WO2008156069A1 - Screening method for antibody and antibody obtained by the method - Google Patents
Screening method for antibody and antibody obtained by the method Download PDFInfo
- Publication number
- WO2008156069A1 WO2008156069A1 PCT/JP2008/061017 JP2008061017W WO2008156069A1 WO 2008156069 A1 WO2008156069 A1 WO 2008156069A1 JP 2008061017 W JP2008061017 W JP 2008061017W WO 2008156069 A1 WO2008156069 A1 WO 2008156069A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibody
- cells
- production
- screening method
- specific surface
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5052—Cells of the immune system involving B-cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5412—IL-6
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5428—IL-10
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Computational Biology (AREA)
Abstract
It is intended to provide a novel screening method for an antibody, an antibody obtained by the method and a pharmaceutical composition containing the antibody as an active ingredient. The screening method for an antibody against a B-cell specific surface antigen, comprising the steps of: i) adding an antibody against a B-cell specific surface antigen to B cells; ii) confirming that IL-6 production by B cells is changed and/or confirming that IL-10 production by B cells is changed. The antibody which is against a B-cell specific surface antigen and has an action of changing IL-6 production by B cells and/or has an action of changing IL-10 production by B cells. The pharmaceutical composition containing the antibody as an active ingredient.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007160531A JP2010222255A (en) | 2007-06-18 | 2007-06-18 | Method for screening antibody and antibody obtained by the method |
JP2007-160531 | 2007-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008156069A1 true WO2008156069A1 (en) | 2008-12-24 |
Family
ID=40156228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/061017 WO2008156069A1 (en) | 2007-06-18 | 2008-06-17 | Screening method for antibody and antibody obtained by the method |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP2010222255A (en) |
TW (1) | TW200920399A (en) |
WO (1) | WO2008156069A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102239181A (en) * | 2009-02-24 | 2011-11-09 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | Methods for identifying immunobinders of cell-surface antigens |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005526501A (en) * | 2002-02-21 | 2005-09-08 | デューク・ユニヴァーシティ | Reagents and therapeutic methods for autoimmune diseases |
-
2007
- 2007-06-18 JP JP2007160531A patent/JP2010222255A/en active Pending
-
2008
- 2008-06-17 WO PCT/JP2008/061017 patent/WO2008156069A1/en active Application Filing
- 2008-06-18 TW TW097122680A patent/TW200920399A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005526501A (en) * | 2002-02-21 | 2005-09-08 | デューク・ユニヴァーシティ | Reagents and therapeutic methods for autoimmune diseases |
Non-Patent Citations (5)
Title |
---|
CROSS J.T. ET AL.: "The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus", INFLAMM. RES., vol. 48, no. 5, 1999, pages 255 - 261, XP002506261 * |
EDWARDS J.C. ET AL.: "Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis", N. ENGL. J. MED., vol. 350, no. 25, 2004, pages 2572 - 2581, XP008067127 * |
FILLATREAU S. ET AL.: "B cells regulate autoimmunity by provision of IL-10", NAT. IMMUNOL., vol. 3, no. 10, 2002, pages 944 - 950 * |
OTSUKA J. ET AL.: "Jiko Men'eki Shikkan o Megutte SLE ni Okeru B-Saibo Kogen Juyotai Signal Dentatsu Ijo", CLINICAL IMMUNOLOGY, vol. 40, no. 1, 2003, pages 43 - 49 * |
SATO S.: "Jiko Kotai no Sansei Kijo to Sono Byogensei Zenshinsei Kyohisho ni Okeru B-Saibo Ijo to Jiko Kotai Sansei", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 29, no. 2, 2006, pages 73 - 84 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102239181A (en) * | 2009-02-24 | 2011-11-09 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | Methods for identifying immunobinders of cell-surface antigens |
US8465937B2 (en) | 2009-02-24 | 2013-06-18 | ESBATech, an Alcon Biomedical Research Unit, LLC | Methods for identifying B-clones which bind cell-surface antigens |
US9221905B2 (en) | 2009-02-24 | 2015-12-29 | Esbatech, An Alcon Biomedical Research Unit Llc | Methods for producing immunobinders of cell-surface antigens |
US9908940B2 (en) | 2009-02-24 | 2018-03-06 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanized immunobinders of cell-surface antigens |
Also Published As
Publication number | Publication date |
---|---|
JP2010222255A (en) | 2010-10-07 |
TW200920399A (en) | 2009-05-16 |
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