WO2008155818A1 - Preventive or therapeutic agent for frequent urination and urinary incontinence - Google Patents

Preventive or therapeutic agent for frequent urination and urinary incontinence Download PDF

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Publication number
WO2008155818A1
WO2008155818A1 PCT/JP2007/062308 JP2007062308W WO2008155818A1 WO 2008155818 A1 WO2008155818 A1 WO 2008155818A1 JP 2007062308 W JP2007062308 W JP 2007062308W WO 2008155818 A1 WO2008155818 A1 WO 2008155818A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
aryl
hydrogen atom
preventive
therapeutic agent
Prior art date
Application number
PCT/JP2007/062308
Other languages
French (fr)
Japanese (ja)
Inventor
Sayoko Nakazawa
Asao Tanioka
Ryuichi Kurata
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Nissin Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd., Nissin Pharma Inc. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to PCT/JP2007/062308 priority Critical patent/WO2008155818A1/en
Publication of WO2008155818A1 publication Critical patent/WO2008155818A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A preventive or therapeutic agent for frequent urination and urinary incontinence containing as an active ingredient, a 1,4-benzodioxine derivative represented by the general formula (I): (wherein A represents an aryl group or a C3-8 cycloalkyl group, R1 and R2 are the same or different and represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a trifluoromethyl group, a C1-6 alkoxy group, an aryl group, an aryloxy group or an aryl C1-6 alkyloxy group (the aryl group, aryloxy group or aryl C1-6 alkyloxy group may be optionally substituted with one or two halogen atoms), or R1 and R2 are combined to represent -OCH2O-, R3 represents a hydrogen atom or a C1-6 alkyl group, R4 represents a hydrogen atom or CO2R5, R5 represents a hydrogen atom or a C1-6 alkyl group, X represents a divalent group having a moiety of the general formula (II) (wherein n represents 1 or 2), or (III) ) or a pharmacologically acceptable salt thereof.
PCT/JP2007/062308 2007-06-19 2007-06-19 Preventive or therapeutic agent for frequent urination and urinary incontinence WO2008155818A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/062308 WO2008155818A1 (en) 2007-06-19 2007-06-19 Preventive or therapeutic agent for frequent urination and urinary incontinence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/062308 WO2008155818A1 (en) 2007-06-19 2007-06-19 Preventive or therapeutic agent for frequent urination and urinary incontinence

Publications (1)

Publication Number Publication Date
WO2008155818A1 true WO2008155818A1 (en) 2008-12-24

Family

ID=40155983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/062308 WO2008155818A1 (en) 2007-06-19 2007-06-19 Preventive or therapeutic agent for frequent urination and urinary incontinence

Country Status (1)

Country Link
WO (1) WO2008155818A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007445A1 (en) * 1996-08-19 1998-02-26 Kissei Pharmaceutical Co., Ltd. Preventive/remedy for frequent urination and urinary incontinence
WO2006051797A1 (en) * 2004-11-10 2006-05-18 Kissei Pharmaceutical Co., Ltd. Therapeutic agent for interstitial cystitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007445A1 (en) * 1996-08-19 1998-02-26 Kissei Pharmaceutical Co., Ltd. Preventive/remedy for frequent urination and urinary incontinence
WO2006051797A1 (en) * 2004-11-10 2006-05-18 Kissei Pharmaceutical Co., Ltd. Therapeutic agent for interstitial cystitis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUBOTA Y. ET AL.: "Kakutsudo Boko no Saikin no Kiso Kenkyu", JAPANESE JOURNAL OF CLINICAL UROLOGY, vol. 57, no. 12, 2003, pages 961 - 969, XP003023945 *
YAMAGUCHI O.: "Kakatsudo Boko no Byotai to Yakubutsu Ryoho", FOLIA PHARMACOLOGICA JAPONICA, vol. 121, no. 5, 2003, pages 331 - 338, XP003023944 *
YANAGISAWA T. ET AL.: "Selectivity and Potency of Agonists for the Three Subtypes of Cloned Human beta-Adrenoceptors Expressed in Chinese Hamster Ovary Cells", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 3, 2000, pages 181 - 193, XP003015467 *

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