WO2008156752A3 - Vitreous biomarkers and related diagnostics and therapeutics - Google Patents

Vitreous biomarkers and related diagnostics and therapeutics Download PDF

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Publication number
WO2008156752A3
WO2008156752A3 PCT/US2008/007527 US2008007527W WO2008156752A3 WO 2008156752 A3 WO2008156752 A3 WO 2008156752A3 US 2008007527 W US2008007527 W US 2008007527W WO 2008156752 A3 WO2008156752 A3 WO 2008156752A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
vitreous
therapeutics
analysis
related diagnostics
Prior art date
Application number
PCT/US2008/007527
Other languages
French (fr)
Other versions
WO2008156752A2 (en
Inventor
Bert M Glaser
Geetanjali Davuluri
Lance A Liotta
Original Assignee
Nat Retina Inst
Bert M Glaser
Geetanjali Davuluri
Lance A Liotta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Retina Inst, Bert M Glaser, Geetanjali Davuluri, Lance A Liotta filed Critical Nat Retina Inst
Priority to US12/337,602 priority Critical patent/US20090318856A1/en
Publication of WO2008156752A2 publication Critical patent/WO2008156752A2/en
Publication of WO2008156752A3 publication Critical patent/WO2008156752A3/en
Priority to PCT/US2009/047638 priority patent/WO2009155330A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology

Abstract

The present invention relates to the analysis and monitoring of ocular fluids for determining the physiological state of an organism, to monitor drug efficacy and dynamics, for early disease detection, as well as to certain molecular markers and fingerprints of identified molecules or molecule fragments in such analysis. An ophthalmic aspirating device is provided that allows the relatively non-invasive removal of small volumes of ocular vitreous fluid for diagnostic and other purposes.
PCT/US2008/007527 2007-06-18 2008-06-18 Vitreous biomarkers and related diagnostics and therapeutics WO2008156752A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/337,602 US20090318856A1 (en) 2008-06-18 2008-12-17 Sampling Ocular Fluid
PCT/US2009/047638 WO2009155330A1 (en) 2008-06-18 2009-06-17 Sampling ocular fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92920007P 2007-06-18 2007-06-18
US60/929,200 2007-06-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/337,602 Continuation-In-Part US20090318856A1 (en) 2008-06-18 2008-12-17 Sampling Ocular Fluid

Publications (2)

Publication Number Publication Date
WO2008156752A2 WO2008156752A2 (en) 2008-12-24
WO2008156752A3 true WO2008156752A3 (en) 2009-02-19

Family

ID=40156856

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/007527 WO2008156752A2 (en) 2007-06-18 2008-06-18 Vitreous biomarkers and related diagnostics and therapeutics

Country Status (1)

Country Link
WO (1) WO2008156752A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN204050005U (en) 2014-09-09 2014-12-31 赵潺 Disposable negative pressure paracentesis needle

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6520955B2 (en) * 2000-12-28 2003-02-18 Michael Reynard Phacophotolysis method and apparatus
US20060189608A1 (en) * 2005-02-23 2006-08-24 Alcon, Inc. Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6520955B2 (en) * 2000-12-28 2003-02-18 Michael Reynard Phacophotolysis method and apparatus
US20060189608A1 (en) * 2005-02-23 2006-08-24 Alcon, Inc. Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors

Also Published As

Publication number Publication date
WO2008156752A2 (en) 2008-12-24

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