WO2009001840A1 - ADCC活性又はCDC活性を有する抗Prominin-1抗体 - Google Patents

ADCC活性又はCDC活性を有する抗Prominin-1抗体 Download PDF

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Publication number
WO2009001840A1
WO2009001840A1 PCT/JP2008/061516 JP2008061516W WO2009001840A1 WO 2009001840 A1 WO2009001840 A1 WO 2009001840A1 JP 2008061516 W JP2008061516 W JP 2008061516W WO 2009001840 A1 WO2009001840 A1 WO 2009001840A1
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WIPO (PCT)
Prior art keywords
antibody
activity
humanized
adcc
human
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PCT/JP2008/061516
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English (en)
French (fr)
Inventor
Kenji Yoshida
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Forerunner Pharma Research Co., Ltd.
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Publication date
Application filed by Forerunner Pharma Research Co., Ltd. filed Critical Forerunner Pharma Research Co., Ltd.
Priority to EP08777573A priority Critical patent/EP2175016A4/en
Priority to JP2009520606A priority patent/JP5469456B2/ja
Priority to US12/666,418 priority patent/US8722858B2/en
Publication of WO2009001840A1 publication Critical patent/WO2009001840A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

Abstract

　本発明は、Prominin-1に結合し、ADCC活性及び／又はCDC活性を有する抗体、並びに該抗体を有効成分とする医薬組成物を提供することを目的とする。 　本発明者らは、上記の課題を解決するために、AC133の抗体可変領域塩基配列をクローニングし、組換え抗体を作製することで、もともとのAC133抗体には存在しないADCC/CDC誘導作用が組換え抗体に付与されていることを見出し、本発明を完成させた。定常領域配列をヒトIgG1/kに変換したキメラ抗体は、ヒトキメラ抗体・ヒトエフェクター細胞との組み合わせにおいて強いADCCが誘導されることを見出した。また、本発明者らはAC133抗体のCDRをヒト抗体配列に移植したヒト化抗体を作製し、さらにヒト化L鎖配列にアミノ酸置換を導入することでキメラ抗体と同等の結合活性を有するヒト化抗体を作製した。本発明により抗腫瘍作用を有する非標識のAC133ヒトキメラ抗体、そしてヒト化抗体が提供される。
PCT/JP2008/061516 2007-06-25 2008-06-25 ADCC活性又はCDC活性を有する抗Prominin-1抗体 WO2009001840A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08777573A EP2175016A4 (en) 2007-06-25 2008-06-25 ANTI-PROMININ-1 ANTIBODIES WITH ADCC ACTIVITY OR CDC ACTIVITY
JP2009520606A JP5469456B2 (ja) 2007-06-25 2008-06-25 ＡＤＣＣ活性又はＣＤＣ活性を有する抗Ｐｒｏｍｉｎｉｎ−１抗体
US12/666,418 US8722858B2 (en) 2007-06-25 2008-06-25 Anti-Prominin-1 antibody having ADCC activity or CDC activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-166253 2007-06-25
JP2007166253 2007-06-25

Publications (1)

Publication Number Publication Date
WO2009001840A1 true WO2009001840A1 (ja) 2008-12-31

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PCT/JP2008/061516 WO2009001840A1 (ja) 2007-06-25 2008-06-25 ADCC活性又はCDC活性を有する抗Prominin-1抗体

Country Status (4)

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US (1) US8722858B2 (ja)
EP (1) EP2175016A4 (ja)
JP (1) JP5469456B2 (ja)
WO (1) WO2009001840A1 (ja)

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WO2011089211A1 (en) * 2010-01-22 2011-07-28 Synimmune Gmbh Anti-cd133 antibodies and methods of using the same
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2024081820A1 (en) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells

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WO2005056605A1 (ja) * 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha ３量体以上の受容体を認識する改変抗体
TW200722518A (en) * 2005-03-31 2007-06-16 Chugai Pharmaceutical Co Ltd Sc(fv)2 structural isomers
US9309322B2 (en) * 2010-11-12 2016-04-12 Scott & White Healthcare (Swh) Antibodies to tumor endothelial marker 8
WO2012065705A1 (en) * 2010-11-19 2012-05-24 Roche Diagnostics Gmbh Novel complex mutation in the epidermal growth factor receptor kinase domain
WO2013173745A1 (en) * 2012-05-18 2013-11-21 Galaxy Biotech, Llc Monoclonal antibodies to macrophage stimulating protein
EP2769989A1 (en) 2013-02-21 2014-08-27 Universitätsklinikum Freiburg Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor
US10711068B2 (en) 2015-03-26 2020-07-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-CD133 monoclonal antibodies and related compositions and methods
WO2022011270A2 (en) * 2020-07-09 2022-01-13 Lankenau Institute For Medical Research Compositions comprising antibodies to human ido-2
CN114057875B (zh) * 2020-07-31 2023-05-05 北京市神经外科研究所 抗cd133的单链抗体及其在制备治疗肿瘤的药物中的用途
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

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WO2011089211A1 (en) * 2010-01-22 2011-07-28 Synimmune Gmbh Anti-cd133 antibodies and methods of using the same
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2024081820A1 (en) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells

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