcing medicine and food composition each containing at oligonucleotide as active ingredient |
JP2006325540A (en) * | 2005-05-30 | 2006-12-07 | Takanashi Milk Products Co Ltd | Oligodeoxynucleotide and immunomodulating agent utilizing the same |
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JPH0680575A (en) | 1991-03-05 | 1994-03-22 | Meiji Milk Prod Co Ltd | Oral immunopotentiating agent |
JP3174611B2 (en) | 1992-02-28 | 2001-06-11 | 明治乳業株式会社 | Immunostimulating composition |
JP4112021B2 (en) | 1994-02-16 | 2008-07-02 | 明治乳業株式会社 | Immunostimulant using lactic acid bacteria |
JPH0899887A (en) | 1994-08-01 | 1996-04-16 | Nichinichi Seiyaku Kk | Immunopotentiator |
JPH092959A (en) | 1995-06-16 | 1997-01-07 | Yakult Honsha Co Ltd | Immuno-globulin e antibody production suppressant and antiallergic agent |
JPH09124496A (en) | 1995-10-31 | 1997-05-13 | Nichinichi Seiyaku Kk | Infection inihibitor |
JPH09188627A (en) | 1996-01-10 | 1997-07-22 | Kyoto Pasutouule Kenkyusho | Substance for improving interferon-producing ability and its production |
JP3040711B2 (en) | 1996-02-21 | 2000-05-15 | ニチニチ製薬株式会社 | Antitumor agent and method for producing the same |
JP4064481B2 (en) | 1996-10-11 | 2008-03-19 | ハウスウェルネスフーズ株式会社 | Immunostimulator |
JPH10309178A (en) | 1997-05-09 | 1998-11-24 | Wakamoto Pharmaceut Co Ltd | Antiallergic agent and fermented food containing bifidus bacterium as active component |
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JP2006028047A (en) | 2004-07-14 | 2006-02-02 | Kikkoman Corp | Interleukin 12 production promoter and method for producing the same |
JP5312322B2 (en) * | 2007-07-03 | 2013-10-09 | キッコーマン株式会社 | Interferon β production promoter and method for producing the same |
-
2008
- 2008-07-03 CN CN200880105541A patent/CN101796187A/en active Pending
- 2008-07-03 US US12/452,405 patent/US8334371B2/en active Active
- 2008-07-03 EP EP08777818.9A patent/EP2169057B1/en active Active
- 2008-07-03 WO PCT/JP2008/062066 patent/WO2009005124A1/en active Application Filing
- 2008-07-03 JP JP2009521668A patent/JP5099649B2/en active Active
- 2008-07-03 CA CA2694354A patent/CA2694354C/en active Active
Patent Citations (2)
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JP2006232790A (en) * | 2005-02-28 | 2006-09-07 | Meiji Milk Prod Co Ltd | Immune response-reinforcing medicine and food composition each containing at oligonucleotide as active ingredient |
JP2006325540A (en) * | 2005-05-30 | 2006-12-07 | Takanashi Milk Products Co Ltd | Oligodeoxynucleotide and immunomodulating agent utilizing the same |
Non-Patent Citations (6)
Title |
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ICHIKAWA S. ET AL.: "MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 71, no. 12, December 2007 (2007-12-01), pages 3026 - 3032, XP008128031 * |
KITAZAWA H. ET AL.: "AT Oligonucleotides Inducing B Lymphocyte Activation Exist in Probiotic Lactobacillus gasseri", INT. J. FOOD MICROBIOL., vol. 65, no. 3, 2001, pages 149 - 162, XP003002302 * |
KITAZAWA H. ET AL.: "IMmunostimulatory Oligonucleotide, CpG-like Motif Exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6", INT. J. FOOD MICROBIOL., vol. 85, no. 1-2, 2003, pages 11 - 21, XP008128035 * |
MASUDA S. ET AL.: "Immunomodulatory Effect of Halophilic Lactic Acid Bacterium Tetragenococcus halophilus Th221 from Soy Sauce Moromi Grown in High-salt Medium", INT. J. FOOD MICROBIOL., vol. 121, no. 3, February 2008 (2008-02-01), pages 245 - 252, XP022439569 * |
NISHIMURA I.: "Tetragenococcus halophilus KK221 Kabu (Th221 Kabu) no Nihonsa RNA wa TLR3 o Kaishite Kogen Teiji Saibo Karano IL-12 Sansei o Yudo suru", JOURNAL OF JAPAN SOCIETY FOR LACTIC ACID BACTERIA, vol. 19, no. 2, June 2008 (2008-06-01), pages 117 * |
TAKAHASHI N. ET AL.: "An Immunostimulatory DNA Sequence from a Probiotic Strain of Bifidobacterium longum Inhibits IgE Production in vitro", FEMS IMMUNOL. MED. MICROBIOL., vol. 46, no. 3, 2006, pages 461 - 469, XP009069320 * |
Cited By (23)
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JP5690270B2 (en) * | 2009-09-02 | 2015-03-25 | 京都府公立大学法人 | A composition comprising RNA derived from lactic acid bacteria as an active ingredient |
JPWO2011027829A1 (en) * | 2009-09-02 | 2013-02-04 | 京都府公立大学法人 | A composition comprising RNA derived from lactic acid bacteria as an active ingredient |
US8765706B2 (en) | 2009-09-02 | 2014-07-01 | Kyoto Prefectural Public University Corporation | Composition comprising rna derived from lactic acid bacterium as effective component |
WO2011027829A1 (en) * | 2009-09-02 | 2011-03-10 | 京都府公立大学法人 | Composition containing rna derived from lactic acid bacterium as active ingredient |
US11944657B2 (en) | 2010-12-28 | 2024-04-02 | Kirin Holdings Kabushiki Kaisha | Agent for inducing interferon production containing lactic acid bacteria |
US9549956B2 (en) | 2010-12-28 | 2017-01-24 | Kirin Holdings Kabushiki Kaisha | Agent for inducing interferon production containing lactic acid bacteria |
US11224623B2 (en) | 2010-12-28 | 2022-01-18 | Kirin Holdings Kabushiki Kaisha | Agent for inducing interferon production containing lactic acid bacteria |
US10220060B2 (en) | 2010-12-28 | 2019-03-05 | Kirin Holdings Kabushiki Kaisha | Agent for inducing interferon production containing lactic acid bacteria |
US10064903B2 (en) | 2013-07-12 | 2018-09-04 | Morinaga Milk Industry Co., Ltd. | Lactic acid bacterium, drug, food or drink, and feed which contain the lactic acid bacterium |
WO2015004949A1 (en) | 2013-07-12 | 2015-01-15 | 森永乳業株式会社 | Novel lactobacillus and novel lactobacillus-containing medicine, food, beverage and feed |
US11241463B2 (en) | 2013-07-12 | 2022-02-08 | Morinaga Milk Industry Co., Ltd. | Lactic acid bacterium, drug, food or drink, and feed which contain the lactic acid bacterium |
US10653730B2 (en) | 2013-07-12 | 2020-05-19 | Morinaga Milk Industry Co., Ltd. | Lactic acid bacterium, drug, food or drink, and feed which contain the lactic acid bacterium |
JP2017112901A (en) * | 2015-12-24 | 2017-06-29 | キッコーマン株式会社 | Method for producing high-molecular-weight hyaluronic acid |
WO2017110421A1 (en) * | 2015-12-24 | 2017-06-29 | キッコーマン株式会社 | Method for producing macromolecular hyaluronic acid |
WO2017175774A1 (en) * | 2016-04-04 | 2017-10-12 | キッコーマン株式会社 | COMPOSITION FOR PROMOTING INTERFERON λ PRODUCTION AND METHOD FOR PRODUCING SAME |
JPWO2017175774A1 (en) * | 2016-04-04 | 2019-02-21 | キッコーマン株式会社 | Composition for promoting production of interferon λ and method for producing the same |
JP2018016580A (en) * | 2016-07-27 | 2018-02-01 | 株式会社東洋発酵 | Immunostimulatory composition |
JP7165363B2 (en) | 2016-07-27 | 2022-11-04 | 株式会社東洋発酵 | Immunostimulatory composition |
JP2021107446A (en) * | 2016-07-27 | 2021-07-29 | 株式会社東洋発酵 | Immunostimulatory composition |
JP2018048087A (en) * | 2016-09-21 | 2018-03-29 | アダプトゲン製薬株式会社 | Body weight or visceral fat increase inhibitor, or food composition for inhibiting increase of body weight or visceral fat, or feed composition for inhibiting increase of body weight or visceral fat |
JP6480090B1 (en) * | 2017-05-12 | 2019-03-06 | キッコーマン株式会社 | Method for producing lactic acid bacteria having high double-stranded RNA content and the lactic acid bacteria |
US11518976B2 (en) | 2017-05-12 | 2022-12-06 | Kikkoman Corporation | Method for producing double-stranded RNA-rich lactic acid bacterium, and said lactic acid bacterium |
WO2018207924A1 (en) * | 2017-05-12 | 2018-11-15 | キッコーマン株式会社 | Method for producing double-stranded rna-rich lactic acid bacterium, and said lactic acid bacterium |
Also Published As
Publication number | Publication date |
---|---|
EP2169057A4 (en) | 2010-07-28 |
CA2694354C (en) | 2018-01-16 |
JPWO2009005124A1 (en) | 2010-08-26 |
EP2169057A1 (en) | 2010-03-31 |
EP2169057B1 (en) | 2015-09-30 |
US8334371B2 (en) | 2012-12-18 |
JP5099649B2 (en) | 2012-12-19 |
CN101796187A (en) | 2010-08-04 |
CA2694354A1 (en) | 2009-01-08 |
US20110159552A1 (en) | 2011-06-30 |
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