WO2009001840A1 - Anti-prominin-1 antibody having adcc activity or cdc activity - Google Patents

Anti-prominin-1 antibody having adcc activity or cdc activity Download PDF

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Publication number
WO2009001840A1
WO2009001840A1 PCT/JP2008/061516 JP2008061516W WO2009001840A1 WO 2009001840 A1 WO2009001840 A1 WO 2009001840A1 JP 2008061516 W JP2008061516 W JP 2008061516W WO 2009001840 A1 WO2009001840 A1 WO 2009001840A1
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WO
WIPO (PCT)
Prior art keywords
antibody
activity
humanized
adcc
human
Prior art date
Application number
PCT/JP2008/061516
Other languages
French (fr)
Japanese (ja)
Inventor
Kenji Yoshida
Original Assignee
Forerunner Pharma Research Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forerunner Pharma Research Co., Ltd. filed Critical Forerunner Pharma Research Co., Ltd.
Priority to JP2009520606A priority Critical patent/JP5469456B2/en
Priority to EP08777573A priority patent/EP2175016A4/en
Priority to US12/666,418 priority patent/US8722858B2/en
Publication of WO2009001840A1 publication Critical patent/WO2009001840A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification

Abstract

Disclosed is an antibody capable of binding to Prominin-1 and having an ADCC activity and/or a CDC activity. Also disclosed is a pharmaceutical composition comprising the antibody as an active ingredient. A nucleotide sequence of a variable region of an AC133 antibody is cloned to produce a recombinant antibody, and it is found that the recombinant antibody is imparted with an ADCC/CDC-inducing activity which is not found in the original AC133 antibody. It is also found that a chimeric antibody in which the sequence of a constant region is changed to human IgGl/k can induce potent ADCC when used in combination with a human effector cell. A humanized antibody having a CDR of an AC133 antibody grafted into a human antibody sequence therein is produced. The substitution of an amino acid residue is introduced into a humanized L-chain sequence in the humanized antibody to produce a humanized antibody having the same level of binding activity as that of the chimeric antibody. Thus, it becomes possible to provide an unlabeled AC133 human chimeric antibody having an anti-tumor activity and a humanized antibody.
PCT/JP2008/061516 2007-06-25 2008-06-25 Anti-prominin-1 antibody having adcc activity or cdc activity WO2009001840A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009520606A JP5469456B2 (en) 2007-06-25 2008-06-25 Anti-Prominin-1 antibody having ADCC activity or CDC activity
EP08777573A EP2175016A4 (en) 2007-06-25 2008-06-25 Anti-prominin-1 antibody having adcc activity or cdc activity
US12/666,418 US8722858B2 (en) 2007-06-25 2008-06-25 Anti-Prominin-1 antibody having ADCC activity or CDC activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-166253 2007-06-25
JP2007166253 2007-06-25

Publications (1)

Publication Number Publication Date
WO2009001840A1 true WO2009001840A1 (en) 2008-12-31

Family

ID=40185652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061516 WO2009001840A1 (en) 2007-06-25 2008-06-25 Anti-prominin-1 antibody having adcc activity or cdc activity

Country Status (4)

Country Link
US (1) US8722858B2 (en)
EP (1) EP2175016A4 (en)
JP (1) JP5469456B2 (en)
WO (1) WO2009001840A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011089211A1 (en) * 2010-01-22 2011-07-28 Synimmune Gmbh Anti-cd133 antibodies and methods of using the same
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses

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WO2005056605A1 (en) * 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha Modified antibodies recognizing trimer receptor or higher
EP1870458B1 (en) * 2005-03-31 2018-05-09 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 STRUCTURAL ISOMERS
WO2012065161A2 (en) 2010-11-12 2012-05-18 Scott & White Healthcare Antibodies to tumor endothelial marker 8
WO2012065705A1 (en) * 2010-11-19 2012-05-24 Roche Diagnostics Gmbh Novel complex mutation in the epidermal growth factor receptor kinase domain
WO2013173745A1 (en) * 2012-05-18 2013-11-21 Galaxy Biotech, Llc Monoclonal antibodies to macrophage stimulating protein
EP2769989A1 (en) 2013-02-21 2014-08-27 Universitätsklinikum Freiburg Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor
WO2016154623A2 (en) 2015-03-26 2016-09-29 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anti-cd133 monoclonal antibodies and related compositions and methods
US20230242674A1 (en) * 2020-07-09 2023-08-03 Lankenau Institute For Medical Research Compositions comprising antibodies to human ido-2
CN114057875B (en) * 2020-07-31 2023-05-05 北京市神经外科研究所 anti-CD 133 single-chain antibody and application thereof in preparation of medicines for treating tumors
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011089211A1 (en) * 2010-01-22 2011-07-28 Synimmune Gmbh Anti-cd133 antibodies and methods of using the same
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses

Also Published As

Publication number Publication date
US20100209439A1 (en) 2010-08-19
EP2175016A1 (en) 2010-04-14
JPWO2009001840A1 (en) 2010-08-26
EP2175016A4 (en) 2012-03-28
US8722858B2 (en) 2014-05-13
JP5469456B2 (en) 2014-04-16

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