WO2008149962A1 - Thioimidate compound and use thereof for controlling pests - Google Patents
Thioimidate compound and use thereof for controlling pests Download PDFInfo
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- WO2008149962A1 WO2008149962A1 PCT/JP2008/060407 JP2008060407W WO2008149962A1 WO 2008149962 A1 WO2008149962 A1 WO 2008149962A1 JP 2008060407 W JP2008060407 W JP 2008060407W WO 2008149962 A1 WO2008149962 A1 WO 2008149962A1
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- 0 C*(SC(C*)CCC1CCCCC1)=Nc1ccccc1 Chemical compound C*(SC(C*)CCC1CCCCC1)=Nc1ccccc1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/58—Derivatives of thiocarboxylic acids, the doubly-bound oxygen atoms being replaced by nitrogen atoms, e.g. imino-thio ethers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Definitions
- the present invention relates to a thioimidate compound and use thereof for controlling pests.
- JP 9-202766 A describes a thioimidate compound.
- An object of the present invention is to provide a compound which has an excellent control efficacy against pests .
- the present inventor have intensively studied and found that a thioimidate compound represented by the following formula (I) has an excellent control efficacy against pests, and thus the present invention has been completed. That is, the present invention provides: [I) A thioimidate compound represented by the formula
- R represents a C 6 -12 bicycloalkyl group or a C1-3 alkyl group substituted with a C6- 12 bicycloalkyl group;
- m represents an integer of 0 to 2;
- n represents an integer of 0 to 2;
- X represents a halogen atom, a C 1 - 3 alkyl group, a Ci- 3 haloalkyl group, a C 1 - 4 alkoxy group, or a nitro group, and two X's are the same or different when m is 2; and
- Z represents a halogen atom, a C 1 - 3 alkyl group, a C 1 - 3 haloalkyl group, or a Ci_ 4 alkoxy group, and two Z's are the same or different when n is 2 (hereinafter referred to as the compound (I));
- a pest control method which comprises applying the compound according to any one of the above (1) to (3) to pests or habitats of pests; and the like.
- the compound (I) has an excellent control efficacy against pests.
- C ⁇ -i2 bicycloalkyl group examples include Ce bicycloalkyl groups such as a bicyclo [3.1.0] -2- hexyl group of the formula:
- C 7 bicycloalkyl groups such as a bicyclo [4.1.0] -2-heptyl group, a bicyclo [4.1.0] -3-heptyl group, a bicyclo [3.2.0] -3- heptyl group, a bicyclo [2.2.1] -1-heptyl group, a bicyclo [2.2.1] -2-heptyl group and a bicyclo [2.2.1] -7-heptyl group of the formulas:
- Cs bicycloalkyl groups such as a bicyclo [4.2.0] -3-octyl group, a bicyclo [3.3.0] -2-octyl group and a bicyclo [3.3.0] 3-octyl group of the formulas :
- Cg bicycloalkyl groups such as a bicyclo [4.3.0] -2-nonyl group, a bicyclo [4.3.0] -3-nonyl group, a bicyclo [4.3.0] -7- nonyl group and a bicyclo [4.3.0] -8-nonyl group of the formulas :
- Cio bicycloalkyl groups such as a bicyclo [4.4.0] -2- decyl group and a bicyclo [4.4.0] -3-decyl group of the formulas : with C 7 _io bicycloalkyl groups being preferred.
- the "Ci- 3 alkyl group” includes a methyl, ethyl, propyl or isopropyl group.
- Ci_ 3 alkyl group substituted with a C 6 -i 2 bicycloalkyl group examples include a (bicyclo [2.2.1] -1- heptyl) methyl group, a (bicyclo [2.2.1] -2-heptyl) methyl group, a (bicyclo [2.2.1] -7-heptyl) methyl group, a (bicyclo [4.4.0] -2-decyl) methyl group, a (bicyclo [4.4.0] -3- decyl) methyl group, a 1- (bicyclo [4.4.0] -2-decyl) ethyl group and a 2- (bicyclo [4.4.0] -3-decyl) ethyl group.
- halogen atom includes a fluorine, chlorine, bromine or iodine atom.
- C 1 - 3 haloalkyl group include linear or branched alkyl groups substituted with at least one halogen atom, such as fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, bromomethyl, iodomethyl, pentafluoroethyl, 2, 2, 2-trifluoroethyl, and 2,2,2- trifluoro-1- (trifluoromethyl) ethyl groups .
- halogen atom such as fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, bromomethyl, iodomethyl, pentafluoroethyl, 2, 2, 2-trifluoroethyl, and 2,2,2- trifluoro-1- (trifluoromethyl) ethyl groups .
- the Ci- 4 alkoxy group denotes a methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy or tert- butoxy group.
- Preferred examples of the phenyl group substituted with (X) m include 4-fluorophenyl, 4-chlorophenyl, 4- bromophenyl, 4-methylphenyl, 4-trifluoromethylphenyl, 4- methoxyphenyl, 4-nitrophenyl, 3-fluorophenyl, 3- chlorophenyl, 3-bromophenyl, 3-methylphenyl, 3- trifluoromethylphenyl, 3-methoxyphenyl, 3-nitrophenyl, 2- fluorophenyl, 2-chlorophenyl, 2-bromophenyl, 2-methylphenyl, 2-trifluoromethylphenyl, 2-methoxyphenyl, 2-nitrophenyl, 3, 4-difluorophenyl, 3, 4-dichlorophenyl, 3, 4-dimethylphenyl, 3, 5-difluorophenyl, 3, 5-dichlorophenyl, 3, 5-dimethylphenyl, 2-fluoro-4-methylphenyl, 3-fluor
- Preferred examples of a phenyl group substituted with (Z) n include 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-methylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl, 4- (tert-butoxy) phenyl, 3-fluorophenyl, 3-chlorophenyl, 3- bromophenyl, 3-methylphenyl, 3-trifluoromethylphenyl, 3- methoxyphenyl , 2-fluorophenyl, 2-chlorophenyl, 2- bromophenyl, 2-methylphenyl, 2-trifluoromethylphenyl, 2- methoxyphenyl, 3, 4-difluorophenyl, 3, 4-dichlorophenyl, 3,4- dimethylphenyl, 3, 5-difluorophenyl, 3, 5-dichlorophenyl, 3, 5-dimethylphenyl, 2-fluoro-4-methylphenyl, 3-fluoro-4
- Embodiments of the compound (I) include as follows: a thioimidate compound of the formula (I) wherein R is a C 6 -12 bicycloalkyl group; a thioimidate compound of the formula (I) wherein R is a C 7 -I 0 bicycloalkyl; a thioimidate compound of the formula (I) wherein R is a bicyclo [3.1.0] hexyl group, a bicyclo [4.1.0] heptyl group, bicyclo [3.2.0] heptyl group, a bicyclo [2.2.1] heptyl group, a bicyclo [3.3.0] octyl group, a bicyclo [4.2.0] octyl group, a bicyclo [4.3.0] nonyl group or a bicyclo [4.4.0] decyl group; a thioimidate compound of the formula (I) wherein R is a bicyclo [3.1.0] -2
- the compound (I) is produced by reacting a compound represented by the formula (II) : wherein R, Z and n are as defined above (hereinafter referred to as the compound (II)), with a compound represented by the formula (III) :
- the compound (III) can be used in an excessive amount, but is preferably from 0.8 to 5 equivalents, and more preferably from 0.8 to 1.2 equivalents, based on the compound (II) .
- This reaction can be carried out in a reaction system containing the compound (II) and the compound (III) in the presence of a base.
- a base examples include alkali metal alcoholates such as sodium ethylate, sodium methylate and potassium tert-butoxide; nitrogen-containing compounds such as triethylamine, diisopropylethylamine, pyridine, 4- dimethylaminopyridine and N,N-dimethylaniline; carbonates such as potassium carbonate, sodium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate; hydroxides such as sodium hydroxide and potassium hydroxide; metal hydrides such as lithium hydride, sodium hydride and potassium hydride; and organic lithium such as butyl lithium and lithium diisopropylamide .
- the amount of the base to be used is not particularly limited as long as it does not adversely affect the reaction.
- This reaction can be carried out in an appropriate solvent.
- the solvent include aliphatic hydrocarbons such as pentane, hexane, heptane and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; esters such as methyl acetate, ethyl acetate, ethyl formate and ethyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tetrahydrofuran and dioxane; nitriles such as acetonitrile and propionitrile; acid amides such as dimethylformamide and dimethylacetamide; sulfoxides such as dimethyl sulfoxide; sulf
- the reaction temperature is from -50 to 150 0 C, preferably from -20 to 120°C, and more preferably from -10 to 60 0 C.
- the reaction time is usually from 0.1 to 96 hours, and preferably from 0.1 to 24 hours.
- the compound (I) can be isolated by a conventional workup procedure such as concentrating the reaction mixture; or pouring the reaction mixture into water, extracting it with an organic solvent, and concentrating the extract.
- the resultant compound (I) can be purified by a conventional method such as distillation, reprecipitation, recrystallization or chromatography.
- a process for producing a starting compound used for the production of the compound (I) will be illustrated.
- the compound (II) is prepared from a compound of the formula (IV) :
- R, Z and n are as defined above (hereinafter, referred to as the compound (IV)) by a known method (e.g., method described in Synthesis (1), p 100, 1999, and Chem. Lett., p 1261, 1989) .
- the compound (III) is a known compound or prepared by a known method.
- the compound (IV) is prepared by reacting a compound of the formula (V) : Me 3 Si C ⁇ CH ( V )
- Examples of the leaving group represented by L in the formula (VII) include a halogen atom and a group represented by the formula: L 2 SO 3 , wherein L 2 represents an optionally halogenated C 1 - 3 alkyl group such as a methyl group or a trifluoromethyl group or a phenyl group which may be substituted with a C 1 - 3 alkyl group.
- the compound (VI) in the reaction of the compound (V) with the compound (VI), can be used in an excessive amount, but is preferably from 0.8 to 5 equivalents based on the compound (V) .
- Examples of the base used for the reaction include alkali metal alcoholates such as sodium ethylate, sodium methylate and potassium tert-butoxide; nitrogen-containing compounds such as triethylamine, diisopropylethylamine, pyridine, 4-dimethylaminopyridine and N, N-dimethylaniline; carbonates such as potassium carbonate, sodium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate; hydroxides such as sodium hydroxide and potassium hydroxide; metal hydrides such as lithium hydride, sodium hydride and potassium hydride; and organic lithium such as butyl lithium and lithium diisopropylamide .
- the amount of the base is preferably from 0.8 to 1.2 equivalents based on the compound (V) .
- the reaction can be carried out in an appropriate solvent.
- the solvent include aliphatic hydrocarbons such as pentane, hexane, heptane and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; esters such as methyl acetate, ethyl acetate, ethyl formate and ethyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tetrahydrofuran and dioxane; nitriles such as acetonitrile and propionitrile; acid amides such as dimethylformamide and dimethylacetamide; sulfoxides such as dimethyl sulfoxide; sulfones such as sulfolane; phosphoric acid amides such as hexamethylphospho
- the reaction temperature is from -100 to 100 0 C, and preferably from -80 to 80 0 C.
- the reaction time is usually from 0.1 to 96 hours, preferably from 0.1 to 72 hours, and more preferably from 0.1 to 24 hours.
- the amount of the compound (VII) is preferably from 0.8 to 5 equivalents based on the compound (V) .
- the reaction can be carried out in an appropriate solvent. It is possible to use the same solvent as shown in the reaction of the compound (V) and the compound (VI) .
- the reaction temperature is from -50 to 200 0 C, preferably from -20 to 150 0 C, and more preferably from -10 to 12O 0 C.
- the reaction time is usually from 0.1 to 96 hours, preferably from 0.1 to 72 hours, and more preferably from 0.1 to 24 hours.
- the compound (IV) can be isolated by a conventional workup procedure such as concentrating the reaction mixture; or pouring the reaction mixture into water, extracting it with an organic solvent, and concentrating the extract.
- the resultant compound (IV) can be purified by a conventional method such as distillation, reprecipitation, recrystallization or chromatography.
- the reaction mixture itself can be used as a starting material of a subsequent reaction.
- the compound (IV) can be prepared by a known method described in Chem. Lett., p 1261, 1989.
- the compound (I) can exist in the form of various isomers such as geometric isomers and stereoisomers.
- the compound (I) includes any of the respective isomers and a mixture thereof.
- the compound (I) has an excellent control efficacy against pests such as sanitary pests, animal parasitic pests and plant parasitic pests, and is effective for controlling these pests.
- the compound (I) exerts an excellent control effect by applying it directly to pests or habitats thereof (e.g. animals or plants where pests inhabit) .
- the compound (I) When the compound (I) is used as a composition for control of pests, i.e., is used as a pest control preparation, it is usually formulated into an appropriate form that can be employed in a conventional pesticide or veterinary drug. That is, the compound (I) is dissolved or dispersed in an appropriate liquid carrier, mixed with an appropriate solid carrier or adsorbed in an appropriate solid carrier before application, to formulate into a preparation form such as emulsion, liquid preparation, microemulsion, flowable preparation, oily preparation, wettable powder, powder, granule, fine granule, seed coating preparation, smoking preparation, tablet, microcapsule, air spray, aerosol propellant, carbon dioxide formulation, heat transpiration preparations such as mosquito coil, electric mosquito mat and electric mosquito liquid repellents, smoking preparation, EW preparation, ointment, poison bait, capsule, pellet, injectable solution, resin formulation and shampoo.
- Additives such as emulsifier, suspension, spreading agent, penetrant, moistening agent, tack
- liquid carrier used for the above preparations examples include water, alcohols (such as methyl alcohol, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, benzyl alcohol and ethylene glycol), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone) , ethers (such as tetrahydrofuran, ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and propylene glycol monomethyl ether), aliphatic hydrocarbons (such as kerosene, paraffin oil, fuel oil and machine oil), aromatic hydrocarbons (such as toluene, xylene, solvent naphtha and methylnaphthalene) , halogenated hydrocarbons (such as dichloromethane, chloroform and carbon tetrachloride), acid amides (such as N, N-dimethyl,
- solid carrier examples include vegetable powders (e.g. soybean powder, tobacco powder, wheat flour and wood flour) , mineral powders (e.g. clays such as kaolin, bentonite and acidic white clay, talcs such as talcum powder and pyrophyllite, silicas such as diatom earth and mica) , alumina, sulfur powder, active carbon, calcium carbonate, potassium chloride, ammonium sulfate, sodium hydrogen carbonate, lactose and urea. These solid carriers can be used by mixing one or more kinds (preferably one to three kinds) in an appropriate ratio.
- vegetable powders e.g. soybean powder, tobacco powder, wheat flour and wood flour
- mineral powders e.g. clays such as kaolin, bentonite and acidic white clay, talcs such as talcum powder and pyrophyllite, silicas such as diatom earth and mica
- mineral powders e.g. clays such as kaolin, bentonite and acidic white clay,
- gaseous carrier examples include fluorocarbon, butane gas, LPG (liquefied petroleum gas), dimethyl ether and carbon dioxide. These gaseous monomer can be used by mixing one or two kinds in an appropriate ratio, or in combination with an appropriate liquid carrier.
- ointment base used for the above preparations examples include polyethylene glycol, pectin, polyhydric alcohol ester of a higher fatty acid such as monostearic acid glycerin ester, cellulose derivatives such as methyl cellulose, sodium alginate, bentonite, higher alcohol, polyhydric alcohols such as glycerin, vaseline, white vaseline, liquid paraffin, lard, various vegetable oils, lanoline, dehydrated lanoline, hardened oil and resins.
- These ointment bases can be used by mixing one or more kinds (preferably one to three kinds), or by adding a surfactant as described hereinafter.
- surfactant which is used for the above preparations as an emulsifier, spreading agent, penetrant or dispersant
- non-ionic and anionic surfactants such as soaps, polyoxyethylene alkyl aryl ether (e.g. Noigen and EA142 (trade names) manufactured by DAI- ICHI KOGYO SEIYAKU CO., LTD.; Nonal (trade name) manufactured by TOHO CHEMICAL INDUSTRY CO., LTD.), alkyl sulfate (e.g. Emal 10 (trade name) and Emal 40 (trade name) manufactured by KAO CORPORATION) , alkylbenzene sulfonate (e.g.
- non-ionic and anionic surfactants such as soaps, polyoxyethylene alkyl aryl ether (e.g. Noigen and EA142 (trade names) manufactured by DAI- ICHI KOGYO SEIYAKU CO., LTD.; Nonal (trade name) manufactured by TOHO CHEMICAL INDUST
- Neogen (trade name) and Neogen T (trade name) manufactured by DAI-ICHI KOGYO SEIYAKU CO., LTD.; Neopelex manufactured by KAO CORPORATION)
- polyoxyethylene alkyl ether e.g. Noigen ET-135 (trade name) manufactured by DAI- ICHI KOGYO SEIYAKU CO., LTD.
- polyoxyethylene polyoxypropylene block polymer e.g. NEWPOL PE-64 (trade name) manufactured by SANYO CHEMICAL INDUSTRIES, LTD.
- polyhydric alcohol ester e.g. Tween 20 (trade name) and Tween 80 (trade name) manufactured by KAO CORPORATION
- alkyl sulfosuccinate e.g.
- SANMORIN OT 20 (trade name) manufactured by SANYO CHEMICAL INDUSTRIES, LTD.; Newkalgen EX70 (trade name) manufactured by TAKEMOTO OIL & FAT CO., LTD.) and alkenyl sulfonate (e.g. Sorpol 5115 (trade name) manufactured by TOHO CHEMICAL INDUSTRY CO., LTD.).
- These surfactants can be used by mixing one or more kinds (preferably one to three kinds) in an appropriate ratio. It is also possible that the compound (I) is mixed with other active components of pesticides, such as an insecticide (e.g.
- a pyrethroid insecticide organic phosphorus insecticide, carbamate insecticide, neonicotinoid insecticide and natural insecticide
- acaricide machine oil, nematocide, herbicide, plant hormone agent, plant growth regulator, fungicide (e.g. a copper fungicide, organic chlorine fungicide, organic sulfur fungicide and phenol fungicide) , synergist, attractant, repellent, safener, pigment, fertilizer, animal feed (e.g. feed for livestock such as cows, pigs and chickens, feed for pet animals such as dogs and cats, and feed for farmed fishes such as yellowtail and sea bream) , medical supplies for animals (e.g. treatment and prevention drugs for livestock, pet animals and cultured fish) and nutritional supplement for animals.
- livestock feed e.g. feed for livestock such as cows, pigs and chickens, feed for pet animals such as dogs and cats, and feed for farmed fishes such as yellowtail and sea bream
- medical supplies for animals
- the content of the compound (I) in the pest control preparation of the present invention is usually from 0.1 to 80% by weight, preferably from 1 to 20% by weight based on the total amount of the pest control preparation of the present invention. Specifically, the content is usually from 1 to 80% by weight, preferably from 1 to 20% by weight in the case of using the compound (I) as an emulsion, liquid preparation or wettable powder (e.g. water dispersible granule) . In the case of using it as an oil or powder preparation, usually, the content of from 0.1 to 50% by weight, preferably from 0.1 to 20% by weight is suitable. In the case of using it as a granular preparation, usually, the content of from 1 to 50% by weight, preferably from 1 to 20% by weight is suitable.
- pesticides e.g. insecticide, herbicide, acaricide and fungicide
- Other active components of pesticides e.g. insecticide, herbicide, acaricide and fungicide
- insecticides e.g. insecticide, herbicide, acaricide and fungicide
- fungicide e.g. insecticide, herbicide, acaricide and fungicide
- the content of additives other than the above active components is usually from 0.001 to 99.9% by weight, preferably from 1 to 99% by weight, although it varies depending on kinds and contents of the active components of a pesticide, and a form of a preparation. More specifically, the content of a surfactant is usually from 1 to 20% by weight, preferably from 1 to 15% by weight, the content of a fluidity auxiliary is from 1 to 20% by weight, the content of a carrier is from 1 to 90% by weight, preferably from 1 to 70% by weight, based on the total amount of the pest control preparation of the present invention.
- a certain preparation such as an emulsion or wettable powder (e.g. water dispersible granule) is appropriately diluted with water (100 to 5000 times) when it is used.
- the compound (I) can be used as a pest control preparation for farmlands such as upland fields, paddy fields, turf or fruit orchards and uncultivated lands.
- farmlands such as upland fields, paddy fields, turf or fruit orchards and uncultivated lands.
- the compound (I) can control pests in a farmland where crops listed below are cultivated, without causing crop damage. "Crops"
- Agricultural crops corn, rice, wheat, barley, rye, Avena sativa, sorghum, cotton, soybean, peanut, buckwheat, sugar beet, rape, sunflower, sugarcane and tobacco Vegetables: solanaceous vegetables (e.g. eggplant, tomato, green pepper, chili pepper and potato) , cucurbitaceous vegetables (e.g. cucumber, pumpkin, zucchini, water melon and melon), brassicaceous vegetables (e.g. radish, turnip, western horseradish, kohlrabi, celery cabbage, cabbage, leaf mustard, broccoli and cauliflower) , asteraceous vegetables (e.g.
- solanaceous vegetables e.g. eggplant, tomato, green pepper, chili pepper and potato
- cucurbitaceous vegetables e.g. cucumber, pumpkin, zucchini, water melon and melon
- brassicaceous vegetables e.g. radish, turnip, western horseradish, kohlrabi, celery cabbage, cabbage, leaf mustard,
- liliaceous vegetables e.g. green onion, onion, garic and asparagus
- umbelliferous vegetables e.g. carrot, parsley, celery and parsnip
- chenopodiaceous vegetables spinach and chard
- labiate vegetables e.g. Japanese basil, mint and basil
- strawberry sweet potato, Japanese yam and aroid
- Fruits pomaceous fruits (e.g. apple, pear, Japanese pear, Chinese quince and quince), stone fruits (e.g. peach, plum, nectarine, Japanese apricot, yellow peach, apricot and prune), citrus fruits (e.g. satsuma orange, orange, lemon, lime and grapefruit), nuts (e.g. chestnut, walnut, aglet, almond, pistachio, cashew nut and macadamia nut) , berries (blueberry, cranberry, blackberry and raspberry) , grape, persimmon, olive, loquat, banana, coffee, date palm and coconut Trees other than fruit trees: tea, mulberry, flowering trees, roadside trees (e.g.
- the above crops include those provided with resistance against herbicides including a HPPD inhibitor such as isoxaflutole, ALS inhibitor such as imazethapyr and thifen sulfuronmethyl, EPSP synthesis enzyme inhibitor, glutamine synthesis enzyme inhibitor, acetyl CoA carboxylase inhibitor, and bromoxynyl, by a traditional breeding method or a gene recombinant technology.
- a HPPD inhibitor such as isoxaflutole
- ALS inhibitor such as imazethapyr and thifen sulfuronmethyl
- EPSP synthesis enzyme inhibitor glutamine synthesis enzyme inhibitor
- acetyl CoA carboxylase inhibitor acetyl CoA carboxylase inhibitor
- bromoxynyl by a traditional breeding method or a gene recombinant technology.
- Examples of the crops provided with resistance by a traditional breeding method include Clearfield ® , canola, which is resistant to an imidazolinone-based herbicide such as imazethapyr, and STS soybean, which is resistant to a sulfonyl urea ALS inhibitor-type herbicide such as thifen sulfuronmethyl .
- examples of a crop provided with resistance by a traditional breeding method include SR corn, which is resistant to an acetyl CoA carboxylase inhibitor such as trione oxime and aryloxy phenoxypropionic acid herbicides, and the like.
- the crops with resistance against the acetyl CoA inhibitor is fabricated by introducing such a mutated acetyl CoA carboxylase gene into a crop by means of a gene recombinant technology, or by introducing mutation relating to provision of resistance into acetyl CoA carboxylase of the crop.
- the above crops include those that enable to synthesize some kind of toxin selectively, known as genus Bacillus, by means of a gene recombinant technology.
- insecticidal toxin examples include insecticidal protein derived from Bacillus cereus and Bacillus popilliae; insecticidal protein such as ⁇ -endotoxin, e.g. CrylAb,
- the toxins expressed in such gene recombinant crops include a hybrid toxin of insecticidal proteins such as ⁇ - endotoxin, e.g. CrylAb, CrylAc, CrylF, CrylFa2, Cry2Ab, Cry3A, Cry3Bbl and Cry9C, VIPl, VIP2, VIP3 and VIP3A, partially deficient toxin and modified toxin.
- the hybrid toxin is formed by new combination of different domains of these proteins, by means of a gene recombinant technology.
- a typical example of the partially deficient toxin is CrylAb, in which a part of an amino acid sequence is deleted.
- a modified toxin is exemplified by a natural toxin, in which single or plural amino acids are substituted.
- toxin and gene recombinant plants that are able to synthesize the toxin are described in e.g. EP- A-0374753, WO93/07278, WO95/34656, EP-A-0427529, EP-A- 451878 and WO03/052073.
- the toxins contained in these gene recombinant plants provide resistance particularly against coleoptera pests, diptera pests and lepidoptera (butterfly and moth) pests.
- the above crops include those provided with capability of producing an anti-pathogenic substance having selective activities by means of a gene recombinant technology.
- the anti-pathogenic substances are exemplified by those produced by microorganisms, such as PR protein (PRPs, described in EP-A-0392225) ; ion channel inhibitors such as a sodium channel inhibitor and calcium channel inhibitor (KPl, KP4 and KP6 toxins produced by viruses are known) ; stilbene synthase; bibenzyl synthase; chitinase; glucanase; and a peptide antibiotic, an antibiotic having a hetero ring and protein factor related to plant disease resistance (called a plant disease resistant gene, and described in WO03/000906) .
- PR protein PRPs, described in EP-A-0392225
- ion channel inhibitors such as a sodium channel inhibitor and calcium channel inhibitor (KPl, KP4 and KP6 toxins produced by viruses are known)
- fungicides examples include fungicides, plant hormone agents, plant growth regulators, herbicides, insecticides, acaricides and nematocides which can be formulated together with the compound (I) are as follows.
- insecticides examples include:
- EPN EPN
- ethion ethoprophos, etrimfos, fenthion (MPP) , fenitrothion (MEP) , fosthiazate, formothion, hydrogen phosphide, isofenphos, isoxathion, malathion, mesulfenfos, methidathion (DMTP), monocrotophos, naled (BRP), oxydeprofos (ESP), parathion, phosalone, phosmet (PMP), pirimiphos-methyl, pyridafenthion, quinalphos, phenthoate
- PAP profenofos, propaphos, prothiofos, pyraclorfos, salithion, sulprofos, tebupirimfos, temephos, tetrachlorvinphos, terbufos, thiometon, trichlorphon (DEP) , vamidothion, and the like;
- Neonicotinoid compounds imidacloprid, nitenpyram, acetamiprid, thiamethoxam, thiacloprid, clothianidin, dinotefuran, and the like;
- Benzoylurea compounds chlorfluazuron, bistrifluron, diafenthiuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, and the like;
- Phenylpyrazzole compounds acetoprole, fipronil, " vaniliprole, pyriprole, pyrafluprole, and the like;
- Bt toxin insecticides living spores derived from Bacillus thuringiensis and crystalline toxin produced therefrom, as well as a mixture thereof;
- insecticides avermectin-B, bromopropylate, buprofezin, chlorphenapyr, cyromazine, 1, 3-dichloropropene, emamectin- benzoate, fenazaquin, flupyrazofos, hydroprene, indoxacarb, metoxadiazone, milbemycin-A, pymetrozine, pyridalyl, pyriproxyfen, spinosad, sulfluramide, tolfenpyrad, triazamate, flubendiamide, SI-0009, cyflumetofen, arsenic acid, benclothiaz, calcium cyanamide, calcium polysulfide, chlordane, DDT, DSP, flufenerim, flonicamide, flurimfen, formethanate, metam-ammonium, metam-sodium, methyl bromide, nidinotefuran, potassium o
- R 1 represents a methyl group, a chlorine atom, a bromine atom, or a fluorine atom
- R represents a fluorine atom, a chlorine atom, a bromine atom, a C 1 -4 haloalkyl group, or a C 1 - 4 haloalkoxy group
- R 3 represents a fluorine, chlorine or bromine atom
- R 4 represents a hydrogen atom, a Ci_ 4 alkyl group, a C 3 _ 4 alkenyl group, a C 3 - 4 alkynyl group, or a C 3 - 5 cycloalkyl group (the Ci_ 4 alkyl, C 3 _ 4 alkenyl, C 3 _ 4 alkynyl and C 3 - 5 cycloalkyl groups may be optionally substituted with one or more groups selected from a halogen atom, a cyano group, a methylthio group, a methanesulfinyl group
- arcaricides active components of arcaricides
- examples of arcaricides include: acequinocyl, amitraz, benzoximate, bifenazate, bromopropylate, chinomethionat, chlorobenzilate, CPCBS (chlorfenson) , clofentezine, cyflumetofen, dicofol, etoxazole, fenbutatin oxide, fenothiocarb, fenpyroximate, fluacrypyrim, fluproxyfen, hexythiazox, propargite (BPPS) , polynactins, pyridaben, pyrimidifen, tebufenpyrad, tetradifon, spirodiclofen, amidoflumet , cyenopyrafen, and the like.
- CPCBS chlorfenson
- clofentezine cyflumetofen
- nematocides active components of nematocides
- DCIP fosthiazate
- levamisol levamisol
- methyisothiocyanate morantel tartarate
- imicyafos and the like.
- fungicides include: acibenzolar-S-methyl, amobam, ampropylfos, anilazine, azoxystrobin, benalaxyl, benodanil, benomyl, benthiavalicarb, benthiazole, bethoxazin, bitertanol, blasticidin-S, Bordeaux mixture, boscalid, bromuconazole, buthiobate, calcium hypochlorite, calcium polysulfide, captan, carbendazol, carboxin, carpropamid, chlobenthiazone, chloroneb, chloropicrin, chlorothalonil (TPN) , chlorthiophos, cinnamaldehyde, clozylacon, CNA (2,6- dichloro-4-nitroaniline) , copper hydroxide, copper sulfate, cyazofamid, cyfluphenamid, cymoxanil,
- herbicides, plant hormone agents and plant growth regulators include: abscisic acid, acetochlor, acifluorfen-sodium, alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, aminoethoxyvinylglycine, aminopyralid, AC94 , 377, amiprofos-methyl, ancymidol, asulam, atrazine, aviglycine, azimsulfuron, beflubutamid, benfluralin, benfuresate, bensulfuron-methyl, bensulide (SAP), bentazone, benthiocarb, benzamizole, benzfendizone, benzobicyclon, benzofenap, benzyl adenine, benzylaminopurine, bialaphos, bifenox, Brassinolide, bromacil, bromobutide, butachlor, butafenacil, butam
- the pest control preparation of the -present invention can be used by mixing with a synergist such as piperonyl butoxide, sesamex, sulfoxide, N- (2-ethylhexyl) - 8.9, 10-torinorborn-5-ene-2, 3-dicaroboxyimide (MGK 264), N- declyimidazole, WARF-antiresistant, TBPT, TPP, IBP, PSCP, CH 3 I, t-phenylbutenone, diethylmaleate, DMC, FDMC, ETP, ETN, or the like.
- a synergist such as piperonyl butoxide, sesamex, sulfoxide, N- (2-ethylhexyl) - 8.9, 10-torinorborn-5-ene-2, 3-dicaroboxyimide (MGK 264), N- declyimidazole, WARF-antiresistant, TBPT, TPP, IBP, PSCP, CH 3 I,
- a safener such as benoxacor, cloquintocet-mexyl, cyometrinil, daimuron, dichlormid, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, mefenpyr-diethyl, MG191, naphthalic anhydride, oxabetrinil, or the like.
- the pest control preparation of the present invention can be used in the form of a mixture with external parasitic arthropod control agents such as a pyrethroid agent, IGR agent (e.g. juvenile hormone mimics such as methoprene and fenoxycarb, chitin synthesis inhibitors such as lufenuron, flufenoxuron, novalron, hexaflumuron, teflubenzron, diflubenzron and triflumuron, and insect growth regulators such as cyromazine and pyriproxyphen) , or neonicotinoid compounds (e.g. nitenpyram) .
- IGR agent e.g. juvenile hormone mimics such as methoprene and fenoxycarb
- chitin synthesis inhibitors such as lufenuron, flufenoxuron, novalron, hexaflumuron, teflubenzron, diflubenzron and triflumuron
- IGR agents for internal administration to animals or internal parasite control agents (e.g. macrolide compounds such as celamectin, ivermectin, milbemycin and moxidectin) . It can also be used in the form of a mixture with fungicides for animals, vaccines, curative drugs, nutritional supplements or feed.
- internal parasite control agents e.g. macrolide compounds such as celamectin, ivermectin, milbemycin and moxidectin.
- pests against which the compound (I) is effective include harmful arthropods such as harmful insects, harmful acaridae and the like. Specific examples thereof are as follows. Hemiptera :
- Delphacidae such as Laodelphax striatellus, Nilaparvata lugens, Sogatella furcifera, and the like; Deltocephalidae such as Nephotettix cincticeps, Nephotettix virescensm and the like; Aphididae such as Aphis gossypii, Myzus persicae, Brevicoryne brassicae, Macrosiphum euphorbiae, Aulacorthum solani, Rhopalosiphum padi, Toxoptera citricidus, and the like; Pentatomidae such as Nezara antennata, Riptortus clavetus, Leptocorisa chinensis, Eysarcoris parvus, Halyomorpha mista, and the like; Aleyrodidae such as Trialeurodes vaporariorum, Bemisia argentifolii, Bemisia
- Pyralidae such as Chilo suppressalis, Tryporyza incertulas, Cnaphalocrocis medinalis, Notarcha derogata, Plodia interpunctella, Ostrinia furnacalis, Hellula undalis, Pediasia teterrellus,* and the like; Noctudidae such as Spodoptera litura, Spodoptera exigua, Pseudaletia separata, Mamestra brassicae, Agrotis ipsilon, Plusia nigrisigna, Trichopulcia spp., Heliothis spp., Helicoverpha spp .
- Piperidae such as Pieris rapae, and the like
- Tortricidae such as Adoxophyes spp., Grapholita molesta, Leguminivora glycinivorella, Matsumuraeses azukivora, Adoxophyes orana fasciata, Adoxophyes spp., Homona magnanima, Archips fuscocupreanus, Cydia pomonella, and the like
- Gracillariidae such as Caloptilia theivora, Phyllonorycter ringoneella, and the like
- Carposinidae such as Carposina niponensis, and the like
- Lyonetiidae such as Lyonetia spp., and the like
- Lymantriidae such as Lymantria spp., Euproctis spp., and the like
- Yponomeutida such as Plutella x
- Thrips such as Frankliniella occidentalis, Thrips peri, Scirtothrips dorsalis, and Thrips tabaci, Frankliniella intonsa, etc.
- Dipteria Musca domestica, Culex popiens pallens, Tabanus trigonus, Hylemya antique, Hylemya platura, Anopheles sinensis, Agromyza oryzae, Hydrellia griseola, Chlorops oryzae, Dacus ' cucurbitae, Ceratitis capitata, Liriomyza trifolii, etc.
- Coleoptera Musca domestica, Culex popiens pallens, Tabanus trigonus, Hylemya antique, Hylemya platura, Anopheles sinensis, Agromyza oryzae, Hydrellia griseola, Chlorops oryzae, Dacus ' cucurbitae, Ceratitis capitata, Liriomyza trifolii, etc
- Orthoptera Locusta migratoria, Gryllotalpa africana, Oxya yezoensis, Oxya japonica, etc.
- Hymenoptera
- Nematode Aphelenchoides besseyi, Nothotylenchus acris, etc.
- Dyctyoptera
- Acarina Tetranychidae such as Tetranychus urticae, Panonychus citri, Oligonichus spp . , and the like; Eriophyidae such as Aculops pelekassi, and the like; Tarsonemidae such as Polyphagotarsonemus latus, and the like; Tenuipalpidae; Tuckerellidae; Ixodes spp.
- Haemaphysalis longicornis Haemaphysalis flava, Dermacentor taiwanicus, Ixodes ovatus, Ixodes persulcatus, Boophilus microplus, Rhipicephalus sanguineus, and the like
- Acaridae such as Tyrophagus putrescentiae, and the like, Dermatophagoides such as Dermatophagoides farinae, Dermatophagoides ptrenyssnus, and the like
- Cheyletus such as Cheyletus eruditus, Cheyletus malaccensis, Cheyletus moorei, and the like
- Dermanyssas spp. etc.
- the preparation comprising the compound (I) of the present invention or a salt thereof can also be used in the field of treatment of diseases of livestock and stock raising, and further, it can be used for exterminating arthropod or parasites that are parasitic inside and/or outside vertebrate such as human being, cattle, sheep, goat, pig, fowl, dog, cat, fish, and the like so as to maintain public hygiene.
- arthropod or parasites that are parasitic inside and/or outside vertebrate such as human being, cattle, sheep, goat, pig, fowl, dog, cat, fish, and the like so as to maintain public hygiene.
- these harmful pests includes Ixodes spp. (e.g. Ixodes scapularis), Boophilus spp. (e.g. Boophilus microplus), Amblyomma spp., Hyalomma spp., Rhipicephalus spp. (e.g.
- Rhipicephalus sanguineus Haemaphysalis spp. (e.g. Haemaphysalis longicornis), Dermacentor spp., Ornithodoros spp. (e.g. Ornithodoros moubata) , Dermahyssus gallinae, Ornithonyssus sylviarum, Sarcoptes spp. (e.g. Sarcoptes scabiei), Psoroptes spp., Chorioptes spp., Demodex spp., Eutrombicula spp., Aedes spp. (e.g.
- Aedes albopictus Anopheles spp., Culex spp., Culicodes spp., Musca spp., Hypoderma spp., Gasterophilus spp., Haematobia spp., Tabanus spp., Simulium spp., Triatoma spp., Phthiraptera (e.g. Damalinia spp., Linognathus spp., Haematopinus spp.), Ctenocephalides spp. (e.g.
- Trichostrongylus spp. e.g. Nippostrongylus brasiliensis, Trichostrongylus axei, Trichostrongylus colubriformis
- Trichinella spp. e.g. Trichinella spiralis
- Haemonchus spp. e.g. Haemonchus contortus
- Nematodirus spp. e.g. Nematodirus battus
- Ostertagia spp. e.g. Ostertagia circumcincta
- Cooperia spp. Hymenolepis nana, and the like.
- the compound (I) or its salt can be used as it is.
- the compound (I) or its salt is formulated into the above-mentioned pest control preparation of the present invention, and applied to pests or habitat thereof in the same manner as a conventional pest control preparation so that pests grown contact or ingest it.
- habitats of pests in the present invention inciude paddy fields, upland fields, fruit orchards, uncultivated lands and residential buildings.
- the application method examples include spray treatment, soil treatment, seed treatment and treatment of hydroponic water.
- the spray treatment in the present invention is such a treatment method that an active component (the compound (I) or its salt) is applied to a plant surface, such as foliage spray and truck spray, so as to exert a control effect on pests.
- the soil treatment is such a treatment method that soil or irrigation water is treated with the active component so that the active component can permeate and transfer into inside of crops to be protected from damages such as eating damage by pests from their roots.
- the soil treatment include planting hole treatment (planting hole spray, and soil incorporation after planting hole treatment) , strain root treatment (strain root spray, soil incorporation at strain root, strain root irrigation, and strain root treatment in a late seedling period) , planting groove treatment (planting groove spray, and soil incorporation at planting grooves), row treatment (row spray, soil incorporation at rows, and row spray in a growth period) , row treatment in a sowing period (row spray in a sowing period, and soil incorporation at rows in a sowing period) , overall treatment (overall soil treatment, and overall soil incorporation) , other soil spray treatment (foliar spray of a granular preparation in a growth period, spraying -under trunks or around main stems, soil surface spray, soil surface incorporation, sowing hole treatment, ridge surface spray, and inter-strain spray) , other irrigation treatment (soil irrigation, irrigation in a seedling period, instillation treatment, irrigation at a basal part, drip irrigation of an agrochemical solution, and
- the seed treatment is such a treatment method that the active component is applied directly to or in the vicinity of seeds, seed potatoes or bulbs of the crops to be protected from damages such as eating damage by pests, so as to exert a control effect on the pests.
- Specific examples thereof include spray, smear, immersion, impregnation, coating, film coat and pellet coat treatment.
- the hydroponic water treatment is such a treatment method that the active component is added to hydroponic water so that the active component can permeate and transfer into inside of crops to be protected from damages such as eating damage by pests from their roots.
- Specific examples thereof include hydroponic water mixing and hydroponic water infusion.
- the amount to be applied in these application methods can be varied depending on when, where and how the preparation is applied. In general, it is preferred that the preparation is applied so that the active component (the compound (I) or its salt) becomes from 0.3 to 3,000 g, preferably from 3 to 3,000 g, per hectare.
- the preparation can be diluted so that the concentration of the active component becomes 0.1 to 1,000 ppm, preferably from 10 to 500 ppm, when it is applied (dilution with water) .
- Another aspect of the present invention is to provide a method of internal (in the body) or external (on the body surface) administration of the pest control preparation of the present invention to a vertebrate, which enables systemic or non-systemic extermination of arthropod or parasites that inhabit in the vertebrate.
- the internal administration method includes oral administration, anal administration, implant, and subcutaneous, intramuscular and intravenous injection.
- the external administration method includes transcutaneous administration. It is also possible to feed livestock with the preparation so as to exterminate insanitary pests that emerge in the excretion of the livestock.
- the administration amount is greatly variable according to an administering method.
- the preparation is administered so that the active component (the compound (I) or the salt) becomes from 0.1 to 2,000 mg, preferably from 0.5 to 1,000 mg, per kg of the animal body weight.
- Ultrapack fill: silica gel
- YAMAZEN CO. YAMAZEN CO.
- the NMR spectra were taken by proton NMR with tetramethylsilane as an internal standard, using JEOL AL-400 (400MHz) -type and Bruker AVANCE 400 (400MHz) -type spectrometers. All the ⁇ values were shown by ppm. The measurement temperature was 25°C unless otherwise noted.
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Abstract
The present invention provides a thioimidate compound having an excellent control efficacy against pests, which is represented by the formula (I): wherein R represents a C6-12 bicycloalkyl group or a C1-3 alkyl group substituted with a C6-12 bicycloalkyl group; m represents an integer of 0 to 2; n represents an integer of 0 to 2; X represents a halogen atom, a C1-3 alkyl group, a C1-3 haloalkyl group a C1-4 alkoxy group, or a nitro group, and two X's are the same or different when m is 2; and Z represents a halogen atom, a C1-3 alkyl group, a C1-3 haloalkyl group, or a C1-4 alkoxy group, and two Z's are the same or different when n is 2.
Description
DESCRIPTION
THIOIMIDATE COMPOUND AND USE THEREOF FOR CONTROLLING PESTS
Technical Field
The present invention relates to a thioimidate compound and use thereof for controlling pests.
Background Art Various compounds have been studied and practically used for the purpose of controlling pests (specifically described in The Pesticide Manual (published by British
Crop Protection Council, 13th edition) ) .
JP 9-202766 A describes a thioimidate compound.
Disclosure of the Invention
An object of the present invention is to provide a compound which has an excellent control efficacy against pests . The present inventor have intensively studied and found that a thioimidate compound represented by the following formula (I) has an excellent control efficacy against pests, and thus the present invention has been completed. That is, the present invention provides:
[I) A thioimidate compound represented by the formula
(2) The thioimidate compound according to the above (1), wherein R in the formula (I) represents a C6-12 bicycloalkyl group;
(3) The thioimidate compound according to the above (1), wherein R in the formula (I) represents a bicyclo [4.4.0] decyl group; (4) A pest control preparation comprising the compound according to any one of the above (1) to (3) as an active component;
(5) Use of the compound according to any one of the
above (1) to (3) for controlling pests;
(6) Use of the compound according to any one of the above (1) to (3) for production of a pest control preparation; (7) A pest control method which comprises applying the compound according to any one of the above (1) to (3) to pests or habitats of pests; and the like.
The compound (I) has an excellent control efficacy against pests.
Best Mode for Carrying Out the Invention
Hereinafter, specific examples of the substituents used in the present invention will be illustrated.
Preferred examples of the Cβ-i2 bicycloalkyl group include Ce bicycloalkyl groups such as a bicyclo [3.1.0] -2- hexyl group of the formula:
C7 bicycloalkyl groups such as a bicyclo [4.1.0] -2-heptyl group, a bicyclo [4.1.0] -3-heptyl group, a bicyclo [3.2.0] -3- heptyl group, a bicyclo [2.2.1] -1-heptyl group, a bicyclo [2.2.1] -2-heptyl group and a bicyclo [2.2.1] -7-heptyl group of the formulas:
Cs bicycloalkyl groups such as a bicyclo [4.2.0] -3-octyl group, a bicyclo [3.3.0] -2-octyl group and a bicyclo [3.3.0] 3-octyl group of the formulas :
Cg bicycloalkyl groups such as a bicyclo [4.3.0] -2-nonyl group, a bicyclo [4.3.0] -3-nonyl group, a bicyclo [4.3.0] -7- nonyl group and a bicyclo [4.3.0] -8-nonyl group of the formulas :
and Cio bicycloalkyl groups such as a bicyclo [4.4.0] -2- decyl group and a bicyclo [4.4.0] -3-decyl group of the formulas :
with C7_io bicycloalkyl groups being preferred.
The "Ci-3 alkyl group" includes a methyl, ethyl, propyl or isopropyl group.
Preferred examples of the Ci_3 alkyl group substituted with a C6-i2 bicycloalkyl group include a (bicyclo [2.2.1] -1-
heptyl) methyl group, a (bicyclo [2.2.1] -2-heptyl) methyl group, a (bicyclo [2.2.1] -7-heptyl) methyl group, a (bicyclo [4.4.0] -2-decyl) methyl group, a (bicyclo [4.4.0] -3- decyl) methyl group, a 1- (bicyclo [4.4.0] -2-decyl) ethyl group and a 2- (bicyclo [4.4.0] -3-decyl) ethyl group.
The "halogen atom" includes a fluorine, chlorine, bromine or iodine atom.
Preferred examples of the C1-3 haloalkyl group include linear or branched alkyl groups substituted with at least one halogen atom, such as fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, bromomethyl, iodomethyl, pentafluoroethyl, 2, 2, 2-trifluoroethyl, and 2,2,2- trifluoro-1- (trifluoromethyl) ethyl groups .
The Ci-4 alkoxy group denotes a methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy or tert- butoxy group.
Preferred examples of the phenyl group substituted with (X) m include 4-fluorophenyl, 4-chlorophenyl, 4- bromophenyl, 4-methylphenyl, 4-trifluoromethylphenyl, 4- methoxyphenyl, 4-nitrophenyl, 3-fluorophenyl, 3- chlorophenyl, 3-bromophenyl, 3-methylphenyl, 3- trifluoromethylphenyl, 3-methoxyphenyl, 3-nitrophenyl, 2- fluorophenyl, 2-chlorophenyl, 2-bromophenyl, 2-methylphenyl, 2-trifluoromethylphenyl, 2-methoxyphenyl, 2-nitrophenyl, 3, 4-difluorophenyl, 3, 4-dichlorophenyl, 3, 4-dimethylphenyl,
3, 5-difluorophenyl, 3, 5-dichlorophenyl, 3, 5-dimethylphenyl, 2-fluoro-4-methylphenyl, 3-fluoro-4-methylphenyl, 2-chloro- 4-methylphenyl, 3-chloro-4-methylphenyl, 4-fluoro-2- methylphenyl, 2-chloro-4-trifluoromethylphenyl, 3-chloro-4- trifluoromethylphenyl, 2-fluoro-4-methoxyphenyl, 3-fluoro- 4-methoxyphenyl and 4-chloro-3-methoxyphenyl groups.
Preferred examples of a phenyl group substituted with (Z)n include 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-methylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl, 4- (tert-butoxy) phenyl, 3-fluorophenyl, 3-chlorophenyl, 3- bromophenyl, 3-methylphenyl, 3-trifluoromethylphenyl, 3- methoxyphenyl , 2-fluorophenyl, 2-chlorophenyl, 2- bromophenyl, 2-methylphenyl, 2-trifluoromethylphenyl, 2- methoxyphenyl, 3, 4-difluorophenyl, 3, 4-dichlorophenyl, 3,4- dimethylphenyl, 3, 5-difluorophenyl, 3, 5-dichlorophenyl, 3, 5-dimethylphenyl, 2-fluoro-4-methylphenyl, 3-fluoro-4- methylphenyl, 2-chloro-4-methylphenyl, 3-chloro-4- methylphenyl, 4-fluoro-2-methylphenyl, 4-fluoro-2- methylphenyl, 2-chloro-4-trifluoromethylphenyl, 3-chloro-4- trifluoromethylphenyl, 2-fluoro-4-methoxyphenyl, 3-fluoro- 4-methoxyphenyl and 4-chloro-3-methoxyphenyl groups.
Embodiments of the compound (I) include as follows: a thioimidate compound of the formula (I) wherein R is a C6-12 bicycloalkyl group; a thioimidate compound of the formula (I) wherein R is a
C7-I0 bicycloalkyl; a thioimidate compound of the formula (I) wherein R is a bicyclo [3.1.0] hexyl group, a bicyclo [4.1.0] heptyl group, bicyclo [3.2.0] heptyl group, a bicyclo [2.2.1] heptyl group, a bicyclo [3.3.0] octyl group, a bicyclo [4.2.0] octyl group, a bicyclo [4.3.0] nonyl group or a bicyclo [4.4.0] decyl group; a thioimidate compound of the formula (I) wherein R is a bicyclo [3.1.0] -2-hexyl group, a bicyclo [4.1.0] -2-heptyl group, a bicyclo [4.1.0] -3-heptyl group, a bicyclo [3.2.0] -3- heptyl group, a bicyclo f2.2.1] -1-heptyl group, a bicyclo[2.2.1] -2-heptyl group, a bicyclo [2.2.1] -7-heptyl group, a bicyclo [4.2.0] -3-octyl group, a bicyclo [3.3.0] -2- octyl group, a bicyclo [3.3.0] -3-octyl group, a bicyclo [4.3.0] -2-nonyl group, a bicyclo [4.3.0] -3-nonyl group, a bicyclo [4.3.0] -7-nonyl group, a bicyclo [4.3.0] -8- nonyl group, a bicyclo [4.4.0] -2-decyl group or a bicyclo f4.4.0] -3-decyl group; and a thioimidate compound of the formula (I) wherein R is a bicyclo [4.4.0] decyl group; and the following thioimidate compounds: bicyclo [4.4.0] -3-decyl 3- (3, 5-dichlorophenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0]-3-decyl 3- (4-chlorophenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- (4-methylphenylthio) -N-
(phenyl) thioacrylimidate; bicyclo[4.4.0]-3-decyl 3- (4-methoxγphenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- (3-chlorophenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- (3-methylphenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- (3-fluorophenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- (4-nitrophenylthio) -N- (phenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl N-phenyl-3- (3- trifluoromethylphenylthio) thioacrylimidate; bicyclo [4.4.0] -3-decyl N-phenyl-3- (4- trifluoromethylphenylthio) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- ( 4-fluorophenylthio) -N- (4- methylphenyl) thioacrylimidate; bicyclo [4.4.0] -3-decyl 3- ( 4-fluorophenylthio) -N- (phenyl) thioacrylimidate; and bicyclo [4.4.0] -3-decyl N- (4-chlorophenyl) -3- (4- fluorophenylthio) thioacrylimidate .
Hereinafter, a process for producing the compound (I] will be illustrated.
The compound (I) is produced by reacting a compound represented by the formula (II) :
wherein R, Z and n are as defined above (hereinafter referred to as the compound (II)), with a compound represented by the formula (III) :
In this reaction, the compound (III) can be used in an excessive amount, but is preferably from 0.8 to 5 equivalents, and more preferably from 0.8 to 1.2 equivalents, based on the compound (II) .
This reaction can be carried out in a reaction system containing the compound (II) and the compound (III) in the presence of a base. Examples of the base include alkali metal alcoholates such as sodium ethylate, sodium methylate and potassium tert-butoxide; nitrogen-containing compounds such as triethylamine, diisopropylethylamine, pyridine, 4- dimethylaminopyridine and N,N-dimethylaniline; carbonates such as potassium carbonate, sodium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate; hydroxides such as sodium hydroxide and potassium hydroxide; metal hydrides such as lithium hydride, sodium
hydride and potassium hydride; and organic lithium such as butyl lithium and lithium diisopropylamide . The amount of the base to be used is not particularly limited as long as it does not adversely affect the reaction. This reaction can be carried out in an appropriate solvent. Examples of the solvent include aliphatic hydrocarbons such as pentane, hexane, heptane and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; esters such as methyl acetate, ethyl acetate, ethyl formate and ethyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tetrahydrofuran and dioxane; nitriles such as acetonitrile and propionitrile; acid amides such as dimethylformamide and dimethylacetamide; sulfoxides such as dimethyl sulfoxide; sulfones such as sulfolane; phosphoric acid amides such as hexamethylphosphoramide; halogenated hydrocarbons such as dichloromethane, chloroform, 1, 2-dichloroethane and carbon tetrachloride; and aromatic amines such as pyridine, picoline, lutidine and quinoline. These solvents can be used alone or by a combination thereof, or used as a mixed solvent with water.
Usually, the reaction temperature is from -50 to 1500C, preferably from -20 to 120°C, and more preferably from -10 to 600C. The reaction time is usually from 0.1 to 96 hours,
and preferably from 0.1 to 24 hours.
After the completion of the reaction, the compound (I) can be isolated by a conventional workup procedure such as concentrating the reaction mixture; or pouring the reaction mixture into water, extracting it with an organic solvent, and concentrating the extract.
The resultant compound (I) can be purified by a conventional method such as distillation, reprecipitation, recrystallization or chromatography. Hereinafter, a process for producing a starting compound used for the production of the compound (I) will be illustrated.
The compound (II) is prepared from a compound of the formula (IV) :
The compound (IV) is prepared by reacting a compound of the formula (V) :
Me3Si C≡≡CH ( V )
(hereinafter referred to as the compound (V) ) with a compound of the formula (VI) :
wherein Z and n are as defined above (hereinafter referred to as the compound (VI)) usually in the presence of a base, followed by reacting the reaction product with a compound of the formula (VII) :
R-L ( vπ ) wherein R is as defined above, and L represents a leaving group (hereinafter referred to as the compound (VII)).
Examples of the leaving group represented by L in the formula (VII) include a halogen atom and a group represented by the formula: L2SO3, wherein L2 represents an optionally halogenated C1-3 alkyl group such as a methyl group or a trifluoromethyl group or a phenyl group which may be substituted with a C1-3 alkyl group.
In the reaction of the compound (V) with the compound (VI), the compound (VI) can be used in an excessive amount, but is preferably from 0.8 to 5 equivalents based on the compound (V) .
Examples of the base used for the reaction include alkali metal alcoholates such as sodium ethylate, sodium methylate and potassium tert-butoxide; nitrogen-containing
compounds such as triethylamine, diisopropylethylamine, pyridine, 4-dimethylaminopyridine and N, N-dimethylaniline; carbonates such as potassium carbonate, sodium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate; hydroxides such as sodium hydroxide and potassium hydroxide; metal hydrides such as lithium hydride, sodium hydride and potassium hydride; and organic lithium such as butyl lithium and lithium diisopropylamide . The amount of the base is preferably from 0.8 to 1.2 equivalents based on the compound (V) .
The reaction can be carried out in an appropriate solvent. Examples of the solvent include aliphatic hydrocarbons such as pentane, hexane, heptane and petroleum ether; aromatic hydrocarbons such as benzene, toluene and xylene; esters such as methyl acetate, ethyl acetate, ethyl formate and ethyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tetrahydrofuran and dioxane; nitriles such as acetonitrile and propionitrile; acid amides such as dimethylformamide and dimethylacetamide; sulfoxides such as dimethyl sulfoxide; sulfones such as sulfolane; phosphoric acid amides such as hexamethylphosphoramide; halogenated hydrocarbons such as dichloromethane, chloroform, 1, 2-dichloroethane and carbon tetrachloride; and aromatic amines such as pyridine,
picoline, lutidine and quinoline. These solvents can be used alone or by a combination thereof, or used as a mixed solvent with water.
Usually, the reaction temperature is from -100 to 1000C, and preferably from -80 to 800C. The reaction time is usually from 0.1 to 96 hours, preferably from 0.1 to 72 hours, and more preferably from 0.1 to 24 hours.
In the case of further reacting the compound (VII), the amount of the compound (VII) is preferably from 0.8 to 5 equivalents based on the compound (V) .
The reaction can be carried out in an appropriate solvent. It is possible to use the same solvent as shown in the reaction of the compound (V) and the compound (VI) .
Usually, the reaction temperature is from -50 to 2000C, preferably from -20 to 1500C, and more preferably from -10 to 12O0C. The reaction time is usually from 0.1 to 96 hours, preferably from 0.1 to 72 hours, and more preferably from 0.1 to 24 hours.
After the completion of the reaction, the compound (IV) can be isolated by a conventional workup procedure such as concentrating the reaction mixture; or pouring the reaction mixture into water, extracting it with an organic solvent, and concentrating the extract.
The resultant compound (IV) can be purified by a conventional method such as distillation, reprecipitation,
recrystallization or chromatography. Alternatively, the reaction mixture itself can be used as a starting material of a subsequent reaction.
The compound (IV) can be prepared by a known method described in Chem. Lett., p 1261, 1989.
The compound (I) can exist in the form of various isomers such as geometric isomers and stereoisomers. In the present invention, the compound (I) includes any of the respective isomers and a mixture thereof. The compound (I) has an excellent control efficacy against pests such as sanitary pests, animal parasitic pests and plant parasitic pests, and is effective for controlling these pests. The compound (I) exerts an excellent control effect by applying it directly to pests or habitats thereof (e.g. animals or plants where pests inhabit) .
When the compound (I) is used as a composition for control of pests, i.e., is used as a pest control preparation, it is usually formulated into an appropriate form that can be employed in a conventional pesticide or veterinary drug. That is, the compound (I) is dissolved or dispersed in an appropriate liquid carrier, mixed with an appropriate solid carrier or adsorbed in an appropriate solid carrier before application, to formulate into a preparation form such as emulsion, liquid preparation,
microemulsion, flowable preparation, oily preparation, wettable powder, powder, granule, fine granule, seed coating preparation, smoking preparation, tablet, microcapsule, air spray, aerosol propellant, carbon dioxide formulation, heat transpiration preparations such as mosquito coil, electric mosquito mat and electric mosquito liquid repellents, smoking preparation, EW preparation, ointment, poison bait, capsule, pellet, injectable solution, resin formulation and shampoo. Additives such as emulsifier, suspension, spreading agent, penetrant, moistening agent, tackifier and/or stabilizer can be added to the preparation as needed, and the composition can be produced according to a known method.
Examples of the liquid carrier used for the above preparations include water, alcohols (such as methyl alcohol, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, benzyl alcohol and ethylene glycol), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone) , ethers (such as tetrahydrofuran, ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and propylene glycol monomethyl ether), aliphatic hydrocarbons (such as kerosene, paraffin oil, fuel oil and machine oil), aromatic hydrocarbons (such as toluene, xylene, solvent naphtha and methylnaphthalene) , halogenated hydrocarbons (such as
dichloromethane, chloroform and carbon tetrachloride), acid amides (such as N, N-dimethylformamide, N, N- dimethylacetamide, N-methylpyrrolidone and N- octylpyrrolidone) , esters (such as ethyl acetate, butyl acetate, fatty acid glycerin ester and γ-butyrolactone) , nitriles (such as acetonitrile and propionitrile) , carbonates (such as propylene carbonate) , and vegetable oils (such as rapeseed oil, cotton seed oil, corn oil, safflower oil and orange oil) . These liquid carriers can be used by mixing one or more kinds (preferably one to three kinds) in an appropriate ratio.
Examples of the solid carrier (diluent/extender) used for the above preparations include vegetable powders (e.g. soybean powder, tobacco powder, wheat flour and wood flour) , mineral powders (e.g. clays such as kaolin, bentonite and acidic white clay, talcs such as talcum powder and pyrophyllite, silicas such as diatom earth and mica) , alumina, sulfur powder, active carbon, calcium carbonate, potassium chloride, ammonium sulfate, sodium hydrogen carbonate, lactose and urea. These solid carriers can be used by mixing one or more kinds (preferably one to three kinds) in an appropriate ratio.
Examples of the gaseous carrier used for the above preparations include fluorocarbon, butane gas, LPG (liquefied petroleum gas), dimethyl ether and carbon
dioxide. These gaseous monomer can be used by mixing one or two kinds in an appropriate ratio, or in combination with an appropriate liquid carrier.
Examples of the ointment base used for the above preparations include polyethylene glycol, pectin, polyhydric alcohol ester of a higher fatty acid such as monostearic acid glycerin ester, cellulose derivatives such as methyl cellulose, sodium alginate, bentonite, higher alcohol, polyhydric alcohols such as glycerin, vaseline, white vaseline, liquid paraffin, lard, various vegetable oils, lanoline, dehydrated lanoline, hardened oil and resins. These ointment bases can be used by mixing one or more kinds (preferably one to three kinds), or by adding a surfactant as described hereinafter. Examples of the surfactant, which is used for the above preparations as an emulsifier, spreading agent, penetrant or dispersant, include non-ionic and anionic surfactants such as soaps, polyoxyethylene alkyl aryl ether (e.g. Noigen and EA142 (trade names) manufactured by DAI- ICHI KOGYO SEIYAKU CO., LTD.; Nonal (trade name) manufactured by TOHO CHEMICAL INDUSTRY CO., LTD.), alkyl sulfate (e.g. Emal 10 (trade name) and Emal 40 (trade name) manufactured by KAO CORPORATION) , alkylbenzene sulfonate (e.g. Neogen (trade name) and Neogen T (trade name) manufactured by DAI-ICHI KOGYO SEIYAKU CO., LTD.; Neopelex
manufactured by KAO CORPORATION) , polyoxyethylene alkyl ether (e.g. Noigen ET-135 (trade name) manufactured by DAI- ICHI KOGYO SEIYAKU CO., LTD.), polyoxyethylene polyoxypropylene block polymer (e.g. NEWPOL PE-64 (trade name) manufactured by SANYO CHEMICAL INDUSTRIES, LTD.), polyhydric alcohol ester (e.g. Tween 20 (trade name) and Tween 80 (trade name) manufactured by KAO CORPORATION) , alkyl sulfosuccinate (e.g. SANMORIN OT 20 (trade name) manufactured by SANYO CHEMICAL INDUSTRIES, LTD.; Newkalgen EX70 (trade name) manufactured by TAKEMOTO OIL & FAT CO., LTD.) and alkenyl sulfonate (e.g. Sorpol 5115 (trade name) manufactured by TOHO CHEMICAL INDUSTRY CO., LTD.). These surfactants can be used by mixing one or more kinds (preferably one to three kinds) in an appropriate ratio. It is also possible that the compound (I) is mixed with other active components of pesticides, such as an insecticide (e.g. a pyrethroid insecticide, organic phosphorus insecticide, carbamate insecticide, neonicotinoid insecticide and natural insecticide) , acaricide, machine oil, nematocide, herbicide, plant hormone agent, plant growth regulator, fungicide (e.g. a copper fungicide, organic chlorine fungicide, organic sulfur fungicide and phenol fungicide) , synergist, attractant, repellent, safener, pigment, fertilizer, animal feed (e.g. feed for livestock such as cows, pigs and
chickens, feed for pet animals such as dogs and cats, and feed for farmed fishes such as yellowtail and sea bream) , medical supplies for animals (e.g. treatment and prevention drugs for livestock, pet animals and cultured fish) and nutritional supplement for animals.
The content of the compound (I) in the pest control preparation of the present invention is usually from 0.1 to 80% by weight, preferably from 1 to 20% by weight based on the total amount of the pest control preparation of the present invention. Specifically, the content is usually from 1 to 80% by weight, preferably from 1 to 20% by weight in the case of using the compound (I) as an emulsion, liquid preparation or wettable powder (e.g. water dispersible granule) . In the case of using it as an oil or powder preparation, usually, the content of from 0.1 to 50% by weight, preferably from 0.1 to 20% by weight is suitable. In the case of using it as a granular preparation, usually, the content of from 1 to 50% by weight, preferably from 1 to 20% by weight is suitable. Other active components of pesticides (e.g. insecticide, herbicide, acaricide and fungicide) , which may be mixed in the pest control preparation of the present invention is used in an amount of usually from 0.1 to 80% by weight, preferably from 1 to 20% by weight based on the total amount of the pest control preparation of the present
invention .
The content of additives other than the above active components is usually from 0.001 to 99.9% by weight, preferably from 1 to 99% by weight, although it varies depending on kinds and contents of the active components of a pesticide, and a form of a preparation. More specifically, the content of a surfactant is usually from 1 to 20% by weight, preferably from 1 to 15% by weight, the content of a fluidity auxiliary is from 1 to 20% by weight, the content of a carrier is from 1 to 90% by weight, preferably from 1 to 70% by weight, based on the total amount of the pest control preparation of the present invention. Preferably, a certain preparation such as an emulsion or wettable powder (e.g. water dispersible granule) is appropriately diluted with water (100 to 5000 times) when it is used.
The compound (I) can be used as a pest control preparation for farmlands such as upland fields, paddy fields, turf or fruit orchards and uncultivated lands. The compound (I) can control pests in a farmland where crops listed below are cultivated, without causing crop damage. "Crops"
Agricultural crops: corn, rice, wheat, barley, rye, Avena sativa, sorghum, cotton, soybean, peanut, buckwheat, sugar beet, rape, sunflower, sugarcane and tobacco
Vegetables: solanaceous vegetables (e.g. eggplant, tomato, green pepper, chili pepper and potato) , cucurbitaceous vegetables (e.g. cucumber, pumpkin, zucchini, water melon and melon), brassicaceous vegetables (e.g. radish, turnip, western horseradish, kohlrabi, celery cabbage, cabbage, leaf mustard, broccoli and cauliflower) , asteraceous vegetables (e.g. burdock, garland chrysanthemum, artichoke and lettuce), liliaceous vegetables (e.g. green onion, onion, garic and asparagus), umbelliferous vegetables (e.g. carrot, parsley, celery and parsnip), chenopodiaceous vegetables (spinach and chard), labiate vegetables (e.g. Japanese basil, mint and basil), strawberry, sweet potato, Japanese yam and aroid;
Flowers and ornamental plants : Foliage plants:
Fruits: pomaceous fruits (e.g. apple, pear, Japanese pear, Chinese quince and quince), stone fruits (e.g. peach, plum, nectarine, Japanese apricot, yellow peach, apricot and prune), citrus fruits (e.g. satsuma orange, orange, lemon, lime and grapefruit), nuts (e.g. chestnut, walnut, aglet, almond, pistachio, cashew nut and macadamia nut) , berries (blueberry, cranberry, blackberry and raspberry) , grape, persimmon, olive, loquat, banana, coffee, date palm and coconut Trees other than fruit trees: tea, mulberry, flowering
trees, roadside trees (e.g. ash, birch, dogwood, eucalypt, ginkgo, lilac, maple, oak, poplar, cercis, liquidambar, plane, zelkova, arborvitae, fir, hemlock fir, juniper, pine, spruce and yew The above crops include those provided with resistance against herbicides including a HPPD inhibitor such as isoxaflutole, ALS inhibitor such as imazethapyr and thifen sulfuronmethyl, EPSP synthesis enzyme inhibitor, glutamine synthesis enzyme inhibitor, acetyl CoA carboxylase inhibitor, and bromoxynyl, by a traditional breeding method or a gene recombinant technology.
Examples of the crops provided with resistance by a traditional breeding method include Clearfield®, canola, which is resistant to an imidazolinone-based herbicide such as imazethapyr, and STS soybean, which is resistant to a sulfonyl urea ALS inhibitor-type herbicide such as thifen sulfuronmethyl . In the same way, examples of a crop provided with resistance by a traditional breeding method include SR corn, which is resistant to an acetyl CoA carboxylase inhibitor such as trione oxime and aryloxy phenoxypropionic acid herbicides, and the like. Examples of the crops provided with resistance against the acetyl CoA carboxylase inhibitor are described in The Proceeding of The National Academy of Sciences of The United States of America (Proc. Natl. Acad. Sci . USA), Vol.87, P7175-7179,
1990. Mutated acetyl CoA carboxylase, which is resistant to the acetyl CoA carboxylase inhibitor, is reported in the Weed Science, Vol. 53, P728-746, 2005. The crops with resistance against the acetyl CoA inhibitor is fabricated by introducing such a mutated acetyl CoA carboxylase gene into a crop by means of a gene recombinant technology, or by introducing mutation relating to provision of resistance into acetyl CoA carboxylase of the crop.
As the crops provided with resistance by means of a gene recombinant technology, glyphosate and glufosinate resistant corn are exemplified. They have already been on the market with trade names of RoundupReady® and LibertyLink®.
The above crops include those that enable to synthesize some kind of toxin selectively, known as genus Bacillus, by means of a gene recombinant technology.
Examples of the insecticidal toxin, which is exhibited by gene recombinant plants, include insecticidal protein derived from Bacillus cereus and Bacillus popilliae; insecticidal protein such as δ-endotoxin, e.g. CrylAb,
CrylAc, CrylF, CrylFa2, Cry2Ab, Cry3A, Cry3Bbl and Cry9C, VIPl, VIP2, VIP3 and VIP3A derived from Bacillus thuringiensis; insecticidal protein derived from nematoda; toxin produced by animals such as scorpion toxin, spider toxin, wasp toxin and insect specific neurotoxin; toxin of
fungus; plant lectine; agglutinin; protease inhibitors such as trypsin inhibitor, serine protease inhibitor, patatin, cystatin and papain inhibitor; ribosome inactivation proteins (RIP) such as lysine, maize-RIP, abrin, saporin and bryodin; steroid metabolic enzymes such as 3- hydroxysteroid oxidase, ecdysteroid-UDP-glucosyl transferase and cholesterol oxidase; ecdysone inhibitor; HMG-CoA reductase; ion channel inhibitors such as a sodium channel inhibitor and calcium channel inhibitor; juvenile hormone esterase; diuretic hormone acceptor; stilbene synthase; bibenzyl synthase; chitinase; and glucanase.
The toxins expressed in such gene recombinant crops include a hybrid toxin of insecticidal proteins such as δ- endotoxin, e.g. CrylAb, CrylAc, CrylF, CrylFa2, Cry2Ab, Cry3A, Cry3Bbl and Cry9C, VIPl, VIP2, VIP3 and VIP3A, partially deficient toxin and modified toxin. The hybrid toxin is formed by new combination of different domains of these proteins, by means of a gene recombinant technology. A typical example of the partially deficient toxin is CrylAb, in which a part of an amino acid sequence is deleted. A modified toxin is exemplified by a natural toxin, in which single or plural amino acids are substituted.
Examples of the toxin and gene recombinant plants that are able to synthesize the toxin are described in e.g. EP-
A-0374753, WO93/07278, WO95/34656, EP-A-0427529, EP-A- 451878 and WO03/052073.
The toxins contained in these gene recombinant plants provide resistance particularly against coleoptera pests, diptera pests and lepidoptera (butterfly and moth) pests.
It has been already known that there is a gene recombinant plant that contains single or plural insecticidal pest resistant genes and produces single or plural toxins. Some of them are commercially available. Examples of the gene recombinant plants include YieldGard® (belong to a corn variety that expresses CrylAb toxin) , YieldGard Rootworm® (belong to a corn variety that expresses Cry3Bbl toxin) , YieldGard Plus® (belong to a corn variety that expresses CrylAb and Cry3Bbl toxins), Herculex I® (belong to a corn variety that expresses phosphinotricine N-acetyltransferase (PAT) for providing resistance against CrylFa2 toxin and glufosinate) , NuCOTN33B® (belong to a cotton variety that expresses CrylAc toxin) , Bollgard I® (belong to a cotton variety that expresses CrylAc toxin) , "Bollgard II® (belong to a cotton variety that expresses CrylAb and Cry2Ab toxins), VIPCOT® (belong to a cotton variety that expresses VIP toxin) , NewLeaf® (belong to a potato variety that expresses Cry3A toxin) , NatureGard® Agrisure® GT Advantage (GA21 glyphosate resistant trait) , Agrisure® CB Advantage (BtIl Corn Borer
(CB) trait) and Protecta®.
The above crops include those provided with capability of producing an anti-pathogenic substance having selective activities by means of a gene recombinant technology. The anti-pathogenic substances are exemplified by those produced by microorganisms, such as PR protein (PRPs, described in EP-A-0392225) ; ion channel inhibitors such as a sodium channel inhibitor and calcium channel inhibitor (KPl, KP4 and KP6 toxins produced by viruses are known) ; stilbene synthase; bibenzyl synthase; chitinase; glucanase; and a peptide antibiotic, an antibiotic having a hetero ring and protein factor related to plant disease resistance (called a plant disease resistant gene, and described in WO03/000906) . These anti-pathogenic substances and gene recombinant plants producing them are described in EP-A- 0392225, WO95/33818 and EP-A-0353191.
Examples of fungicides, plant hormone agents, plant growth regulators, herbicides, insecticides, acaricides and nematocides which can be formulated together with the compound (I) are as follows.
Examples of insecticides include:
(1) Organic phosphorus compounds aluminium phosphide, butathiofos, cadusafos, chlorethoxyfos, chlorfenvinphos, chlorpyrifos, chlorpyrifos-methyl, cyanophos (CYAP) , diazinon, DCIP
(dichlorodiisopropyl ether) , dichlofenthion (ECP) , dichlorvos (DDVP) , dimethoate, dimethylvinphos, disulfoton,
EPN, ethion, ethoprophos, etrimfos, fenthion (MPP) , fenitrothion (MEP) , fosthiazate, formothion, hydrogen phosphide, isofenphos, isoxathion, malathion, mesulfenfos, methidathion (DMTP), monocrotophos, naled (BRP), oxydeprofos (ESP), parathion, phosalone, phosmet (PMP), pirimiphos-methyl, pyridafenthion, quinalphos, phenthoate
(PAP), profenofos, propaphos, prothiofos, pyraclorfos, salithion, sulprofos, tebupirimfos, temephos, tetrachlorvinphos, terbufos, thiometon, trichlorphon (DEP) , vamidothion, and the like;
(2) Carbameta compounds alanycarb, bendiocarb, benfuracarb, BPMC, carbaryl, carbofuran, carbosulfan, cloethocarb, ethiofencarb, fenobucarb, fenothiocarb, fenoxycarb, furathiocarb, isoprocarb (MIPC) , metolcarb, methomyl, methiocarb, NAC, oxamyl, pirimicarb, propoxur (PHC), XMC, thiodicarb, xylylcarb, and the like; (3) Synthetic pyrethroid compounds acrinathrin, allethrin, benfluthrin, beta-cyfluthrin, bifenthrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, deltamethrin, esfenvalerate, ethofenprox, fenpropathrin, fenvalerate, flucythrinate, flufenoprox, flumethrin, fluvalinate, halfenprox, imiprothrin,
permethrin, prallethrin, pyrethrins, resmethrin, sigma- cyperinethrin, silafluofen, tefluthrin, tralomethrin, transfluthrin, 2,3,5, 6-tetrafluoro-4- (methoxymethyl) benzyl (EZ) - (IRS, 3RS; IRS, 3SR) -2 , 2-dimethyl-3-prop-l- enylcyclopropanecarboxylate, 2, 3, 5, 6-teterafluoro-4- methylbenzyl (EZ) - (IRS, 3RS; IRS, 3SR) -2, 2-dimethyl-3-prop-l- enylcyclopropanecarboxylate, 2,3,5, 6-tetrafluoro-4- (methoxymethyl) benzyl (IRS, 3RS; IRS, 3SR) -2, 2-dimethyl-3- (2- methyl-1-propenyl) cyclopropanecarboxylate, and the like; (4) Nereisetoxin compounds cartap, bensultap, thiocyclam, monosultap, bisultap, and the like;
(5) Neonicotinoid compounds imidacloprid, nitenpyram, acetamiprid, thiamethoxam, thiacloprid, clothianidin, dinotefuran, and the like;
(6) Benzoylurea compounds chlorfluazuron, bistrifluron, diafenthiuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, and the like;
(7) Phenylpyrazzole compounds acetoprole, fipronil, " vaniliprole, pyriprole, pyrafluprole, and the like;
(8) Bt toxin insecticides living spores derived from Bacillus thuringiensis and
crystalline toxin produced therefrom, as well as a mixture thereof;
(9) Hydrazine compounds chromafenozide, halofenozide, methoxyfenozide, tebufenozide, and the like;
(10) Organic chlorine-based compounds aldrin, dieldrin, dienochlor, endosulfan, methoxychlor and the like;
(11) Natural insecticides machine oil and nicotine-sulfate;
(12) Other insecticides avermectin-B, bromopropylate, buprofezin, chlorphenapyr, cyromazine, 1, 3-dichloropropene, emamectin- benzoate, fenazaquin, flupyrazofos, hydroprene, indoxacarb, metoxadiazone, milbemycin-A, pymetrozine, pyridalyl, pyriproxyfen, spinosad, sulfluramide, tolfenpyrad, triazamate, flubendiamide, SI-0009, cyflumetofen, arsenic acid, benclothiaz, calcium cyanamide, calcium polysulfide, chlordane, DDT, DSP, flufenerim, flonicamide, flurimfen, formethanate, metam-ammonium, metam-sodium, methyl bromide, nidinotefuran, potassium oleate, protrifenbute, spiromesifen, lepimectin, sulfur, metaflumizone, spirotetramat , NNI-0101, chlorantraniliprole, and a compound represented by the formula (A) : Formula (A) :
Examples of arcaricides (active components of arcaricides) include: acequinocyl, amitraz, benzoximate, bifenazate, bromopropylate, chinomethionat, chlorobenzilate, CPCBS (chlorfenson) , clofentezine, cyflumetofen, dicofol, etoxazole, fenbutatin oxide, fenothiocarb, fenpyroximate, fluacrypyrim, fluproxyfen, hexythiazox, propargite (BPPS) ,
polynactins, pyridaben, pyrimidifen, tebufenpyrad, tetradifon, spirodiclofen, amidoflumet , cyenopyrafen, and the like.
Examples of nematocides (active components of nematocides) include:
DCIP, fosthiazate, levamisol, methyisothiocyanate, morantel tartarate, imicyafos, and the like.
Examples of fungicides include: acibenzolar-S-methyl, amobam, ampropylfos, anilazine, azoxystrobin, benalaxyl, benodanil, benomyl, benthiavalicarb, benthiazole, bethoxazin, bitertanol, blasticidin-S, Bordeaux mixture, boscalid, bromuconazole, buthiobate, calcium hypochlorite, calcium polysulfide, captan, carbendazol, carboxin, carpropamid, chlobenthiazone, chloroneb, chloropicrin, chlorothalonil (TPN) , chlorthiophos, cinnamaldehyde, clozylacon, CNA (2,6- dichloro-4-nitroaniline) , copper hydroxide, copper sulfate, cyazofamid, cyfluphenamid, cymoxanil, cyproconazole, cyprodinil, cyprofuram, dazomet, debacarb, dichlofluanid, D-D (1, 3-dichloropropene) , diclocymet, diclomezine, diethofencarb, difenoconazole, diflumetorim, dimefluazole, dimethirimol, dimethomorph, • M (diniconazole-M) , dinocap, edifenphos, epoxiconazole, nickel dithiocarbamate, etaconazole, ethaboxam, ethirimol, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fendazosulam,
fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fentiazon, fentin hydroxide, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, fluoroiinide, fluotrimazole, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, fosetyl-Al, fthalide, fuberidazole, furalaxyl, furametpyr, furcarbanil, furconazole-cis, hexaconazole, hymexazol, IBP, imazalil, imibenconazole, iminoctadine-albesilate, iminoctadine- triacetate, iodocarb, ipconazole, iprodione, iprovalicarb, isoprothiolane, kasugamycin,- kresoxim-methyl, mancozeb, maneb, mepanipyriin, mepronil, metalaxyl, metalaxyl-M, metam-sodium, methasulfocarb, methyl bromide, metconazole, methfuroxam, metominostrobin, metrafenone, metsulfovax, mildiomycin, milneb, myclobutanil, myclozolin, nabam, orysastrobin, ofurace, oxadixyl, oxolinic acid, oxpoconazole, oxycarboxin, oxytetracycline, pefurazoate, penconazole, pencycuron, picoxystrobin, polycarbamate, polyoxin, potassium hydrogen carbonate, probenazole, prochloraz, procymidone, propamocarb-hydrochloride, propiconaole, propineb, proquinazid, prothiocarb, prothioconazole, pyracarbolid, pyraclostrobin, pyrazophos, pyributicarb, pyrifenox, pyrimethanil, pyroquilon, quinoxyfen, quintozene (PCNB), silthiopham, simeconazole, sipconazole, sodium bibarbonate, sodium hypochlorite, spiroxamine, SSF-129 ( (E) -2- [2- (2, 5-
dimethylphenoxymethyl ) phenyl] -2-methoxyimino-N- methylacetamide) , streptomycin, sulfur, tebuconazole, tecloftalam, tetraconazole, thiabendazole, thiadinil, thiram (TMTD) , thifluzamide, thiophanate-methyl, tolclofos- methyl, TPN, triadimefon, triadimenol, triazoxide, triclamide, tricyclazole, tridemorph, triflumizole, trifloxystrobin, triforine, triticonazole, validamycin, vinclozolin, viniconazole, zineb, ziram, zoxamide, amisulbrom, enestroburin, mandipropamid, meptyldinocap, and the like.
Examples of herbicides, plant hormone agents and plant growth regulators include: abscisic acid, acetochlor, acifluorfen-sodium, alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, aminoethoxyvinylglycine, aminopyralid, AC94 , 377, amiprofos-methyl, ancymidol, asulam, atrazine, aviglycine, azimsulfuron, beflubutamid, benfluralin, benfuresate, bensulfuron-methyl, bensulide (SAP), bentazone, benthiocarb, benzamizole, benzfendizone, benzobicyclon, benzofenap, benzyl adenine, benzylaminopurine, bialaphos, bifenox, Brassinolide, bromacil, bromobutide, butachlor, butafenacil, butamifos, butylate, cafenstrole, calcium carbonate, calcium peroxide, carbaryl, chlomethoxynil, chloridazon, chlorimuron-ethyl , chlorphthalim, chlorpropham, chlorsulfuron, chlorthal-dimethyl, chlorthiamid (DCBN),
choline chloride, cinidon-ethyl, cinmethylin, cinosulfuron, clethodim, clomeprop, cloxyfonac-sodium, chlormequat chloride, 4-CPA (4-chlorophenoxyacetic acid), cliprop, clofencet, cumyluron, cyanazine, cyclanilide, cyclosulfamron, cyhalofop-butyl, 2, 4-Dichlorophenoxyacetic acid salts, dichlorprop (2, 4-DP), daimuron, dalapon (DPA), dimethenamid-P, daminozide, dazomet, n-decyl alcohol, dicamba-sodium (MDBA) , dichlobenil (DBN) , diflufenican, dikegulac, dimepiperate, dimethametryn, dimethenamid, diquat, dithiopyr, diuron, endothal, epocholeone, esprocarb, ethephon, ethidiinuron, ethoxysulfuron, ethychlozate, etobenzanid, fenarimol, fenoxaprop-ethyl, fentrazamide, flazasulfuron, florasulam, fluazifop-butyl, fluazolate, flucarbazone, flufenacet, flufenpyr, flumetralin, flumioxazin, flupropanate-sodium, flupyrsulfuron-methyl- sodium, flurprimidol, fluthiacet-methyl, foramsulfuron, forchlorfenuron, formesafen, gibberellin, glufosinate, glyphosate, halosulfuron-methyl, hexazinone, imazamox, imazapic, imazapyr, imazaquin, imazosulfuron, inabenfide, indole acetic acid (IAA), indole butyric acid, iodosulfuron, ioxynil-octanoate, isouron, isoxachlortole, isoxadifen, karbutilate, lactofen, lenacil, linuron, LGC-42153, maleic hydrazide, mecoprop (MCPP) , 2-methyl-4-chlorophenoxyacetic acid salts, MCPA-thioethyl, 2-methyl-4- chlorophenoxybutanoic acid ethyl ester, mefenacet,
mefluidide, mepiquat, mesosulfuron, mesotrione, methyl daimuron, metolachlor, metribuzin, itietsulfuron-methyl, molinate, naphthylacetic acid, 1-naphthaleneacetamide, naproanilide, napropamide, n-decyl alcohol, nicosulfuron, n-phenylphthalamic acid, orbencarb, oxadiazon, oxaziclomefone, oxine-sulfate, paclobutrazol, paraquat, pelargonic acid, pendimethalin, penoxsulam, pentoxazone, pethoxamide, phenmedipham, picloram, picolinafen, piperonyl butoxide, piperophos, pretilachlor, primisulfuron-methyl, procarbazone, prodiamine, profluazol, profoxydim, prohexadione-calcium, prohydrojasmon, prometryn, propanil, propoxycarbazone, propyzamide, pyraflufen-ethyl, pyrazolate, pyrazosulfuron-ethyl, pyrazoxyfen, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac- methyl, pyrithiobac, quiclorac, quinoclamine, quizalofop- ethyl, rimsulfuron, sethoxydim, siduron, simazine, simetryn, sodium chlorate, sulfosulfuron, swep (MCC) , tebuthiuron, tepraloxydim, terbacil, terbucarb (MBPMC) , thenylchlor, thiazafluron, thiziazuron, thifensulfuron-methyl, triaziflam, tribufos, triclopyr, tridiphane, trifloxysulfuron, trifluralin, trinexapac-ethyl, tritosulfuron, uniconazole-P, vemolate (PPTC) , flucetosulfuron, orthosulfanuron, pinozaden, pyrasulfotole, tefuryltrione, tembotrione, thiencarbazone-methyl, and the like.
Further, the pest control preparation of the -present invention can be used by mixing with a synergist such as piperonyl butoxide, sesamex, sulfoxide, N- (2-ethylhexyl) - 8.9, 10-torinorborn-5-ene-2, 3-dicaroboxyimide (MGK 264), N- declyimidazole, WARF-antiresistant, TBPT, TPP, IBP, PSCP, CH3I, t-phenylbutenone, diethylmaleate, DMC, FDMC, ETP, ETN, or the like. In addition, it can be used by mixing with a safener such as benoxacor, cloquintocet-mexyl, cyometrinil, daimuron, dichlormid, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, mefenpyr-diethyl, MG191, naphthalic anhydride, oxabetrinil, or the like.
Furthermore, the pest control preparation of the present invention can be used in the form of a mixture with external parasitic arthropod control agents such as a pyrethroid agent, IGR agent (e.g. juvenile hormone mimics such as methoprene and fenoxycarb, chitin synthesis inhibitors such as lufenuron, flufenoxuron, novalron, hexaflumuron, teflubenzron, diflubenzron and triflumuron, and insect growth regulators such as cyromazine and pyriproxyphen) , or neonicotinoid compounds (e.g. nitenpyram) . It can also be used in the form of a mixture with the above IGR agents for internal administration to animals or internal parasite control agents (e.g. macrolide compounds such as celamectin, ivermectin, milbemycin and moxidectin) . It can also be used in the form of a mixture
with fungicides for animals, vaccines, curative drugs, nutritional supplements or feed.
Examples of pests against which the compound (I) is effective include harmful arthropods such as harmful insects, harmful acaridae and the like. Specific examples thereof are as follows. Hemiptera :
Delphacidae such as Laodelphax striatellus, Nilaparvata lugens, Sogatella furcifera, and the like; Deltocephalidae such as Nephotettix cincticeps, Nephotettix virescensm and the like; Aphididae such as Aphis gossypii, Myzus persicae, Brevicoryne brassicae, Macrosiphum euphorbiae, Aulacorthum solani, Rhopalosiphum padi, Toxoptera citricidus, and the like; Pentatomidae such as Nezara antennata, Riptortus clavetus, Leptocorisa chinensis, Eysarcoris parvus, Halyomorpha mista, and the like; Aleyrodidae such as Trialeurodes vaporariorum, Bemisia argentifolii, Bemisia tabaci, and the like; Coccidae such as Aonidiella aurantii, Comstockaspis perniciosa, Unaspis citri, Ceroplastes rubens, Icerya purchasi, and the like; Tingidae; Psyllidae; etc. Lipidoptera :
Pyralidae such as Chilo suppressalis, Tryporyza incertulas, Cnaphalocrocis medinalis, Notarcha derogata, Plodia interpunctella, Ostrinia furnacalis, Hellula undalis,
Pediasia teterrellus,* and the like; Noctudidae such as Spodoptera litura, Spodoptera exigua, Pseudaletia separata, Mamestra brassicae, Agrotis ipsilon, Plusia nigrisigna, Trichopulcia spp., Heliothis spp., Helicoverpha spp . , and the like; Piperidae such as Pieris rapae, and the like; Tortricidaesuch as Adoxophyes spp., Grapholita molesta, Leguminivora glycinivorella, Matsumuraeses azukivora, Adoxophyes orana fasciata, Adoxophyes spp., Homona magnanima, Archips fuscocupreanus, Cydia pomonella, and the like; Gracillariidae such as Caloptilia theivora, Phyllonorycter ringoneella, and the like; Carposinidae such as Carposina niponensis, and the like; Lyonetiidae such as Lyonetia spp., and the like, Lymantriidae such as Lymantria spp., Euproctis spp., and the like; Yponomeutida such as Plutella xylostella, and the like; Gelechiidae such as Pectinophora gossypiella, Phthorimaea operculella, and the like; Arctiidae such as Hyphantria cunea, and the like; Tineidae such as Tinea translucens, Tineola bisselliella, and the like, etc. Thysanoptera:
Thrips such as Frankliniella occidentalis, Thrips parmi, Scirtothrips dorsalis, and Thrips tabaci, Frankliniella intonsa, etc. Dipteria : Musca domestica, Culex popiens pallens, Tabanus
trigonus, Hylemya antique, Hylemya platura, Anopheles sinensis, Agromyza oryzae, Hydrellia griseola, Chlorops oryzae, Dacus' cucurbitae, Ceratitis capitata, Liriomyza trifolii, etc. Coleoptera:
Epilachna vigintioctopunctata, Aulacophora femoralis, Phyllotreta striolata, Oulema oryzae, Echinocnemus squameus, Lissorhoptrus oryzophilus, Anthonomus grandis, Callosobruchus chinensis, Sphenophorus venatus, Popillia japonica, Anomala cuprea, Diabrotica spp., Leptinotarsa decemlineata, Agriotes spp., Lasioderma serricorne, Anthrenus verbasci, Tribolium castaneum, Lyctus brunneus, Anoplophora malasiaca, Tomicus piniperda, etc.
Orthoptera : Locusta migratoria, Gryllotalpa africana, Oxya yezoensis, Oxya japonica, etc.
Hymenoptera :
Athalia rosae, Acromyrmex spp., Solenopsis spp., etc.
Nematode : Aphelenchoides besseyi, Nothotylenchus acris, etc.
Dyctyoptera :
Blattella germanica, Periplaneta fuliginosa, Periplaneta americana, Periplaneta brunnea, Blatta orientalis, etc. Acarina:
Tetranychidae such as Tetranychus urticae, Panonychus citri, Oligonichus spp . , and the like; Eriophyidae such as Aculops pelekassi, and the like; Tarsonemidae such as Polyphagotarsonemus latus, and the like; Tenuipalpidae; Tuckerellidae; Ixodes spp. such as Haemaphysalis longicornis, Haemaphysalis flava, Dermacentor taiwanicus, Ixodes ovatus, Ixodes persulcatus, Boophilus microplus, Rhipicephalus sanguineus, and the like; Acaridae such as Tyrophagus putrescentiae, and the like, Dermatophagoides such as Dermatophagoides farinae, Dermatophagoides ptrenyssnus, and the like; Cheyletus such as Cheyletus eruditus, Cheyletus malaccensis, Cheyletus moorei, and the like; Dermanyssas spp.; etc.
The preparation comprising the compound (I) of the present invention or a salt thereof can also be used in the field of treatment of diseases of livestock and stock raising, and further, it can be used for exterminating arthropod or parasites that are parasitic inside and/or outside vertebrate such as human being, cattle, sheep, goat, pig, fowl, dog, cat, fish, and the like so as to maintain public hygiene. Examples of these harmful pests includes Ixodes spp. (e.g. Ixodes scapularis), Boophilus spp. (e.g. Boophilus microplus), Amblyomma spp., Hyalomma spp., Rhipicephalus spp. (e.g. Rhipicephalus sanguineus, Haemaphysalis spp. (e.g. Haemaphysalis longicornis),
Dermacentor spp., Ornithodoros spp. (e.g. Ornithodoros moubata) , Dermahyssus gallinae, Ornithonyssus sylviarum, Sarcoptes spp. (e.g. Sarcoptes scabiei), Psoroptes spp., Chorioptes spp., Demodex spp., Eutrombicula spp., Aedes spp. (e.g. Aedes albopictus), Anopheles spp., Culex spp., Culicodes spp., Musca spp., Hypoderma spp., Gasterophilus spp., Haematobia spp., Tabanus spp., Simulium spp., Triatoma spp., Phthiraptera (e.g. Damalinia spp., Linognathus spp., Haematopinus spp.), Ctenocephalides spp. (e.g. Ctenocephalides felis) , Xenosylla spp., Monomorium pharaonis, and Nematode such as Trichostrongylus spp. (e.g. Nippostrongylus brasiliensis, Trichostrongylus axei, Trichostrongylus colubriformis, Trichinella spp. (e.g. Trichinella spiralis, Haemonchus spp. (e.g. Haemonchus contortus, Nematodirus spp. (e.g. Nematodirus battus ) , Ostertagia spp. (e.g. Ostertagia circumcincta) , Cooperia spp., Hymenolepis nana, and the like.
In the pest control method of the present invention, the compound (I) or its salt can be used as it is. Alternatively, the compound (I) or its salt is formulated into the above-mentioned pest control preparation of the present invention, and applied to pests or habitat thereof in the same manner as a conventional pest control preparation so that pests grown contact or ingest it. Examples of habitats of pests in the present invention
inciude paddy fields, upland fields, fruit orchards, uncultivated lands and residential buildings.
Examples of the application method include spray treatment, soil treatment, seed treatment and treatment of hydroponic water. Specifically, the spray treatment in the present invention is such a treatment method that an active component (the compound (I) or its salt) is applied to a plant surface, such as foliage spray and truck spray, so as to exert a control effect on pests. The soil treatment is such a treatment method that soil or irrigation water is treated with the active component so that the active component can permeate and transfer into inside of crops to be protected from damages such as eating damage by pests from their roots. Specific examples of the soil treatment include planting hole treatment (planting hole spray, and soil incorporation after planting hole treatment) , strain root treatment (strain root spray, soil incorporation at strain root, strain root irrigation, and strain root treatment in a late seedling period) , planting groove treatment (planting groove spray, and soil incorporation at planting grooves), row treatment (row spray, soil incorporation at rows, and row spray in a growth period) , row treatment in a sowing period (row spray in a sowing period, and soil incorporation at rows in a sowing period) , overall treatment (overall soil treatment, and overall soil
incorporation) , other soil spray treatment (foliar spray of a granular preparation in a growth period, spraying -under trunks or around main stems, soil surface spray, soil surface incorporation, sowing hole treatment, ridge surface spray, and inter-strain spray) , other irrigation treatment (soil irrigation, irrigation in a seedling period, instillation treatment, irrigation at a basal part, drip irrigation of an agrochemical solution, and chemigation) , seedling box treatment (seedling box spray, and seedling box irrigation) , seedling tray treatment (seedling tray spray, and seedling tray irrigation) , nursery bed treatment (nursery bed spray, nursery bed irrigation, lowland nursery bed spray, and seedling immersion) , bed soil incorporation treatment (bed soil incorporation, and bed soil incorporation before sowing) , and other treatment (listing incorporation, plowing and fertilizing, surface soil incorporation, soil incorporation under canopy edge, planting position treatment, flower cluster treatment with a granule formulation, and paste fertilizer incorporation) . The seed treatment is such a treatment method that the active component is applied directly to or in the vicinity of seeds, seed potatoes or bulbs of the crops to be protected from damages such as eating damage by pests, so as to exert a control effect on the pests. Specific examples thereof include spray, smear, immersion,
impregnation, coating, film coat and pellet coat treatment. The hydroponic water treatment is such a treatment method that the active component is added to hydroponic water so that the active component can permeate and transfer into inside of crops to be protected from damages such as eating damage by pests from their roots. Specific examples thereof include hydroponic water mixing and hydroponic water infusion.
The amount to be applied in these application methods can be varied depending on when, where and how the preparation is applied. In general, it is preferred that the preparation is applied so that the active component (the compound (I) or its salt) becomes from 0.3 to 3,000 g, preferably from 3 to 3,000 g, per hectare. When the pest control preparation of the present invention is a wettable powder, preferably, the preparation can be diluted so that the concentration of the active component becomes 0.1 to 1,000 ppm, preferably from 10 to 500 ppm, when it is applied (dilution with water) . Another aspect of the present invention is to provide a method of internal (in the body) or external (on the body surface) administration of the pest control preparation of the present invention to a vertebrate, which enables systemic or non-systemic extermination of arthropod or parasites that inhabit in the vertebrate. The internal
administration method includes oral administration, anal administration, implant, and subcutaneous, intramuscular and intravenous injection. The external administration method includes transcutaneous administration. It is also possible to feed livestock with the preparation so as to exterminate insanitary pests that emerge in the excretion of the livestock.
When the pest control preparation of the present invention is applied to livestock or pet animals with pests living in, the administration amount is greatly variable according to an administering method. In general, it is preferred that the preparation is administered so that the active component (the compound (I) or the salt) becomes from 0.1 to 2,000 mg, preferably from 0.5 to 1,000 mg, per kg of the animal body weight.
Hereinafter, the present invention will be further illustrated in detail by way of Production Examples, Reference Production Examples, Formulation Examples and Test Examples. However, the present invention is not limited thereto.
Elution of column chromatography in Examples and Reference Production Examples was carried out with monitoring by TLC (thin layer chromatography) . The monitor by TLC was conducted by using Kieselgel 60F254 (70 to 230 mesh) manufactured by MERCK & CO., LTD. as a TLC plate, the
same solvent as the elution solvent used in the column chromatography as a developing solvent, and a UV detector for detection. Silica gel 60 manufactured by KANTO CHEMICAL CO., LTD. (spherical shape, particle size of 63 to 210 niti) was used as the silica gel of the column, and Florisil (100 to 200 mesh) manufactured by WAKO PURE CHEMICAL INDUSTRIES LTD. was used for the florisil of the column. As a medium pressure preparative HPLC, Ultrapack (filler: silica gel) manufactured by YAMAZEN CO. was used. When a mixed solvent was used as a developing solvent, the mixing ratio was indicated by volume in brackets . The NMR spectra were taken by proton NMR with tetramethylsilane as an internal standard, using JEOL AL-400 (400MHz) -type and Bruker AVANCE 400 (400MHz) -type spectrometers. All the δ values were shown by ppm. The measurement temperature was 25°C unless otherwise noted.
Abbreviations and terms used in the following Production Examples and Reference Production Examples mean as follows . s: singlet, br; broad, brs : broad singlet, d: doublet, t: triplet, q: quartet, Me: methyl group, Et: ethyl group, Ph: phenyl group, Pr-n (or n-Pr) : propyl group, Pr-i (or i-Pr or 1Pr) : isopropyl group, Pr-cyclo (or cyclo-Pr) : cyclopropyl group, Bu-n (or n-Bu) : butyl group, Bu-i (or i- Bu) : isobutyl group, Bu-s (or s-Bu) : sec-butyl group, Bu-t
(or t-Bu) : tert-butyl group, THF: tetrahydrofran, DMF: dimethylformamide, room temperature: about 15 to '25°C
Specific examples of the compound (I) are as follows.
Compounds 3-1 to 3-6690, wherein R represents a bicyclo [4.3.0] -2-nonyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 4-1 to 4-6690, wherein R represents a bicyclo [4.3.0] nonan-3-yl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 5-1 to 5-6690, wherein R represents a bicyclo [4.3.0] -7-nonyl group, and the geometric isomer at the double bonds of (X)1n, (Z)n and CH=CH is the following
"combination G";
Compounds 6-1 to 6-6690, wherein R represents a bicyclo [4.3.0] -8-nonyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 7-1 to 7-6690, wherein R represents a bicyclo [ 4.2.0] -2-octyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G"; Compounds 8-1 to 8-6690, wherein R represents a bicyclo [4.2.0] -3-octyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G"; Compounds 9-1 to 9-6690, wherein R represents a bicyclo [ 4.2.0] -7-octyl group, and the geometric isomer at the double bonds of (X) ra, (Z)n and CH=CH is the following "combination G";
Compounds 10-1 to 10-6690, wherein R represents a bicyclo [4.1.0] -2-heptyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 11-1 to 11-6690, wherein R represents a bicyclo [4.1.0] -3-heptyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 12-1 to 12-6690, wherein R represents bicyclo [4.1.0] -7-heptyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G"; Compounds 13-1 to 13-6690, wherein R represents a bicyclo [3.3.0] -2-octyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G"; Compounds 14-1 to 14-6690, wherein R represents a bicyclo [3.3.0] -3-octyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 15-1 to 15-6690, wherein R represents a bicyclo [3.2.0] -2-heptyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 16-1 to 16-6690, wherein R represents a bicyclo [3.2.0] -3-heptyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 17-1 to 17-6690, wherein R represents a bicyclo [3.2.0] -6-heptyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G"; Compounds 18-1 to 18-6690, wherein R represents a
bicyclo [3.1.0] -2-hexyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 19-1 to 19-6690, wherein R represents a bicyclo [3.1.0] -3-hexyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 20-1 to 20-6690, wherein R represents a bicyclo [3.1.0] -6-hexyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 25-1 to 25-6690, wherein R represents a (bicyclo [4.4.0] -2-decyl) methyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 26-1 to 26-6690, wherein R represents (bicyclo [4.4.0] -3-decyl) methyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the ' following "combination G"; Compounds 27-1 to 27-6690, wherein R represents a
(bicyclo [3.3.0] -2-octyl) methyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G"; Compounds 28-1 to 28-6690, wherein R represents (bicyclo [3.3.0] -3-octyl) methyl group, and the geometric
isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 29-1 to 29-6690, wherein R represents a (bicyclo [4.3.0] -7-nonyl) methyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 30-1 to 30-6690, wherein R represents a (bicyclo [4.3.0] -8-nonyl) methyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 31-1 to 31-6690, wherein R represents a (bicyclo [4.1.0] -2-heptyl) methyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G"; Compounds 32-1 to 32-6690, wherein R represents a
(bicyclo [4.1.0] -3-heptyl) methyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G"; Compounds 33-1 to 33-6690, wherein R represents a (bicyclo [2.2.1] -2-heptyl) methyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 34-1 to 34-6690, wherein R represents a 1- (bicyclo [4.4.0] -2-decyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the
following "combination G";
Compounds 35-1 to 35-6690, wherein R represents a 1-
(bicyclo [4.4.0] -3-decyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 36-1 to 36-6690, wherein R represents a 1-
(bicyclo [3.3.0] -2-octyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the foll'owing "combination G"; Compounds 37-1 to 37-6690, wherein R represents a 1-
(bicyclo [3.3.0] -3-octyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 38-1 to 38-6690, wherein R represents a 1- (bicyclo [4.3.0] -7-nonyl) ethyl group, and the geometric isomer at the double bonds of (X)n,, (Z)n and CH=CH is the following "combination G";
Compounds 39-1 to 39-6690, wherein R represents a 1-
(bicyclo [4.3.0] -8-nonyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 40-1 to 40-6690, wherein R represents a 1- (bicyclo [4.1.0] -2-heptyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 41-1 to 41-6690, wherein R represents 1- (bicyclo [4.1.0] -3-heptyl) ethyl group, and the geometric isomer at the double bonds of (X)1n, (Z)n and CH=CH is the following "combination G"; Compounds 42-1 to 42-6690, wherein R represents a 1-
(bicyclo [2.2.1] -2-heptyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G"; Compounds 43-1 to 43-6690, wherein R represents a 2- (bicyclo [4.4.0] -2-decyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 44-1 to 44-6690, wherein R represents a 2- (bicyclo [4.4.0] -3-decyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 45-1 to 45-6690, wherein R represents a 2- (bicyclo [3.3.0] -2-octyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 46-1 to 65-6690, wherein R represents a 2- (bicyclo [3.3.0] -3-octyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G"; Compounds 47-1 to 47-6690, wherein R represents a 2-
(bicyclo [4.3.0] -7-nonyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 48-1 to 48-6690, wherein R represents a 2- (bicyclo [4.3.0] -8-nonyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 49-1 to 49-6690, wherein R represents a 2- (bicyclo [4.1.0] -2-heptyl) ethyl group, and the geometric isomer at the double bonds of (X)m, (Z)n and CH=CH is the following "combination G";
Compounds 50-1 to 50-6690, wherein R represents a 2- (bicyclo [ 4.1.0] -3-heptyl ) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G";
Compounds 51-1 to 51-6690, wherein R represents a 2- (bicyclo [2.2.1] -2-heptyl) ethyl group, and the geometric isomer at the double bonds of (X) m, (Z)n and CH=CH is the following "combination G". • "Combination G"
[Compound Branch Number: (X) m, (Z)n, Geometric isomers of the double bond in CH=CH] =
C-1:H,H,E] , [-2:4-F,H,E] , [-3:4-F,H,Z] , [-4 : 4-Cl , H, E] , (- 5:4-Cl,H,z] , [-6 : 4-Br, H, E] , [-7:4-1, H, E] , [-8 : 4-Me, H, E] , [-9:4-Me,H,Z] , (-10 : 4-Et, H, E] , [-11 : 4-C3 H7 , H, E] , (-12:4-
(Me) 2 CH, H, E ] , [ -13 : 4-CF3 , H, E ] , [ -14 : 4-CF3, H, Z ] , [-15:4-
C2F5,H,E] , [-16.4-C3F7, H,E] , [-17 : 4- (CF3 ) 2 CF, H, E] , [-18:4-
(CF3 )2CH,H,E) , [-19.4-CHF2, H, E] , [-20 : 4-CH2 F, H, E] , [-21:4-
CF3CH2, H, E) , [-22:4-MeO,H,E] , [ -23 : 4-MeO, H, Z ] , [-24:4- EtO, H, E] , [-25:4-C3H7O,H,E] , [-26 : 4- (Me) 2 CHO, H, E] , [-27:4-
NO2, H, E] , C-28:4-NO2 ,H,Z] , [-29 : 3-F, H, E] , [-30 : 3-F, H, Z] ,
[-31:3-C1,H,E] , [-32 : 3-Cl, H, z] , [-33 : 3-Br, H, E] , [-34:3-
I, H, E] , [-35:3-Me,H,E] , [-36 : 3-Me, H, z] , [-37 : 3-Et , H, E] ,
[-38:3-C3H7 ,H,E] , [-39 : 3- (Me) 2 CH, H, E] , [-40 : 3-CF3 , H, E] , [-41:3-CF3,H,Z] , [-42 : 3-C2 F5 , H, E] , [-43 : 3-C3 F7 , H, E] , [-
44:3- (CF3 )2CF,H,E ] , [ -45 : 3- (CF3 ) 2 CH, H, E ] , [ -46:3-
CHF2, H, E] , C-47:3-CHF2 ,H,Z] , [ -48 : 3-CH2 F, H, E ] , [-49:3-
CH2F, H, Z] , [-50:3-CF3CH2 ,H,E] , [ -51 : 3-MeO, H, E ] , [-52:3-
MeO, H, Z] , [ -53:3-EtO,H,E ] , [ -54 : 3-C3 H7 O, H, E ] , [-55:3- (Me)2CHO, H, E] , [ -56 : 3-NO2 , H, E ] , [ -57 : 2-F, H, E ] , [-58:2-
Cl, H, E] , [-59:2-Br,H,E] , [-60 : 2-1, H, E] , [-61 : 2 -Me, H, E] ,
[-62:2-Et,H,E] , [-63 : 2-C3 H7 , H, E] , [-64 : 2- (Me) 2 CH, H, E] , [-
65:2-CF3 ,H,E] , [-66 : 2-C2 F5 , H, E] , [-67 : 2-C3 F7 , H, E] , [-68:2-
(CF3 )2CF,H,E] , [-69:2-(CF3 )2CH,H,E] , [-70 : 2-CHF2 , H, E] , [- 71:2-CH2F,H,E] , [ -72 : 2-CF3 CH2 , H, E 3 , [ -73 : 2-MeO, H, E ] , [-
74:2-EtO,H,E] , [-75 : 2-C3 H7 O, H, E] , [-76 : 2- (Me) 2 CHO, H, E] , [-
77:2-NO2 ,H,E] , [ -78 : 2 , 3-F2 , H, E ] , [ -79 : 2 , 4-F2 , H, E ] , [-
80:2, 5-F2 , H, E] , [ -81 : 2 , 6-F2 , H, E ] , [ -82 : 3, 4-F2 , H, E ] , [-
83:3, 4-F2 , H, Z] , [ -84 : 3, 5-F2 , H, E ) , [ -85 : 3, 5-F2 , H, Z ] , [- 86:2, 3-Cl2 , H, E] , [-87-: 2, 3-Cl2 , H, z] , [-88 : 2, 4-Cl2 , H, E] , [-
89:2, 4-Cl2, H, Z] , [-90 : 2, 5-Cl2 , H, E] , [-91 : 2 , 5-Cl2 , H, Z] , [-
92:2, 6-Cl2, H, E] , [-93 : 3, 4-Cl2 , H, E] , [-94 : 3, 5-Cl2 , H, E] , [-
95:2, 3-Br2 , H, E) , [-96 : 2 , 4-Br2 , H, E] , [-97 : 2, 5-Br2 , H, E) , [-
98:2, 6-Br2 , H, E] , [-99 : 3, 4-Br2 , H, E] , [-100:3, 5-Br2 , H, E] , [- 101:2, 3-Me2 , H, E) , [-102 : 2, 4-Me2 , H, E) , [-103 : 2, 5-Me2 , H, E] ,
[ -104:2, 6-Me2 , H, E ) , [ -105 : 3, 4-Me2 , H, E ) , [ -106:3,5-
Me2, H, E] , [ -107:2, 3-Et2 , H, E ) , [ -108 : 2, 4-Et2 , H, E ) , [ -
109:2, 5-Et2 , H, E) , [-110 : 2, 6-Et2 , H, E] , [-111 : 3, 4-Et2 , H, E] ,
[ -112:3, 5-Et2, H, E ) , [ -113 : 2, 3- (CF3 ) 2 , H, E ) , [ -114:2,4- (CF3)2, H, E) , [-115:2, 5-(CF3J2, H, E] , [-116 : 2 , 6- (CF3 ) 2 , H, E) ,
[-117:3, 4-(CF3J2, H, E) , [ -118 : 3, 5- (CF3 ) 2 , H, E ) , [-119:2,3-
(CHF2)2, H, E ) , [ -120:2, 4- (CHF2 )2, H, E ) , [ -121:2,5-
(CHF2) 2, H, E ) [ -122:2, 6-(CHF2 J2 , H, E ) , -123:3,4-
(CHF2 J2, H, E ) [ -124:3, 5-(CHF2 )2 , H, E ) , -125:2,3-
(CH2F)2 , H, E ) [ -126:2, 4-(CH2F)2 , H, E ) , -127:2,5-
(CH2F)2 , H, E ) [ -128:2, 6-(CH2F)2 , H, E ) -129:3,4- (CH2F)2, H, E ) , C -130:3, 5-(CH2F)2, H, E ) , [ -131:2,3- (MeO)2, H, E) , [-132:2,4- (MeO)2 , H, E) , [-133 : 2 , 5- (MeO) 2 , H, E) , [-134:2, 6-(MeO)2 , H, E) , [-135:3, 4- (MeO) 2 , H, E] , [-136:3,5- (MeO)2, H, E) , [-137 : 2, 3- (EtO) 2 , H, E) , [-138 : 2, 4- (EtO) 2 , H, E) ,
[-139:2,5- (EtO)2 , H, E) , [-140:2, 6- (EtO) 2 , H, E] , [-141:3,4- (EtO)2, H, E) , [-142:3, 5-(EtO)2 , H, E) , [-143 : 2-C1-3-F, H, E] , [-144:2-Cl-4-F,H,E] , [ -145 : 2-C1-5-F, H, E ) , [ -146: 2-C1-6- F, H, E) , [-147:3-Cl-2-F,H,E] , [-148 : 3-C1-4-F, H, E] , [-149:3- Cl-5-F,H,E) , [-150:4-Cl-2-F,H,E] , [-151 : 4-C1-3-F, H, E] , [-
152:2-F-3-Me,H,E ] , C -153 : 2-F-4-Me, H, E ) , [ -154:2-F-5- Me, H, E] , [ -155:2-F-6-Me,H,E ] , [ -156: 3-F-2-Me,H,E ] , C- 157:3-F-4-Me,H,E ] , [ -158 : 3-F-5-Me, H, E ] , [ -159.4-F-2- Me, H, E] , [-160:4-F-3-Me,H,E] , [ -161 : 2-Cl-3-Me, H, E ] , [- 162:2-Cl-4-Me,H,E] , [ -163 : 2-Cl-5-Me, H, E ] , [ -164 : 2-C1-6-
Me, H, E] , [-165:3-Cl-2-Me,H,E] , [ -166 : 3-Cl-4-Me, H, E ] , [- 167:3-Cl-5-Me,H,E ] , [ -168 : 4-Cl-2-Me, H, E ] , [ -169 : 4-C1-3- Me, H, E] , [-170:2-F-3-CF3,H,E] , [ -171 : 2-F-4-CF3 , H, E ] , [- 172:2-F-5-CF3 ,H,E ] , [ -173 : 2-F-6-CF3 , H, E ] , [ -174.3-F-2- CF3, H, E] , C-175:3-F-4-CF3 ,H,E] , C -176 : 3-F-5-CF3 , H, E] , (-
177:4-F-2-CF3 ,H,E ] , [ -178 : 4-F-3-CF3 , H, E ] , [ -179 : 2-C1-3- CF3, H, E] , [-180-2-C1-4-CF3 ,H,E] , C-181:2-Cl-5-CF3 , H, E] , [- 182:2-Cl-6-CF3 ,H,E] , [-183 : 3-Cl-2-CF3 , H, E] , [-184 : 3-C1-4- CF3, H, E] , [-185.3-Cl-S-CF3^E] , [-186 : 4-Cl-2-CF3 , H, E] , C- 187:4-Cl-3-CF3 ,H,E] , [-188 : 2-Me-3-CF3 , H, E] , [-189 : 2-Me-4-
CF3, H, E] , [-190:2-Me-5-CF3 ,H,E] , [-191 : 2-Me-6-CF3 , H, E] , [- 192:3-Me-2-CF3 ,H,E] , [-193 : 3-Me-4-CF3 , H, E] , [-194 : 3-Me-5- CF3, H, E] , [-195:4-Me-2-CF3 ,H,E] , [-196 : 4-Me-3-CF3 , H, E] , [- 197:2-F-3-MeO,H,E ] , [ -198 : 2-F-4-MeO, H, E ] , [ -199.2-F-5- MeO, H, E] , [-200 : 2-F-6-MeO, H, E] , (-201 : 3-F-2-MeO, H, E] , [-
202:3-F-4-MeO,H,E ] , [ -203 : 3-F-5-MeO, H, E ] , [ -204.4-F-2- MeO, H, E] , C-205:4-F-3-MeO,H,E] , (-206 : 2-Cl-3-MeO, H, E] , [- 207:2-Cl-4-MeO,H,E] , [-208 : 2-Cl-5-MeO, H, E] , [-209 : 2-C1-6- MeO, H, E] , [-210:3-Cl-2-MeO,H,E] , [-211 : 3-Cl-4-MeO, H, E] , [- 212:3-Cl-5-MeO,H,E] , (-213 : 4-Cl-2-MeO, H, E] , (-214 : 4-C1-3-
MeO, H, E) , C-215:2-Me-3-MeO,H,E] , [-216 : 2-Me-4-MeO, H, E] , [-
217:2-Me-5-MeO,H,E] , [-218 : 2-Me-6-MeO, H, E] , [-219 : 3-Me-2-
- MeO, H, E"] , [-220:3-Me-4-MeO,H,E] , [-221 : 3-Me-5-MeO, H, E] , [-
222:4-Me-2-MeO,H,E ] , [ -223 : 4-Me-3-MeO, H, E ] , [ -224:H,4- F, E] , [-225:4-F,4-F,E] , [ -226 : 4-F, 4-F, Z ] , [ -227 : 4-Cl, 4-
F, E] , [-228:4-Cl,4-F,Z] , [-229 : 4-Br, 4-F, E] , [-230:4-1,4-
F, E] , C-231:4-Me,4-F,E] , [-232 : 4-Me, 4-F, Z] , [-233 : 4-Et, 4-
F, E] , [ -234:4--C3H7 ,4-F,E] , [ -235 : 4- (Me) 2 CH, 4-F, E ] , [-
236:4-CF3,4-F,E] , [-237 : 4-CF3 , 4-F, Z] , [-238 : 4-C2 F5 , 4-F, E] , [ -239:4-C3F7 ,4-F,E ] , [ -240 : 4- (CF3 ) 2 CF, 4-F, E ] , [-241:4-
(CF3 )2CH,4-F,E] , [-242:4-CHF2 ,4-F,E] , [-243 : 4-CH2 F, 4-F, E] ,
[-244:4-CF3CH2 ,4-F,E] , [-245 : 4-MeO, 4-F, E] , [-246 : 4-MeO, 4-
F,Z] , [-247:4-EtO,4-F,E] , [ -248 : 4-C3 H7 O, 4-F, E] , [-249:4-
(Me)2CHO, 4-F, E] , [-250 : 4-NO2 , 4-F, E] , [ -251 : 4-NO2 , 4-F, Z ] , [-252:3-F,4-F,E] , [-253 : 3-F, 4-F, Z] , [-254 : 3-Cl, 4-F, E] , [-
255:3-Cl,4-F,Z] , [-256 : 3-Br, 4-F, E] , [-257 : 3-1, 4-F, E] , [-
258:3-Me,4-F,E] , [-259 : 3-Me, 4-F, z] -, [-260 : 3-Et, 4-F, E] , [-
261.3-C3H7 ,4-F,E] , [ -262 : 3- (Me) 2 CH, 4-F, E] , [-263 : 3-CF3 , 4-
F, E] , [-264:3-CF3,4-F,Z] , [ -265 : 3-C2 F5 , 4-F, E ] , [-266:3- . C3F7, 4-F, E] , [-267:3- (CF3 )2CF, 4-F, E] , [ -268 : 3- (CF3 ) 2 CH, 4-
F,E] , [-269:3-CHF2 ,4-F,E] , [ -270 : 3-CHF2 , 4-F, Z ] , [-271:3-
CH2F, 4-F, E] , [-272:3-CH2F,4-F,Z] , [ -273 : 3-CF3 CH2 , 4-F, E] ,
[ -274:3-MeO,4-F,E ] , [ -275 : 3-MeO, 4-F, Z ] , [ -276 : 3-EtO, 4-
F,E] , [-277:3-C3H7O,4-F,E] , [ -278 : 3- (Me) 2 CHO, 4-F, E ] , [- 279:3-NO2 ,4-F,E] , [-280 : 2-F, 4-F, E] , [-281 : 2-Cl, 4-F, E] , [-
282:2-Br,4-F,E] , [-283 :2-I, 4-F, E] , [-284 : 2-Me, 4-F, E] , [■
285:2-Et,4-F,E] , [ -286 : 2-C3 H7 , 4-F, E ] , [ -287 : 2- (Me) 2 CH, 4- F, E] , [-288.2-CF3, 4-F, E] , [ -289 : 2-C2 F5 , 4-F, E ] , (-290:2-
C3F7, 4-F, E] , [-291.2-(CF3 )2CF,4-F,E] , [ -292 : 2- (CF3 ) 2 CH, 4- F, E] , [-293:2-CHF2 ,4-F,E] , [ -294 : 2-CH2 F, 4-F, E] , [-295:2-
CF3CH2 , 4-F, E] , [-296:2-MeO, 4-F,E] , [-297 : 2-EtO, 4-F, E] , [■
298:2-C3H7O,4-F,E ] , [ -299 : 2- (Me) 2 CHO, 4-F, E ] , ( -300:2-
NO2, 4-F, E] , [-301:2, 3-F2 , 4-F, E] , [-302 : 2 , 4-F2 , 4-F, E] , (■
303:2, 5-F2, 4-F, E] , [ -304 : 2, 6-F2 , 4-F, E ] , [ -305 : 3, 4-F2 , 4- F,E] , [-306:3, 4-F2 , 4-F, Z] , [-307 : 3, 5-F2 , 4-F, E] , [-308:3,5-
F2, 4-F, Z] , [-309:2, 3-Cl2 , 4-F, E] , [-310 : 2, 3-Cl2 , 4-F, Z] , [- 311:2, 4-Cl2, 4-F, E] , [-312 : 2 , 4-Cl2 , 4-F, z] , [-313 : 2, 5-Cl2 , 4- F, E] , [ -314:2, 5-Cl2 , 4-F, Z ] , [ -315 : 2 , 6-Cl2 , 4-F, E ] , [ - 316:3, 4-Cl2 , 4-F, E] , [-317 : 3 , 5-Cl2 , 4-F, E] , (-318 : 2, 3-Br2 , 4- F, E] , [ -319:2, 4-Br2 , 4-F, E ] , [ -320 : 2, 5-Br2 , 4-F, E ] , [ -
321:2, 6-Br2 , 4-F, E] , [-322 : 3, 4-Br2 , 4-F, E] , [-323 : 3, 5-Br2 , 4- F, E] , [ -324:2, 3-Me2, 4-F, E ] , [ -325 : 2 , 4-Me2 , 4-F, E ] , [ - 326:2, 5-Me2 , 4-F, E] , [-327 : 2, 6-Me2 , 4-F, E] , [-328 : 3, 4-Me2 , 4- F,E] , [ -329:3, 5-Me2 , 4-F, E ] , [ -330 : 2, 3-Et2 , 4-F, E ] , [ - 331:2, 4-Et2 , 4-F, E] , [-332 : 2 , 5-Et2 , 4-F, E] , [-333 : 2, 6-Et2 , 4-
F, E] , [ -334:3, 4-Et2 , 4-F, E ] , [ -335 : 3, 5-Et2 , 4-F, E ] , [ - 336:2, 3-(CF3 )2 , 4-F, E] , [-337 : 2 , 4- (CF3 ) 2 , 4-F, E] , [-338:2,5- (CF3)2,4-F,E ] , [ -339:2, 6- (CF3 )2 , 4-F, E ] , [ -340:3,4- (CF3)2,4-F,E ] , [ -341.3,5-(CF3J2, 4-F,E ] , [ -342:2,3- (CHF2 )2 ,4-F,E ] , [ -343 : 2 , 4- (CHF2 ) 2 , 4-F, E ] , [ -344:2,5-
(CHF2 )2 ,4-F,E ] , C -345:2, 6- (CHF2 )2 , 4-F, E 3 , ( -346:3,4- (CHF2 )2, 4-F, E 3 , [ -347:3, 5-(CHF2 )2, 4-F, E 3 , [ -348:2,3-
(CH2F)2, 4-F, E 3 [ -349:2, 4-(CH2F)2, 4-F, E 3 [ -350:2,5- (CH2F)2, 4-F, E 3 [ -351:2, 6-(CH2F)2 ,4-F,E ] C -352:3,4- (CH2 F) 2, 4-F, E ] [ -353:3,5- (CH2F)2 , 4-F, E ] ( -354:2,3-
(MeO)2 ,4-F,E 3 [ -355:2,4- (MeO)2 , 4-F, E ] C -356:2,5- (MeO)2, 4-F, E ] [ -357:2,6- (MeO)2 , 4-F, E ] , [ -358:3,4- (MeO)2 ,4-F,E 3 C -359:3, 5-(MeO)2, 4-F, E 3 , [ -360:2,3- (EtO)2, 4-F, E ] [ -361:2,4- (EtO)2 , 4-F, E 3 , C -362:2,5- ((EEttOO))22,, 44--FF,, EE ]J [ -363:2, 6-(EtO)2 , 4-F, E 3 , [ -364:3,4- (EtO)2 , 4-F, E] , [-365:3,5- (EtO)2 , 4-F, E] , ( -366 : 2-C1-3-F, 4- F,E3 , C-367:2-C1-4-F,4-F,E3 , [ -368 : 2-C1-5-F, 4-F, E 3 , [- 369:2-C1-6-F, 4-F,E3 , [-370 : 3-C1-2-F, 4-F, E3 , (-371 : 3-C1-4- F, 4-F, E] , C-372:3-Cl-5-F,4-F,E] , [-373 : 4-C1-2-F, 4-F, E] , [- 374 :4-C1'-3-F, 4-F,E3 ,, [ -375 : 2-F-3-Me, 4-F, E ] , [ -376 : 2-F-4- Me,4-F,E3 , (-377:2-F-5-Me,4-F,E3 , [-378 : 2-F-6-Me, 4-F, E3 , [-379:3-F-2-Me,4-F,E3 , [-380 : 3-F-4-Me, 4-F, E] , [-381.3-F- 5-Me,4-F,E3 , [-382 : 4-F-2-Me, 4-F, E3 , [-383 : 4-F-3-Me, 4-F, E3 ,
[-384:2-Cl-3-Me,4-F,E3 , [-385 : 2-Cl-4-Me, 4-F, E3 , [-386:2- Cl-5-Me,4-F,E3 , [-387 : 2-Cl-6-Me, 4-F, E3 , (-388 : 3-Cl-2-Me, 4- F,E3 , (-389:3-Cl-4-Me,4-F,E3 , (-390 : 3-Cl-5-Me, 4-F, E3 , C- 391:4-Cl-2-Me,4-F,E3 -, [-392 : 4-Cl-3-Me, 4-F, E] , [-393:2-F-3- CF3, 4-F, E ] , [ -394:2-F-4-CF3 ,4-F,E 3 , ( -395 : 2-F-5-CF3 , 4- F,E3 , (-396:2-F-6-CF3 ,4-F,E3 , (-397 : 3-F-2-CF3 , 4-F, E3 , C- 398:3-F-4-CF3 , 4-F,E3 , [-399 : 3-F-5-CF3 , 4-F, E3 , [-400:4-F-2-
CF3, 4-F, E] , [ -401:4-F-3-CF3 f 4-F,E] , [ -402 : 2-Cl-3-CF3 , 4- F, E] , [-403:2-Cl-4-CF3 ,4-F,E] , [-404 : 2-Cl-5-CF3 , 4-F, E] , C- 405:2-Cl-6-CF3 ,4-F,E] , [ -406 : 3-Cl-2-CF3 , 4-F, E ] , [-407:3- Cl-4-CF3 ,4-F,E ] , [ -408:3-Cl-5-CF3 ,4-F,E ] , [-409:4-01-2- CF3, 4-F, E] , [-4IO.4-CI-3-CF3 ,4-F,E] , [ -411 : 2-Me-3-CF3 , 4-
F,E] , [-412:2-Me-4-CF3 , 4-F,E] , [-413 : 2-Me-5-CF3 , 4-F, E] , [- 414:2-Me-6-CF3 ,4-F,E] , [ -415 : 3-Me-2-CF3 , 4-F, E ] , [-416:3- Me-4-CF3 ,4-F,E ] , [ -417:3-Me-5-CF3 ,4-F,E ] , [ -418 : 4-Me-2- CF3, 4-F, E] , [ -419:4-Me-3-CF3 , 4-F, E ] , [ -420 : 2-F-3-MeO, 4- F,E] , [-421:2-F-4-MeO,4-F,E] , [-422 : 2-F-5-MeO, 4-F, E] , [-
423:2-F-6-MeO,4-F,E] , [-424 : 3-F-2-MeO, 4-F, E] , [-425:3-F-4- MeO, 4-F, E ] , [ -426:3-F-5-MeO, 4-F, E ] , [ -427 : 4-F-2-MeO, 4- F, E] , [-428:4-F-3-MeO,4-F,E] , [-429 : 2-Cl-3-MeO, 4-F, E] , [- 430:2-Cl-4-MeO,4-F,E] , [ -431 : 2-Cl-5-MeO, 4-F, E ] , [-432:2- Cl-6-MeO,4-F,E ] , [ -433 : 3-01-2-MeO, 4-F, E ] , [-434:3-01-4-
MeO, 4-F, E] , [-435:3-Cl-5-MeO,4-F,E] , [ -436 : 4-Cl-2-MeO, 4- F,E] , [-437:4-Cl-3-MeO,4-F,E] , [-438 : 2-Me-3-MeO, 4-F, E] , [- 439:2-Me-4-MeO,4-F,E] , [ -440 : 2-Me-5-MeO, 4-F, E ] , [-441:2- Me-6-MeO, 4-F, E ] , [ -442 : 3-Me-2-MeO, 4-F, E ] , [ -443 : 3-Me-4- MeO, 4-F, E] , [ -444 : 3-Me-5-MeO, 4-F, E ] , [ -445 : 4-Me-2-MeO, 4-
F, E] , [-446:4-Me-3-MeO,4-F,E] , [-447 :H, 4-Cl, E] , [-448:4- F,4-C1,E] , [-449:4-F,4-Cl,Z] , [-450 : 4-Cl, 4-Cl, E] , [-451:4- C1,4-C1,Z] , [ -452:4-Br,4-Cl,E ] , [ -453 : 4-1, 4-Cl, E ] , [- 454:4-Me,4-Cl,E] , [-455 : 4 -Me, 4-Cl, z] , [-456 : 4-Et, 4-Cl, E] , C-457:4-C3H7,4-Cl,E] , [ -458 : 4- (Me) 2 CH, 4-Cl, E ] , [-459:4-
CF3 ,4-Cl, E] , [-460:4-CF3 ,4-Cl,Z] , [-461 : 4-C2 F5 , 4-Cl, E] , [-
462:4-C3F7,4-Cl,E ] , [ -463 : 4- (CF3 ) 2 CF, 4-Cl,E ] , [ -464:4-
(CF3 )2CH,4-C1,E ] , [ -465:4-CHF2 ,4-C1,E] , [ -466 : 4-CH2 F, 4-
Cl, E] , [-467:4-CF3CH2,4-Cl,E] , [ -468 : 4-MeO, 4-Cl,E ] , [- 469:4-MeO,4-Cl,Z] , [ -470 : 4-EtO, 4-Cl, E ] , [ -471 : 4-C3 H7 O, 4-
Cl, E] , [-472:4-(Me)2CHO,4-Cl,E] , [-473 : 4-NO2 , 4-Cl, E] , [-
474:4-NO2,4-Cl,Z] , [-475 : 3-F, 4-Cl, E] , [-476 : 3-F, 4-Cl, Z ] ,
[ -477:3-Cl,4-Cl,E ] , [ -478 : 3-Cl, 4-Cl , Z ] , [ -479 : 3-Br , A-
Cl, E] , [-480:3-1, 4-Cl, E] , [ -481 : 3-Me, 4-Cl, E ] , [-482:3- Me, 4-Cl, Z] , [-483 : 3-Et, 4-Cl, E] , [-484 : 3-C3 H7 , 4-Cl, E] , [-
485.3-(Me)2CH, 4-Cl, E] , [-486 : 3-CF3 , 4-Cl, E] , [-487 : 3-CF3 , 4- Cl, Z] , [-488.3-C2F5, 4-Cl, E] , [ -489 : 3-C3 F7 , 4-Cl, E ] , [- 490:3-(CF3)2CF,4-Cl,E] , [-491 : 3- (CF3 ) 2 CH, 4-Cl, E] , [-492:3- CHF2, 4-Cl, E] , C-493:3-CHF2,4-Cl,Z] , [-494 : 3-CH2 F, 4-Cl, E] , [ -495:3-CH2F,4-Cl,Z ] , [ -496 : 3-CF3 CH2 , 4-Cl, E ] , [-497:3-
MeO, 4-Cl, E] , [-498 : 3-MeO, 4-Cl, z] , [-499 : 3-EtO, 4-Cl, E] , [- 500:3-C3H7O,4-Cl,E ] , [ -501 : 3- (Me) 2 CHO, 4-Cl, E ] , [-502:3- NO2, 4-Cl, E] , [-503:2-F, 4-Cl,E] , [ -504 : 2-Cl, 4-Cl, E ] , [- 5O5:2-Br,4-C1,E] , [-506:2-1, 4-Cl, E] , [-507 : 2-Me, 4-Cl, E] , [ -5O8:2-Et,4-C1,E ] , [ -509 : 2-C3 H7 , 4-Cl, E ] , [ -510:2-
(Me)2CH, 4-Cl, E ] , [ -511 : 2-CF3 , 4-Cl, E ] , [ -512 : 2-C2 F5 , 4- Cl, E] , C-513:2-C3F7 ,4-Cl,E] , [-514 :2- (CF3 ) 2 CF, 4-Cl, E] , [- 515:2-(CF3)2CH,4-C1,E ] , [ -516 : 2-CHF2 , 4-Cl, E ] , [ -517:2- CH2F, 4-Cl, E] , [-518:2-CF3CH2 ,4-Cl,E] , [-519 : 2-MeO, 4-Cl, E] , [ -520:2-EtO,4-Cl,E ] , [ -521 : 2-C3 H7 O, 4-Cl, E ] , [ -522:2-
(Me) 2 CHO, 4 -Cl, E ] , [ -523 : 2-NO2 , 4-Cl , E ] , [ -524 : 2, 3-F2 , 4- Cl, E] , [ -525:2, 4-F2 ,4-Cl, E ] , [ -526 : 2 , 5-F2 , 4-Cl, E ] , [- 527:2, 6-F2 ,4-Cl, E] , [-528 : 3, 4-F2 , 4-Cl, E] , [-529 : 3, 4-F2 , 4- Cl, Z] , [ -530:3, 5-F2 , 4-Cl, E ] , [ -531 : 3, 5-F2 , 4-Cl, Z ] , [- 532:2, 3-Cl2 , 4-Cl, E ] , [ -533 : 2, 3-Cl2 , 4-Cl, Z ] , [ -534:2,4-
Cl2, 4-Cl, E] , [-535:2, 4-Cl2 , 4-Cl, Z] , [-536 : 2, 5-Cl2 , 4-Cl, E] ,
[-537:2, 5-Cl2 , 4-Cl, Z] , [-538 : 2, 6-Cl2 , 4-Cl, E] , [-539:3,4- Cl2, 4-Cl, E] , [-540:3, 5-Cl2 ,4-Cl, E] , [-541 : 2, 3-Br2 , 4-Cl, E] ,
[-542:2, 4-Br2 , 4-Cl, E] , [-543 : 2, 5-Br2 , 4-Cl, E] , [-544:2,6- Br2, 4-Cl, E] , [-545 : 3, 4-Br2 , 4-Cl, E] , [-546 : 3, 5-Br2 , 4-Cl, E] ,
[-547:2, 3-Me2 , 4-Cl, E] , [-548 : 2 , 4-Me2 , 4-Cl, E] , [-549:2,5- Me2, 4-Cl, E] , 1-550:2, 6-Me2 ,4-Cl, E] , [-551 :"3, 4-Me2 , 4-Cl, E] ,
[-552:3, 5-Me2 , 4-Cl,:E] , [-553 : 2, 3-Et2 , 4-Cl, E] , [-554:2,4-
Et2, 4-Cl, E] , [-555:2, 5-Et2 ,4-Cl, E] , [-556: 2, 6-Et2 , 4-Cl, E] , [-557:3, 4-Et2 , 4-Cl, E] , [ -558 : 3, 5-Et2 , 4-Cl, E] , [-559:2,3-
(CF3 )2 ,4-Cl, E ] , [ -560:2,4- (CF3 )2 , 4-Cl, E ] , [ -561:2,5-
(CF3 )2, 4-Cl, E ] , [ -562:2, 6-(CF3 )2, 4-Cl, E ] , [ -563:3,4-
(CF3)Z, 4-Cl, E ] , [ -564:3, 5-(CF3)2, 4-Cl, E ] , [ -565:2,3-
(CHF2 )2 , 4-Cl, E ] , [ -566:2,4- (CHF2 )2 , 4-Cl, E ] , [ -567:2,5- (CHF2 )2 , 4-Cl, E ] , [ -568 : 2 , 6- (CHF2 ) 2 , 4-Cl, E ] , [ -569:3,4-
(CHF2 )2 , 4-Cl, E ] , [ -570:3, 5-(CHF2 )2 , 4-Cl, E ] , [ -571:2,3-
(CH2 F)2, 4-Cl, E ] , [ -572:2, 4-(CH2F)2 , 4-Cl, E ] , [ -573:2,5-
(CH2F)2 , 4-Cl, E ] , [ -574:2, 6-(CH2F)2 , 4-Cl, E ] , [ -575:3,4-
(CH2F)2, 4-Cl, E ] , [ -576:3, 5-(CH2F)2, 4-Cl, E ] , [ -577:2,3- (MeO)2 , 4-Cl, E ] , [ -578 : 2, 4- (MeO) 2 , 4-Cl, E ] , [ -579:2,5-
(MeO)2 ,4-Cl, E ] , [ -580 : 2, 6- (MeO) 2 , 4-Cl, E ] , [ -581:3,4-
(MeO)2 ,4-Cl, E ) , [ -582 : 3, 5- (MeO) 2 , 4-Cl, E ] , [ -583:2,3-
(EtO)2 ,4-Cl, E ] , [ -584:2, 4-(EtO)2 , 4-Cl, E ] , [ -585:2,5-
(EtO)2 , 4-Cl, E ) , [ -586:2, 6- (EtO)2 , 4-Cl, E ] , [ -587:3,4- (EtO)2 , 4-Cl, E ] , [ -588:3,5- (EtO)2 , 4-Cl, E ] , [-589:2-01-3-
F, 4-Cl, E] , [-590:2-Cl-4-F,4-Cl,E] , [-591 : 2-C1-5-F, 4-Cl, E] ,
C-592:2-Cl-6-F,4-Cl,E] , [-593 : 3-C1-2-F, 4-Cl, E] , [-594:3-
Cl-4-F,4-Cl,E] , [-595:3-Cl-5-F,4-Cl,E] , [ -596 : 4-C1-2-F, 4-
Cl, E] , [-597:4-Cl-3-F,4-Cl,E] , [-598 : 2-F-3-Me, 4-Cl, E] , [- 599:2-F-4-Me,4-Cl,E] , [-600 : 2-F-5-Me, 4-Cl, E] , [-601.2-F-6- Me, 4-Cl, E ] , [ -602:3-F-2-Me,4-Cl,E ] , [ -603 : 3-F-4-Me, 4- Cl, E] , [-604:3-F-5-Me,4-Cl,E] , [-605 : 4-F-2-Me, 4-Cl, E] , [- 606:4-F-3-Me,4-Cl,E] , [-607 : 2-Cl-3-Me, 4-Cl, E] , [-608.2-C1- 4-Me,4-Cl,E] , [-609 : 2-Cl-5-Me, 4-Cl, E] , [-610 : 2-Cl-6-Me, 4- Cl, E] , [-611:3-Cl-2-Me,4-Cl,E] , [-612 : 3-Cl-4-Me, 4-Cl, E] ,
[ -613:3-Cl-5-Me,4-Cl,E ] , [ -614 : 4-Cl-2-Me, 4-Cl, E ] , [-
615:4-Cl-3-Me,4-Cl,E] , [-616 : 2-F-3-CF3 , 4-Cl, E] , [-617.2-F-
4-CF3 , 4-Cl, E] , [-618:2-F-5-CF3 ,4-Cl,E] , [-619 : 2-F-6-CF3 , 4-
Cl, E] , [-620:3-F-2-CF3 ,4-Cl,E] , [-621 : 3-F-4-CF3 , 4-Cl, E] , [ -622:3-F-5-CF3 ,4-Cl, E ] , [ -623 : 4-F-2-CF3 , 4-Cl, E ] , [- 624:4-F-3-CF3 ,4-Cl,E] , [-625 : 2-Cl-3-CF3 , 4-Cl, E] , [-626:2- CI-4-CF3 ,4-Cl,E] , C-627:2-C1-5-CF3,4-C1,E] , [-628 : 2-C1-6- CF3, 4-Cl, E] , [-629:3-Cl-2-CF3 ,4-Cl,E] , [-630 : 3-Cl-4-CF3 , 4- Cl, E] , [-631:3-Cl-5-CF3 ,4-Cl,E] , [-632 : 4-Cl-2-CF3 , 4-Cl, E] , [ -633:4-Cl-3-CF3 ,4-Cl, E ] , [ -634 : 2-Me-3-CF3 , 4-Cl, E ] , [-
635:2-Me-4-CF3 ,4-Cl,E] , [-636 : 2-Me-5-CF3 , 4-Cl, E] , [-637:2-
Me-6-CF3 ,4-Cl,E] , [-638 : 3-Me-2-CF3 , 4-Cl, E] , [-639 : 3-Me-4-
CF3, 4-Cl, E] , [-640:3-Me-5-CF3 ,4-Cl,E] , [-641 : 4-Me-2-CF3 , 4-
Cl, E] , C-642:4-Me-3-CF3 ,4-Cl,E] , [-643 : 2-F-3-MeO, 4-Cl, E] , [ -644:2-F-4-MeO,4-Cl,E ] , [ -645 : 2-F-5-MeO, 4-Cl, E ] , [ -
646:2-F-6-MeO,4-Cl,E] , [-647 : 3-F-2-MeO, 4-Cl, E] , [-648.3-F-
4-MeO, 4-Cl, E] , [-649 : 3-F-5-MeO, 4-Cl, E] , [-650 : 4-F-2-MeO, 4-
Cl, E] , [-651:4-F-3-MeO,4-Cl,E] , [-652 : 2-Cl-3-MeO, 4-Cl, E] ,
[ -653:2-Cl-4-MeO,4-Cl,E] , [ -654 : 2-Cl-5-MeO, 4-Cl, E ] , [- 655:-2-Cl-6-MeO,4-Cl,E] , [-656 : 3-Cl-2-MeO, 4-Cl, E] , [-657:3-
Cl-4-Meθ', 4-Cl, E]" , [r658 : 3-Cl-5-MeO, 4-Cl, E] , [-659 : 4-C1-2-
MeO, 4-Cl, E] , [-660 : 4-Cl-3-MeO, 4-Cl, E] , [-661 : 2-Me-3-MeO, 4-
Cl, E] , [-662:2-Me-4-MeO,4-Cl,E] , [-663 : 2-Me-5-MeO, 4-Cl, E] ,
[ -664:2-Me-6-MeO,4-Cl,E] , [ -665 : 3-Me-2-MeO, 4-Cl, E ] , [- 666:3-Me-4-MeO, 4-Cl,E] , [-667 : 3-Me-5-MeO, 4-Cl, E] , [-668:4-
Me-2-MeO,4-Cl,E ] , [ -669 : 4-Me-3-MeO, 4-Cl, E ] , [ -670:H,4- CF3, E] , C-671:4-F, 4-CF3 ,E] , [-672 : 4-F, 4-CF3 , Z ] , [-673:4- Cl, 4-CF3, E] , [-674.4-C1, 4-CF3 ,Z] , [-675 : 4-Br , 4-CF3 , E] , [- 676:4-1, 4-CF3 ,E ] , [ -677 : 4-Me, 4-CF3 , E ] , [ -678 : 4-Me, 4- CF3, Z] , [-679:4-Et,4-CF3 ,E] , [ -680 : 4-C3 H7 , 4-CF3 , E ] , [-
681:4- (Me)2CH, 4-CF3 ,E ] , [ -682 : 4-CF3 , 4-CF3 , E ] , [ -683:4- CF3, 4-CF3, Z ] , [ -684:4-C2F5 ,4-CF3 ,E ] , [ -685 : 4-C3 F7 , A- CF3, E ] , [ -686:4-(CF3 )2CF,4-CF3 ,E ] , [ -687 : 4- (CF3 ) 2 CH, A- CF3, E] , [-688:4-CHF2 ,4-CF3 ,E] , [ -689 : 4-CH2 F, 4-CF3 , E] , [- 690:4-CF3CH2 ,4-CF3 ,E ] , [ -691 : 4-MeO, 4-CF3 , E ] , [ -692:4-
MeO, 4-CF3, Z ] , C -693 : 4-EtO, 4-CF3 , E ] , [ -694 : 4-C3 H70, 4-
CF3, E] , [-695:4- (Me)2CHO, 4-CF3 ,E] , [ -696 : 4-NO2 , 4-CF3 , E] ,
[ -697:4-NO2 ,4-CF3 ,Z ] , [ -698 : 3-F, 4-CF3 , E ] , [-699:3-F,4-
CF3, Z] , [-700:3-Cl,4-CF3 ,E] , [-701 : 3-Cl, 4-CF3 , Z] , [-702:3- Br, 4-CF3, E] , [-703 : 3-1 , 4-CF3 , E] , [-704 : 3-Me, 4-CF3 , E] , [-
705:3-Me,4-CF3 ,Z ] , [ -706 : 3-Et, 4-CF3 , E ] , [ -707 : 3-C3 H7 , 4-
CF3, E] , [-708:3- (Me)2CH, 4-CF3 ,E] , [-709 : 3-CF3 , 4-CF3 , E] , (-
710:3-CF3,4-CF3,Z] , [-711 : 3-C2 F5 , 4-CF3 , E] , [-712 : 3-C3 F7 , 4-
CF3, E ] , [ -713:3-(CF3 )2CF,4-CF3 ,E ] , [ -714 : 3- (CF3 ) 2 CH, 4- CF3, E] , [-715:3-CHF2 ,4-CF3 ,E] , [ -716 : 3-CHF2 , 4-CF3 , Z ] , [-
717: 3-CH2 F, 4-CF3 ,E ] , [ -718 : 3-CH2 F, 4-CF3 , Z ] , [ -719:3- CF3CH2 ,4-CF3, E ] , [ -720:3-MeO,4-CF3 ,E ] , ( -721 : 3-MeO, 4- CF3, Z] , [-722:3-EtO,4-CF3 ,E] , [ -723 : 3-C3 H7 O, 4-CF3 , E] , [- 724:3-(Me)2CHO,4-CF3 ,E ] , [ -725 : 3-NO2 , 4-CF3 , E ] , [-726:2- F,4-CF3,E] , [-727:2-Cl,4-CF3 ,E] , [-728 : 2-Br, 4-CF3 , E] , [- 729:2-1, 4-CF3 ,E ] , [ -730 : 2-Me, 4-CF3 , E ] , [ -731 : 2-Et , 4-
CF3, E] , [-732:2-C3H7 ,4-CF3,E] , [ -733 : 2- (Me) 2 CH, 4-CF3 , E] ,
[ -734:2-CF3,4-CF3 ,E ] , [ -735 : 2-C2 F5 , 4-CF3 , E ] , [ -736:2-
C3F7, 4-CF3, E ] , [ -737:2- (CF3 )2CF, 4-CF3 , E ] , [ -738:2- (CF3 )2CH, 4-CF3 ,E] , [ -739 : 2-CHF2 , 4-CF3 , E ] , [ -740 : 2-CH2 F, 4-
CF3, E] , [-741.2-CF3CH2, 4-CF3, E] , [-742 : 2-MeO, 4-CF3 , E] , (-
743:2-EtO,4-CF3 ,E ] , [ -744 : 2-C3 H7 O, 4-CF3 , E ] , [ -745:2-
(Me)2CHO, 4-CF3 ,E] , [ -746 : 2-NO2 , 4-CF3 , E ] , [ -747 : 2 , 3-F2 , 4-
CF3, E] , [-748:2, 4-F2, 4-CF3, E] , [ -749 : 2 , 5-F2 , 4-CF3 , E] , C- 750:2, 6-F2 ,4-CF3 ,E ] , [ -751 : 3, 4-F2 , 4-CF3 , E ] , [ -752:3,4-
F2, 4-CF3, Z] , [-753:3, 5-F2, 4-CF3, E] , [-754 : 3, 5-F2 , 4-CF3 , Z) ,
[ -755:2, 3-Cl2 ,4-CF3, E ] , [ -756 : 2 , 3-Cl2 , 4-CF3 , Z ] , [ -
757:2, 4-Cl2 ,4-CF3 ,E] , [ -758 : 2, 4-Cl2 , 4-CF3 , Z ] , [-759:2,5-
Cl2, 4-CF3, E ] , [ -760:2, 5-Cl2 ,4-CF3 ,Z ] , [ -761 : 2 , 6-Cl2 , 4- CF3, E] , [-762:3, 4-Cl2, 4-CF3 , E] , [-763 : 3, 5-Cl2 , 4-CF3 , E] , [-
764:2, 3-Br2 ,4-CF3 ,E] , [ -765 : 2 , 4-Br2 , 4-CF3 , E ] , [-766:2,5-
Br2, 4-CF3, E ] , [ -767 : 2 , 6-Br2 , 4-CF3 , E ] , [ -768 : 3, 4-Br2 , 4-
CF3, E] , [-769:3, 5-Br2 ,4-CF3, E] , [-770 : 2, 3-Me2 , 4-CF3 , E] , [-
771:2, 4-Me2 ,4-CF3 ,E] , [ -772 : 2, 5-Me2 , 4-CF3 , E ] , [-773:2,6- Me2, 4-CF3, E ] , [ -774 : 3, 4-Me2 , 4-CF3 , E ] , [ -775 : 3, 5-Me2 , 4-
CF3, E] , [-776:2, 3-Et2 ,4-CF3 ,E] , [-777 : 2 , 4"-Et2 , 4-CF3 , E] , [- 778:2, 5-Et2 ,4-CF3 ,E] , [ -779 : 2 , 6-Et2 , 4-CF3 , E ] , [-780:3,4- Et2, 4-CF3, E] , [-781:3, 5-Et2 ,4-CF3 , E] , [ -782 : 2 , 3- (CF3 ) 2 , A- CF3, E ] , [ -783:2,4-(CF3)2,4-CF3,E ] , [ -784 : 2 , 5- (CF3 ) 2 , A- CF3, E ] , [ -785:2,6-(CF3)2,4-CF3,E ] , [ -786 : 3, 4- (CF3 ) 2 , A-
CF3, E] , [-787:3, 5-(CF3)2, 4-CF3, E] , [ -788 : 2 , 3- (CHF2 ) 2 , 4- CF3, E] , [-789:2, 4-(CHF2 )2 ,4-CF3, E] , [ -790 : 2 , 5- (CHF2 ) 2 , A- CF3, E] , [-791:2, 6-(CHF2 )2, 4-CF3 , E] , [ -792 : 3, 4- (CHF2 ) 2 , A- CF3, E] , [-793:3, 5-(CHF2)2, 4-CF3, E] , [ -794 : 2 , 3- (CH2 F) 2 , 4- CF3, E] , [-795:2, 4--(CH2F)2, 4-CF3 , E] , [ -796 : 2, 5- (CH2 F) 2 , 4-
CF3, E] , [-797:2, 6-(CH2F)2 ,4-CF3 , E] , [ -798 : 3, 4- (CH2 F) 2 , A- CF3, E] , [ -799:3,5- (CH2F)2 ,4-CF3 ,E ] , [ -800 : 2 , 3- (MeO) 2 , A- CF3, E ] , [ -801:2, 4-(MeO)2 ,4-CF3 ,E ] , [ -802 : 2 , 5- (MeO) 2 , A- CF3, E ] , [ -803:2, 6-(MeO)2 ,4-CF3, E ] , [ -804 : 3, 4- (MeO) 2 , A- CF3, E ] , [ -805:3, 5-(MeO)2 ,4-CF3 ,E ] , [ -806:2, 3- (EtO) 2 , 4-
CF3, E ] , [ -807:2, 4-(EtO)2 ,4-CF3, E ] , .[ -808 : 2 , 5- (EtO) 2 , 4- CF3, E ] , C -809:2, 6-(EtO)2 ,4-CF3, E ] , [ -810:3, 4- (EtO) 2 , 4- CF3, E ] , [ -811:3,5- (EtO)2 ,4-CF3 ,E ] , C -812 : 2-C1-3-F, 4- CF3, E] , [-813:2-Cl-4-F,4-CF3,E] , [-814 : 2-C1-5-F, 4-CF3 , E] , [ -815:2-Cl-6-F,4-CF3 ,E ] , [ -816 : 3-C1-2-F, 4-CF3 , E ] , [ -
817:3-Cl-4-F,4-CF3 ,E] , ( -818 : 3-C1-5-F, 4-CF3 , E ] , [-819:4- Cl-2-F,4-CF3 ,E ] , [ -820:4-Cl-3-F,4-CF3 ,E ] , [ -821 :2-F-3- Me, 4-CF3, E] , [ -822 : 2-F-4-Me, 4-CF3 , E ] , [ -823 : 2-F-5-Me, 4- CF3, E]-, [-824:'2-F-6-Me,-4-CF3 ,E] , [-825 : 3-F-2-Me, 4-CF3 , E] ,J [ -826:3-F-4-Me,4-CF3 ,E ] , [ -827 : 3-F-5-Me, 4-CF3 , E ] , ( -
828:4-F-2-Me,4-CF3 ,E] , [ -829 : 4-F-3-Me, 4-CF3 , E ] , [-830:2- Cl-3-Me,4-CF3 ,E] , [ -831 : 2-Cl-4-Me, 4-CF3 , E] , .[-832 : 2-C1-5- Me, 4-CF3, E] , [-833 : 2-Cl-6-Me, 4-CF3 , E] , [-834 : 3-Cl-2-Me, 4- CF3, E ] , [ -835:3-Cl-4-Me,4-CF3 ,E ] , [ -836 : 3-Cl-5-Me, 4- CF3, E ] , [ -837:4-Cl-2-Me,4-CF3,E ] , [ -838 : 4-Cl-3-Me, 4-
CF3, E ] , [ -839:2-F-3-CF3 ,4-CF3 ,E ] , [ -840 : 2-F-4-CF3 , 4- CF3, E ] , [ -841:2-F-5-CF3 ,4-CF3 ,E ] , [ -842 : 2-F-6-CF3 , 4- CF3, E ] , [ -843:3-F-2-CF3,4-CF3,E ] , [ -844 : 3-F-4-CF3 , 4- CF3, E ] , [ -845:3-F-5-CF3 ,4-CF3, E ] , [ -846 : 4-F-2-CF3 , 4- CF3, E ] , [ -847:4-F-3-CF3 ,4-CF3 ,E ] , [ -848 : 2-Cl-3-CF3 , 4-
CF3, E ] , [ -849:2-Cl-4-CF3,4-CF3,E ] , [ -850 : 2-Cl-5-CF3 , 4- CF3, E ] , [ -851:2-Cl-6-CF3 ,4-CF3 ,E ] , [ -852 : 3-Cl-2-CF3 , 4- CF3, E ] , [ -853:3-Cl-4-CF3 ,4-CF3 ,E ] , [ -854 : 3-Cl-5-CF3 , 4- CF3, E ] , [ -855:4-Cl-2-CF3 ,4-CF3, E ] , [ -856 : 4-Cl-3-CF3 , 4- CF3, E ] , [ -857:2-Me-3-CF3 ,4-CF3 ,E ] , [ -858 : 2-Me-4-CF3 , 4-
CF3, E ] , [ -859:2-Me-5-CF3 ,4-CF3 ,E ] , [ -860 : 2-Me-6-CF3 , 4- CF3, E ] , C -861:3-Me-2-CF3 ,4-CF3 ,E ] , [ -862 : 3-Me-4-CF3 , 4- CF3, E ] , [ -863:3-Me-5-CF3 ,4-CF3 ,E ] , [ -864 : 4-Me-2-CF3 , 4- CF3, E ] , [ -865:4-Me-3-CF3 ,4-CF3 ,E ] , [ -866 : 2-F-3-MeO, 4- CF3, E ] , C -867:2-F-4-MeO,4-CF3 ,E ] , [ -868 : 2-F-5-MeO, 4-
CF3, E ] , [ -869:2-F-6-MeO,4-CF3 ,E ] , [ -870 : 3-F-2-MeO, 4- CF3, E ] , [ -871:3-F-4-MeO, 4-CF3 ,E ] , [ -872 : 3-F-5-MeO, 4- CF3, E ] , ( -873:4-F-2-MeO,4-CF3 ,E ] , [ -874 : 4-F-3-MeO, 4- CF3, E ] , C -875:2-Cl-3-MeO,4-CF3 ,E ] , [ -876 : 2-Cl-4-MeO, 4- CF3, E ] , [ -877:2-Cl-5-MeO, 4-CF3 ,E ] , C -878 : 2-Cl-6-MeO, 4-
CF3, E ] , [ -879:3-Cl-2-MeO,4-CF3 ,E ] , [ -880 : 3-Cl-4-MeO, 4- CF3, E ] , [ -881:3-Cl-5-MeO,4-CF3 ,E ] , [ -882 : 4-Cl-2-MeO, 4- CF3, E ] , [ -883:4-Cl-3-MeO,4-CF3 ,E ] , [ -884 : 2-Me-3-MeO, 4- CF3, E ] , [ -885:2-Me-4-MeO,4-CF3 ,E ] , [ -886 : 2-Me-5-MeO, 4- CF3, E ] , [ -887:2-Me-6-MeO, 4-CF3 ,E ] , [ -888 : 3-Me-2-MeO, 4-
CF3, E ] , [ -889:3-Me-4-MeO,4-CF3 ,E ] , C -890 : 3 -Me -5 -MeO, 4- CF3, E ] , [ -891:4-Me-2-MeO,4-CF3 ,E ] , [ -892 : 4-Me-3-MeO, 4- CF3, E] , [-893:H, 4-MeO, E] , [-894 : 4-F, 4-MeO, E] , [-895:4-F,4- MeO, Z] , [-896:4-Cl,4-MeO,E] , [-897 : 4-Cl, 4-MeO, z] , [-898:4- Br, 4-MeO, E] , [-899 : 4-1, 4-MeO, E] , [-900 : 4 -Me, 4-MeO, E] , [-
901:4-Me,4-MeO,Z ] , [ -902 : 4-Et, 4-MeO, E ] , [ -903 : 4-C3 H7 , 4- MeO, E] , [-904:4-{Me)2CH,4-MeO,E] , [-905 : 4-CF3 , 4-MeO, E] , [- 906:4-CF3 ,4-MeO,z] , [-907 : 4-C2 F5 , 4-MeO, E] , [-908 : 4-C3 F7 , 4- MeO, E ] , [ -909:4-(CF3 )2CF,4-Me0,E ] , [ -910 : 4- (CF3 ) 2 CH, 4- MeO, E] , [-911.4-CHF2, 4-MeO, E] , [-912 : 4-CH2 F, 4-MeO, E] , [-
913:4-CF3CH2 ,4-MeO, E ] , [ -914 : 4-MeO, 4-MeO, E ] , ( -915:4-
MeO, 4-MeO, Z ] , [ -916 : 4-EtO, 4-MeO, E ] , [ -917 : 4-C3 H70, A-
MeO, E] , [-918:4- (Me)2CHO, 4-MeO, E] , [-919 : 4-NO2 , 4-MeO, E] ,
[ -920:4-NO2 ,4-MeO, Z ] , [ -921 : 3-F, 4-MeO, E ] , [-922:3-F,4- MeO, Z] , [-923:3-Cl,4-MeO,E] , [-924 : 3-Cl, 4-MeO, Z] , [-925:3-
Br, 4-MeO, E] , (-926 : 3-1, 4-MeO, E] , [-927 : 3-Me, 4-MeO, E] , [-
928:3-Me,4-MeO,Z ] , [ -929 : 3-Et , 4-MeO, E ] , [ -930 : 3-C3 H7 , A-
MeO, E] , [-931:3- (Me)2CH, 4-MeO, E] , [-932 : 3-CF3 , 4-MeO, E] , [-
933 : 3-CF3 ,4-MeO, Z] , [-934 : 3-C2 F5 , 4-MeO, E] , [-935 : 3-C3 F7 , 4- MeO, E] , [ -936:3- (CF3 )2CF, 4-MeO, E ] , [ -937 : 3- (CF3 ) 2 CH, A-
MeO, E] , [-938:3-CHF2 ,4-Me0,E] , [-939 : 3-CHF2 , 4-MeO, Z] , [- 940:3-CH2F,4-MeO,E ] , [ -941 : 3-CH2 F, 4-MeO, Z ] , [ -942:3- CF3CH2 ,4-MeO, E ] , [ -943 : 3-MeO, 4-MeO, E ] , [ -944 : 3-MeO, A- MeO, Z] , [-945:3-EtO,4-MeO,E] , [-946 : 3-C3 H70, 4-MeO, E] , [- 947:3- (Me)2CHO, 4-MeO, E ] , [ -948 : 3-NO2 , 4-MeO, E ] , (-949:2-
F,4-Me0,E] , [-950 : 2-Cl, 4-MeO, E] , [-951 : 2-Br, 4-MeO, E] , [-
952:2-1, 4-MeO, E ] , [ -953 : 2-Me, 4-MeO, E ] , [ -954 : 2-Et, A-
MeO, E] , [-955:2-C3H7 ,4-Me0,E] , [-956 : 2- (Me) 2 CH, 4-MeO, E] ,
[ -957:2-CF3 ,4-MeO, E ] , [ -958 : 2-C2 F5 , 4-MeO, E ] , [ -959:2- C3F7, 4-MeO, E ] , [ -960 : 2- (CF3 ) 2 CF, 4-MeO, E ] , [ -961:2-
(CF3 )2CH,4-Me0,E] , [ -962 : 2-CHF2 , 4-MeO, E] , [-963 : 2-CH2 F, A-
MeO, E] , [-964:2-CF3CH2 , 4-MeO, E] , [-965 : 2-MeO, 4-MeO, E] , [-
966:2-EtO, 4-MeO, E ] , [ -967 : 2-C3 H70, 4-MeO, E ] , [ -968:2-
(Me) 2 CHO, 4-MeO, E] , [ -969 : 2-NO2 , 4-MeO, E ] , [ -970 : 2, 3-F2 , A- MeO, E] , [-971:2, 4-F2 , 4-MeO, E] , [-972 : 2, 5-F2 , 4-MeO, E] , [-
973:2, 6-F2 ,4-MeO, E ] , ( -974 : 3, 4-F2 , 4-MeO, E ] , [ -975:3,4-
F2, 4-MeO, Z] , [-976:3, 5-F2 , 4-MeO, E] , [-977 : 3, 5-F2 , 4-MeO, Z] ,
[ -978:2, 3-Cl2 ,4-MeO, E ] , [ -979 : 2, 3-Cl2 , 4-MeO, Z ] , C -
980:2, 4-Cl2 ,4-MeO, E] , [ -981 : 2, 4-Cl2 , 4-MeO, Z ] , [-982:2,5- Cl2, 4-MeO, E ] , [ -983 : 2, 5-Cl2 , 4-MeO, Z ] , [ -984 : 2 , 6-Cl2 , 4-
MeO, E] , [-985:3, 4-Cl2 ,4-MeO, E] , [-986 : 3, 5-Cl2 , 4-MeO, E] , [-
987:2, 3-Br2 ,4-MeO, E] , [ -988 : 2, 4-Br2 , 4-MeO, E ] , [-989:2,5-
Br2, 4-MeO, E ] , [ -990 : 2 , 6-Br2 , 4-MeO, E ] , [ -991 : 3, 4-Br2 , 4-
MeO, E] , [-992 : 3, 5-Br2 ,4-MeO, E] , [-993 : 2, 3-Me2 , 4-MeO, E] , [- 994:2, 4-Me2 ,4-MeO, E] , [ -995 : 2, 5-Me2 , 4-MeO, E ] , [-996:2,6-
Me2, 4-MeO, E ] , [ -997 : 3, 4-Me2 , 4-MeO, E ] , [ -998 : 3, 5-Me2 , 4-
MeO, E] , [-999:2, 3-Et2 , 4-MeO, E] , [-1000 : 2, 4-Et2 , 4-MeO, E] ,
[ -1001:2, 5-Et2 ,4-MeO, E ] , [ -1002 : 2, 6-Et2 , 4-MeO, E ] , [ -
1003:3, 4-Et2 , 4-MeO, E ] , [ -1004 : 3, 5-Et2 , 4-MeO, E ] , [ - 1005:2, 3-(CF3 )2 ,4-MeO, E] , [ -1006 : 2, 4- (CF3 ) 2 , 4-MeO, E ] , [-
1007:2,5- (CF3 )2 , 4-MeO, E] , [ -1008 : 2, 6- (CF3 ) 2 , 4-MeO, E ] , [- 1009:3, 4-(CF3 )2 ,4-MeO, E] , [ -1010 : 3, 5- (CF3 ) 2 , 4-MeO, E ] , [- 1011:2,3- (CHF2 )2 ,4-MeO, E] , [-1012 : 2, 4- (CHF2 ) 2 , 4-MeO, E] , [- 1013:2,5- (CHF2 )2 , 4-MeO, E] , [-1014 : 2, 6- (CHF2 ) 2 , 4-MeO, E] , [- 1015:3,4- (CHF2 )2 , 4-MeO, E] , [-1016 : 3, 5- (CHF2 ) 2 , 4-MeO, E] , [-
1017:2,3- (CH2F)2 ,4-MeO, E] , [-1018 : 2, 4- (CH2 F) 2 , 4-MeO, E] , [- 1019:2, 5- (CH2F)2 , 4-MeO, E] , [-1020 : 2, 6- (CH2 F) 2 , 4-MeO, E] , [- 1021:3,4- (CH2F)2 ,4-MeO, E] , [-1022 : 3 , 5- (CH2 F) 2 , 4-MeO, E] , [- 1023:2,3- (MeO)2 ,4-MeO, E] , [ -1024 : 2, 4- (MeO) 2 , 4-MeO, E ] , [- 1025:2, 5- (MeO)2 , 4-MeO, E] , [ -1026 : 2 , 6- (MeO) 2 , 4-MeO, E ] , [-
1027:3,4- (MeO)2 ,4-MeO, E ) , [ -1028 : 3, 5- (MeO) 2 , 4-MeO, E ] , C
1029:2,3- (EtO)2 ,4-MeO, E] , [ -1030 : 2, 4- (EtO) 2 , 4-MeO, E ] , [
1031:2,5- (EtO)2 ,4-MeO, E] , C -1032 : 2, 6- (EtO) 2 , 4-MeO, E ] , [
1033:3,4- (EtO)2 ,4-MeO, E] , [ -1034 : 3, 5- (EtO) 2 , 4-MeO, E ] , [ 1035:2-Cl-3-F,4-MeO,E ] , [ -1036 : 2-C1-4-F, 4-MeO, E ) , [
1037:2-Cl-5-F,4-MeO,E ] , [ -1038 : 2-C1-6-F, 4-MeO, E ] , [
1039:3-Cl-2-F,4-MeO,E ] , C -1040 : 3-C1-4-F, 4-MeO, E ] , (
1041:3-Cl-5-F,4-MeO,E ] , [ -1042 : 4-C1-2-F, 4-MeO, E ) , [
1043:4-Cl-3-F,4-MeO,E ] , [ -1044 : 2-F-3-Me, 4-MeO, E ] , [ 1045:2-F-4-Me,4-MeO,E ) , [ -1046 : 2-F-5-Me, 4-MeO, E ] , [
1047 :2-F-6-Me,4-MeO,E ] , [ -1048 : 3-F-2-Me, 4-MeO, E ] , [
1049:3-F-4-Me,4-MeO,E ] , ( -1050 : 3-F-5-Me, 4-MeO, E ] , (
1051:4-F-2-Me,4-MeO,E } , [ -1052 : 4-F-3-Me, 4-MeO, E ] , (
1053:2-Cl-3-Me,4-MeO,E ] , [ -1054 : 2-Cl-4-Me, 4-MeO, E ] , C 1055:2-Cl-5-Me,4-MeO,E ) , [ -1056 : 2-Cl-6-Me, 4-MeO, E ] , (
1057:3-Cl-2-Me,4-MeO,E ] , [ -1058 : 3-Cl-4-Me, 4-MeO, E ] , [■
1059:3-Cl-5-Me,4-MeO,E ] , [ -1060 : 4-Cl-2-Me, 4-MeO, E ] , [■
1061:4-Cl-3-Me,4-MeO,E ] , [ -1062 : 2-F-3-CF3 , 4-MeO, E 3 , [■
1063:2-F-4-CF3 ,4-MeO, E ] , [ -1064 : 2-F-5-CF3 , 4-MeO, E ) , [■ 1065:2-F-6-CF3 ,4-MeO, E ] , [ -1066 : 3-F-2-CF3 , 4-MeO, E ] , [•
1067 :3-F-4-CF3 ,4-MeO, E ] , [ -1068 : 3-F-5-CF3 , 4-MeO, E ] , [■
1069:4-F-2-CF3 ,4-MeO, E ] , [ -1070 : 4-F-3-CF3 , 4-MeO, E ] , [■
1071:2-Cl-3-CF3 ,4-MeO,E] , [ -1072 : 2-01-4-CF3 , 4-MeO, E ] , [•
1073:2-Cl-5-CF3 ,4-MeO,E] , [ -1074 : 2-Cl-6-CF3 , 4-MeO, E ] , C- 1075:3-Cl-2-CF3 ,4-MeO,E] , [ -1076 : 3-01-4-CF3 , 4-MeO, E ] , [■
1077:3-Cl-5-CF3 ,4-MeO,E] , [ -1078 : 4-Cl-2-CF3 , 4-MeO, E ] , [ 1079:4-Cl-3-CF3 ,4-MeO, E] , C -1080 : 2-Me-3-CF3 , 4-MeO, E ] , C 1081:2-Me-4-CF3 ,4-MeO, E] , [ -1082 : 2-Me-5-CF3 , 4-MeO, E ] , [ 1083:2-Me-6-CF3 , 4-MeO, E] , [ -1084 : 3-Me-2-CF3 , 4-MeO, E ] , C 1085:3-Me-4-CF3 ,4-MeO,E] , [ -1086 : 3-Me-5-CF3 , 4-MeQ, E ] , (■
1087:4-Me-2-CF3 ,4-MeO, E] , [ -1088 : 4-Me-3-CF3 , 4-MeO, E ] , [■ 1089:2-F-3-MeO, 4-MeO, E ] , [ -1090 : 2-F-4-MeO, 4-MeO, E ] , [ 109.1:2-F-5-MeO,4-MeO,E ] , [ -1092 : 2-F-6-MeO, 4-MeO, E ] , ( 1093:3-F-2-MeO,4-MeO,E ] , [ -1094 : 3-F-4-MeO, 4-MeO, E ] , C 1095:3-F-5-MeO,4-MeO,E ] , [ -1096 : 4-F-2-MeO, 4-MeO, E ] , [
1097 :4-F-3-MeO,4-MeO,E ] , C -1098 : 2-Cl-3-MeO, 4-MeO, E ] , [■ 1099:2-Cl-4-MeO,4-MeO,E] , [ -1100 : 2-Cl-5-MeO, 4-MeO, E ] , C 1101:2-Cl-6-MeO,4-MeO,E] , [ -1102 : 3-Cl-2-MeO, 4-MeO, E ] , [• 1103:3-Cl-4-MeO,4-MeO,E] , [ -1104 : 3-Cl-5-MeO, 4-MeO, E ] , [• 1105:4-Cl-2-MeO, 4-MeO, E] , ( -1106 : 4-Cl-3-MeO, 4-MeO, E ] , [■
1107:2-Me-3-MeO,4-MeO,E] , [ -1108 : 2-Me-4-MeO, 4-MeO, E ] , [■ 1109:2-Me-5-MeO,4-MeO,E] , [ -1110 : 2-Me-6-MeO, 4-MeO, E ] , [■ llll:3-Me-2-MeO, 4-MeO, E] , [ -1112 : 3-Me-4-MeO, 4-MeO, E ] , [■ 1113:3-Me-5-MeO,4-MeO,E] , [ -1114 : 4-Me-2-MeO, 4-MeO, E ] , [■ 1115:4-Me-3-MeO, 4-MeO, E] , [-1116 : H, 4- (Me) 3 CO, E] , [-1117:4-
F, 4-(Me)3CO, E ] , [ -1118 : 4-F, 4- (Me) 3 CO, Z ] , [-1119:4-01,4- (Me)3CO, E ] , [ -1120:4-01,4- (Me)3CO, Z ] , [ -1121 : 4-Br, 4- (Me)3CO, E ] , [ -1122:4-1, 4-(Me)3CO, E ] , [ -1123 : 4 -Me, 4- (Me)3CO, E ] , [ -1124 :4-Me, 4- (Me) 3CO,Z ] , [ -1125 : 4-Et , 4- (Me)3CO, E ] , [ -1126 : 4-C3 H7 , 4- (Me) 3 CO, E ] , [ -1127:4-
(Me)2CH, 4- (Me)3CO, E] , [-1128 : 4-CF3 , 4- (Me) 3 CO, E] , [-1129:4-
CF3, 4-(Me)3CO, Z ] , [ -1130 : 4-C2 F5 , 4- (Me) 3 CO, E ] , [-1131:4-
C3F7, 4-(Me)3CO, E ] , [ -1132 : 4- (CF3 ) 2 CF, 4- (Me) 3 CO, E ] , [ -
1133:4-(CF3 )2CH, 4- (Me)3CO, E] , [-1134 : 4-CHF2 , 4- (Me) 3 CO, E) , [-1135'.4-CH2F, 4- (Me)3CO, E] , [-1136 : 4-CF3 CH2 , 4- (Me) 3 CO, E] ,
[-1137: 4-MeO, 4- (Me)3CO, E] , [-1138 : 4-MeO, 4- (Me) 3 CO, Z] , [-
1139:4-EtO, 4-(Me)3CO, E] , [ -ll40 : 4-C3 H70, 4- (Me) 3 CO, E ] , [-
1141.4-(Me)2CHO, 4- (Me)3CO, E] , [ -1142 : 4-NO2 , 4- (Me) 3 CO, E ] ,
[ -1143:4-NO2 ,4- (Me)3CO, Z ] , [ -1144 : 3-F, 4- (Me) 3 CO, E ] , [- 1145:3-F,4- (Me)3CO, z] , [-1146 : 3-Cl, 4- (Me) 3 CO, E] , [-1147:3-
Cl, 4-(Me)3CO, Z] , [ -1148 : 3-Br, 4- (Me) 3 CO, E ] , [-1149:3-1,4- (Me)3CO, E ] , [ -1150:3-Mef 4-(Me)3CO, E ] , [ -1151 : 3-Me, 4- (Me)3CCZ ] , [ -1152:3-Et,4- (Me)3CO, E ] , [ -1153 : 3-C3H7 , 4- (Me)3CO, E] , [-1154 :3- (Me)2CH, 4- (Me)3CO, E] , [-1155 : 3-CF3 , 4- (Me)3CO, E] , [ -1156:3-CF3,4- (Me)3CO, Z ] , [ -1157 : 3-C2 F5 , 4-
(Me)3CO, E ] , [ -1158:3-C3F7 , 4- (Me)3CO, E ] , [ -1159:3- (CF3)2CF, 4-(Me)3CO, E] , [ -1160 : 3- (CF3 ) 2 CH, 4- (Me) 3 CO, E] , [- 1161:3-CHF2 ,4- (Me)3CO, E] , [ -1162 : 3-CHF2 , 4- (Me) 3 CO, Z ] , [- 1163:3-CH2F,4- (Me)3CO, E] , [ -1164 : 3-CH2 F, 4- (Me) 3 CO, Z ] , [- 1165:3-CF3CH2 ,4- (Me)3CO, E] , [-1166 : 3-MeO, 4- (Me) 3 CO, E] , [-
1167:3-MeO, 4-(Me)3CO, Z ] , [ -1168 : 3-EtO, 4- (Me) 3 CO, E ] , [ -
1169:3-C3H7O, 4- (Me)3CO, E] , [-1170 : 3- (Me) 2 CHO, 4- (Me) 3 CO, E] ,
[-1171.3-NO2, 4-(Me)3CO, E] , [ -1172 : 2-F, 4- (Me) 3 CO, E ] , [-
1173.2-C1, 4-(Me)3CO, E ] , [ -1174 : 2-Br, 4- (Me) 3 CO, E ] , [ - 1175:2-1, 4-(Me)3CO, E] , [-1176 : 2 -Me, 4- (Me) 3 CO, E] , [-1177:2-
Et, 4- (Me) 3 CO, E ] , [ -1178 : 2-C3 H7 , 4- (Me) 3 CO, E ] , [ -1179:2-
(Me)2CH, 4- (Me)3CO, E) , [-1180 : 2-CF3 , 4- (Me) 3 CO, E] , [-1181:2-
C2F5 ,4- (Me)3 CO, E ] , [ -1182 : 2-C3 F7 , 4- (Me) 3 CO, E ] , [-1183:2-
(CF3 )2CF, 4-(Me)3CO, E] , [ -1184 : 2- (CF3 ) 2 CH, 4- (Me) 3 CO, E ] , [- 1185:2-CHF2 ,4- (Me)3CO, E] , [ -1186 : 2-CH2 F, 4- (Me) 3 CO, E ] , [-
1187:2-CF3CH2 ,4-(Me)3CO, E] , [ -1188 : 2-MeO, 4- (Me) 3 CO, E] , C-
1189:2-EtO, 4- (Me)3CO, E] , [ -1190 : 2-C3 H7 O, 4- (Me) 3 CO, E ] , [-
1191:2- (Me)2CHO, 4- (Me)3CO, E] , [ -1192 : 2-NO2 , 4- (Me) 3 CO, E ] ,
[-1193:2, 3-F2, 4-(Me)3CO, E] , [ -1194 : 2, 4-F2 , 4- (Me) 3 CO, E ] , [-1195:2, 5-F2 ,4-(Me)3CO, E] , [ -1196 : 2, 6-F2 , 4- (Me) 3 CO, E ] ,
[-1197:3, 4-F2 ,4- (Me)3CO, E] , [ -1198 : 3, 4-F2 , 4- (Me) 3 CO, Z ] ,
[-1199:3, 5-F2 ,4- (Me)3CO, E] , [ -1200 : 3, 5-F2 , 4- (Me) 3 CO, Z ] ,
[-1201:2, 3-Cl2 ,4-(Me)3CO, E] , [-1202 : 2 , 3-Cl2 , 4- (Me) 3 CO, Z] ,
[-1203:2, 4-Cl2 ,4- (Me)3CO, E] , [-1204 : 2, 4-Cl2 , 4- (Me) 3 CO, Z] , [-1205:2, 5-Cl2 ,4-(Me)3CO, E] , [-1206 : 2, 5-Cl2 , 4- (Me) 3 CO, Z] ,
[-1207:2, 6-Cl2 ,4- (Me)3CO, E] , [-1208 : 3, 4-Cl2 , 4- (Me) 3 CO, E] ,
[-1209:3, 5-Cl2 ,4- (Me)3CO, E] , [-1210 : 2 , 3-Br2 , 4- (Me) 3 CO, E] ,
[-1211:2, 4-Br2 ,4-(Me)3CO, E] , [-1212 : 2, 5-Br2 , 4- (Me) 3 CO, E] ,
[-1213:2, 6-Br2 ,4- (Me)3CO, E] , [-1214 : 3, 4-Br2 , 4- (Me) 3 CO, E] , [-1215:3, 5-Br2 ,4-(Me)3CO, E] , [-1216 : 2, 3-Me2 , 4- (Me) 3 CO, E] ,
[-1217:2, 4-Me2 ,4-(Me)3CO, E] , [-1218 : 2, 5-Me2 , 4- (Me) 3 CO, E] ,
[-1219:2, 6-Me2 ,4-(Me)3CO, E] , [-1220 : 3, 4-Me2 , 4- (Me) 3 CO, E] ,
[-1221:3, 5-Me2 ,4-(Me)3CO, E] , [-1222 : 2, 3-Et2 , 4- (Me) 3 CO, E] ,
[-1223:2, 4-Et2 ,4-(Me)3CO, E] , [-1224 : 2, 5-Et2 , 4- (Me) 3 CO, E] , [-1225:2, 6-Et2 ,4- (Me)3CO, E] , [-1226 : 3, 4-Et2 , 4- (Me) 3 CO, E] ,
C -1227:3, 5-Et2 ,4- (Me)3CO, E ] , [ -1228 : 2, 3- (CF3 ) 2 , 4- (Me)3CO, E] , [ -1229:2, 4- (CF3 )2 ,4- (Me)3CO, E ] , [-1230:2,5- (CF3)2 / 4-(Me)3CO, E] , [ -1231 : 2, 6- (CF3 ) 2 , 4- (Me) 3 CO, E ) , (- 1232:3, 4-(CF3)2 ,4-(Me)3CO, E ] , [ -1233 : 3, 5- (CF3 ) 2 , 4- (Me)3CO7E] , (-1234:2,3- (CHF2 )2 ,4- (Me)3CO, E] , [-1235:2,4-
(CHF2 )2 ,4-(Me)3CO, E] , [-1236 : 2, 5- (CHF2 ) 2 , 4- (Me) 3 CO, E] , [- 1237:2, 6- (CHF2 )2 , 4- (Me)3CO, E ] , [ -1238 : 3, 4- (CHF2 ) 2 , 4- (Me)3CO, E] , [-1239:3, 5- (CHF2 )2, 4-(Me)3CO, E] , [-1240:2,3- (CH2F)2, 4-(Me)3CO, E] , [ -1241 : 2 , 4- (CH2 F) 2 , 4- (Me) 3 CO, E ] , [- 1242:2,5- (CH2F)2 ,4- (Me)3CO, E ] , [ -1243 : 2, 6- (CH2 F) 2 , 4-
(Me)3CO, E] , (-1244:3, 4-(CH2F)2, 4-(Me)3CO, E] , [-1245:3,5- (CH2F)2 ,4-(Me)3CO, E] , [ -1246 : 2 , 3- (MeO) 2 , 4- (Me) 3 CO, E ] , (- 1247:2, 4-(MeO)2 ,4- (Me)3CO, E ] , [ -1248 : 2, 5- (MeO) 2 , 4- (Me)3CO, E] , [ -1249:2, 6- (MeO)2 ,4-(Me)3CO,E ] , [-1250:3,4- (MeO)2 ,4-(Me)3CO, E ] , [ -1251 : 3, 5- (MeO) 2 , 4- (Me) 3 CO, E ] , [-
1252:2,3- (EtO)2 ,4- (Me)3CO, E ] , [ -1253 : 2, 4- (EtO) 2 , 4- (Me)3CO, E] , [ -1254:2, 5-(EtO)2 ,4- (Me)3CO, E ] , (-1255:2,6- (EtO)2, 4-(Me)3CO, E] , [ -1256 : 3, 4- (EtO) 2 , 4- (Me) 3 CO, E ] , (- 1257:3,5- (EtO)2 ,4- (Me)3CO, E] , [-1258 : 2-C1-3-F, 4- (Me) 3 CO, E] , ( -1259:2-Cl-4-F,4- (Me)3CO, E ] , [ -1260 : 2-C1-5-F, 4-
(Me)3CO, E] , [-1261.2-C1-6-F, 4-(Me)3CO, E] , [-1262:3-01-2- F, 4- (Me)3CO, E] , [-1263 : 3-C1-4-F, 4- (Me) 3 CO, E] , [-1264:3-01- 5-F, 4-(Me)3CO, E] , (-1265 : 4-C1-2-F, 4- (Me) 3 CO, E] , [-1266:4- Cl-3-F,4- (Me)3CO, E ] , [ -1267 : 2-F-3-Me, 4- (Me) 3 CO, E ] , [ - 1268:2-F-4-Me, 4- (Me)3CO, E] , [-1269 : 2-F-5-Me, 4- (Me) 3 CO, E] ,
[ -1270:2-F-6-Me,4- (Me)3CO, E 3 , C -1271 : 3-F-2-Me, 4-
(Me)3CO, E] , [ -1272:3-F-4-Me,4- (Me)3CO, E ] , [ -1273 : 3-F-5-
Me, 4- (Me)3CO, E] , [-1274 : 4-F-2-Me, 4- (Me) 3 CO, E] , [-1275.4-F-
3-Me,4- (Me)3CO, E ] , C -1276 : 2-Cl-3-Me, 4- (Me) 3 CO, E ] , [ - 1277:2-Cl-4-Me, 4- (Me) 3CO,E] , [-1278 : 2-Cl-5-Me, 4- (Me) 3 CO, E] ,
' [ -1279:2-Cl-6-Me,4- (Me)3CO, E 3 , [ -1280 : 3-Cl-2-Me, 4-
(Me)3CO, E] , [-1281:3-Cl-4-Me, 4- (Me)3CO, E] , [-1282 : 3-C1-5-
Me, 4- (Me)3CO, E] , [-1283 : 4-Cl-2-Me, 4- (Me) 3 CO, E] , [-1284:4-
Cl-3-Me,4- (Me)3CO, E 3 , [ -1285 : 2-F-3-CF3 , 4- (Me) 3 CO, E 3 , [- 1286:2-F-4-CF3 ,4- (Me)3CO, E3 , [-1287 : 2-F-5-CF3 , 4- (Me) 3 CO, E3 ,
[ -1288:2-F-6-CF3 ,4- (Me)3CO, E 3 , C -1289 : 3-F-2-CF3 , 4-
(Me)3CO, E] , [-1290:3-F-4-CF3 ,4-(Me)3CO, E3 , [ -1291 : 3-F-5-
CF3 ,4- (Me)3CO, E] , [-1292 : 4-F-2-CF3 , 4- (Me) 3 CO, E3 , [-1293:4-
F-3-CF3 ,4-(Me)3CO, E] , [ -1294 : 2-Cl-3-CF3 , 4- (Me) 3 CO, E 3 , [- 1295:2-Cl-4-CF3 ,4-(Me)3CO, E 3 , [ -1296 : 2-Cl-5-CF3 , 4-
(Me)3CO, E3 , [-1297:2-Cl-6-CF3 ,4- (Me)3CO, E3 , [-1298 : 3-C1-2- CF3 ,4-(Me)3CO, E 3 , [ -1299 : 3-Cl-4-CF3 , 4- (Me) 3 CO, E 3 , [ - 1300:3-Cl-5-CF3 ,4- (Me)3CO, E 3 , [ -1301 : 4-Cl-2-CF3 , 4-
(Me)3CO, E3 , [-1302:4-Cl-3-CF3 ,4- (Me)3CO, E3 , [-1303 : 2-Me-3- CF3, 4-(Me)3CO, E 3 , [ -1304 : 2-Me-4-CF3 , 4- (Me) 3 CO, E 3 , C -
1305:2-Me-5-CF3 ,4- (Me)3CO, E 3 , C -1306 : 2-Me-6-CF3 , 4-
(Me)3CO, E] , [-1307:3-Me-2-CF3 ,4- (Me)3CO, E] , [-1308 : 3-Me-4-
CF3 ,4-(Me)3CO, E 3 , [ -1309 : 3-Me-5-CF3 , 4- (Me) 3 CO, E 3 , C -
1310:4-Me-2-CF3 ,4- (Me) 3CO,E 3 , C -1311 : 4-Me-3-CF3 , 4- (Me)3CO, E] , [ -1312 : 2-F-3-MeO, 4- (Me) 3 CO, E 3 , [ -1313 : 2-F-4-
MeO, 4" (Me) 3 CO, E] , [-1314 : 2-F-5-MeO, 4- (Me) 3 CO, E) , [-1315:2- F-6-MeO,4- (Me)3CO, E ] , [ -1316 : 3-F-2-MeO, 4- (Me) 3 CO, E ] , [- 1317:3-F-4-MeO, 4- (Me)3CO, E] , [-1318 : 3-F-5-MeO, 4- (Me) 3 CO, E] ,
[ -1319:4-F-2-MeO,4- (Me)3CO, E ] , [ -1320 : 4-F-3-MeO, 4- (Me)3CO, E] , [-1321:2-Cl-3-MeO, 4-(Me)3CO, E] , [-1322 : 2-C1-4-
MeO, 4- (Me) 3CO,E ] , [ -1323 : 2-Cl-5-MeO, 4- (Me) 3 CO, E ] , [ -
1324:2-Cl-6-MeO, 4-(Me)3CO, E ] , [ -1325 : 3-01-2-MeO, 4-
(Me)3CO, E] , [-1326:3-Cl-4-MeO, 4-(Me)3CO, E] , [-1327:3-01-5-
MeO, 4- (Me)3CO7E ] , [ -1328 : 4-Cl-2-MeO, 4- (Me) 3 CO, E ] , [ - 1329:4-Cl-3-MeO,4- (Me)3CO, E ] , [ -1330 : 2-Me-3-MeO, 4-
(Me)3CO, E] , [-1331:2-Me-4-MeO, 4- (Me)3CO, E] , [-1332 : 2-Me-5-
MeO, 4- (Me)3CO, E ] , [ -1333 : 2-Me-6-MeO, 4- (Me) 3 CO, E ] , [ -
1334:3-Me-2-MeO, 4-(Me)3CO, E ] , [ -1335 : 3-Me-4-MeO, 4-
(Me)3CO, E] , [-1336:3-Me-5-MeO, 4- (Me)3CO, E] , [-1337 : 4-Me-2- MeO, 4-(Me)3CO, E ] , [ -1338 : 4-Me-3-MeO, 4- (Me) 3 CO, E ] , [ -
1339:H,3-F,E] , [ -1340 : 4-F, 3-F, E ] , [ -1341 : 4-F, 3-F, Z ] , [-
1342:4-C1,3-F,E] , [-1343 : 4-Cl, 3-F, Z] , [-1344 : 4-Br, 3-F, E] ,
[-1345:4-1, 3-F, E] , [-1346 : 4-Me, 3-F, E] , [-1347 : 4 -Me, 3-F, z] ,
[ -1348:4-Et,3-F,E ] , [ -1349 : 4-C3 H7 , 3-F, E ] , [ -1350:4- (Me)2CH, 3-F, E] , [-1351 : 4-CF3 , 3-F, E] , [-1352 : 4-CF3 , 3-F, Z] ,
[ -1353:4-C2F5 ,3-F,E ] , [ -1354 : 4-C3 F7 , 3-F, E ] , [ -1355:4- (CF3 )2CF,3-F,E ] , [ -1356:4-(CF3 )2CH,3-F,E ] , [ -1357:4- CHF2, 3-F, E] , [-1358:4-CH2F,3-F,E] , [-1359 : 4-CF3 CH2 , 3-F, E] ,
[-1360:4-MeO,3-F,E] , [-1361 : 4-MeO, 3-F, z] , [-1362 : 4-EtO, 3- F, E] , [-1363:4-C3H7O,3-F,E] , [-1364 : 4- (Me) 2 CHO, 3-F, E] , [-
1365:4-NO2 ,3-F,E] , [-1366 : 4-NO2 , 3-F, z] , [-1367 : 3-F, 3-F, E] , [-1368:3-F,3-F,Z] , [-1369 : 3-Cl, 3-F, E] , [-1370 : 3-Cl, 3-F, Z] , [-1371:3-Br,3-F,E] , [-1372 : 3-1 , 3-F, E] , [-1373 : 3-Me, 3-F, E] , C-1374:3-Me,3-F,z] , [-1375 : 3-Et, 3-F, E] , [-1376 : 3-C3 H7 , 3- F,E] , [-1377:3- (Me)2CH, 3-F, E] , [ -1378 : 3-CF3 , 3-F, E ] , [-
1379:3-CF3 ,3-F,Z] , [-1380 : 3-C2 F5 , 3-F, E] , [-1381 : 3-C3 F7 , 3- F, E] , [-1382:3- (CF3 )2CF, 3-F, E] , [-1383 : 3- (CF3 ) 2 CH, 3-F, E] , [ -1384:3-CHF2 ,3-F,E ] , [ -1385 : 3-CHF2 , 3-F, Z ] , [ -1386:3- CH2F, 3-F, E] , [-1387:3-CH2F,3-F,Z] , [-1388 : 3-CF3 CH2 , 3-F, E] , [-1389:3-MeO,3-F,E] , [-1390 : 3-MeO, 3-F, z] , [-1391 : 3-EtO, 3-
F,E] , [-1392:3-C3H7O,3-F,E] , [-1393 : 3- (Me) 2 CHO, 3-F, E] , [- 1394:3-NO2 ,3-F,E] , [-1395 : 2-F, 3-F, E] , [-1396 : 2-Cl, 3-F, E] , [-1397:2-Br,3-F,E] , [-1398 : 2-1, 3-F, E] , [-1399 : 2-Me, 3-F, E] , [ -1400:2-Et,3-F,E ] , [ -1401 : 2-C3 H7 , 3-F, E ] , [ -1402:2- (Me)2CH, 3-F, E] , [-1403 : 2-CF3 , 3-F, E] , [-1404 : 2-C2 F5 , 3-F, E] ,
[-1405:2-C3F7 ,3-F,E] , [-1406 : 2- (CF3 ) 2 CF, 3-F, E] , [-1407:2- (CF3 )2CH,3-F,E ] , [ -1408:2-CHF2 ,3-F,E ] , ( -1409 : 2-CH2 F, 3- F,E] , [ -1410:2-CF3CH2 ,3-F,E ] , [ -1411 : 2-MeO, 3-F, E ] , [- 1412:2-EtO,3-F,E ] , [ -1413 : 2-C3 H7 O, 3-F, E ] , [ -1414:2- (Me)2CHO, 3-F, E ] , [ -1415 : 2-NO2 , 3-F, E ] , [ -1416 : 2 , 3-F2 , 3-
F, E ] , [ -1417:2, 4-F2 , 3-F, E ] , [ -1418 : 2 , 5-F2 , 3-F, E ] , [ - 1419:2, 6-F2 , 3-F, E] , [-1420 : 3, 4-F2 , 3-F, E] , [-1421 : 3, 4-F2 , 3- F, Z ] , [ -1422:3, 5-F2, 3-F, E ] , [ -1423 : 3, 5-F2 , 3-F, Z ] , [ - 1424:2, 3-Cl2 , 3-F, E ] , [ -1425 : 2, 3-Cl2 , 3-F, Z ] , [-1426:2,4- Cl2, 3-F, E] , [-1427:2, 4-Cl2 , 3-F, Z] , [-1428 : 2 , 5-Cl2 , 3-F, E] ,
[-1429:2, 5-Cl2, 3-F,z] , [-1430 : 2, 6-Cl2 , 3-F, E] , [-1431:3,4-
Cl2, 3-F, E) , [-1432:3, 5-Cl2, 3-F,E] , [-1433 : 2, 3-Br2 , 3-F, E] ,
[-1434:2, 4-Br2 , 3-F, E] , [-1435 : 2, 5-Br2 , 3-F, E) , [-1436:2,6-
Br2, 3-F, E] , [-1437:3, 4-Br2 , 3-F, E] , [-1438 : 3, 5-Br2 , 3-F, E) , [-1439:2, 3-Me2, 3-F, E] , [-1440 : 2, 4-Me2 , 3-F, E) , [-1441:2,5-
Me2, 3-F, E) , [-1442:2, 6-Me2 , 3-F, E) , [-1443 : 3, 4-Me2 , 3-F, E) ,
[-1444:3, 5-Me2 , 3-F, E) , [-1445 : 2 , 3-Et2 , 3-F, E) , [-1446:2,4-
Et2, 3-F, E) , [-1447:2, 5-Et2 , 3-F, E) , [-1448 : 2 , 6-Et2 , 3-F, E) ,
[-1449:3, 4-Et2 , 3-F, E) , [-1450 : 3, 5-Et2 , 3-F, E) , [-1451:2,3- (CF3 )2 ,3-F,E ) , [ -1452:2, 4- (CF3 )2, 3-F, E ) , [ -1453:2,5-
(CF3 )2,3-F,E ) , [ -1454:2, 6-(CF3 )2 / 3-F, E ) , [ -1455:3,4- (CF3J2, 3-F, E ] , [ -1456:3, 5- (CF3 )2 , 3-F, E ) , [ -1457:2,3- (CHF2 )2, 3-F, E ) , [ -1458:2, 4- (CHF2 J2 , 3-F, E ) , [ -1459:2,5- (CHF2 )2, 3-F, E ) , [ -1460:2, 6-(CHF2 )2 , 3-F, E ) , [ -1461:3,4- (CHF2 )2 ,3-F,E ) , [ -1462 : 3, 5- (CHF2 ) 2 , 3-F, E ) , [ -1463:2,3-
(CH2F)2, 3-F, E ) , [ -1464:2, 4-(CH2F)2, 3-F, E ) , [ -1465:2,5- (CH2F)2 , 3-F, E ) , [ -1466:2, 6-(CH2F)2, 3-F, E ) , [ -1467:3,4- (CH2F)2 , 3-F, E ) , [ -1468:3, 5-(CH2F)2 , 3-F, E ) , [ -1469:2,3- (MeO)2, 3-F, E ) , [ -1470 : 2, 4- (MeO) 2 , 3-F, E ) , [ -1471:2,5- (MeO)2 , 3-F, E ) , [ -1472 : 2, 6- (MeO) 2 , 3-F, E ) , [ -1473:3,4-
(MeO)2 , 3-F, E ) , [ -1474 : 3, 5- (MeO) 2 , 3-F, E ) , [ -1475:2,3- (EtO)2, 3-F, E ) , [ -1476:2, 4-(EtO)2, 3-F, E ] , [ -1477:2,5- (EtO)2, 3-F, E ) , [ -1478:2, 6-(EtO)2 , 3-F, E ) , [ -1479:3,4- (EtO)2 , 3-F, E ) , [ -1480:3,5- (EtO)2 , 3-F, E ) , [ -1481 : 2-C1-3- F, 3-F, E) , [-1482:2-Cl-4-F,3-F,E) , [-1483 : 2-C1-5-F, 3-F, E) ,
[-1484:2-Cl-6-F,3-F,E] , (-1485 : 3-C1-2-F, 3-F, E] , (-1486:3- Cl-4-F,3-F,E] , [-1487:3-Cl-5-F,3-F,E] , [-1488 : 4-C1-2-F, 3- F,E] , C-1489:4-Cl-3-F,3-F,E] , (-1490 : 2-F-3-Me, 3-F, E] , C- 1491:2-F-4-Me,3-F,E] , [-1492 : 2-F-5-Me, 3-F, E] , [-1493.2-F- β-Me,3-F,E ] , ( -1494 : 3-F-2-Me, 3-F, E ] , ( -1495 : 3-F-4-Me, 3-
F,E] , (-1496:3-F-5-Me,3-F,E] , [-1497 : 4-F-2-Me, 3-F, E] , [- 1498:4-F-3-Me,3-F,E] , ( -1499 : 2-Cl-3-Me, 3-F, E ] , [-1500:2- Cl-4-Me,3-F,E ] , [ -1501 : 2-Cl-5-Me, 3-F, E ] , [ -1502 : 2-C1-6- Me, 3-F, E] , [ -1503:3-Cl-2-Me,3-F,E ] , ( -1504 : 3-Cl-4-Me, 3- F, E] , [-1505:3-Cl-5-Me,3-F,E] , [-1506 : 4-Cl-2-Me, 3-F, E] , (-
1507:4-Cl-3-Me,3-F,E] , (-1508 : 2-F-3-CF3 , 3-F, E] , [-1509:2- F-4-CF3 ,3-F,E ] , [ -1510:2-F-5-CF3 ,3-F,E ] , ( -1511 : 2-F-6- CF3, 3-F, E] , [-1512:3-F-2-CF3,3-F,E] , [ -1513 : 3-F-4-CF3 , 3- F,E] , (-1514:3-F-5-CF3 ,3-F,E] , [-1515 : 4-F-2-CF3 , 3-F, E] , [- 1516:4-F-3-CF3,3-F,E] , (-1517 : 2-Cl-3-CF3 , 3-F, E] , [-1518:2-
Cl-4-CF3 ,3-F,E] , [-1519.2-CI-5-CF3 ,3-F,E] , [-1520 : 2-C1-6-
CF3, 3-F, E] , [-1521:3-Cl-2-CF3 ,3-F,E] , (-1522 : 3-Cl-4-CF3 , 3-
F,E] , [-1523:3-Cl-5-CF3 ,3-F,E] , (-1524 : 4-Cl-2-CF3 , 3-F, E] ,
[ -1525:4-Cl-3-CF3 ,3-F,E] , [ -1526 : 2-Me-3-CF3 , 3-F, E ] , [- 1527:2-Me-4-CF3 ,3-F,E ] , [ -1528 : 2-Me-5-CF3 , 3-F, E ] , [ -
1529:2-Me-6-CF3 ,3-F,E ] , [ -1530 : 3-Me-2-CF3 , 3-F, E ] , ( - 1531:3-Me-4-CF3 ,3-F,E ] , [ -1532 : 3-Me-5-CF3 , 3-F, E ] , [ - 1533:4-Me-2-CF3 ,3-F,E ] , ( -1534 : 4-Me-3-CF3 , 3-F, E ] , [ - 1535 :2-F-3-MeO, 3-F, E] , [-1536 : 2-F-4-MeO, 3-F, E] , [-1537:2- F-5-MeO,3-F,E ] , [ -1538 : 2-F-6-MeO, 3-F, E ] , ( -1539 : 3-F-2-
MeO,3-F,E] , ( -1540 : 3-F-4-MeO, 3-F, E ] , C -1541 : 3-F-5-MeO, 3- F, E] , [-1542:4-F-2-MeO,3-F,E] , [-1543 : 4-F-3-MeO, 3-F, E] , [- 1544:2-Cl-3-MeO,3-F,E ] , [ -1545 : 2-Cl-4-MeO, 3-F, E ] , [ - 1546:2-Cl-5-MeO,3-F,E ] , [ -1547 : 2-Cl-6-MeO, 3-F, E ] , C - 1548:3-Cl-2-MeO,3-F,E ] , [ -1549 : 3-Cl-4-MeO, 3-F, E ] , [ -
1550:3-Cl-5-MeO,3-F,E ] , [ -1551 : 4-Cl-2-MeO, 3-F, E ] , C - 1552:4-Cl-3-MeO,3-F,E ] , [ -1553 : 2-Me-3-MeO, 3-F, E ] , [ - 1554 :2-Me-4-MeO,3-F,E ] , [ -1555 : 2-Me-5-MeO, 3-F, E ] , C - 1556:2-Me-6-MeO,3-F,E ] , [ -1557 : 3-Me-2-MeO, 3-F, E ) , [ - 1558:3-Me-4-MeO,3-F,E ] , C -1559 : 3-Me-5-MeO, 3-F, E ] , [ -
1560:4-Me-2-MeO,3-F,E ] , [ -1561 : 4-Me-3-MeO, 3-F, E ] , [ - 1562:H,3-C1,E] , [-1563 : 4-F, 3-Cl, E] , [-1564 : 4-F, 3-Cl, z] , [- 1565:4-C1,3-C1,E ] , [ -1566: 4-Cl, 3-Cl, Z ] , [ -1567 : 4-Br, 3- Cl, E] , [-1568:4-1, 3-Cl, E] , [-1569 : 4 -Me, 3-Cl, E] , [-1570:4- Me, 3-Cl, Z] , [-1571 : 4-Et, 3-Cl, E] , [-1572 : 4-C3 H7 , 3-Cl, E] , C-
1573:4-(Me)2CH,3-Cl,E ] , [ -1574 : 4-CF3 , 3-Cl, E ] , [-1575:4-
CF3, 3-Cl, Z] , [-1576.4-C2F5, 3-Cl, E] , [-1577 : 4-C3 F7 , 3-Cl, E] ,
[-1578:4-(CF3)2CF,3-C1,E] , [-1579 : 4- (CF3 ) 2 CH, 3-Cl, E] , [-
158O:4-CHF2,3-C1,E ] , [ -1581 : 4-CH2 F, 3-Cl, E ] , [ -1582:4- CF3CH2 , 3-Cl, E ] , [ -1583 : 4-MeO, 3-Cl, E ] , [ -1584 : 4-MeO, 3-
Cl, Z] , [-1585:4-EtO,3-Cl,E] , [ -1586 : 4-C3 H7 O, 3-Cl, E ] , [- 1587.4-(Me)2CHO, 3-Cl, E] , [ -1588 : 4-NO2 , 3-Cl, E] , [-1589:4- NO2, 3-Cl, Z] , [-159O:3-F,3-C1,E] , [ -1591 : 3-F, 3-Cl, Z ] , [- 1592:3-C1,3-C1,E ] , [ -1593 : 3-Cl, 3-Cl, Z ] , [ -1594 : 3-Br, 3- Cl, E] , [-1595:3-1, 3-Cl, E] , [-1596 : 3-Me, 3-Cl, E] , [-1597:3-
Me,3-Cl,Z] , [-1598:3-Et,3-C1,E] , (-1599 : 3-C3 H7 , 3-Cl, E] , C-
1600:3-(Me)2CH,3-Cl,E ] , [ -1601 : 3-CF3 , 3-Cl, E ] , [-1602:3-
CF3, 3-Cl, z] , (-1603:3-C2F5 ,3-Cl,E] , [-1604 : 3-C3 F7 , 3-Cl , E] ,
[-1605:3- (CF3 )2CF, 3-Cl, E] , [-1606 : 3- (CF3 ) 2 CH, 3-Cl, E) , (- 1607:3-CHF2 ,3-Cl, E ] , [ -1608 : 3-CHF2 , 3-Cl, Z ] , [ -1609:3-
CH2F, 3-Cl, E] , [ -161O:3-CH2F,3-C1,Z ] , [ -1611 : 3-CF3 CH2 , 3-
Cl, E] , [ -1612: 3-MeO, 3-Cl, E ] , [ -1613 : 3-MeO, 3-Cl, Z ] , [-
1614:3-EtO,3-Cl,E ] , [ -1615 : 3-C3 H7 O, 3-Cl, E ] , [ -1616:3-
(Me)2CHO, 3-Cl, E ] , [ -1617 : 3-NO2 , 3-Cl, E ] , [ -1618 : 2-F, 3- Cl, E] , [-1619:2-C1,3-C1,E] , [-1620 : 2-Br, 3-Cl, E] , (-1621:2-
I, 3-Cl, E] , [-1622:2-Me,3-C1,E] , [ -1623 : 2-Et, 3-Cl, E ] , [-
1624.2-C3H7, 3-Cl, E] , [ -1625 : 2- (Me) 2 CH, 3-Cl, E ] , [-1626:2-
CF3, 3-Cl, E] , [-1627:2-C2F5 ,3-Cl,E] , [-1628 : 2-C3 F7 , 3-Cl, E] ,
[-1629:2- (CF3 )2CF, 3-Cl, E] , [-1630 : 2- (CF3 ) 2 CH, 3-Cl, E] , [- 1631: 2-CHF2 ,3-Cl, E ] , [ -1632 : 2-CH2 F, 3-Cl, E ] , ( -1633:2-
CF3CH2 , 3-Cl, E ] , [ -1634:2-MeO,3-Cl,E ] , [ -1635 : 2-EtO, 3-
Cl, E] , [-1636:2-C3H7O,3-C1,E] , [-1637 : 2- (Me) 2 CHO, 3-Cl, E] ,
[-1638:2-NO2 ,3-Cl,E] , [-1639:2, 3-F2 , 3-Cl, E] , [-1640:2,4-
F2, 3-Cl, E] , [-1641:2, 5-F2 , 3-Cl, E] , [-1642 :2, 6-F2 , 3-Cl, E] , [-1643:3, 4-F2, 3-Cl, E] , (-1644 : 3, 4-F2 , 3-Cl, Z] , [-1645:3,5-
F2, 3-Cl, E] , [-1646:3, 5-F2 , 3-Cl, Z] , [-1647 : 2, 3-Cl2 , 3-Cl, E] ,
( -1648:2, 3-Cl2 ,3-Cl, Z ] , [ -1649 : 2 , 4-Cl2 , 3-Cl, E ] , ( - 1650:2, 4-Cl2 , 3-Cl, Z] , [-1651 : 2, 5-Cl2 , 3-Cl, E] , [-1652:2,5- Cl2, 3-Cl, Z ] , [ -1653:2, 6-Cl2, 3-Cl, E ] , [ -1654 : 3, 4-Cl2 , 3- Cl, E] , [-1655:3, 5-Cl2 ,3-Cl, E] , [-1656 : 2, 3-Br2 , 3-Cl, E] , [-
1657:2, 4-Br2 ,3-Cl, E] , [-1658 : 2, 5-Br2 , 3-Cl, E] , (-1659:2,6- Br2,3-C1,E ] , [ -1660^,41Br2 ,3-Cl, E ] , [ -1661 : 3, 5-Br2 , 3- Cl, E] -, [-1662:2, 3-Me2 ,3-Cl, E] , [-1663 : 2, 4-Me2 ', 3-Cl, E] , [- 1664:2, 5-Me2 ,3-Cl, E] , [-1665 : 2, 6-Me2 /3-Cl, E] , "[-1666:3,4- Me2, 3-Cl, E ] , ( -1667 : 3, 5-Me2 , 3-Cl, E ] , [ -1668 : 2, 3-Et2 , 3-
Cl, E] , [-1669:2, 4-Et2 , 3-Cl, E] , [-1670 : 2, 5-Et2 , 3-Cl, E] , [- 1671:2, 6-Et2, 3-Cl, E] , (-1672 : 3, 4-Et2 , 3-Cl, E] , [-1673:3,5- Et2, 3-Cl, E ] , [ -1674:2, 3-(CF3)2 , 3-Cl, E ] , [ -1675:2,4- (CF3 )2, 3-Cl, E ] , [ -1676:2, 5-(CF3)2, 3-Cl, E ] , [ -1677:2,6- (CF3)2, 3-Cl, E ] , [ -1678:3, 4-(CF3)2, 3-Cl, E ] , [ -1679:3,5-
(CFs)2 , 3-Cl, E ] , [ -1680:2, 3-(CHF2 )2, 3-Cl, E] , [-1681:2,4- (CHF2 )2 ,3-Cl, E] , [-1682:2, 5- (CHF2 )2 , 3-Cl, E] , [-1683:2,6- (CHF2 J2 ,3-Cl, E] , [-1684:3, 4-(CHF2 )2 ,3-Cl, E] , [-1685:3,5- (CHF2 )2, 3-Cl, E] , [-1686:2, 3-(CH2F)2, 3-Cl, E] , [-1687:2,4- (CH2F)2, 3-Cl, E] , ( -1688 : 2 , 5- (CH2 F) 2 , 3-Cl, E ] , (-1689:2,6-
(CH2F)2 ,3-Cl, E] , [-1690:3, 4-(CH2F)2 ,3-Cl, E] , [-1691:3,5- (CH2F)2 , 3-Cl, E ] , [ -1692:2,3- (MeO)2 , 3-Cl, E ] , [-1693:2,4- (MeO)2 , 3-Cl, E ] , [ -1694 : 2, 5- (MeO) 2 , 3-Cl, E ] , [ -1695:2,6- (MeO)2, 3-Cl, E ] , ( -1696 : 3, 4- (MeO) 2 , 3-Cl, E ] , ( -1697:3,5- (MeO)2 , 3-Cl, E ] , [ -1698 : 2 , 3- (EtO) 2 , 3-Cl, E ] , [ -1699:2,4-
(EtO)2, 3-Cl, E ] , ( -1700:2, 5-(EtO)2, 3-Cl, E ] , ( -1701:2,6- (EtO)2 , 3-Cl, E ] , [ -1702:3, 4-(EtO)2 , 3-Cl, E ] , [ -1703:3,5- (EtO)2, 3-Cl, E] , [ -1704:2-Cl-3-F,3-Cl,E ] , ( -1705 : 2-C1-4- F, 3-Cl, E ] , ( -1706:2-Cl-5-F,3-Cl,E ] , [ -1707 : 2-C1-6-F, 3- Cl, E] , [-1708:3-Cl-2-F,3-Cl,E] , [-1709 : 3-C1-4-F, 3-Cl, E] ,
C -1710:3-Cl-5-F,3-Cl,E ] , [ -1711 : 4-C1-2-F, 3-Cl, E ] , C-
1712:4-Cl-3-F,3-Cl,E] , [ -1713 : 2-F-3-Me, 3-Cl, E) , [-1714:2-
F-4-Me,3-Cl,E ] , [ -1715 : 2-F-5-Me, 3-Cl, E ] , ( -1716 : 2-F-6-
Me, 3-Cl, E] , C -1717:3-F-2-Me,3-Cl,E ] , [ -1718 : 3-F-4-Me, 3- Cl, E] , [-1719:3-F-5-Me,3-Cl,E] , [-1720 : 4-F-2-Me, 3-Cl, E] ,
[ -1721:4-F-3-Me,3-Cl,E ] , [ -1722 : 2-Cl-3-Me, 3-Cl, E ] , [-
1723:2-Cl-4-Me,3-Cl,E ] , [ -1724 : 2-Cl-5-Me, 3-Cl, E ) , [ -
1725:2-Cl-6-Me,3-Cl,E ] , [ -1726 : 3-Cl-2-Me, 3-Cl, E ] , [ -
1727:3-Cl-4-Me,3-Cl,E ] , [ -1728 : 3-Cl-5-Me, 3-Cl, E ] , [ - 1729:4-Cl-2-Me,3-Cl,E ] , [ -1730 : 4-Cl-3-Me, 3-Cl, E ] , [ - 1731:2-F-3-CF3 ,3-Cl, E ] , [ -1732 : 2-F-4-CF3 , 3-Cl, E ] , [ - 1733:2-F-5-CF3,3-Cl,E ] , [ -1734 : 2-F-β-CF3 , 3-Cl, E ] , [ - 1735:3-F-2-CF3 ,3-Cl,E ] , [ -1736 : 3-F-4-CF3 , 3-Cl, E ] , [ - 1737:3-F-5-CF3,3-Cl,E ] , [ -1738 : 4-F-2-CF3 , 3-Cl, E ] , [ - 1739:4-F-3-CF3 ,3-Cl, E ] , [ -1740 : 2-Cl-3-CF3 , 3-Cl, E ] , [ - 1741:2-Cl-4-CF3 ,3-Cl, E ] , [ -1742 : 2-Cl-5-CF3 , 3-Cl, E ] , [- 1743:2-Cl-6-CF3 ,3-Cl, E ] , [ -1744 : 3-Cl-2-CF3 , 3-Cl, E ] , [- 1745:3-Cl-4-CF3 ,3-Cl, E ] , [ -1746 : 3-Cl-5-CF3 , 3-Cl, E } , [- 1747:4-Cl-2-CF3 ,3-Cl, E ] , [ -1748 : 4-Cl-3-CF3 , 3-Cl, E ] , [- 1749:2-Me-3-CF3 ,3-Cl, E ] , [ -1750 : 2-Me-4-CF3 , 3-Cl, E ] , [- 1751:2-Me-5-CF3 ,3-Cl, E ] , [ -1752 : 2-Me-6-CF3 , 3-Cl, E ] , [- 1753:3-Me-2-CF3 ,3-Cl, E ] , [ -1754 : 3-Me-4-CF3 , 3-Cl, E ] , [- 1755:3-Me-5-CF3 ,3-Cl, E ] , C -1756 : 4-Me-2-CF3 , 3-Cl, E ] , C- 1757:4-Me-3-CF3 ,3-Cl, E ] , [ -1758 : 2-F-3-MeO, 3-Cl, E ] , C - 1759:2-F-4-MeO,3-Cl,E ] , C -1760 : 2-F-5-MeO, 3-Cl, E ) , C -
17βl:2-F-6-MeO,3-Cl,E ] , [ -1762 : 3-F-2-MeO, 3-Cl, E ] , [ - 1763:3-F-4-MeO,3-Cl,E ] , [ -1764 : 3-F-5-MeO, 3-Cl, E ] , [ - 1765:4-F-2-MeO,3-Cl,E ] , C -1766 : 4-F-3-MeO, 3-Cl, E ] , ( - 1767:2-Cl-3-MeO,3-Cl,E 3 , ( -1768 : 2-Cl-4-MeO, 3-Cl, E ] , [ - 1769:2-Cl-5-MeO,3-Cl,E ] , [ -1770 : 2-Cl-6-MeO, 3-Cl, E ] , ( -
1771:3-Cl-2-MeO,3-Cl,E ] , C -1772 : 3-Cl-4-MeO, 3-Cl, E ] , ( - 1773:3-Cl-5-MeO,3-Cl,E ] , [ -1774 : 4-Cl-2-MeO, 3-Cl, E ] , [ - 1775:4-Cl-3-MeO,3-Cl,E ) , [ -1776 : 2-Me-3-MeO, 3-Cl, E ] , [ - 1777:2-Me-4-MeO,3-Cl,E ] , C -1778 : 2-Me-5-MeO, 3-Cl, E ] , [ - 1779:2-Me-6-MeO,3-Cl,E ] , [ -1780 : 3-Me-2-MeO, 3-Cl, E ] , [ -
1781:3-Me-4-MeO,3-Cl,E ] , [ -1782 : 3-Me-5-MeO, 3-Cl, E ] , C -
1783:4-Me-2-MeO,3-Cl,E ] , [ -1784 : 4-Me-3-MeO, 3-Cl, E ] , ( -
1785:H,3-CF3 ,E] , C-1786 : 4-F, 3-CF3 , E] , (-1787 : 4-F, 3-CF3 , Z] ,
( -1788:4-C1,3-CF3 ,E ] , [ -1789 : 4-Cl, 3-CF3 , Z ] , ( -1790:4- Br, 3-CF3, E) , [-1791 : 4-1, 3-CF3 , E] , [-1792 : 4 -Me, 3-CF3 , E] , [-
1793:4-Me,3-CF3 , Z] , [-1794 : 4-Et , 3-CF3 , E] , [-1795 : 4-C3 H7 , 3-
CF3, E] , (-1796:4-(Me)2CH,3-CF3 ,E] , (-1797 : 4-CF3 , 3-CF3 , E] ,
[-1798:4-CF3 ,3-CF3 ,Z] , (-1799 : 4-C2 F5 , 3-CF3 , E] , [-1800:4-
C3F7 ,3-CF3 ,E ] , [ -1801:4- (CF3 )2CF, 3-CF3 ,E ] , [ -1802:4- (CF3 )2CH, 3-CF3 ,E ] , [ -1803 : 4-CHF2 , 3-CF3 , E ] , [ -1804:4-
CH2F, 3-CF3, E] , [-1805:4-CF3CH2 ,3-CF3 ,E] , ( -1806 : 4-MeO, 3- CF3, E] , (-1807:4-MeO,3-CF3 ,Z] , [-1808 : 4-EtO, 3-CF3 , E] , [- 1809:4-C3H7O,3-CF3 ,E ] , [ -1810 : 4- (Me) 2 CHO, 3-CF3 , E ] , [ - 1811:4-NO2 ,3-CF3 ,E] , [ -1812 : 4-NO2 , 3-CF3 , Z ] , [-1813 : 3-F, 3- CF3, E] , ( -1814:3-F,3-CF3 ,Z ] , ( -1815 : 3-Cl, 3-CF3 , E ] , [-
1816:3-C1,3-CF3,Z ] , [ -1817 : 3-Br, 3-CF3 , E ] , [-1818:3-1,3- CF3, E] , [ -1819 :3-Me, 3-CF3 ,E] , [ -1820 : 3-Me, 3TCF3 , Z ] , [- 1821:3-Et,3-CF3 ,E ] , [ -1822 : 3-C3 H7 , 3-CF3 , E ] , [ -1823:3- (Me)2CH, 3-CF3 ,E] , [ -1824 : 3-CF3 , 3-CF3 , E ] , [ -1825 : 3-CF3 , 3- CF3, z] , [-1826:3-C2F5 ,3-CF3 ,E] , [-1827 : 3-C3 F7 , 3-CF3 , E] , [-
1828:3-(CF3 ) 2 CF, 3-CF3 , E ] , [ -1829 : 3- (CF3 ) 2 CH, 3-CF3 , E ] , [- 1830:3-CHF2 ,3-CF3 ,E ] , [ -1831 : 3-CHF2 , 3-CF3 , Z ] , [-1832:3- CH2F, 3-CF3 ,E] , [-1833:3-CH2F,3-CF3 ,Z] , [ -1834 : 3-CF3 CH2 , 3- CF3, E] , [-1835 : 3-MeO, 3-CF3 ,E] , [-1836 : 3-MeO, 3-CF3 , z] , [- 1837: 3-EtO, 3-CF3 ,E ] , [ -1838 : 3-C3 H70, 3-CF3 , E ] , [-1839:3-
(Me) 2 CHO, 3-CF3 ,E ] , [ -1840 : 3-NO2 , 3-CF3 , E ] , [ -1841 : 2-F, 3-
CF3, E] , [-1842:2-C1,3-CF3 ,E] , [ -1843 : 2-Br, 3-CF3 , E ] , [-
1844:2-1, 3-CF3 ,E ] , [ -1845 : 2 -Me, 3-CF3 , E ] , [ -1846 : 2-Et , 3-
CF3, E] , [-1847:2-C3H7 ,3-CF3 ,E] , [-1848 : 2- (Me) 2 CH, 3-CF3 , E] , [-1849:2-CF3 ,3-CF3 ,E] , [ -1850 : 2-C2 F5 , 3-CF3 , E ] , [-1851:2-
C3F7 ,3-CF3 ,E ] , [ -1852:2- (CF3 )2CF, 3-CF3 ,E ] , [ -1853:2- (CF3 )2CH, 3-CF3 ,E ] , [ -1854:2-CHF2 ,3-CF3 ,E ] , [ -1855:2- CH2F, 3-CF3 ,E] , [-1856:2-CF3CH2 ,3-CF3 ,E] , [ -1857 : 2-MeO, 3- CF3, E] , [-1858:2-EtO,3-CF3 ,E] , [-1859 : 2-C3 H70, 3-CF3 , E] , [- 1860:2- (Me)2CHO, 3-CF3 , E ] , [ -1861 : 2-NO2 , 3-CF3 , E ] , [ -
1862:2, 3-F2 ,3-CF3 ,E] , [-1863 : 2, 4-F2 , 3-CF3 , E] , [-1864:2,5- F2, 3-CF3, E ] , [ -1865:2, 6-F2 ,3-CF3 ,E ] , [ -1866 : 3, 4-F2 , 3- CF3, E] , [-1867:3, 4-F2 ,3-CF3 ,Z] , [-1868 : 3, 5-F2 , 3-CF3 , E] , [- 1869:3, 5-F2 ,3-CF3 , Z] , [-1870 : 2, 3-Cl2 , 3-CF3 , E] , [-1871:2,3- Cl2, 3-CF3, Z] , [-1872:2, 4-Cl2 ,3-CF3 ,E] , [ -1873 : 2, 4-Cl2 , 3-
CF3, Z] , [-1874:2, 5-Cl2, 3-CF3 , E] , [-1875 : 2, 5-Cl2 , 3-CF3 , z] , [ -1876:2, 6-Cl2, 3-CF3 ,E ] , [ -1877 : 3, 4-Cl2 , 3-CF3 , E ] , [ - 1878:3, 5-Cl2 ,3-CF3 , E ] , [ -1879 : 2, 3-Br2 , 3-CF3 , E ] , [ -
1880:2, 4-Br2 ,3-CF3 , E ] [ -1881:2, 5-Br2, 3-CF3, E ] , [ - 1882:2, 6-Br2 ,3-CF3 ,E ] [ -1883:3, 4-Br2, 3-CF3, E ] , [ - 1884:3, 5-Br2 ,3-CF3, E ] [ -1885:2, 3-Me2 ,3-CF3 , E ] , [ - 1886:2, 4-Me2 ,3-CF3, E ] [ -1887:2, 5-Me2 ,3-CF3, E ] , [ - 1888:2, 6-Me2 ,3-CF3 , E ] [ -1889:3, 4-Me2 ,3-CF3 , E ] , [ - 1890:3, 5-Me2 ,3-CF3 ,E ] [ -1891:2, 3-Et2, 3-CF3 , E ] , [ - 11889922::22,, 44--EEtt22 ,,33--CCFF33,, EE ]] , [ -1893 : 2 , 5-Et2 , 3-CF3 , E ] , [ -
1894:2, 6-Et2 ,3-CF3 , E ] , [ -1895 : 3, 4-Et2 , 3-CF3 , E ] , [ - 1896:3, 5-Et2 ,3-CF3, E ] , [ -1897 : 2, 3- (CF3 ) 2 , 3-CF3 , E ] , [ - 1898:2, 4-(CF3J2, 3-CF3 , E] , [ -1899 : 2 , 5- (CF3 ) 2 , 3-CF3 , E ] , [- 1900:2, 6-(CFa)2, 3-CF3, E] , [ -1901 : 3, 4- (CF3 ) 2 , 3-CF3 , E ] , [- 1902:3,5- (CF3 )2 ,3-CF3 ,E] , [ -1903 : 2, 3- (CHF2 ) 2 , 3-CF3 , E] , [-
1904:2,4- (CHF2 )2 ,3-CF3 ,E] , [-1905 : 2 , 5- (CHF2 ) 2 , 3-CF3 , E] , [- 1906:2, 6- (CHF2 )2 ,3-CF3 ,E] , [-1907 : 3, 4- (CHF2 ) 2 , 3-CF3 , E] , [- 1908:3, 5-(CHF2 )2 ,3-CF3, E] , [-1909 : 2, 3- (CH2 F) 2 , 3-CF3 , E] , [- 1910:2, 4-(CH2F)2, 3-CF3, E] , [-1911 : 2 , 5- (CH2 F) 2 , 3-CF3 , E] , [- 1912:2,6- (CH2F)2 ,3-CF3 ,E] , [-1913 : 3, 4- (CH2 F) 2 , 3-CF3 , E] , [-
1914:3, 5-(CH2F)2, 3-CF3, E] , [ -1915 : 2 , 3- (MeO) 2 , 3-CF3 , E] , [- 1916:2,4- (MeO)2 ,3-CF3 ,E] , [ -1917 : 2, 5- (MeO) 2 , 3-CF3 , E ] , [- 1918:2,6- (MeO)2 ,3-CF3 ,E] , [ -1919 : 3, 4- (MeO) 2 , 3-CF3 , E ] , [- 1920:3, 5-(MeO)2 ,3-CF3, E] , [ -1921 : 2, 3- (EtO) 2 , 3-CF3 , E ] , [- 1922:2, 4-(EtO)2 ,3-CF3, E] , [ -1923 : 2, 5- (EtO) 2 , 3-CF3 , E ] , [-
1924:2, 6-(EtO)2 ,3-CF3, E] , [ -1925:3, 4- (EtO) 2 , 3-CF3 ,E ] , C
1926:'3, 5- (EtOJ2 ,3-CF3 ,E ] , [ -1927 : 2-C1-3-F, 3-CF3 , E ] , [
1928.'2-C1-4-F, 3-CF3 ,E ] , [ -1929 : 2-C1-5-F, 3-CF3 , E ] , [
1930:2-Cl-6-F,3-CF3,E ] , [ -1931 : 3-C1-2-F, 3-CF3 , E ] , [ 1932:3-Cl-4-F,3-CF3 ,E ] , C -1933 : 3-C1-5-F, 3-CF3 , E ] , [
1934:4-Cl-2-F,3-CF3 ,E ] ', ( -1935 : 4-C1-3-F, 3-CF3 , E ] , [
1936:2-F-3-Me,3-CF3 ,E ] , [ -1937 : 2-F-4-Me, 3-CF3 , E ] , [
1938:2-F-5-Me,3-CF3 ,E ] , C -1939 : 2-F-6-Me, 3-CF3 , E ] , [
1940:3-F-2-Me,3-CF3 ,E ] , C -1941 : 3-F-4-Me, 3-CF3 , E ] , [ 1942:3-F-5-Me,3-CF3 ,E ] , [ -1943 : 4-F-2-Me, 3-CF3 , E ] , [
1944 :4-F-3-Me, 3-CF3 ,E ] , [ -1945 : 2-Cl-3-Me, 3-CF3 , E ] , [
1946:2-Cl-4-Me,3-CF3 ,E ] , [ -1947 : 2-Cl-5-Me, 3-CF3 , E ] , (
1948:2-Cl-6-Me,3-CF3 ,E ] , [ -1949 : 3-Cl-2-Me, 3-CF3 , E ] , [ ■
1950:3-Cl-4-Me,3-CF3 ,E ] , C -1951 : 3-Cl-5-Me, 3-CF3 , E ] , [ ■ 1952:4-Cl-2-Me,3-CF3 ,E ] , [ -1953 : 4-Cl-3-Me, 3-CF3 , E ] , [ ■
1954 :2-F-3-CF3 ,3-CF3 ,E ] , [ -1955 : 2-F-4-CF3 , 3-CF3 , E ] , [ •
1956:2-F-5-CF3 ,3-CF3 ,E ] , [ -1957 : 2-F-6-CF3 , 3-CF3 , E ] , [ ■
1958:3-F-2-CF3 ,3-CF3 ,E ] , [ -1959 : 3-F-4-CF3 , 3-CF3 , E ] , [ ■
1960:3-F-5-CF3 , 3-CF3 ,E ] , [ -1961 : 4-F-2-CF3 , 3-CF3 , E ] , [ ■ 1962 :4-F-3-CF3 ,3-CF3 ,E ] , C -1963 : 2-Cl-3-CF3 , 3-CF3 , E ] , [-
1964:2-Cl-4-CF3 ,3-CF3 ,E] , [ -1965:2-Cl-5-CF3 , 3-CF3 ,E] , [■
1966:2-Cl-6-CF3 ,3-CF3 ,E] , [ -1967 : 3-Cl-2-CF3 , 3-CF3 , E ] , [■
1968:3-Cl-4-CF3 ,3-CF3 ,E] , ( -1969 : 3-Cl-5-CF3 , 3-CF3 , E ] , [■
1970:4-Cl-2-CF3 ,3-CF3 ,E] , [ -1971 : 4-Cl-3-CF3 , 3-CF3 , E ] , [■ 1972:2-Me-3-CF3 ,3-CF3 ,E] , [ -1973 : 2-Me-4-CF3 , 3-CF3 , E ] , [■
1974 :2-Me-5-CF3, 3-CF3 ,EJ , [ -1975 : 2-Me-6-CF3 , 3-CF3 , E ] , [- 1976:3-Me-2-CF3 ,3-CF3 ,E] , [ -1977 : 3-Me-4-CF3 , 3-CF3 , E ] , [- 1978:3-Me-5-CF3 ,3-CF3 ,E] , [ -1979 : 4-Me-2-CF3 , 3-CF3 , E ] , [- 1980:4-Me-3-CF3 ,3-CF3 ,E ] , C -1981 : 2-F-3-MeO, 3-CF3 , E ] , [- 1982:2-F-4-MeO,3-CF3 ,E ] , [ -1983 : 2-F-5-MeO, 3-CF3 , E ] , [ -
1984 :2-F-6-MeO, 3-CF3 ,E ] , [ -1985 : 3-F-2-MeO, 3-CF3 , E ] , [ - 1986:3-F-4-MeO,3-CF3 ,E ] , [ -1987 : 3-F-5-MeO, 3-CF3 , E ] , [ - 1988 :4-F-2-MeO, 3-CF3 ,E ] , C -1989 : 4-F-3-MeO, 3-CF3 , E ] , [ - 1990 :2-Cl-3-MeO, 3-CF3 ,E] , [ -1991 : 2-Cl-4-MeO, 3-CF3 , E ] , [- 1992:2-Cl-5-MeO,3-CF3 ,E] , [ -1993 : 2-Cl-6-MeO, 3-CF3 , E ] , [-
1994 :3-Cl-2-MeO,3-CF3 ,E] , [ -1995 : 3-Cl-4-MeO, 3-CF3 , E ] , [- 1996:3-Cl-5-MeO,3-CF3 ,E] , [ -1997 : 4-Cl-2-MeO, 3-CF3 , E ] , [- 1998 :4-Cl-3-MeO, 3-CF3 ,E] , C -1999 : 2-Me-3-MeO, 3-CF3 , E ] , [- 2000:2-Me-4-MeO,3-CF3 ,E] , [ -2001 : 2-Me-5-MeO, 3-CF3 , E ] , [- 2002 :2-Me-6-MeO, 3-CF3 ,E] , [ -2003 : 3-Me-2-MeO, 3-CF3 , E ] , [-
2004 :3-Me-4-MeO,3-CF3 ,E] , [ -2005 : 3-Me-5-MeO, 3-CF3 , E ] , [-
2006: 4-Me-2-MeO, 3-CF3 ,E] , C -2007 : 4-Me-3-MeO, 3-CF3 , E ] , [-
2008:H,3-MeO,E] , [-2009 : 4-F, 3-MeO, E] , [-2010 : 4-F, 3-MeO, z] ,
[ -2011:4-Cl,3-MeO,E ] , [ -2012 : 4-Cl, 3-MeO, Z ] , [-2013:4- Br, 3-MeO, E] , [-2014 : 4-1, 3-MeO, E] , [-2015 : 4-Me, 3-MeO, E] , [-
2016:4-Me,3-MeO,Z] , [-2017 : A-Et, 3-MeO, E] , [-2018 : 4-C3 H7 , 3-
MeO, E] , [-2019:4- (Me)2CH, 3-MeO, E] , [-2020 : 4-CF3 , 3-MeO, E] ,
[-2021M-CF3, 3-MeO, Z] , [-2022 : 4-C2 F5 , 3-MeO, E] , [-2023:4-
C3F7 ,3-MeO, E ] , [ -2024 : 4- (CF3 ) 2 CF, 3-MeO, E ] , [ -2025:4- (CF3 ) 2 CH, 3-MeO, E ] , [ -2026 : 4-CHF2 , 3-MeO, E ] , [ -2027:4-
CH2F, 3-MeO, E] , [ -2028 : 4-CF3 CH2 , 3-MeO, E ] , [ -2029 : 4-MeO, 3-
MeO, E] , [-2030:4-MeO,3-MeO,z] , [-2031 : 4-EtO, 3-MeO, E] , C-
2032:4-C3H7O,3-MeO,E ] , [ -2033 : 4- (Me) 2 CHO, 3-MeO, E ] , [ -
2034:4-NO2 ,3-MeO,E] , [-2035 : 4-NO2 , 3-MeO, Z] , [-2036 : 3-F, 3- MeO, E] , [ -2037:3-F,3-MeO,Z ] , [ -2038 : 3-Cl, 3-MeO, E ] , [-
2039:3-Cl,3-MeO,Z ] , [ -2040 : 3-Br, 3-MeO, E ] , [-2041:3-1,3-
MeO, E] , [-2042:3-Me,3-MeO,E] , [ -2043 : 3-Me, 3-MeO, Z ] , [-
2044:3-Et,3-MeO,E ] , [ -2045 : 3-C3 H7 , 3-MeO, E ] , [ -2046:3-
(Me)2CH, 3-MeO, E] , [ -2047 : 3-CF3 , 3-MeO, E ] , [ -2048 : 3-CF3 , 3- MeO, Z] , [-2049:3-C2F5 ,3-Me0,E] , [-2050 : 3-C3 F7 , 3-MeO, E] , [-
2051:3- (CF3 )2CF, 3-MeO, E] , [ -2052 : 3- (CF3 ) 2 CH, 3-MeO, E ] , [- 2053 : 3-CHF2 ,3-MeO, E ] , [ -2054 : 3-CHF2 , 3-MeO, Z ] , [-2055:3- CH2F, 3-MeO, E] , [ -2056 : 3-CH2 F, 3-MeO, Z ] , [-2057 : 3-CF3 CH2 , 3- MeO, E] , [-2058:3-MeO,3-MeO,E] , [-2059 : 3-MeO, 3-MeO, Z] , [- 2060:3-EtO, 3-MeO, E ] , [ -2061 : 3-C3H7 O, 3-MeO, E ] , [-2062:3-
(Me)2CHO, 3-MeO, E ] , [ -2063 : 3-NO2 , 3-MeO, E ] , [ -2064 : 2-F, 3-
MeO, E] , [-2065:2-Cl,3-MeO,E] , [ -2066 : 2-Br, 3-MeO, E ] , [-
2067:2-1, 3-MeO, E ] , [ -2068 : 2-Me, 3-MeO, E ] , [ -2069 : 2-Et, 3-
MeO, E] , [-2070:2-C3H7 ,3-Me0,E] , [-2071 : 2- (Me) 2 CH, 3-MeO, E] , [-2072:2-CF3 ,3-MeO,E] , [-2073 : 2-C2 F5 , 3-MeO, E] , [-2074:2-
C3F7 ,3-MeO, E ] , [ -2075 : 2- (CF3 ) 2 CF, 3-MeO, E ] , [ -2076:2-
(CF3 )2CH,3-Me0,E ] , [ -2077 : 2-CHF2 , 3-MeO, E ] , [ -2078:2-
CH2F, 3-MeO, E] , [ -2079 : 2-CF3 CH2 , 3-MeO, E 3 , [ -2080 : 2-MeO, 3-
MeO, E] , [-2081:2-EtO,3-MeO,E] , [-2082 : 2-C3 H7 O, 3-MeO, E] , [- 2083:2- (Me)2CHO, 3-MeO, E ] , [ -2084 : 2-NO2 , 3-MeO, E ] , [ -
2085:2, 3-F2 ,3-MeO, E] , [-2086 : 2, 4-F2 , 3-MeO, E] , [-2087:2,5-
F2, 3-MeO, E ] , [ -2088 : 2, 6-F2 , 3-MeO, E ] , [ -2089.: 3, 4-F2 , 3-
MeO, E] , [-2090:3, 4-F2 ,3-MeO, z] , [-2091 : 3, 5-F2 , 3-MeO, E] , [-
2092:3, 5-F2 ,3-MeO, Z] , [-2093 : 2 , 3-Cl2 , 3-MeO, E] , [-2094:2,3- Cl2, 3-MeO, Z] , [ -2095 : 2, 4-Cl2 , 3-MeO, E ] , [ -2096 : 2, 4-Cl2 , 3-
MeO, Z] , [-2097:2, 5-Cl2 ,3-MeO, E] , [-2098 : 2, 5-Cl2 , 3-MeO, Z] ,
[ -2099:2, 6-Cl2 ,3-MeO, E ] , [ -2100 : 3, 4-Cl2 , 3-MeO, E ] , [ -
2101:3, 5-Cl2 ,3-MeO, E ] , [ -2102 : 2, 3-Br2 , 3-MeO, E ] , [ -
2103:2, 4-Br2 ,3-MeO, E ] , [ -2104 : 2, 5-Br2 , 3-MeO, E ] , [ - 2105:2, 6-Br2 ,3-MeO, E ] , [ -2106 : 3, 4-Br2 , 3-MeO, E ] , [ -
2107:3, 5-Br2 ,3-MeO, E ] , [ -2108 : 2, 3-Me2 , 3-MeO, E ] , [ - 2109:2, 4-Me2 ,3-MeO, E ] , [ -2110 : 2 , 5-Me2 , 3-MeO, E ] , [ - 2111:2, 6-Me2 ,3-MeO, E ] , [ -2112 : 3, 4-Me2 , 3-MeO, E ] , [ - 2113:3, 5-Me2 ,3-MeO, E ] , [ -2114 : 2, 3-Et2 , 3-MeO, E ] , [ - 2115:2, 4-Et2 ,3-MeO, E ] , [ -2116 : 2, 5-Et2 , 3-MeO, E ] , [ -
2117:2, 6-Et2 ,3-MeO, E ] , [ -2118 : 3, 4-Et2 , 3-MeO, E ] , [ - 2119:3, 5-Et2 ,3-MeO, E ] , [ -2120 : 2, 3- (CF3 ) 2 , 3-MeO, E ] , [ - 2121:2,4- (CF3 )2 ,3-MeO, E] , [ -2122 : 2, 5- (CF3 ) 2 , 3-MeO, E ] , [- 2123:2, 6- (CF3 )2 ,3-MeO, E] , [ -2124 : 3, 4- (CF3 ) 2 , 3-MeO, E ] , [- 2125:3,5- (CF3 )2 ,3-MeO, E] , [-2126 : 2, 3- (CHF2 ) 2 , 3-MeO, E] , C-
2127:2,4- (CHF2 )2 ,3-MeO, E] , [-2128 : 2, 5- (CHF2 ) 2 , 3-MeO, E] , C- 2129:2, 6-(CHF2 )2 ,3-MeO, E] , [-2130 : 3, 4- (CHF2 ) 2 , 3-MeO, E] , [- 2131:3, 5-(CHF2 )2 ,3-MeO, E] , [-2132 : 2, 3- (CH2 F) 2 , 3-MeO, E] , [- 2133:2,4- (CH2F)2 ,3-MeO, E] , [-2134 : 2 , 5- (CH2 F) 2 , 3-MeO, E] , [- 2135:2, 6- (CH2F)2 ,3-MeO, E] , [-2136 : 3, 4- (CH2 F) 2 , 3-MeO, E] , [-
2137:3,5- (CH2F)2 ,3-MeO, E] , [-2138 : 2, 3- (MeO) 2 , 3-MeO, E] , [■
2139:2,4- (MeO)2 ,3-MeO, E3 , [ -2140 : 2 , 5- (MeO) 2 , 3-MeO, E 3 , [■
2141:2,6- (MeO)2 ,3-MeO, E] , ( -2142 : 3, 4- (MeO) 2 , 3-MeO, E 3 , [■
2143:3,5- (MeO)2 ,3-MeO, E] , [ -2144 : 2, 3- (EtO) 2 , 3-MeO, E ] , [-
2145:2, 4-(EtO)2 ,3-MeO, E3 , [ -2146:2, 5- (EtO) 2 , 3-MeO, E ] , [■
2147:2,6- (EtO)2 ,3-MeO, E] , [ -2148 : 3, 4- (EtO) 2 , 3-MeO, E ] , [■ 2149:3, 5-(EtO)2 ,3-MeO, E ] , [ -2150 : 2-C1-3-F, 3-MeO, E ] , C -
2151:2-Cl-4-F,3-MeO,E 3 , C -2152:2-Cl-5-F,3-MeO,E 3 , C ■ 2153:2-Cl-6-F,3-MeO,E 3 , [ -2154:3-Cl-2-F,3-MeO,E ] , [ ■ 2155:3-Cl-4-F,3-MeO,E 3 , C -2156:3-Cl-5-F,3-MeO,E 3 , C ■ 2157:4-Cl-2-F,3-MeO,E 3 r [ -2158:4-Cl-3-F,3-MeO,E 3 , C ■ 2159:2-F-3-Me,3-MeO,E 3 , [ -2160:2-F-4-Me,3-MeO,E ] , [ ■ 2161:2-F-5-Me, 3-MeO, E 3 , [ -2162:2-F-6-Me,3-MeO,E ] , C - 2163:3-F-2-Me,3-MeO,E 3 , [ -2164:3-F-4-Me,3-MeO,E 3 , [ ■ 2165:3-F-5-Me,3-MeO,E ] t [ -2166:4-F-2-Me,3-MeO,E ] , [ -
2167:4-F-3-Me,3-MeO,E ) , [ -2168 : 2-Cl-3-Me, 3-MeO, E 3 , [ ■
2169:2-Cl-4-Me,3-MeO,E 3 , [ -2170 : 2-Cl-5-Me, 3-MeO, E ] , C -
2171:2-Cl-6-Me,3-MeO,E 3 , [ -2172 : 3-Cl-2-Me, 3-MeO, E 3 , [ -
2173:3-Cl-4-Me,3-MeO,E 3 , [ -2174 : 3-Cl-5-Me, 3-MeO, E 3 , C -
2175:4-Cl-2-Me,3-MeO,E 3 , C -2176 : 4-Cl-3-Me, 3-MeO, E 3 , C -
2177:2-F-3-CF3 ,3-MeO, E 3 , C -2178 : 2-F-4-CF3 , 3-MeO, E 3 , C -
2179:2-F-5-CF3 ,3-MeO, E 3 , C -2180 : 2-F-6-CF3 , 3-MeO, E 3 , C -
2181:3-F-2-CF3 ,3-MeO, E 3 , C -2182 : 3-F-4-CF3 , 3-MeO, E 3 , C -
2183:3-F-5-CF3 ,3-MeO, E ] , C -2184 : 4-F-2-CF3 , 3-MeO, E 3 , C -
2185:4-F-3-CF3 ,3-MeO, E 3 , C -2186 : 2-Cl-3-CF3 , 3-MeO, E 3 , C-
2187:2-Cl-4-CF3 ,3-MeO,E] , C -2188 : 2-Cl-5-CF3 , 3-MeO, E ) , [
2189:2-Cl-6-CF3 ,3-Me0,E) , [ -2190 : 3-Cl-2-CF3 , 3-MeO, E ] , C
2191:3-Cl-4-CF3,3-MeO,E] , ( -2192 : 3-Cl-5-CF3 , 3-MeO, E ] , [
2193:4-Cl-2-CF3 ,3-MeO,E] , [ -2194 : 4-Cl-3-CF3 , 3-MeO, E ] , [■ 2195:2-Me-3-CF3 , 3-MeO,E] , [ -2196 : 2-Me-4-CF3 , 3-MeO, E ] , [
2197:2-Me-5-CF3 ,3-Me0,E) , C -2198 : 2-Me-β-CF3 , 3-MeO, E 3 , [•
2199:3-Me-2-CF3 ,3-Me0,E] , C- -2200 : 3-Me-4-CF3 , 3-MeO, E ] , [■
2201:3-Me-5-CF3 ,3-MeO,E] , [ -2202 : 4-Me-2-CF3 , 3-MeO, E ] , [■
2203:4-Me-3-CF3 ,3-MeO, E ] , [ -2204 : 2-F-3-MeO, 3-MeO, E ] , C 2205:2-F-4-MeO,3-MeO,E ] , [ -2206 : 2-F-5-MeO, 3-MeO, E 3 , [■
2207:2-F-6-MeO,3-MeO,E ] , [ -2208 : 3-F-2-MeO, 3-MeO, E ] , [■
2209:3-F-4-MeO,3-MeO,E ] , ( -2210 : 3-F-5-MeO, 3-MeO, E ] , [■
2211:4-F-2-MeO,3-MeO,E 3 , [ -2212 : 4-F-3-MeO, 3-MeO, E ] , [■
2213:2-Cl-3-MeO,3-MeO,E] , ( -2214 : 2-Cl-4-MeO, 3-MeO, E 3 , [■ 2215:2-Cl-5-MeO,3-MeO,E] , [ -2216 : 2-Cl-6-MeO, 3-MeO, E ] , [•
2217:3-Cl-2-MeO,3-MeO,E] , [ -2218 : 3-Cl-4-MeO, 3-MeO, E ] , [■
2219:3-Cl-5-MeO,3-MeO,E] , [ -2220 : 4-Cl-2-MeO, 3-MeO, E ] , [■
2221:4-Cl-3-MeO,3-MeO,E] , C -2222 : 2-Me-3-MeO, 3-MeO, E ] , [•
2223:2-Me-4-MeO,3-MeO,E] , [ -2224 : 2-Me-5-MeO, 3-MeO, E ] , C- 2225:2-Me-6-MeO,3-MeO,E] , [ -2226 : 3-Me-2-MeO, 3-MeO, E ] , [■
2227:3-Me-4-MeO,3-MeO,E] , C -2228 : 3-Me-5-MeO, 3-MeO, E ] , [-
2229:4-Me-2-MeO,3-MeO,E] , C -2230 : 4-Me-3-MeO, 3-MeO, E 3 , C- 2231:H, 3-(Me)3CO, E3 , C -2232 : 4-F, 3- (Me) 3 CO, E 3 , C-2233:4- F, 3-(Me)3CO, Z3 , C -2234 : 4-Cl, 3- (Me) 3 CO, E ] , C -2235 : 4-Cl, 3- (Me)3CO, Z 3 , C -2236 : 4-Br, 3- (Me) 3 CO, E 3 , C -2237:4-1,3-
(Me)3CO, E ] , C -2238:4-Me, 3- (Me)3CO, E ] , [ -2239 : 4 -Me, 3-
(Me)3CCZ ] , [ -2240:4-Et,3- (Me)3CO, E ] , [ -2241 : 4-C3 H7 , 3-
(Me)3CO, E] , [-2242:4-(Me)2CH, 3-(Me)3CO, E] , [-2243 : 4-CF3 , 3-
(Me)3CO, E] , [ -2244:4-CF3, 3-(Me)3CO, Z ] , [ -2245 : 4-C2 F5 , 3- (Me)3CO, E ] , [ -2246:4-C3F7 ,3- (Me)3CO, E ] , [ -2247:4-
(CF3 )2CF, 3-(Me)3CO, E] , ' [-2248 : 4- (CF3 ) 2 CH, 3- (Me) 3 CO, E] , [-
2249:4-CHF2 ,3-(Me)3CO, E] , [ -2250 : 4-CH2 F, 3- (Me) 3 CO, E ] , C-
2251:4-CF3CH2 ,3- (Me)3CO, E] , [-2252 : 4-MeO, 3- (Me) 3 CO, E] , [-
2253:4-MeO,3- (Me)3CO, Z ] , [ -2254 : 4-EtO, 3- (Me) 3 CO, E ] , [ - 2255:4-C3H7O, 3-(Me)3CO, E] , [-2256 : 4- (Me) 2 CHO, 3- (Me) 3 CO, E] ,
[-2257:4-NO2 ,3- (Me)3CO, E] , [ -2258 : 4-NO2 , 3- (Me) 3 CO, Z ] , [-
2259:3-F, 3- (Me)3CO, E] , [-2260 : 3-F, 3- (Me) 3 CO, Z] , [-2261:3-
Cl, 3- (Me)3CO, E] , [-2262 : 3-Cl, 3- (Me) 3 CO, Z] , [-2263 : 3-Br, 3-
(Me)3CO, E ] , [ -2264:3-1,3- (Me)3CO, E ] , [ -2265 : 3-Me, 3- (Me)3CO, E ] , [ -2266 : 3-Me, 3- (Me) 3 CO, Z ] , [ -2267 : 3-Et, 3-
(Me)3CO, E ] , [ -2268:3-C3H7 ,3-(Me)3CO, E ] , [ -2269:3-
(Me)2CH, 3- (Me)3CO, E] , [-2270 : 3-CF3 , 3- (Me) 3 CO, E] , [-2271:3-
CF3, 3- (Me) 3 CO, Z ] , [ -2272 : 3-C2 F5 , 3- (Me) 3 CO, E ] , [-2273:3-
C3F7 ,3-(Me)3CO, E ] , [ -2274 : 3- (CF3 ) 2 CF, 3- (Me) 3 CO, E ] , C - 2275:3- (CF3 )2CH, 3- (Me)3CO, E] , [-2276 : 3-CHF2 , 3- (Me) 3 CO, E] ,
[-2277:3-CHF2 ,3- (Me)3CO, Z] , [ -2278 : 3-CH2 F, 3- (Me) 3 CO, E ] ,
[-2279:3-CH2F, 3- (Me)3CO, Z] , [-2280 : 3-CF3 CH2 , 3- (Me) 3 CO, E] ,
[-2281:3-MeO, 3- (Me)3CO, E] , [-2282 : 3-MeO, 3- (Me) 3 CO, Z ] , [-
2283:3-EtO, 3- (Me)3CO, E] , [ -2284 : 3-C3 H70, 3- (Me) 3 CO, E ] , [- 2285:3- (Me)2CHO, 3- (Me)3CO, E] , [ -2286 : 3-NO2 , 3- (Me) 3 CO, E ] ,
[ -2287:2-F, 3-(Me)3CO, E ] , C -2288 : 2-Cl, 3- (Me) 3 CO, E ] , C -
2289:2-Br, 3- (Me)3CO, E] , [-2290 : 2-1 , 3- (Me) 3 CO, E] , [-2291:2-
Me, 3- (Me)3CO, E ] , [ -2292 : 2-Et , 3- (Me) 3 CO, E ] , [ -2293:2-
C3H7 ,3-(Me)3CO, E ] , [ -2294 : 2- (Me) 2 CH, 3- (Me) 3 CO, E ] , [ - 2295:2-CF3 ,3-(Me)3CO, E ] , [ -2296 : 2-C2 F5 , 3- (Me) 3 CO, E ) , [-
2297:2-C3F7 ,3- (Me)3CO, E] , [-2298 : 2- (CF3 ) 2 CF, 3- (Me) 3 CO, E] ,
[ -2299:2-(CF3 )2CH,3- (Me)3CO, E ] , [ -2300 : 2-CHF2 , 3-
(Me)3CO, E] , [-2301:2-CH2F, 3-(Me)3CO, E] , [-2302 : 2-CF3 CH2 , 3-
(Me)3CO, E ] , [ -2303:2-MeO,3- (Me)3CO, E ] , [ -2304 : 2-EtO, 3- (Me)3CO, E ] , [ -2305:2-C3H7O,3- (Me)3CO, E ] , [ -2306:2-
(Me)2CHO, 3- (Me)3CO, E ] , [ -2307 : 2-NO2 , 3- (Me) 3 CO, E ] , [ -
2308:2, 3-F2 ,3-(Me)3CO, E] , [ -2309 : 2 , 4-F2 , 3- (Me) 3 CO, E ] , [-
2310:2, 5-F2 ,3-(Me)3CO, E] , [ -2311 : 2, 6-F2 , 3- (Me) 3 CO, E ] , [-
2312:3, 4-F2 ,3-(Me)3CO, E] , [ -2313 : 3, 4-F2 , 3- (Me) 3 CO, Z ] , [- 2314:3, 5-F2, 3-(Me)3CO, E] , [ -2315 : 3, 5-F2 , 3- (Me) 3 CO, Z ] , [-
2316:2, 3-Cl2 ,3-(Me)3CO, E] , [-2317 : 2 , 3-Cl2 , 3- (Me) 3 CO, Z] , [-
2318:2, 4-Cl2 ,3-(Me)3CO, E] , [-2319 : 2, 4-Cl2 , 3- (Me) 3 CO, z] , [-
2320:2, 5-Cl2 ,3-(Me)3CO, E] , [-2321 : 2, 5-Cl2 , 3- (Me) 3 CO, Z] , [-
2322:2, 6-Cl2 ,3-(Me)3CO, E] , [-2323 : 3, 4-Cl2 , 3- (Me) 3 CO, E] , C- 2324:3, 5-Cl2 ,3-(Me)3CO, E] , [-2325 : 2, 3-Br2 , 3- (Me) 3 CO, E] , C-
2326:2, 4-Br2 ,3-(Me)3CO, E] , [-2327 : 2, 5-Br2 , 3- (Me) 3 CO, E] , [-
2328:2, 6-Br2 ,3- (Me)3CO, E] , [-2329 : 3, 4-Br2 , 3- (Me) 3 CO, E] , [-
2330:3, 5-Br2 ,3- (Me)3CO, E] , [-2331 : 2, 3-Me2 , 3- (Me) 3 CO, E] , [-
2332:2, 4-Me2 ,3-(Me)3CO, E] , [-2333 : 2, 5-Me2 , 3- (Me) 3 CO, E] , [- 2334:2, 6-Me2 ,3-(Me)3CO, E] , [-2335 : 3, 4-Me2 , 3- (Me) 3 CO, E] , [-
2336:3, 5-Me2 ,3- (Me)3CO, E] , [-2337 : 2, 3-Et2 , 3- (Me) 3 CO, E] , C-
2338:2, 4-Et2 ,3- (Me)3CO, E] , [-2339 : 2 , 5-Et2 , 3- (Me) 3 CO, E] , C-
2340:2, 6-Et2 ,3- (Me)3CO, E] , [-2341 : 3, 4-Et2 , 3- (Me) 3 CO, E] , [-
2342:3, 5-Et2 ,3-(Me)3CO, E] , [-2343 : 2, 3- (CF3 ) 2 , 3- (Me) 3 CO, E] , [ -2344:2, 4- (CF3 )2 ,3-(Me)3CO, E ] , [ -2345 : 2 , 5- (CF3 ) 2 , 3-
(Me)3CO, E] , [ -2346:2,6- (CF3 )2 ,3- (Me)3CO, E ] , [-2347:3,4-
(CF3)2, 3-(Me)3CO, E] , [ -2348 : 3, 5- (CF3 ) 2 , 3- (Me) 3 CO, E ] , [-
2349:2, 3- (CHF2 )2 ,3-(Me)3CO, E ] , [ -2350 : 2 , 4- (CHF2 ) 2 , 3-
(Me)3C0,E] , [-2351:2, 5-(CHF2 )2 ,3- (Me)3CO, E] , [-2352:2,6- (CHF2 )2, 3-(Me)3CO, E] , [ -2353 : 3, 4- (CHF2 ) 2 , 3- (Me) 3 CO, E] , [-
2354:3, 5- (CHF2 )2, 3-(Me)3CO, E ] , [ -2355 : 2 , 3- (CH2 F) 2 , 3-
(Me)3CO, E] , [-2356:2,4- (CH2F)2 ,3- (Me)3CO, E] , [-2357:2,5-
(CH2F)2 ,3-(Me)3CO, E] , [ -2358 : 2 , 6- (CH2 F) 2 , 3- (Me) 3 CO, E] , [-
2359:3,4- (CH2F)2 ,3- (Me)3CO, E ] , [ -2360 : 3, 5- (CH2 F) 2 , 3- (Me)3C0,E] , [ -2361:2,3- (MeO)2 ,3-(Me)3CO, E ] , [-2362:2,4-
(MeO)2 ,3-(Me)3CCE] , [ -2363 : 2, 5- (MeO) 2 , 3- (Me) 3 CO, E ] , [-
2364:2,6- (MeO)2 ,3- (Me)3CO, E ] , [ -2365 : 3, 4- (MeO) 2 , 3-
(Me)3CO, E] , [ -2366:3, 5-(MeO)2 ,3-(Me)3CO, E ] , [-2367:2,3-
(EtO)2, 3-(Me)3CO, E ] , [ -2368 : 2 , 4- (EtO) 2 , 3- (Me) 3 CO, E ] , [- 2369:2,5- (EtO)2 ,3-(Me)3CO, E ] , [ -2370 : 2, 6- (EtO) 2 , 3-
(Me)3CO, E] , [ -2371:3, 4-(EtO)2, 3-(Me)3CCE] , [-2372:3,5-
(EtO)2 ,3- (Me)3CCE ] , [ -2373 : 2-C1-3-F, 3- (Me) 3 CO, E ] , [ -
2374:2-Cl-4-F, 3- (Me)3CO, E] , [-2375 : 2-C1-5-F, 3- (Me) 3 CO, E] ,
[ -2376:2-Cl-6-F, 3-(Me)3CO, E ] , [ -2377 : 3-C1-2-F, 3- (Me)3CO, E] , [ -2378 : 3-C1-4-F, 3- (Me) 3 CO, E ] , [ -2379 : 3-C1-5-
F, 3- (Me)3CO, E] , [-2380 : 4-C1-2-F, 3- (Me) 3 CO, E] , [-2381:4-C1-
3-F, 3- (Me)3CO, E] , [-2382 : 2-F-3-Me, 3- (Me) 3 CO, E] , [-2383:2-
F-4-Me, 3-(Me)3CO, E ] , [ -2384 : 2-F-5-Me, 3- (Me) 3 CO, E ] , [ -
2385:2-F-6-Me, 3- (Me)3CO, E] , [-2386 : 3-F-2-Me, 3- (Me) 3 CO, E] , [ -2387:3-F-4-Me,3- (Me)3CO, E ] , [ -2388 : 3-F-5-Me, 3-
(Me)3CO, E] , [ -2389:4-F-2-Me, 3-(Me)3CO, E ] , [ -2390 : 4-F-3-
Me, 3- (Me) 3CO,E] , [-2391 : 2-Cl-3-Me, 3- (Me) 3 CO, E] , [-2392:2-
Cl-4-Me, 3-(Me)3CO, E ] , [ -2393 : 2-Cl-5-Me, 3- (Me) 3 CO, E ] , [-
2394:2-Cl-6-Me, 3- (Me)3CO, E] , [-2395 : 3-Cl-2-Me, 3- (Me) 3 CO, E] , [ -2396:3-Cl-4-Me, 3-(Me)3CO, E ] , [ -2397 : 3-Cl-5-Me, 3-
(Me)3CO, E] , [-2398:4-Cl-2-Me, 3- (Me)3CO, E] , [-2399 : 4-C1-3-
Me, 3- (Me)3CO, E] , [-2400 : 2-F-3-CF3 , 3- (Me) 3 CO, E] , [-2401:2-
F-4-CF3 ,3-(Me)3CO, E ] , [ -2402 : 2-F-5-CF3 , 3- (Me) 3 CO, E ] , [-
2403:2-F-β-CF3 ,3-(Me)3CO, E] , [-2404 : 3-F-2-CF3 , 3- (Me) 3 CO, E] , [ -2405:3-F-4-CF3 ,3- (Me)3CO, E ] , [ -2406 : 3-F-5-CF3 , 3-
(Me)3CO, E] , [-2407:4-F-2-CF3 ,3- (Me)3CO, E] , [ -2408 : 4-F-3- CF3 ,3- (Me)3CO, E ] , [ -2409 : 2-Cl-3-CF3 , 3- (Me) 3 CO, E ] , [ - 2410:2-Cl-4-CF3 ,3-(Me)3CO, E ] , [ -2411 : 2-Cl-5-CF3 , 3- (Me)3CO, E] , [-2412:2-Cl-6-CF3 ,3- (Me)3CO, E] , [-2413 : 3-C1-2- CF3 ,3- (Me)3CO, E ] , [ -2414 : 3-Cl-4-CF3 , 3- (Me) 3 CO, E ] , [ -
2415:3-Cl-5-CF3 ,3- (Me)3CO, E ] , [ -2416 : 4-Cl-2-CF3 , 3- (Me)3CO, E] , [-2417:4-Cl-3-CF3 ,3- (Me)3CO, E] , [-2418 : 2-Me-3- CF3 ,3-(Me)3CO, E ] , [ -2419 : 2-Me-4-CF3 , 3- (Me) 3 CO, E ] , [ - 2420:2-Me-5-CF3 ,3- (Me)3CO, E ] , [ -2421 : 2-Me-6-CF3 , 3- (Me)3CO, E] , [-2422 : 3-Me-2-CF3 , 3- (Me) 3 CO, E] , [-2423 : 3-Me-4-
CF3 ,3- (Me)3CO,E ] , C -2424 : 3-Me-5-CF3 , 3- (Me) 3 CO, E ] , C -
2425:4-Me-2-CF3 ,3- (Me)3CO, E ] , C -2426 : 4-Me-3-CF3 , 3-
(Me)3CO, E] , C-2427:2-F-3-MeO, 3- (Me)3CO, E] , [ -2428 : 2-F-4-
MeO, 3- (Me)3CO, E] , [-2429 : 2-F-5-MeO, 3- (Me) 3 CO, E] , [-2430:2- F-6-MeO,3- (Me)3CO, E ] , [ -2431 : 3-F-2-MeO, 3- (Me) 3 CO, E ] , [-
2432:3-F-4-MeO, 3- (Me)3CO, E] , [-2433 : 3-F-5-MeO, 3- (Me) 3 CO, E] ,
[ -2434:4-F-2-MeO,3- (Me)3CO, E ] , [ -2435 : 4-F-3-MeO, 3-
(Me)3CO, E] , [-2436:2-Cl-3-MeO, 3- (Me)3CO, E] , [-2437 : 2-C1-4-
MeO, 3-(Me)3CO, E ] , [ -2438 : 2-Cl-5-MeO, 3- (Me) 3 CO, E ] , [ - 2439:2-Cl-6-MeO,3- (Me)3CO, E ] , [ -2440 : 3-Cl-2-MeO, 3-
(Me)3CO, E] , [-2441:3-Cl-4-MeO, 3- (Me)3CO, E] , [-2442 : 3-C1-5-
MeO, 3- (Me)3CO, E ] , [ -2443 : 4-Cl-2-MeO, 3- (Me) 3 CO, E ] , ( -
2444:4-Cl-3-MeO,3- (Me) 3CO,E ] , [ -2445 : 2-Me-3-MeO, 3-
(Me)3CO, E] , [-2446:2-Me-4-MeO, 3- (Me)3CO, E] , [-2447 : 2-Me-5- MeO, 3- (Me)3CO, E ] , [ -2448 : 2-Me-6-MeO, 3- (Me) 3 CO, E ] , [ -
2449:3-Me-2-MeO, 3-(Me)3CO, E ] , [ -2450 : 3-Me-4-MeO, 3-
(Me)3CO, E] , [-2451:3-Me-5-MeO,3- (Me) 3CO,E] , [-2452 : 4-Me-2-
MeO, 3- (Me)3CO, E ] , [ -2453 : 4-Me-3-MeO, 3- (Me) 3 CO, E ] , [ -
2454:H,2-F,E] , [ -2455 : 4-F, 2-F, E ] , [ -2456 : 4-F, 2-F, Z ] , [- 2457:4-Cl,2-F,E] , [-2458 : 4-Cl, 2-F, Z] , [-2459 : 4-Br, 2-F, E] ,
[-2460:4-1, 2-F, E] , [-2461 : 4 -Me, 2-F, E] , [-2462 : 4 -Me, 2-F, Z] ,
[ -2463:4-Et,2-F,E ] , [ -2464 : 4-C3 H7 , 2-F, E ] , [ -2465:4-
(Me)2CH, 2-F, E] , [-2466 : 4-CF3 , 2-F, E] , [-2467 : 4-CF3 , 2-F, Z] ,
[ -2468:4-C2F5 ,2-F,E ] , [ -2469 : 4-C3 F7 , 2-F, E ] , [ -2470:4- (CF3 )2CF,2-F,E ] , [ -2471 : 4- (CF3 ) 2 CH, 2-F, E ] , [ -2472:4-
CHF2,2-F,E] , [-2473:4-CH2F,2-F,E] , [-2474 : 4-CF3 CH2 , 2-F, E] , [-2475:4-MeO,2-F,E] , [-2476 : 4-MeO, 2-F, z] , [-2477 : 4-EtO, 2- F,E] , [-2478:4-C3H7O,2-F,E] , [-2479 : 4- (Me) 2 CHO, 2-F, E] , [- 2480:4-NO2 ,2-F,E] , [-2481 : 4-NO2 , 2-F, Z] , [-2482 : 3-F, 2-F, E] , [-2483:3-F,2-F,Z] , [-2484 : 3-Cl, 2-F, E] , [-2485 : 3-Cl, 2-F, Z] ,
[-248β:3-Br,2-F,E] , [-2487 : 3-1, 2-F, E] , [-2488 : 3-Me, 2-F, E] , [-2489:3-Me,2-F,Z] , [ -2490 : 3-Et, 2-F, E] , C -2491 : 3-C3 H7 , 2- F, E] , [-2492:3-(Me)2CH,2-F,E] , [ -2493 : 3-CF3 , 2-F, E ] , [- 2494:3-CF3 ,2-F,Z] , [-2495 : 3-C2 F5 , 2-F, E] , [-2496 : 3-C3 F7 , 2- F, E] , [-2497:3-(CF3 )2CF,2-F,E] , [-2498 : 3- (CF3 ) 2 CH, 2-F, E] ,
[ -2499:3-CHF2 ,2-F,E] , [ -2500 : 3-CHF2 , 2-F, Z ] , [-2501:3- CH2F, 2-F, E] , [-2502:3-CH2F,2-F,Z] , [-2503 : 3-CF3 CH2 , 2-F, E] , [-2504:3-MeO,2-F,E] , [-2505 : 3-MeO, 2-F, z] , [-2506 : 3-EtO, 2- F, E] , [-2507:3-C3H7O,2-F,E] , [-2508 : 3- (Me) 2 CHO, 2-F, E] , [- 2509:3-NO2 ,2-F,E] , [-2510 : 2-F, 2-F, E] , [-2511 : 2-Cl, 2-F, E] ,
[-2512:2-Br,2-F,E] , [-2513 : 2-1 , 2-F, E] , [-2514 : 2 -Me, 2-F, E] , [ -2515:2-Et,2-F,E ] , [ -2516 : 2-C3 H7 , 2-F, E ] , [ -2517:2- (Me)2CH, 2-F, E] , [-2518 : 2-CF3 , 2-F, E] , [-2519 : 2-C2 F5 , 2-F, E] , [-2520:2-C3F7 ,2-F,E] , [-2521 : 2- (CF3 ) 2 CF, 2-F, E] , [-2522:2- (CF3 )2CH,2-F,E ] , [ -2523 : 2-CHF2 , 2-F, E ] , [ -2524 : 2-CH2 F, 2-
F, E] , [ -2525:2-CF3CH2 ,2-F,E ] , [ -2526 : 2-MeO, 2-F, E ] , [- 2527:2-EtO,2-F,E ] , [ -2528 : 2-C3 H7 O, 2-F, E ] , [ -2529:2- (Me)2CHO, 2-F, E ] , [ -2530 : 2-NO2 , 2-F, E ] , [ -2531 : 2 , 3-F2 , 2- F, E ] , [ -2532:2, 4-F2, 2-F, E ] , [ -2533 : 2 , 5-F2 , 2-F, E ] , [ - 2534:2, 6-F2 , 2-F, E] , [-2535 : 3, 4-F2 , 2-F, E] , [-2536 : 3, 4-F2 , 2-
F, Z ] , [ -2537:3, 5-F2 ,2-F,E ] , [ -2538 : 3, 5-F2 , 2-F, Z ] , [ - 2539:2, 3-Cl2, 2-F, E] , [ -2540 : 2 , 3-Cl2 , 2-F, Z ] , [-2541:2,4- Cl2, 2-F, E] , [-2542:2, 4-Cl2 , 2-F, Z] , [-2543 : 2 , 5-Cl2 , 2-F, E] ,
[-2544:2, 5-Cl2 , 2-F, Z] , [-2545 : 2 , 6-Cl2 , 2-F, E] , [-2546:3,4- Cl2, 2-F, E] , [-2547:3, 5-Cl2 , 2-F, E] , [-2548 : 2 , 3-Br2 , 2-F, E] ,
[-2549:2, 4-Br2 , 2-F, E] , [-2550 : 2 , 5-Br2 , 2-F, E] , [-2551:2,6- Br2, 2-F, E] , [-2552:3, 4-Br2 , 2-F, E] , [-2553 : 3, 5-Br2 , 2-F, E] ,
[-2554:2, 3-Me2 , 2-F, E] , [-2555 : 2 , 4-Me2 , 2-F, E] , [-2556:2,5-
Me2, 2-F, E] , [-2557:2, 6-Me2 , 2-F, E] , [-2558 : 3, 4-Me2 , 2-F, E] , [-2559:3, 5-Me2 , 2-F, E] , [-2560 : 2 , 3-Et2 , 2-F, E] , [-2561:2,4-
Et2, 2-F, E] , [-2562:2, 5-Et2 , 2-F, E] , [-2563 : 2, 6-Et2 , 2-F, E] ,
[-2564:3, 4-Et2 , 2-F, E] , [-2565 : 3, 5-Et2 , 2-F, E] , [-2566:2,3-
(CF3J2, 2-F, E ] , [ -2567:2, 4-(CF3 )2 , 2-F, E ] , [ -2568:2,5-
(CF3 )2 ,2-F,E ] , [ -2569:2, 6-(CF3)2 , 2-F, E ] , [ -2570:3,4- (CF3)2, 2-F, E ] , C -2571:3, 5-(CF3J2, 2-F, E ] , [ -2572:2,3-
(CHF2 )2, 2-F, E ] , [ -2573:2, 4-(CHF2 )2, 2-F, E ] , ( -2574:2,5-
(CHF2)2,2-F,E ] , [ -2575:2, 6-(CHF2)2, 2-F, E ] , [ -2576:3,4-
(CHF2)2,2-F,E ] , [ -2577:3, 5-(CHF2)2, 2-F, E ] , [ -2578:2,3-
(CH2F)2 , 2-F, E ] , [ -2579:2,4- (CH2F)2 , 2-F, E ] , [ -2580:2,5- (CH2F)2 , 2-F, E ] , [ -2581 : 2 , 6- (CH2 F) 2 , 2-F, E ] , [ -2582:3,4-
(CH2F)2 , 2-F, E ] , [ -2583:3,5- (CH2F)2 , 2-F, E ] , [ -2584:2,3-
(MeO)2 , 2-F, E ] , [ -2585 : 2 , 4- (MeO) 2 , 2-F, E ] , [ -2586:2,5-
(MeO)2 , 2-F, E ] , [ -2587 : 2, 6- (MeO) 2 , 2-F, E ] , [ -2588:3,4-
(MeO)2 , 2-F, E ] , [ -2589 : 3, 5- (MeO) 2 , 2-F, E ] , [ -2590:2,3- (EtO)2 , 2-F, E ] , [ -2591:2,4- (EtO)2 , 2-F, E ] , [ -2592:2,5-
(EtO)2 ,2-F, E ] , [ -2593:2, 6-(EtO)2, 2-F, E ] , [ -2594:3,4-
(EtO)2 ,2-F, E ] , C -2595:3,5- (EtO)2 ,2-F, E ] , [-2596:2-01-3-
F,2-F,E] , [-2597:2-Cl-4-F,2-F,E] , [-2598 : 2-C1-5-F, 2-F, E] ,
[-2599:2-Cl-6-F,2-F,E] , [-2600: 3-C1-2-F, 2-F, E] , [-2601:3- Cl-4-F,2-F,E] , [-2602:3-Cl-5-F,2-F,E] , [-2603 : 4-C1-2-F, 2-
F, E] , [-2604:4-Cl-3-F,2-F,E] , [-2605 : 2-F-3-Me, 2-F, E] , [-
2606:2-F-4-Me,2-F,E] , [-2607 : 2-F-5-Me, 2-F, E] , [-2608:2-F-
6-Me,2-F,E] , [ -2609 : 3-F-2-Me, 2-F, E ] , [ -2610 : 3-F-4-Me, 2-
F, E] , [-2611:3-F-5-Me,2-F,E] , [ -2612 : 4-F-2-Me, 2-F, E] , [- 2613:4-F-3-Me,2-F,E] , [ -2614 : 2-Cl-3-Me, 2-F, E ] , [-2615:2-
Cl-4-Me,2-F,E ] , [ -2616 :2-Cl-5-Me, 2-F, E ] , [-2617:2-01-6- Me, 2-F, E] , [ -2618:3-Cl-2-Me,2-F,E] , [ -2619 : 3-Cl-4-Me, 2- F,E] , [-2620:3-Cl-5-Me,2-F,E] , [-2621 : 4-Cl-2-Me, 2-F, E] , [- 2622:4-Cl-3-Me,2-F,E] , [-2623 : 2-F-3-CF3 , 2-F, E] , [-2624:2- F-4-CF3,2-F,E ] , [ -2625 : 2-F-5-CF3 , 2-F, E ] , [ -2626 : 2-F-6-
CF3, 2-F, E] , C-2627:3-F-2-CF3 ,2-F,E] , [ -2628 : 3-F-4-CF3 , 2- F, E] , [-2629:3-F-5-CF3 ,2-F,E] , [-2630 : 4-F-2-CF3 , 2-F, E] , [- 2631:4-F-3-CF3,2-F,E] , [-2632 : 2-01-3-CF3 , 2-F, E] , [-2633:2- 01-4-CF3, 2-F, E] , [-2634:2-Cl-5-CF3,2-F,E] , [-2635 : 2-C1-6- CF3, 2-F, E] , [-2636:3-Cl-2-CF3 ,2-F,E] , [-2637 : 3-Cl-4-CF3 , 2-
F, E] , [-2638:3-Cl-5-CF3 ,2-F,E] , [-2639 : 4-01-2-CF3 , 2-F, E] ,
[ -2640:4-Cl-3-CF3,2-F,E] , [ -2641 : 2-Me-3-CF3 , 2-F, E ] , [-
2642:2-Me-4-CF3 ,2-F, E ] , [ -2643 : 2-Me-5-CF3 , 2-F, E ] , [ -
2644:2-Me-6-CF3 ,2-F, E ] , [ -2645 : 3-Me-2-CF3 , 2-F, E ] , [ - 2646:3-Me-4-CF3 ,2-F, E ] , [ -2647 : 3-Me-5-CF3 , 2-F, E ] , [ -
2648:4-Me-2-CF3 ,2-F,E ] , C -2649 : 4-Me-3-CF3 , 2-F, E ] , [ - 2650:2-F-3-MeO,2-F,E] , [-2651 : 2-F-4-MeO, 2-F, E] , [-2652:2- F-5-MeO,2-F,E ] , [ -2653 : 2-F-6-MeO, 2-F, E ] , [ -2654 : 3-F-2- MeO, 2-F, E] , [ -2655 : 3-F-4-MeO, 2-F, E 3 , [ -2656 : 3-F-5-MeO, 2- F, E] , [-2657:4-F-2-MeO,2-F,E] , [-2658 : 4-F-3-MeO, 2-F, E] , [- 2659:2-Cl-3-MeO,2-F,E ] , [ -2660 : 2-Cl-4-MeO, 2-F, E ] , [ - 2661:2-Cl-5-MeO,2-F,E ] , [ -2662 : 2-Cl-6-MeO, 2-F, E ] , [ - 2663:3-Cl-2-MeO,2-F,E ] , [ -2664 : 3-Cl-4-MeO, 2-F, E ] , [ - 2665:3-Cl-5-MeO,2-F,E ] , [ -2666 : 4-Cl-2-MeO, 2-F, E ] , ( - 2667:4-Cl-3-MeO,2-F,E ] , [ -2668 : 2-Me-3-MeO, 2-F, E ] , [ -
2669:2-Me-4-MeO,2-F,E ] , [ -2670 : 2 -Me -5 -MeO, 2-F, E ] , [ - 2671:2-Me-6-MeO,2-F,E ] , [ -2672 : 3-Me-2-MeO, 2-F, E ] , [ - 2673:3-Me-4-MeO,2-F,E ] , [ -2674 : 3-Me-5-MeO, 2-F, E ] , [ - 2675:4-Me-2-MeO,2-F,E ] , [ -2676 : 4-Me-3-MeO, 2-F, E ] , [ - 2677:H,2-C1,E] , [-2678 : 4-F, 2-Cl, E] , [-2679 : 4-F, 2-Cl, z] , C-
268O:4-C1,2-C1,E ] , [ -2681 : 4-Cl, 2-Cl, Z ] , [ -2682 : 4-Br, 2- Cl, E] , [-2683:4-1, 2-Cl, E] , [-2684 : 4 -Me, 2-Cl, E] , [-2685:4- Me, 2-Cl, Z] , [-2686:4-Et,2-Cl,E] , [-2687 : 4-C3 H7 , 2-Cl, E] , [- 2688:4- (Me)2CH, 2-Cl, E ] , [ -2689 : 4-CF3 , 2-Cl, E ] , [-2690:4- CF3, 2-Cl, Z] , [-2691.4-C2F5, 2-Cl, E] , [-2692 : 4-C3 F7 , 2-Cl, E] ,
[-2693:4- (CF3 )2CF, 2-Cl, E] , [ -2694 : 4- (CF3 ) 2 CH, 2-Cl, E] , [- 2695:4-CHF2,2-Cl,E ] , [ -2696 : 4-CH2 F, 2-Cl, E ] , [ -2697:4- CF3CH2, 2-Cl, E ] , [ -2698:4-MeO,2-Cl,E ] , [ -2699 : 4-MeO, 2- Cl, Z] , C-2700:4-EtO,2-Cl,E] , [ -2701 : 4-C3 H7 O, 2-Cl, E ] , [- 2702:4- (Me)2CHO, 2-Cl, E] , [ -2703 : 4-NO2 , 2-Cl, E ] , [-2704:4-
NO2,2-C1,Z] , [-27O5:3-F,2-C1,E] " , [ -2706 : 3-F, 2-Cl, Z ] , [-
27O7:3-C1,2-C1,E ] , [ -2708 : 3-Cl, 2-Cl, Z ] , [ -2709 : 3-Br, 2-
Cl, E] , [-2710:3-1, 2-Cl, E] , [-2711 : 3-Me, 2-Cl, E] , [-2712:3-
Me, 2-Cl, Z] , [-2713:3-Et,2-C1,E] , [-2714 : 3-C3 H7 , 2-Cl, E] , [- 2715:3-(Me)2CH,2-Cl,E] , [ -2716 : 3-CF3 , 2-Cl, E ] , [-2717:3-
CF3, 2-Cl, Z] , [-2718.3-C2F5, 2-Cl, E] , [-2719 : 3-C3 F7 , 2-Cl, E] ,
[-2720.3-(CF3J2CF, 2-Cl, E] , [-2721 : 3- (CF3 ) 2 CH, 2-Cl, E] , [-
2722:3-CHF2 ,2-Cl, E ] , [ -2723 : 3-CHF2 , 2-Cl, Z ] , [ -2724:3-
CH2F, 2-Cl, E] , [ -2725:3-CH2F,2-Cl, Z ] , [ -2726 : 3-CF3 CH2 , 2- Cl, E] , [ -2727:3-MeO,2-Cl,E] , [ -2728 : 3-MeO, 2-Cl, Z ] , [-
2729:3-EtO,2-Cl,E ] , [ -2730 : 3-C3 H7 O, 2-Cl, E ] , [ -2731:3- (Me) 2 CHO, 2-Cl, E ] , [ -2732 : 3-NO2 , 2-Cl, E ] , [ -2733 : 2-F, 2- Cl, E] , [-2734:2-Cl,2-Cl,E] , [-2735 : 2-Br, 2-Cl, E] , [-2736:2- I, 2-Cl, E] , [-2737:2-Me,2-Cl,E] , [ -2738 : 2-Et, 2-Cl, E ] , [- 2739:2-C3H7 ,2-Cl,E] , [ -2740 : 2- (Me) 2 CH, 2-Cl, E ] , [-2741:2-
CF3, 2-Cl, E] , [-2742:2-C2 F5 ,2-Cl,E] , [-2743 : 2-C3 F7 , 2-Cl, E] ,
[-2744:2-(CF3 )2CF,2-C1,E] , [-2745 : 2- (CF3 ) 2 CH, 2-Cl, E] , [- 2746:2-CHF2,2-Cl,E ] , [ -2747 : 2-CH2 F, 2-Cl, E ] , [ -2748:2- CF3CH2 , 2-Cl, E ] , [ -2749:2-MeO,2-Cl,E ] , [ -2750 : 2-EtO, 2- Cl, E] , C-2751:2-C3H7O,2-C1,E] , [-2752 : 2- (Me) 2 CHO, 2-Cl, E] ,
[-2753:2-NO2,2-Cl,E] , [-2754 : 2, 3-F2 , 2-Cl, E] , [-2755:2,4-
F2, 2-Cl, E] , [-2756:2, 5-F2, 2-Cl, E] , [-2757 : 2 , 6-F2 , 2-Cl, E] ,
[-2758:3, 4-F2, 2-Cl, E] , [-2759 : 3, 4-F2 , 2-Cl, Z] , [-2760:3,5-
F2, 2-Cl, E] , [-2761:3, 5-F2 , 2-Cl, Z] , [-2762 : 2 , 3-Cl2 , 2-Cl, E] , [ -2763:2, 3-Cl2, 2-Cl, Z ] , [ -2764 : 2, 4-Cl2 , 2-Cl, E ] , [ -
2765:2, 4-Cl2 ,2-Cl, Z] , [-2766 : 2, 5-Cl2 , 2-Cl, E] , (-2767:2,5-
C12,2-C1,Z ] , [ -2768:2, 6-Cl2 ,2-Cl, E ] , [ -2769 : 3, 4-Cl2 , 2-
Cl, E] , (-2770:3, 5-Cl2 ,2-Cl, E] , (-2771 : 2, 3-Br2 , 2-Cl, E] , (-
2772:2, 4-Br2 ,2-Cl, E] , (-2773 : 2, 5-Br2 , 2-Cl, E] , [-2774:2,6- Br2, 2-Cl, E ] , [ -2775 : 3, 4-Br2 , 2-Cl, E ] , ( -2776 : 3, 5-Br2 , 2-
Cl, E] , [-2777:2, 3-Me2 , 2-Cl, E] , [-2778 : 2, 4-Me2 , 2-Cl, E] , [■
2779:2, 5-Me2 , 2-Cl, E] , [-2780 : 2 , 6-Me2 , 2-Cl, E] , (-2781:3,4-
Me2, 2-Cl, E ] , [ -2782:3, 5-Me2 , 2-Cl, E ] , [ -2783 : 2, 3-Et2 , 2-
Cl, E] , [-2784:2, 4-Et2 ,2-Cl, E] , (-2785 : 2, 5-Et2 , 2-Cl, E] , C- 2786:2, 6-Et2 , 2-Cl, E] , [-2787 : 3, 4-Et2 , 2-Cl, E] , [-2788:3,5-
Et2, 2-Cl, E ] , [ -2789:2, 3-(CF3 )2 , 2-Cl, E ] , ( -2790:2,4-
(CF3J2, 2-Cl, E ] , [ -2791:2, 5- (CF3 )2 , 2-Cl, E ] , ( -2792:2,6-
(CF3J2, 2-Cl, E ] , [ -2793:3, 4- (CF3 )2 , 2-Cl, E ] , ( -2794:3,5-
(CF3J2, 2-Cl, E] , [ -2795:2,3- (CHF2 J2 , 2-Cl, E ] , (-2796:2,4- (CHF2 J2 ,2-Cl, E] , ( -2797 : 2 , 5- (CHF2 ) 2 , 2-Cl, E ] , (-2798:2,6-
(CHF2 J2 ,2-Cl, E] , (-2799:3, 4-(CHF2 J2 , 2-Cl, E] , (-2800:3,5-
(CHF2 J2 ,2-Cl, E] , [-2801:2, 3-(CH2F)2 ,2-Cl, E] , (-2802:2,4-
(CH2F)2 ,2-Cl, E] , [-2803:2, 5-(CH2F)2 ,2-Cl, E] , [-2804:2,6-
(CH2F)2 ,2-Cl, E] , [-2805:3, 4-(CH2F)2 , 2-Cl, E] , [-2806:3,5- (CH2F)2 , 2-Cl, E ] , ( -2807 : 2 , 3- (MeO) 2 , 2-Cl, E ] , [-2808:2,4-
(MeO)2, 2-Cl, E ] , [ -2809:2, 5- (MeO) 2 , 2-Cl, E 3 , ( -2810:2,6-
(MeO)2, 2-Cl, E ] , [ -2811 : 3, 4- (MeO) 2 , 2-Cl, E ] , [ -2812:3,5-
(MeO)2 , 2-Cl, E ] , [ -2813:2, 3- (EtO) 2 , 2-Cl, E 3 , [ -2814:2,4-
(EtO)2, 2-Cl, E ] , ( -2815:2, 5-(EtO)2 , 2-Cl, E ] , [ -2816:2,6- (EtO)2, 2-Cl, E ] , [ -2817:3, 4-(EtO)2 , 2-Cl, E ] , [ -2818:3,5-
(EtO)2 ,2-Cl, E ] , ( -2819:2-Cl-3-F,2-Cl,E ] , [ -2820 : 2-C1-4-
F,2-C1,E] , [ -2821:2-Cl-5-F,2-Cl,E ] , [ -2822 : 2-C1-6-F, 2-
Cl, E] , [-2823:3-Cl-2-F,2-Cl,E] , [-2824 : 3-C1-4-F, 2-Cl, E] ,
[ -2825:3-Cl-5-F,2-Cl,E ] , [ -2826 : 4-C1-2-F, 2-Cl, E ] , [- 2827:4-Cl-3-F,2-Cl,E] , [-2828 : 2-F-3-Me, 2-Cl, E] , [-2829:2-
F-4-Me,2-Cl,E ] , [ -2830 : 2-F-5-Me, 2-Cl, E ] , [ -2831 : 2-F-6-
Me, 2-Cl, E] , [ -2832:3-F-2-Me,2-Cl,E ] , [ -2833 : 3-F-4-Me, 2-
Cl, E] , [-2834:3-F-5-Me,2-Cl,E] , [-2835 : 4-F-2-Me, 2-Cl, E] ,
[ -283β:4-F-3-Me,2-Cl,E ] , [ -2837 : 2-Cl-3-Me, 2-Cl, E ] , [- 2838:2-Cl-4-Me,2-Cl,E ] , [ -2839 : 2-Cl-5-Me, 2-Cl, E ] , [ - 2840:2-Cl-6-Me,2-Cl,E ] , [ -2841 : 3-Cl-2-Me, 2-Cl, E ] , [ - 2842:3-Cl-4-Me,2-Cl,E ] , [ -2843 : 3-Cl-5-Me, 2-Cl, E ] , [ - 2844:4-Cl-2-Me,2-Cl,E ] , [ -2845 : 4-Cl-3-Me, 2-Cl, E ] , [ - 284β:2-F-3-CF3 ,2-Cl, E ] , [ -2847 : 2-F-4-CF3 , 2-Cl , E ] , [ - 2848:2-F-5-CF3 ,2-Cl, E ] , [ -2849 : 2-F-6-CF3 , 2-Cl, E ] , [ - 2850:3-F-2-CF3,2-Cl,E ] , [ -2851 : 3-F-4-CF3 , 2-Cl, E ) , [ - 2852:3-F-5-CF3 ,2-Cl, E ] , [ -2853 : 4-F-2-CF3 , 2-Cl, E ] , [ - 2854:4-F-3-CF3,2-Cl,E ] , [ -2855 : 2-Cl-3-CF3 , 2-Cl, E ] , [- 2856:2-Cl-4-CF3 ,2-Cl, E ] , [ -2857 : 2-Cl-5-CF3 , 2-Cl, E ] , [- 2858:2-Cl-6-CF3,2-Cl,E ] , [ -2859 : 3-Cl-2-CF3 , 2-Cl, E ] , [- 2860:3-Cl-4-CF3 ,2-Cl, E ] , [ -2861 : 3-Cl-5-CF3 , 2-Cl, E ] , [- 2862:4-Cl-2-CF3 ,2-Cl, E ] , [ -2863 : 4-Cl-3-CF3 , 2-Cl, E ] , [- 2864:2-Me-3-CF3 ,2-Cl, E ] , [ -2865 : 2-Me-4-CF3 , 2-Cl, E ] , [- 2866:2-Me-5-CF3 ,2-Cl, E ] , [ -2867 : 2-Me-6-CF3 , 2-Cl, E ] , [- 2868:3-Me-2-CF3 ,2-Cl, E ] , [ -2869 : 3-Me-4-CF3 , 2-Cl, E ] , [-
2870:3-Me-5-CF3 ,2-Cl, E ] , [ -2871 : 4-Me-2-CF3 , 2-Cl, E ] , C- 2872:4-Me-3-CF3 ,2-Cl, E ] , [ -2873 : 2-F-3-MeO, 2-Cl, E ] , C - 2874:2-F-4-MeO,2-Cl,E ] , [ -2875 : 2-F-5-MeO, 2-Cl, E ] , C - 2876:2-F-6-MeO,2-Cl,E ] , [ -2877 : 3-F-2-MeO, 2-Cl, E ] , [ - 2878:3-F-4-MeO,2-Cl,E ] , [ -2879 : 3-F-5-MeO, 2-Cl, E ] , [ - 2880:4-F-2-MeO,2-Cl,E ] , [ -2881 : 4-F-3-MeO, 2-Cl, E ] , [ - 2882:2-Cl-3-MeO,2-Cl,E ] , [ -2883 : 2-Cl-4-MeO, 2-Cl, E ] , [- 2884:2-Cl-5-MeO,2-Cl,E ] , [ -2885 : 2-Cl-6-MeO, 2-Cl, E ] , [- 2886:3-Cl-2-MeO,2-Cl,E ] , [ -2887 : 3-Cl-4-MeO, 2-Cl, E ] , [- 2888:3-Cl-5-MeO,2-Cl,E ] , [ -2889 : 4-Cl-2-MeO, 2-Cl, E ] , [- 2890:4-Cl-3-MeO,2-Cl,E ] , [ -2891 : 2-Me-3-MeO, 2-Cl, E ) , [- 2892:2-Me-4-MeO,2-Cl,E ] , [ -2893 : 2-Me-5-MeO, 2-Cl, E ] , [- 2894 :2-Me-6-MeO,2-Cl,E ] , C -2895 : 3-Me-2-MeO, 2-Cl, E ] , [- 2896:3-Me-4-MeO,2-Cl,E ] , C -2897 : 3-Me-5-MeO, 2-Cl, E ] , [- 2898:4-Me-2-MeO,2-Cl,E ] , C -2899 : 4-Me-3-MeO, 2-Cl, E ] , C-
2900:H,2-CF3 ,E] , [-2901 : 4-F, 2-CF3 , E] , [-2902 : 4-F, 2-CF3 , Z] ,
[ -2903:4-Cl,2-CF3,E ] , [ -2904 : 4-Cl, 2-CF3 , Z ] , [ -2905:4-
Br, 2-CF3, E] , [-2906:4-1, 2-CF3 ,E] , [-2907 : 4-Me, 2-CF3 , E] , [-
2908:4-Me,2-CF3 ,Z] , [-2909 : 4-Et, 2-CF3 , E] , [-2910 : 4-C3 H7 , 2- CF3, E] , [-2911:4-(Me)2CH,2-CF3 ,E] , [-2912 : 4-CF3 , 2-CF3 , E] ,
[-2913:4-CF3 ,2-CF3 ,Z] , [-2914 : 4-C2 F5 , 2-CF3 , E] , [-2915:4-
C3F7 ,2-CF3 ,E ] , [ -2916:4- (CF3 )2CF, 2-CF3 ,E ] , [ -2917:4-
(CF3 )2CH, 2-CF3 ,E ] , [ τ2918: 4-CHF2 ,2-CF3 ,E ] , [ -2919:4-
CH2 F, 2-CF3 ,E] , [-2920:4-CF3CH2 ,2-CF3 ,E] , [ -2921 : 4-MeO, 2- CF3, E] , [-2922:4-MeO,2-CF3 ,Z] , [-2923 : 4-EtO, 2-CF3 , E] , [-
2924 :4-C3H7O, 2-CF3 ,E ] , [ -2925 : 4- (Me) 2 CHO, 2-CF3 , E ] , [ - 2926:4-NO2 ,2-CF3 ,E] , [-2927 : 4-NO2 , 2-CF3 , z] , [-2928 : 3-F, 2- CF3, E] , [ -2929:3-F, 2-CF3 ,Z ] , [ -2930 : 3-Cl, 2-CF3 , E ] , [- 2931:3-C1,2-CF3 ,Z ] , [ -2932 : 3-Br, 2-CF3 , E ] , [-2933:3-1,2- CF3, E] , [-2934 :3-Me, 2-CF3 ,E] , [ -2935 : 3-Me, 2-CF3 , Z ] , [-
2936:3-Et,2-CF3 ,E ] , [ -2937 : 3-C3 H7 , 2-CF3 , E ] , [ -2938:3- (Me)2CH, 2-CF3, E] , [ -2939 : 3-CF3 , 2-CF3 , E ] , [ -2940 : 3-CF3 , 2- CF3, Z] , [-2941:3-C2F5 ,2-CF3 ,E] , [-2942 : 3-C3 F7 , 2-CF3 , E] , [- 2943:3-(CF3 )2CF,2-CF3 ,E] , [ -2944 : 3- (CF3 ) 2 CH, 2-CF3 , E ] , [- 2945:3-CHF2 ,2-CF3 ,E ] , [ -2946 : 3-CHF2 , 2-CF3 , Z ] , [-2947:3-
CH2F, 2-CF3 ,E] , [-2948:3-CH2F,2-CF3 ,Z] , [ -2949 : 3-CF3 CH2 , 2- CF3, E] , [-2950:3-MeO,2-CF3 ,E] , [-2951 : 3-MeO, 2-CF3 , z] , [- 2952:3-EtO,2-CF3 ,E ] , [ -2953 : 3-C3 H7 O, 2-CF3 , E ] , [-2954:3- (Me)2CHO, 2-CF3 ,E ] , [ -2955 : 3-NO2 , 2-CF3 , E ] , [ -2956 : 2-F, 2- CF3, E] , [-2957:2-Cl,2-CF3 ,E] , [ -2958 : 2-Br, 2-CF3 , E ] , [-
2959:2-1, 2-CF3 ,E ] , [ -2960 : 2-Me, 2-CF3 , E ] , [ -2961 : 2-Et, 2-
CF3, E] , [-2962:2-C3H7 ,2-CF3 ,E] , [-2963 : 2- (Me) 2 CH, 2-CF3 , E] ,
[-2964:2-CF3,2-CF3,E] , [-2965 : 2-C2 F5 , 2-CF3 , E] , [-2966:2-
C3F7 ,2-CF3, E ] , [ -2967:2-(CF3 )2CF,2-CF3 ,E ] , [ -2968:2- (CF3 )2CH, 2-CF3 ,E ] , [ -2969 : 2-CHF2 , 2-CF3 , E ] , [ -2970:2-
CH2F, 2-CF3 ,E] , [-2971.2-CF3CH2 ,2-CF3 ,E] , [ -2972 : 2-MeO, 2- CF3, E] , [-2973:2-EtO,2-CF3 ,E] , [-2974 : 2-C3 H7 O, 2-CF3 , E] , [- 2975:2-(Me)2CHO,2-CF3 ,E ] , [ -2976 : 2-NO2 , 2-CF3 , E ] , [ - 2977:2, 3-F2 ,2-CF3 ,E] , [-2978 : 2, 4-F2 , 2-CF3 , E] , [-2979:2,5- F2, 2-CF3, E ] , [ -2980:2, 6-F2 ,2-CF3 ,E ] , [ -2981 : 3, 4-F2 , 2-
CF3, E] , [-2982:3, 4-F2 ,2-CF3, Z] ,■ [-2983 : 3, 5-F2 , 2-CF3 , E] , C- 2984:3, 5-F2 ,2-CF3 ,Z] , [-2985 : 2 , 3-Cl2 , 2-CF3 , E] , [-2986:2,3- Cl2, 2-CF3, Z] , [-2987:2, 4-Cl2 ,2-CF3 ,E] , [ -2988 : 2, 4-Cl2 , 2- CF3, Z] , [-2989:2, 5-Cl2, 2-CF3, E] , [-2990 : 2, 5-Cl2 , 2-CF3 , z] , [ -2991:2, 6-Cl2 ,2-CF3, E ] , [ -2992 : 3, 4-Cl2 , 2-CF3 , E ] , [ -
2993:3, 5-Cl2 ,2-CF3 , E ] , [ -2994 : 2, 3-Br2 , 2-CF3 , E ] , [ - 2995:2, 4-Br2 ,2-CF3 , E ] , [ -2996 : 2 , 5-Br2 , 2-CF3 , E ] , [ - 2997:2, 6-Br2 ,2-CF3 , E ] , [ -2998 : 3, 4-Br2 , 2-CF3 , E ] , [ - 2999:3, 5-Br2 ,2-CF3 , E ] , [ -3000 : 2, 3-Me2 , 2-CF3 , E ] , [ - 3001:2, 4-Me2 ,2-CF3 , E ] , [ -3002 : 2 , 5-Me2 , 2-CF3 , E ] , [ -
3003:2, 6-Me2 ,2-CF3 , E ] , [ -3004 : 3, 4-Me2 , 2-CF3 , E ] , [ - 3005:3, 5-Me2 ,2-CF3 , E ] , [ -3006 : 2, 3-Et2 , 2-CF3 , E ] , [ - 3007:2, 4-Et2 ,2-CF3 , E 3 , [ -3008 : 2 , 5-Et2 , 2-CF3 , E ] , [ - 3009:2, 6-Et2 ,2-CF3 , E ] , [ -3010 : 3, 4-Et2 , 2-CF3 , E ] , [ - 3011:3, 5-Et2 ,2-CF3, E ] , [ -3012 : 2, 3- (CF3 ) 2 , 2-CF3 , E ] , [ -
3013:2, 4-(CF3 )2, 2-CF3, E] , [ -3014 : 2 , 5- (CF3 ) 2 , 2-CF3 , E ] , [- 3015:2, 6- (CF3 )2 ,2-CF3 ,E] , [ -3016 : 3, 4- (CF3 ) 2 , 2-CF3 , E ] , [- 3017:3, 5-(CF3)2 ,2-CF3, E] , [-3018 : 2, 3- (CHF2 ) 2 , 2-CF3 , E] , [- 3019:2,4- (CHF2 )2 ,2-CF3 ,E] , [-3020 : 2, 5- (CHF2 ) 2 , 2-CF3 , E] , [- 3021:2, 6-(CHF2 )2 ,2-CF3 ,E] , [-3022 : 3, 4- (CHF2 ) 2 , 2-CF3 , E] , [-
3023:3, 5-(CHF2)2, 2-CF3, E] , [-3024 : 2, 3- (CH2 F) 2 , 2-CF3 , E] , C- 3025:2,4- (CH2F)2 ,2-CF3 ,E] , [-3026 : 2, 5- (CH2 F) 2 , 2-CF3 , E] , [- 3027:2, 6-(CH2F)2 ,2-CF3 ,E] , [-3028 : 3 , 4- (CH2 F) 2 , 2-CF3 , E] , [- 3029:3,5- (CH2F)2 ,2-CF3 ,E] , [ -3030 : 2 , 3- (MeO) 2 , 2-CF3 , E] , [- 3031:2,4- (MeO)2 ,2-CF3 ,E] , [ -3032 : 2 , 5- (MeO) 2 , 2-CF3 , E ] , [-
3033:2,6- (MeO)2 ,2-CF3 ,E] , [ -3034 : 3, 4- (MeO) 2 , 2-CF3 , E ] , [
3035:3,5- (MeO)2 ,2-CF3 ,E] , [ -3036 : 2, 3- (EtO) 2 , 2-CF3 , E ) , [
3037:2,4- (EtO)2 ,2-CF3 ,E] , [ -3038 : 2 , 5- (EtO) 2 , 2-CF3 , E J , [
3039:2, 6- (EtO)2 ,2-CF3 ,E] , [ -3040 : 3, 4- (EtO) 2 , 2-CF3 , E ] , [ 3041:3,5- (EtO)2 ,2-CF3 ,E ] , [ -3042 : 2-C1-3-F, 2-CF3 , E ] , [
3043:2-Cl-4-F,2-CF3 ,E ] , [ -3044 : 2-C1-5-F, 2-CF3 , E ] , [
3045:2-Cl-6-F,2-CF3 ,E ] , [ -3046 : 3-C1-2-F, 2-CF3 , E ] , [
3047:3-Cl-4-F,2-CF3 ,E ] , [ -3048 : 3-C1-5-F, 2-CF3 , E ) , [ ■
3049:4-Cl-2-F,2-CF3 ,E ] , [ -3050 : 4-C1-3-F, 2-CF3 , E ] , [ ■ 3051:2-F-3-Me,2-CF3 ,E ] , [ -3052 : 2-F-4-Me, 2-CF3 , E ] , [ ■
3053:2-F-5-Me,2-CF3 ,E ] , [ -3054 : 2-F-6-Me, 2-CF3 , E ] , [ •
3055 :3-F-2-Me, 2-CF3 ,E ] , [ -3056 : 3-F-4-Me, 2-CF3 , E ] , [ ■
3057 :3-F-5-Me, 2-CF3 ,E ] , ( -3058 : 4-F-2-Me, 2-CF3 , E ] , [ ■
3059:4-F-3-Me,2-CF3 ,E ] , [ -3060 : 2-Cl-3-Me, 2-CF3 , E ] , [ ■ 3061:2-Cl-4-Me,2-CF3 ,E ] , [ -3062 : 2-Cl-5-Me, 2-CF3 , E ] , [ ■
3063:2-Cl-6-Me,2-CF3 ,E ] , C -3064 : 3-Cl-2-Me, 2-CF3 , E ] , [ ■
3065:3-Cl-4-Me,2-CF3 ,E ] , C -3066 : 3-Cl-5-Me, 2-CF3 , E ] , [ ■
3067 :4-Cl-2-Me, 2-CF3 ,E ] , [ -3068 : 4-Cl-3-Me, 2-CF3 , E ] , ( ■
3069:2-F-3-CF3 ,2-CF3 ,E ] , [ -3070 : 2-F-4-CF3 , 2-CF3 , E ) , [ ■ 3071:2-F-5-CF3 ,2-CF3 ,E ] , [ -3072 : 2-F-6-CF3 , 2-CF3 , E ] , [ ■
3073:3-F-2-CF3 ,2-CF3 ,E ] , [ -3074 : 3-F-4-CF3 , 2-CF3 , E ] , [ ■
3075:3-F-5-CF3 ,2-CF3 ,E ] , [ -3076: 4-F-2-CF3 , 2-CF3 , E ] , [ ■
3077:4-F-3-CF3 ,2-CF3 ,E ] , [ -3078 : 2-Cl-3-CF3 , 2-CF3 , E ] , [-
3079:2-Cl-4-CF3 ,2-CF3 ,E] , C -3080 : 2-Cl-5-CF3 , 2-CF3 , E ] , [■ 3081:2-Cl-6-CF3 ,2-CF3 ,E] , [ -3082 : 3-Cl-2-CF3 , 2-CF3 , E ] , [■
3083:3-Cl-4-CF3 ,2-CF3 ,E) , [ -3084 : 3-Cl-5-CF3 , 2-CF3 , E ] , C- 3085:4-Cl-2-CF3 ,2-CF3 ,E) , [ -3086 : 4-Cl-3-CF3 , 2-CF3 , E ] , C- 3087:2-Me-3-CF3 ,2-CF3 ,E] , [ -3088 : 2-Me-4-CF3 , 2-CF3 , E ] , [- 3089:2-Me-5-CF3 ,2-CF3 ,E) , ( -3090 : 2-Me-6-CF3 , 2-CF3 , E ) , [- 3091:3-Me-2-CF3 ,2-CF3 ,E) , [ -3092 : 3-Me-4-CF3 , 2-CF3 , E ) , [-
3093 :3-Me-5-CF3 ,2-CF3 ,E) , [ -3094 : 4-Me-2-CF3 , 2-CF3 , E ) , [- 3095 :4-Me-3-CF3 ,2-CF3 ,E ) , [ -3096 : 2-F-3-MeO, 2-CF3 , E ) , (- 3097 :2-F-4-MeO, 2-CF3 ,E ) , [ -3098 : 2-F-5-MeO, 2-CF3 , E ) , [ - 3099:2-F-6-MeO,2-CF3 ,E ) , [ -3100 : 3-F-2-MeO, 2-CF3 , E ) , [ - 3101:3-F-4-MeO,2-CF3 ,E ) , [ -3102 : 3-F-5-MeO, 2-CF3 , E ) , [ -
3103:4-F-2-MeO,2-CF3 ,E ) , [ -3104 : 4-F-3-MeO, 2-CF3 , E ) , [ - 3105:2-Cl-3-MeO,2-CF3 ,E) , [ -3106 : 2-Cl-4-MeO, 2-CF3 , E ) , [- 3107:2-Cl-5-MeO,2-CF3,E) , [ -3108 : 2-Cl-6-MeO, 2-CF3 , E ) , (- 3109 :3-Cl-2-MeO, 2-CF3 ,E) , [ -3110 : 3-Cl-4-MeO, 2-CF3 , E ) , (- 3111:3-Cl-5-MeO,2-CF3,E) , [ -3112 : 4-Cl-2-MeO, 2-CF3 , E ) , [-
3113 :4-Cl-3-MeO, 2-CF3 ,E) , [ -3114 : 2-Me-3-MeO, 2-CF3 , E ) , [- 3115:2-Me-4-MeO,2-CF3 ,E) , ( -3116 : 2-Me-5-MeO, 2-CF3 , E ) , [- 3117 :2-Me-6-MeO, 2-CF3 ,E) , [ -3118 : 3-Me-2-MeO, 2-CF3 , E ) , [- 3119:3-Me-4-MeO,2-CF3,E) , [ -3120 : 3-Me-5-MeO, 2-CF3 , E ) , [- 3121:4-Me-2-MeO,2-CF3,E) , [ -3122 : 4-Me-3-MeO, 2-CF3 , E ) , [-
3123: H, 2-MeO, E) , (-3124 : 4-F, 2-MeO, E) , [-3125 : 4-F, 2-MeO, z) ,
( -3126:4-Cl,2-MeO,E ) , [ -3127 : 4-Cl, 2-MeO, Z ) , [-3128:4-
Br, 2-MeO, E) , [-3129 : 4-1, 2-MeO, E) , [-3130 : 4-Me, 2-MeO, E) , [-
3131:4-Me,2-MeO,Z) , (-3132 : 4-Et, 2-MeO, E) , [-3133 : 4-C3 H7 , 2- MeO, E) , [-3134 : 4- (Me) 2 CH, 2-MeO, E) , (-3135 : 4-CF3 , 2-MeO, E) ,
[-3136:4-CF3 ,2-MeO,Z] , [ -3137 : 4-C2 F5 , 2-MeO, E] , [-3138:4-
C3F7 ,2-MeO, E ] , [ -3139 : 4- (CF3 ) 2 CF, 2-MeO, E ] , [ -3140:4-
(CF3 ) 2CH,2-Me0,E ] , [ -3141 : 4-CHF2 , 2-MeO, E ] , [ -3142:4-
CH2F, 2-MeO, E] , [ -3143 : 4-CF3 CH2 , 2-MeO, E ] , [ -3144 : 4-MeO, 2- MeO, E] , [-3145:4-MeO,2-MeO,Z] , [-3146 : 4-EtO, 2-MeO, E] , [-
3147 :4-C3H7O,2-MeO,E ] , [ -3148 : 4- (Me) 2 CHO, 2-MeO, E ] , [ -
3149:4-NO2 ,2-Me0,E) , [ -3150 : 4-NO2 , 2-MeO, Z ] , [-3151 : 3-F, 2-
MeO, E] , [ -3152:3-F,2-MeO,Z ] , [ -3153 : 3-Cl, 2-MeO, E ] , [-
3154:3-Cl,2-MeO,Z ] , [ -3155 : 3-Br, 2-MeO, E ] , [-3156:3-1,2- MeO, E] , [-3157:3-Me,2-MeO,E] , [ -3158 : 3-Me, 2-MeO, Z ] , [-
3159:3-Et,2-MeO,E ] , [ -3160 : 3-C3 H7 , 2-MeO, E ] , [ -3161:3-
(Me) 2 CH, 2-MeO, E ] , [ -3162 : 3-CF3 , 2-MeO, E ] , [ -3163 : 3-CF3 , 2-
MeO, Z] , [-3164 : 3-C2 F5 ,2-MeO, E] , [-3165 : 3-C3 F7 , 2-MeO, E] , C-
3166:3-(CF3 ) 2 CF, 2-MeO, E ] , [ -3167 : 3- (CF3 ) 2 CH, 2-MeO, E ] , [- 3168 : 3-CHF2 ,2-MeO, E ] , [ -3169 : 3-CHF2 , 2-MeO, Z ] , [-3170:3-
CH2F, 2-MeO, E] , [-3171 : 3-CH2 F, 2-MeO, z] , [-3172 : 3-CF3 CH2 , 2-
MeO, E] , [-3173:3-MeO,2-MeO,E] , [-3174 : 3-MeO, 2-MeO, Z] , [-
3175: 3-EtO, 2-MeO, E ] , [ -3176 : 3-C3 H70, 2-MeO, E ] , [-3177:3-
(Me)2CHO, 2-MeO, E ] , [ -3178 : 3-NO2 , 2-MeO, E ] , [ -3179 : 2-F, 2- MeO, E] , [-3180:2-01, 2-MeO, E] , [ -3181 : 2-Br, 2-MeO, E ] , [-
3182:2-1, 2-MeO, E] , [ -3183 : 2 -Me, 2-MeO, E ] , [ -3184 : 2-Et , 2- MeO, E] , [-3185:2-C3H7 ,2-Me0,E] , [-3186 : 2- (Me) 2 CH, 2-MeO, E] ,
[-3187:2-CF3 ,2-Me0,E] , [ -3188 : 2-C2 F5 , 2-MeO, E] , [-3189:2- C3F7 ,2-MeO, E ] , [ -3190 : 2- (CF3 ) 2 CF, 2-MeO, E ] , [ -3191:2- (CF3 )2CH,2-Me0,E ] , [ -3192 : 2-CHF2 , 2-MeO, E ] , [ -3193:2-
CH2 F, 2-MeO, E ] , [ -3194 : 2-CF3 CH2 , 2-MeO, E ] , C -3195 : 2-MeO, 2- MeO, E] , C-3196:2-EtO,2-MeO,E] , (-3197 : 2-C3 H70, 2-MeO, E] , [- 3198:2-(Me)2CHO,2-MeO,E ] , [ -3199 : 2-NO2 , 2-MeO, E ) , [ - 3200:2, 3-F2 ,2-MeO, E] , [-3201 : 2, 4-F2 , 2-MeO, E] , [-3202:2,5- F2, 2-MeO, E ] , [ -3203 : 2 , 6-F2 , 2-MeO, E ] , ( -3204 : 3, 4-F2 , 2-
MeO, E] , [-3205:3, 4-F2 ,2-MeO, Z] , (-3206 : 3, 5-F2 , 2-MeO, E] , [- 3207 :3, 5-F2 ,2-MeO, Z] , (-3208 : 2, 3-Cl2 , 2-MeO, E] , (-3209:2,3- Cl2, 2-MeO, Z] , [-3210:2, 4-Cl2 ,2-MeO, E] , [ -3211:2, 4-Cl2 , 2- MeO, Z] , [-3212:2, 5-Cl2 ,2-MeO, E] , (-3213 : 2, 5-Cl2 , 2-MeO, Z] , [ -3214:2, 6-Cl2 ,2-MeO, E ] , ( -3215 : 3, 4-Cl2 , 2-MeO, E ] , [ -
3216:3, 5-Cl2 ,2-MeO, E ] , [ -3217 : 2, 3-Br2 , 2-MeO, E ] , [ - 3218:2, 4-Br2 ,2-MeO, E ] , [ -3219 : 2, 5-Br2 , 2-MeO, E ] , ( - 3220:2, 6-Br2 ,2-MeO, E ] , [ -3221 : 3, 4-Br2 , 2-MeO, E ] , [ - 3222: 3, 5-Br2 ,2-MeO, E ] , ( -3223 : 2, 3-Me2 , 2-MeO, E ] , [ - 3224:2, 4-Me2 ,2-MeO, E ] , [ -3225 : 2, 5-Me2 , 2-MeO, E ] , [ -
3226:2, 6-Me2 ,2-MeO, E ] , [ -3227 : 3, 4-Me2 , 2-MeO, E ] , ( - 3228:3, 5-Me2 ,2-MeO, E ] , [ -3229 : 2, 3-Et2 , 2-MeO, E ] , ( - 3230:2, 4-Et2 ,2-MeO, E ] , [ -3231 : 2, 5-Et2 , 2-MeO, E ] , [ - 3232:2, 6-Et2 ,2-MeO, E ] , [ -3233 : 3, 4-Et2 , 2-MeO, E ] , [ - 3234:3, 5-Et2 ,2-MeO, E ] , ( -3235 : 2, 3- (CF3 ) 2 , 2-MeO, E ] , [ -
3236:2, 4-(CF3)2 ,2-MeO, E] , [ -3237 : 2, 5- (CF3 ) 2 , 2-MeO, E ] , (- 3238:2, 6- (CF3 )2 ,2-MeO, E] , [ -3239 : 3, 4- (CF3 ) 2 , 2-MeO, E ] , [- 3240:3,5- (CF3 )2 ,2-MeO, E] , (-3241 : 2, 3- (CHF2 ) 2 , 2-MeO, E] , [- 3242:2, 4-(CHF2 )2 ,2-MeO, E] , (-3243 : 2, 5- (CHF2 ) 2 , 2-MeO, E] , [- 3244:2, 6- (CHF2 )2 ,2-MeO, E] , (-3245 : 3, 4- (CHF2 ) 2 , 2-MeO, E] , (-
3246:3,5- (CHF2 )2 ,2-MeO, E] , [-3247 : 2, 3- (CH2 F) 2 , 2-MeO, E] , [■
3248:2,4- (CH2F)2 ,2-MeO, E] , [-3249 : 2 , 5- (CH2 F) 2 , 2-MeO, E] , C-
3250:2, 6-(CH2F)2, 2-MeO, E] , [-3251 : 3, 4- (CH2 F) 2 , 2-MeO, E] , [-
3252:3,5- (CH2F)2 ,2-MeO, E] , [-3253 : 2, 3- (MeO) 2 , 2-MeO, E] , [- 3254:2,4- (MeO)2 ,2-MeO, E] , [ -3255 : 2, 5- (MeO) 2 , 2-MeO, E ] , [-
3256:2, 6-(MeO)2, 2-MeO, E] , [ -3257 : 3, 4- (MeO) 2 , 2-MeO, E ] , [-
3258:3,5- (MeO)2 ,2-MeO, E] , [ -3259 : 2, 3- (EtO) 2 , 2-MeO, E ] , [-
3260:2,4- (EtO)2 ,2-MeO, E] , [ -3261 : 2, 5- (EtO) 2 , 2-MeO, E ] , [-
3262:2,6- (EtO)2 ,2-MeO, E] , [ -3263 : 3, 4- (EtO) 2 , 2-MeO, E ] , [- 3264:3,5- (EtO)2 ,2-MeO, E ] , [ -3265 : 2-C1-3-F, 2-MeO, E ] , [-
3266:2-Cl-4-F,2-MeO,E ] , [ -3267 : 2-C1-5-F, 2-MeO, E ] , [ -
3268:2-Cl-6-F,2-MeO,E ] , [ -3269 : 3-C1-2-F, 2-MeO, E ] , [ -
3270:3-Cl-4-F,2-MeO,E ] , [ -3271 : 3-C1-5-F, 2-MeO, E ] , [ -
3272:4-Cl-2-F,2-MeO,E ] , [ -3273 : 4-C1-3-F, 2-MeO, E ] , [ - 3274:2-F-3-Me,2-MeO,E ] , [ -3275 : 2-F-4-Me, 2-MeO, E ] , [ -
3276:2-F-5-Me,2-MeO,E ] , [ -3277 : 2-F-6-Me, 2-MeO, E ] , C -
3278:3-F-2-Me,2-MeO,E ] , [ -3279 : 3-F-4-Me, 2-MeO, E ] , [ -
3280:3-F-5-Me,2-MeO,E ] , [ -3281 : 4-F-2-Me, 2-MeO, E ] , [ -
3282:4-F-3-Me,2-MeO,E ] , [ -3283 : 2-Cl-3-Me, 2-MeO, E ] , C - 3284:2-Cl-4-Me,2-MeO,E ] , C -3285 : 2-Cl-5-Me, 2-MeO, E ] , [-
3286:2-Cl-6-Me,2-MeO,E ] , C -3287 : 3-01-2-Me, 2-MeO, E ] , [-
3288:3-Cl-4-Me,2-MeO,E ] , C -3289 : 3-Cl-5-Me, 2-MeO, E ] , C '-
3290:4-Cl-2-Me,2-MeO,E ] , C -3291 : 4-Cl-3-Me, 2-MeO, E ] , C-
3292:2-F-3-CF3 ,2-MeO, E ] , C -3293 : 2-F-4-CF3 , 2-MeO, E ] , C- 3294:2-F-5-CF3,2-MeO,E ] , C -3295 : 2-F-6-CF3 , 2-MeO, E ] , C-
3296:3-F-2-CF3 ,2-MeO, E ] , [ -3297 : 3-F-4-CF3 , 2-MeO, E ] , [
3298:3-F-5-CF3 ,2-MeO, E ] , [ -3299 : 4-F-2-CF3 , 2-MeO, E ) , [
3300:4-F-3-CF3 ,2-MeO, E ] , [ -3301 : 2-Cl-3-CF3 , 2-MeO, E ] , [
3302:2-Cl-4-CF3 ,2-Me0,E] , [ -3303 : 2-Cl-5-CF3 , 2-MeO, E ] , [ 3304:2-Cl-6-CF3 ,2-Me0,E] , [ -3305 : 3-Cl-2-CF3 , 2-MeO, E ) , C
3306:3-Cl-4-CF3 ,2-MeO,E] , C -3307 : 3-Cl-5-CF3 , 2-MeO, E ] , (
3308:4-Cl-2-CF3 ,2-MeO,E] , [ -3309 : 4-Cl-3-CF3 , 2-MeO, E ] , [■
3310:2-Me-3-CF3 ,2-Me0,E] , [ -3311 : 2-Me-4-CF3 , 2-MeO, E ] , [
3312 :2-Me-5-CF3 ,2-MeO, E] , [ -3313 : 2-Me-6-CF3 , 2-MeO, E ] , ( 3314:3-Me-2-CF3 ,2-MeO,E] , C -3315 : 3-Me-4-CF3 , 2-MeO, E ) , C-
3316:3-Me-5-CF3 ,2-MeO,E] , [ -3317 : 4-Me-2-CF3 , 2-MeO, E ] , [•
3318:4-Me-3-CF3 ,2-MeO, E ] , [ -3319 : 2-F-3-MeO, 2-MeO, E ] , [■
3320:2-F-4-MeO,2-MeO,E ] , [ -3321 : 2-F-5-MeO, 2-MeO, E ] , [■
3322:2-F-6-MeO,2-MeO,E J , [ -3323 : 3-F-2-MeO, 2-MeO, E ] , [■ 3324 :3-F-4-MeO,2-MeO,E ] , [ -3325 : 3-F-5-MeO, 2-MeO, E ] , [■
3326:4-F-2-MeO,2-MeO,E ] , [ -3327 : 4-F-3-MeO, 2-MeO, E ] , C-
3328:2-Cl-3-MeO,2-MeO,E) , [ -3329 : 2-Cl-4-MeO, 2-MeO, E 3 , £■
3330:2-Cl-5-MeO,2-MeO,E) , [ -3331 : 2-Cl-6-MeO, 2-MeO, E ] , [■
3332:3-Cl-2-MeO,2-MeO,E] , [ -3333 : 3-Cl-4-MeO, 2-MeO, E ] , [• 3334:3-Cl-5-MeO,2-MeO,E] , [ -3335 : 4-Cl-2-MeO, 2-MeO, E ] , [■
3336:4-Cl-3-MeO,2-MeO,E] , [ -3337 : 2-Me-3-MeO, 2-MeO, E ] , C-
3338:2-Me-4-MeO,2-MeO,E) , [ -3339 : 2-Me-5-MeO, 2-MeO, E ] , [■
3340:2-Me-6-MeO,2-MeO,E] , C -3341 : 3-Me-2-MeO, 2-MeO, E ] , C-
3342:3-Me-4-MeO,2-MeO,E] , C -3343 : 3-Me-5-MeO, 2-MeO, E ] , [■ 3344 :4-Me-2-MeO,2-MeO,E] , C -3345 : 4-Me-3-MeO, 2-MeO, E ] , C-
334β:H, 2-(Me)3CO, E ] , [ -3347 : 4-F, 2- (Me) 3 CO, E ] , [-3348:4- F, 2- (Me)3CO, Z] , ( -3349 : 4-Cl, 2- (Me) 3 CO, E ] , [ -3350 : 4-Cl, 2- (Me)3CO, Z ] , [ -3351:4-Br, 2-(Me)3CO, E ] , C -3352:4-1,2- (Me)3CO, E ] , [ -3353:4-Me, 2-(Me)3CO, E ) , [ -3354 : 4 -Me, 2- (Me)3CO, Z ] , [ -3355:4-Et, 2-(Me)3CO, E ) , [ -3356 : 4-C3 H7 , 2-
(Me)3CO, E] , [-3357:4- (Me)2CH, 2- (Me)3CO, E] , [-3358 : 4-CF3 , 2- (Me)3CO, E] , [ -3359:4-CF3 ,2-(Me)3CO, Z ] , ( -3360 : 4-C2 F5 , 2- (Me)3CO, E ] , [ -3361.4-C3F7 ,2-(Me)3CO, E ] , [ -3362:4- (CF3 )2CF, 2-(Me)3CO, E] , [ -3363 : 4- (CF3 ) 2 CH, 2- (Me) 3 CO, E ] , [- 3364:4-CHF2 ,2- (Me)3CO, E] , [ -3365 : 4-CH2 F, 2- (Me) 3 CO, E ] , [-
3366:4-CF3CH2 ,2- (Me)3CO, E] , [-3367 : 4-MeO, 2- (Me) 3 CO, E] , [-
3368:4-MeO, 2-(Me)3CO, Z ] , [ -3369 : 4-EtO, 2- (Me) 3 CO, E ] , [ -
3370:4-C3H7O, 2- (Me)3CO, E] , [-3371 : 4- (Me) 2 CHO, 2- (Me) 3 CO, E] ,
[-3372:4-NO2 ,2- (Me)3CO, E] , [-3373 : 4-NO2 , 2- (Me) 3 CO, Z ] , [- 3374:3-F, 2-(Me)3CO, E] , [-3375 : 3-F, 2- (Me) 3 CO, Z] , [-3376:3-
Cl, 2- (Me)3CO, E] , [-3377 : 3-Cl, 2- (Me) 3 CO, Z ] , [-3378 : 3-Br, 2- (Me)3CO, E ] , [ -3379:3-1, 2-(Me)3CO, E ] , [ -3380 : 3-Me, 2- (Me)3CO, E ] , [ -3381:3-Me,2- (Me)3CO, Z ] , [ -3382 : 3-Et, 2- (Me)3CO, E ] , [ -3383:3-C3H7 ,2- (Me)3CO, E ] , [ -3384:3- (Me)2CH, 2- (Me)3CO, E] , [-3385 : 3-CF3 , 2- (Me) 3 CO, E] , [-3386:3-
CF3 ,2-(Me)3CO, Z ] , [ -3387 : 3-C2 F5 , 2- (Me) 3 CO, E ] , [-3388:3-
C3F7 ,2-(Me)3CO, E ] , [ -3389 : 3- (CF3 ) 2 CF, 2- (Me) 3 CO, E ] , [ -
3390:3- (CF3 )2CH, 2-(Me)3CO, E] , [-3391 : 3-CHF2 , 2- (Me) 3 CO, E] ,
[ -3392: 3-CHF2 ,^2- (Me)3CO, Z ] , [ -3393 : 3-CH2 F, 2- (Me) 3 CO, E ] , [-3394:3-CH2F, 2- (Me)3CO, Z] , [-3395 : 3-CF3 CH2 , 2- (Me) 3 CO, E] ,
[-339β:3-MeO, 2- (Me)3CO, E] , [-3397 : 3-MeO, 2- (Me) 3 CO, Z] , C-
3398:3-EtO, 2-(Me)3CO, E] , [ -3399 : 3-C3 H7 O, 2- (Me) 3 CO, E ] , [-
3400:3- (Me)2CHO, 2- (Me)3CO, E] , C -3401 : 3-NO2 , 2- (Me) 3 CO, E ] ,
[ -3402:2-F,2- (Me)3CO, E ] , [ -3403 : 2-Cl, 2- (Me) 3 CO, E ] , [ - 3404:2-Br, 2- (Me)3CO, E] , [-3405 : 2-1, 2- (Me) 3 CO, E] , [-3406:2-
Me, 2- (Me)3CO, E ] , [ -3407 : 2-Et , 2- (Me) 3 CO, E ] , [ -3408:2-
C3H7 ,2-(Me)3CO, E ] , [ -3409 : 2- (Me) 2 CH, 2- (Me) 3 CO, E ] , [ -
3410:2-CF3 ,2- (Me)3CO, E ] , [ -3411 : 2-C2 F5 , 2- (Me) 3 CO, E ] , [-
3412:2-C3F7 ,2-(Me)3CO, E] , [-3413 : 2- (CF3 ) 2 CF, 2- (Me) 3 CO, E] , [ -3414:2- (CF3 )2CH, 2-(Me)3CO, E ] , [ -3415 : 2-CHF2 , 2-
(Me)3CO, E] , [-3416:2-CH2F, 2-(Me)3CO, E] , [-3417 : 2-CF3 CH2 , 2- (Me)3CO, E ] , [ -3418:2-MeO, 2-(Me)3CO, E ] , [ -3419 : 2-EtO, 2- (Me)3CO, E ] , [ -3420:2-C3H7O,2- (Me)3CO, E ] , [ -3421:2- (Me)2CHO, 2- (Me)3CO, E ] , [ -3422 : 2-NO2 , 2- (Me) 3 CO, E ] , [ - 3423:2, 3-F2, 2-(Me)3CO, E] , [ -3424 : 2, 4-F2 , 2- (Me) 3 CO, E ] , [-
3425:2, 5-F2 ,2- (Me)3CO, E] , [ -3426 : 2, 6-F2 , 2- (Me) 3 CO, E ] , [- 3427:3, 4-F2 ,2-(Me)3CO, E] , [ -3428 : 3, 4-F2 , 2- (Me) 3 CO, Z ] , [- 3429:3, 5-F2, 2-(Me)3CO, E] , [ -3430 : 3, 5-F2 , 2- (Me) 3 CO, Z ] , [- 3431:2, 3-Cl2 ,2- (Me)3CO, E] , [-3432 : 2, 3-Cl2 , 2- (Me) 3 CO, Z] , [- 3433:2, 4-Cl2 ,2- (Me)3CO, E] , [-3434 : 2, 4-Cl2 , 2- (Me) 3 CO, Z] , [-
3435:2, 5-Cl2 ,2- (Me)3CO, E] , [-3436 : 2, 5-Cl2 , 2- (Me) 3 CO, Z] , [- 3437:2, 6-Cl2 ,2- (Me)3CO, E] , [-3438 : 3, 4-Cl2 , 2- (Me) 3 CO, E] , [- 3439:3, 5-Cl2 ,2- (Me)3CO, E] , [-3440 : 2, 3-Br2 , 2- (Me) 3 CO, E] , [- 3441:2, 4-Br2 ,2- (Me)3CO, E] , C-3442 : 2, 5-Br2 , 2- (Me) 3 CO, E] , [- 3443:2, 6-Br2 ,2- (Me)3CO, E] , [-3444 : 3, 4-Br2 , 2- (Me) 3 CO, E] , [-
3445:3, 5-Br2 ,2-(Me)3CO, E] , [-3446 : 2 , 3-Me2 , 2- (Me) 3 CO, E] , C-
3447:2, 4-Me2 ,2- (Me)3CO, E] , [-3448 : 2, 5-Me2 , 2- (Me) 3 CO, E] , [-
3449:2, 6-Me2 ,2- (Me)3CO, E] , [-3450 : 3, 4-Me2 , 2- (Me) 3 CO, E] , [-
3451:3, 5-Me2, 2-(Me)3CO, E] , [-3452 : 2, 3-Et2 , 2- (Me) 3 CO, E] , [- 3453:2, 4-Et2 ,2-(Me)3CO, E] , [-3454 : 2, 5-Et2 , 2- (Me) 3 CO, E] , [-
3455:2, 6-Et2 ,2- (Me)3CO, E] , [-3456 : 3, 4-Et2 , 2- (Me) 3 CO, E] , [-
3457:3, 5-Et2, 2-(Me)3CO, E] , [-3458 : 2 , 3- (CF3 ) 2 , 2- (Me) 3 CO, E] ,
[ -3459:2, 4-(CF3 )2 ,2-(Me)3CO, E ] , [ -3460 : 2 , 5- (CF3 ) 2 , 2-
(Me)3CO, E] , [ -3461:2, 6- (CF3 )2 ,2-(Me)3CO, E] , [-3462:3,4- (CF3 )2 ,2-(Me)3CO, E ] , [ -3463 : 3, 5- (CF3 ) 2 , 2- (Me) 3 CO, E ] , [-
3464:2, 3- (CHF2 )2 ,2-(Me)3CO, E ] , [ -3465 : 2, 4- (CHF2 ) 2 , 2- (Me)3CO, E] , [-3466:2, 5-(CHF2 )2 ,2-(Me)3CO, E] , [-3467:2,6- (CHF2 )2, 2-(Me)3CO, E] , [ -3468 : 3, 4- (CHF2 ) 2 , 2- (Me) 3 CO, E ] , [- 3469:3, 5-(CHF2 )2 ,2-(Me)3CO, E ] , [ -3470 : 2, 3- (CH2 F) 2 , 2- (Me)3CO, E] , [ -3471 : 2, 4- (CH2 F) 2 , 2- (Me) 3 CO, E ] , [-3472:2,5-
(CH2F)2 ,2-(Me)3CO, E] , [ -3473 : 2 , 6- (CH2 F) 2 , 2- (Me) 3 CO, E ] , [- 3474:3,4- (CH2F)2 ,2-(Me)3CO, E ] , [ -3475 : 3, 5- (CH2 F) 2 , 2- (Me)3CO, E] , [ -3476:2, 3-(MeO)2 ,2-(Me)3CO, E] , [-3477:2,4- (MeO)2 ,2- (Me)3CO, E ] , [ -3478 : 2, 5- (MeO) 2 , 2- (Me) 3 CO, E ] , [- 3479:2, 6-(MeO)2 ,2-(Me)3CO, E ] , [ -3480 : 3, 4- (MeO) 2 , 2-
(Me)3C0,E] , [ -3481:3, 5-(MeO)2, 2-(Me)3CO, E] , [-3482:2,3- (EtO)2 ,2-(Me)3CO, E] , [ -3483 : 2 , 4- (EtO) 2 , 2- (Me) 3 CO, E ] , [- 3484:2, 5-(EtO)2, 2-(Me)3CO, E ] , [ -3485 : 2 , 6- (EtO) 2 , 2- (Me)3CO, E] , [ -3486:3, 4-(EtO)2 ,2-(Me)3CO, E ] , [-3487:3,5- (EtO)2 ,2- (Me)3CO, E ] , [ -3488 : 2-C1-3-F, 2- (Me) 3 CO, E ] , [ -
3489:2-Cl-4-F, 2- (Me)3CO, E] , [-3490 : 2-C1-5-F, 2- (Me) 3 CO, E] ,
[ -3491:2-Cl-β-F, 2-(Me)3CO, E ] , [ -3492 : 3-C1-2-F, 2-
(Me)3CO, E] , [-3493:3-Cl-4-F, 2- (Me)3CO, E] , [ -3494 : 3-C1-5-
F, 2-(Me)3CO, E] , [-3495 : 4-C1-2-F, 2- (Me) 3 CO, E] , [-3496.4-C1- 3-F, 2-(Me)3CO, E] , [-3497 : 2-F-3-Me, 2- (Me) 3 CO, E] , [-3498:2-
F- 4 -Me, 2- (Me)3CO, E ] , [ -3499 : 2-F-5-Me, 2- (Me) 3 CO, E ] , [ -
3500:2-F-6-Me, 2- (Me)3CO, E] , [-3501 : 3-F-2-Me, 2- (Me) 3 CO, E] ,
[ -3502:3-F-4-Me,2- (Me)3CO, E ] , [ -3503 : 3-F-5-Me, 2-
(Me)3CO, E] , [ -3504:4-F-2-Me,2- (Me) 3CO,E ] , [ -3505 : 4-F-3- Me, 2-(Me)3CO, E] , [-3506 : 2-Cl-3-Me, 2- (Me) 3 CO, E] , [-3507:2-
Cl-4-Me,2- (Me)3CO, E ] , [ -3508 : 2-Cl-5-Me, 2- (Me) 3 CO, E ] , [-
3509:2-Cl-6-Me, 2-(Me)3CO, E] , [-3510 : 3-Cl-2-Me, 2- (Me) 3 CO, E] ,
[ -3511:3-Cl-4-Me, 2-(Me)3CO, E ] , [ -3512 : 3-Cl-5-Me, 2-
(Me)3CO, E] , [-3513:4-Cl-2-Me, 2- (Me)3CO, E] , [-3514 : 4-C1-3- Me, 2-(Me)3CO, E] , [-3515 : 2-F-3-CF3 , 2- (Me) 3 CO, E] , [-3516:2-
F-4-CF3 ,2- (Me)3CO, E ] , [ -3517 : 2-F-5-CF3 , 2- (Me) 3 CO, E ] , [-
3518:2-F-6-CF3 ,2- (Me)3CO, E] , [-3519 : 3-F-2-CF3 , 2- (Me) 3 CO, E] ,
[ -3520:3-F-4-CF3 ,2- (Me)3CO, E ] , [ -3521 : 3-F-5-CF3 , 2-
(Me)3CO, E] , [-3522:4-F-2-CF3 ,2-(Me)3CO, E] , [ -3523 : 4-F-3- CF3 ,2- (Me)3 CO, E ] , [ -3524 : 2-Cl-3-CF3 , 2- (Me) 3 CO, E ] , [ -
3525:2-Cl-4-CF3 ,2-(Me)3CO, E ] , [ -3526 : 2-Cl-5-CF3 , 2-
(Me)3CO, E] , [-3527:2-Cl-6-CF3 ,2- (Me)3CO, E] , [-3528 : 3-C1-2-
CF3 ,2- (Me)3CO, E ] , [ -3529 : 3-Cl-4-CF3 , 2- (Me) 3 CO, E ] , [ -
3530:3-Cl-5-CF3 ,2- (Me)3CO, E ] , [ -3531 : 4-Cl-2-CF3 , 2- (Me)3CO, E] , [-3532 : 4-Cl-3-CF3 , 2- (Me) 3 CO, E] , [-3533 : 2-Me-3-
CF3 ,2-(Me)3CO, E ] , ( -3534 : 2-Me-4-CF3 , 2- (Me) 3 CO, E ] , [ -
3535:2-Me-5-CF3 ,2- (Me)3CO, E ] , C -3536 : 2-Me-6-CF3 , 2-
(Me)3CO, E] , [-3537:3-Me-2-CF3 ,2- (Me) 3CO,E) , [-3538 : 3-Me-4-
CF3 ,2-(Me)3CO, E ] , C -3539 : 3-Me-5-CF3 , 2- (Me) 3 CO, E ] , ( - 3540:4-Me-2-CF3 ,2-(Me)3CO, E ) , C -3541 : 4-Me-3-CF3 , 2-
(Me)3CO, E] , [-3542:2-F-3-MeO, 2- (Me)3CO, E] , [ -3543 : 2-F-4-
MeO, 2-(Me)3CO, E] , [-3544 : 2-F-5-MeO, 2- (Me) 3 COZE] , [-3545:2-
F-6-MeO,2- (Me)3CO, E ] , [ -3546 : 3-F-2-MeO, 2- (Me) 3 CO, E ] , [-
3547 :3-F-4-MeO, 2- (Me)3CO, E] , [-3548 : 3-F-5-MeO, 2- (Me) 3 CO, E] , [ -3549:4-F-2-MeO, 2-(Me)3CO, E ] , [ -3550 : 4-F-3-MeO, 2-
(Me)3CO, E] , [-3551:2-Cl-3-MeO, 2-(Me)3CO, E] , [-3552 : 2-C1-4-
MeO, 2- (Me)3CO, E ] , [ -3553 : 2-Cl-5-MeO, 2- (Me) 3 CO, E ] , [ -
3554:2-Cl-6-MeO,2- (Me)3CO, E ] , [ -3555 : 3-Cl-2-MeO, 2-
(Me)3CO, E] , [-3556:3-Cl-4-MeO, 2- (Me)3CO, E] , [-3557 : 3-C1-5- MeO, 2-(Me)3CO, E ] , [ -3558 : 4-Cl-2-MeO, 2- (Me) 3 CO, E ] , [ -
3559:4-Cl-3-MeO,2- (Me)3CO, E ] , [ -3560 : 2-Me-3-MeO, 2-
(Me)3CO, E] , [-3561:2-Me-4-MeO, 2- (Me)3CO, E] , [-3562 : 2-Me-5-
MeO, 2-(Me)3CO, E ] , [ -3563 : 2-Me-6-MeO, 2- (Me) 3 CO, E ] , [ -
3564:3-Me-2-MeO, 2-(Me)3CO, E ] , [ -3565 : 3-Me-4-MeO, 2- (Me)3CO, E] , [-3566:3-Me-5-MeO,2- (Me) 3CO,E] , [-3567 : 4-Me-2-
MeO, 2-(Me)3CO, E ] , [ -3568 : 4-Me-3-MeO, 2- (Me) 3 CO, E ] , [ - 3569:H,2,3-F2 ,E ] , [ -3570 : 4-F, 2, 3-F2 , E ] , [ -3571 : 4-F, 2, 3- F2, Z] , [-3572:4-Cl,2,3-F2,E] , [ -3573 : 4-Cl, 2 , 3-F2 , Z ] , [- 3574:4-Br,2,3-F2 ,E ] , [ -3575 : 4-1, 2, 3-F2 , E ] , [ -3576:4- Me, 2, 3-F2, E ] , [ -3577 : 4-Me, 2 , 3-F2 , Z ] , [ -3578 : 4-Et , 2, 3-
F2, E ) , C -3579:4-C3H7 ,2,3-F2 ,E ] , [ -3580 : 4- (Me) 2 CH, 2, 3-
F2, E] , [-3581:4-CF3,2,3-F2,E] , [-3582 : 4-CF3 , 2 , 3-F2 , z] , [-
3583:4-C2F5 ,2,3-F2 ,E] , [-3584 : 4-C3 F7 , 2 , 3-F2 , E] , [-3585:4-
(CF3 )2CF,2,3-F2 ,E] , [-3586 : 4- (CF3 ) 2 CH, 2 , 3-F2 , E] , [-3587:4- CHF2 ,2,3-F2 , E ] , [ -3588 : 4-CH2 F, 2 , 3-F2 , E ] , [ -3589:4-
CF3CH2 ,2,3-F2 , E ] , [ -3590 : 4-MeO, 2 , 3-F2 , E ] , [ -3591:4-
MeO, 2, 3-F2 , z] , [-3592 : 4-EtO, 2 , 3-F2 , E] , [-3593 : 4-C3 H7 O, 2, 3-
F2, E ] , [ -3594:4-(Me)2CHO,2,3-F2 ,E ] , [ -3595 : 4-NO2 , 2, 3-
F2, E] , [-3596:4-NO2 ,2,3-F2,z] , [ -3597 : 3-F, 2, 3-F2 , E ] , [- 3598:3-F,2,3-F2 ,Z ] , [ -3599 : 3-Cl, 2, 3-F2 , E ] , [ -3600:3-
Cl, 2, 3-F2, Z] , [-3601:3-Br,2,3-F2 ,E] , [-3602 : 3-1, 2, 3-F2 , E] ,
[-3603:3-Me,2,3-F2 ,E] , [ -3604 : 3-Me, 2, 3-F2 , Z ] , [-3605:3-
Et, 2, 3-F2, E ] , [ -3606:3-C3H7 ,2, 3-F2, E ] , [ -3607:3-
(Me)2CH, 2, 3-F2 ,E ] , [ -3608 : 3-CF3 , 2 , 3-F2 , E ] , [ -3609:3- CF3, 2, 3-F2 ,Z] , [-3610:3-C2F5,2,3-F2,E] , [-3611 : 3-C3 F7 , 2, 3-
F2, E] , [-3612:3- (CF3 ) 2 CF, 2, 3-F2 , E] , [-3613 : 3- (CF3 ) 2 CH, 2 , 3-
F2, E] , [-3614:3-CHF2 ,2,3-F2 ,E] , [-3615 : 3-CHF2 , 2, 3-F2 , Z] ,
[ -3616:3-CH2F,2,3-F2 ,E ] , [ -3617 : 3-CH2 F, 2, 3-F2 , Z ] , [ -
3618:3-CF3CH2 ,2,3-F2 ,E] , [-3619 : 3-MeO, 2, 3-F2 , E] , [-3620:3- MeO, 2, 3-F2 ,Z] , [-3621 : 3-EtO, 2, 3-F2 , E] , [-3622 : 3-C3 H7 O, 2, 3-
F2, E ] , [ -3623:3- (Me)2CHO, 2, 3-F2 ,E ] , [ -3624 : 3-NO2 , 2, 3- F2, E] , [-3625:2-F,2,3-F2,E] , [ -3626 : 2-Cl, 2, 3-F2 , E ] , [- 3627:2-Br,2,3-F2 ,E ] , [ -3628 : 2-1, 2, 3-F2 , E ] , [ -3629:2- Me, 2, 3-F2, E] , [ -3630 : 2-Et , 2, 3-F2 , E ] , [ -3631 : 2-C3 H7 , 2, 3- F2, E] , [-3632:2- (Me)2CH, 2, 3-F2 , E] , [-3633 : 2-CF3 , 2 , 3-F2 , E] ,
C -3634:2-C2F5,2,3-F2,E ] , [ -3635 : 2-C3 F7 , 2, 3-F2 , E ] , C -
3636:2- (CF3 )2CF, 2, 3-F2 ,E] , [-3637 : 2- (CF3 ) 2 CH, 2, 3-F2 , E] , C-
3638:2-CHF2 ,2,3-F2 ,E] , [-3639 : 2-CH2 F, 2 , 3-F2 , E] , [-3640:2-
CF3CH2 ,2,3-F2 , E ] , [ -3641 : 2-MeO, 2 , 3-F2 , E ] , [ -3642:2- EtO, 2, 3-F2, E ] , [ -3643:2-C3H7O,2,3-F2 ,E ] , [ -3644:2-
(Me)2CHO, 2, 3-F2 ,E ] , [ -3645 : 2-NO2 , 2, 3-F2 , E ] , [-3646:2,3-
F2, 2, 3-F2, E] , [-3647:2, 4-F2, 2, 3-F2, E] , [-3648 : 2 , 5-F2 , 2 , 3-
F2, E] , [-3649:2, 6-F2, 2, 3-F2, E] , [-3650 : 3, 4-F2 , 2, 3-F2 , E] ,
[ -3651:3, 4-F2, 2, 3-F2, Z ] , [ -3652 : 3, 5-F2 , 2, 3-F2 , E ] , [ - 3653:3, 5-F2, 2, 3-F2, Z ] , [ -3654 : 2, 3-Cl2 , 2, 3-F2 , E ] , [ -
3655:2, 3-Cl2 ,2,3-F2 ,Z ] , [ -3656 : 2, 4-Cl2 , 2 , 3-F2 , E ] , [ - 3657:2, 4-Cl2 ,2,3-F2 ,Z ] , [ -3658 : 2, 5-Cl2 , 2, 3-F2 , E ] , [ - 3659:2, 5-Cl2 ,2,3-F2 ,Z ] , [ -3660 : 2, 6-Cl2 , 2, 3-F2 , E ] , [ - 3661:3, 4-Cl2 ,2,3-F2 ,E ] , [ -3662 : 3, 5-Cl2 , 2, 3-F2 , E ] , [ - 3663:2, 3-Br2 ,2,3-F2 ,E ] , [ -3664 : 2 , 4-Br2 , 2 , 3-F2 , E ] , ( -
3665:2, 5-Br2 ,2,3-F2 ,E ] , [ -3666 : 2, 6-Br2 , 2, 3-F2 , E ] , [ - 3667:3, 4-Br2 ,2,3-F2 ,E ] , [ -3668 : 3, 5-Br2 , 2, 3-F2 , E ] , [ - 3669:2, 3-Me2 ,2,3-F2 ,E ] , [ -3670 : 2 , 4-Me2 , 2 , 3-F2 , E ] , [ - 3671:2, 5-Me2 ,2,3-F2 ,E ] , [ -3672 : 2, 6-Me2 , 2, 3-F2 , E ] , [ - 3673:3, 4-Me2, 2, 3-F2 ,E ] , [ -3674 : 3, 5-Me2 , 2, 3-F2 , E ] , [ -
3675:2, 3-Et2 ,2,3-F2 ,E ] , [ -3676 : 2 , 4-Et2 , 2 , 3-F2 , E ] , [ - 3677:2, 5-Et2 ,2,3-F2 ,E ] , [ -3678 : 2 , 6-Et2 , 2 , 3-F2 , E ] , [ - 3679:3, 4-Et2 ,2,3-F2 ,E ] , [ -3680 : 3, 5-Et2 , 2 , 3-F2 , E ] , [ - 3681:2, 3-(CF3)2, 2,3-F2, E] , [-3682 : 2, 4- (CF3 ) 2 , 2, 3-F2 , E] , [- 3683:2, 5-(CF3 )2 ,2,3-F2 ,E] , [-3684 : 2, 6- (CF3 ) 2 , 2, 3-F2 , E] , [-
3685:3, 4-(CF3 )2 ,2,3-F2 , E] , [-3686 : 3, 5- (CF3 ) 2 , 2, 3-F2 , E] , [-
3687:2,3- (CHF2 )2 ,2,3-F2 ,E] , [-3688 : 2 , 4- (CHF2 ) 2 , 2 , 3-F2 , E] ,
[ -3689:2, 5-(CHF2 )2 ,2,3-F2 , E ] , [ -3690 : 2 , 6- (CHF2 ) 2 , 2, 3-
F2, E ] , [ -3691:3, 4- (CHF2 )2, 2, 3-F2, E ] , [ -3692:3,5- (CHF2 ) 2,2, 3-F2 ,E ) , [ -3693 : 2 , 3- (CH2 F) 2 , 2 , 3-F2 , E ] , [ -
3694:2, 4-(CH2F)2, 2, 3-F2, E] , [-3695 : 2, 5- (CH2 F) 2 , 2 , 3-F2 , E] ,
[ -3696:2, 6- (CH2F)2 ,2,3-F2 , E ] , [ -3697 : 3, 4- (CH2 F) 2 , 2, 3-
F2, E ] , [ -3698:3, 5-(CH2F)2, 2, 3-F2, E ] , [ -3699:2,3-
(MeO)2, 2, 3-F2 , E] , [-3700 : 2, 4- (MeO) 2 , 2, 3-F2 , E] , [-3701:2,5- (MeO)2 ,2,3-F2 , E] , [-3702 : 2, 6- (MeO) 2 , 2, 3-F2 , E] , [-3703:3,4-
(MeO)2 ,2,3-F2 ,E] , [-3704 : 3, 5- (MeO) 2 , 2, 3-F2 , E] , [-3705:2,3-
(EtO)2, 2, 3-F2, E] , [-3706:2, 4-(EtO)2, 2, 3-F2, E] , [-3707:2,5-
(EtO)2 ,2,3-F2 ,E] , [-3708:2, 6-(EtO)2 ,2,3-F2 ,E] , [-3709:3,4-
(EtO)2, 2, 3-F2 , E] , [-3710:3, 5-(EtO)2 ,2,3-F2 , E] , [-3711:2- Cl-3-F,2,3-F2 ,E] , [-3712 : 2-C1-4-F, 2, 3-F2 , E] , [-3713.2-C1-
5-F,2,3-F2 ,E] , C-3714:2-Cl-6-F,2,3-F2 ,E] , [ -3715 : 3-C1-2-
F, 2, 3-F2, E ] , [ -3716:3-Cl-4-F,2,3-F2 ,E ] , [ -3717 : 3-C1-5-
F, 2, 3-F2, E ] , [ -3718:4-Cl-2-F,2,3-F2 ,E ] , [ -3719 : 4-C1-3-
F, 2, 3-F2, E ] , [ -3720:2-F-3-Me,2,3-F2 ,E ] , [ -3721 : 2-F-4- Me, 2, 3-F2, E ] , [ -3722 : 2-F-5-Me, 2 , 3-F2 , E ] , [ -3723 : 2-F-6-
Me, 2, 3-F2, E ] , [ -3724:3-F-2-Me,2,3-F2 ,E ] , [ -3725 : 3-F-4-
Me, 2, 3-F2, E] , [ -3726 : 3-F-5-Me, 2, 3-F2 , E ] , [ -3727 : 4-F-2-
Me, 2, 3-F2, E] , [ -3728 : 4-F-3-Me, 2, 3-F2 , E ] , [ -3729 : 2-C1-3-
Me, 2, 3-F2, E] , [ -3730 : 2-Cl-4-Me, 2, 3-F2 , E ] , [ -3731 : 2-C1-5- Me, 2, 3-F2, E] , [ -3732 : 2-Cl-6-Me, 2, 3-F2 , E ] , [ -3733 : 3-C1-2-
Me, 2, 3-F2, E] , [ -3734 : 3-Cl-4-Me, 2 , 3-F2 , E ] , C -3735 : 3-C1-5-
Me, 2, 3-F2 ,E) , ( -3736 : 4-Cl-2-Me, 2, 3-F2 , E ] , [ -3737 : 4-C1-3-
Me, 2, 3-F2, E] , C -3738 : 2-F-3-CF3 , 2, 3-F2 , E ] , C -3739 : 2-F-4-
CF3 ,2,3-F2 ,E] , [-3740:2-F-5-CF3 ,2,3-F2 ,E] , [ -3741 : 2-F-6- CF3 ,2,3-F2 ,E] , [-3742:3-F-2-CF3 ,2,3-F2 ,E] , C -3743 : 3-F-4-
CF3, 2, 3-F2 , E] , [-3744:3-F-5-CF3,2,3-F2,E] , [ -3745 : 4-F-2-
CF3, 2, 3-F2 , E] , [-3746:4-F-3-CF3,2,3-F2 ,E] , [ -3747 : 2-C1-3-
CF3 ,2,3-F2 ,E] , [-3748:2-Cl-4-CF3 ,2,3-F2 ,E] , [-3749 : 2-C1-5-
CF3, 2, 3-F2 , E] , [-3750:2-Cl-6-CF3 ,2,3-F2 ,E] , [-3751:3-01-2- CF3 ,2,3-F2 ,E] , [-3752:3-Cl-4-CF3 ,2,3-F2 ,E] , [-3753 : 3-C1-5-
CF3 ,2,3-F2 ,E] , [-3754:4-Cl-2-CF3 ,2,3-F2 ,E] , [-3755 : 4-C1-3-
CF3 ,2,3-F2 ,E] , [-3756:2-Me-3-CF3 ,2,3-F2 ,E] , [-3757 : 2-Me-4-
CF3 ,2,3-F2 ,E] , [-3758:2-Me-5-CF3 ,2,3-F2 ,E] , [-3759 : 2-Me-β-
CF3 ,2,3-F2 ,E] , [-3760:3-Me-2-CF3 ,2,3-F2 ,E] , [-3761 : 3-Me-4- CF3, 2, 3-F2 ,E] , [-3762:3-Me-5-CF3 ,2,3-F2 ,E] , [-3763 : 4-Me-2- CF3 ,2,3-F2 ,E] , [-3764:4-Me-3-CF3 ,2,3-F2 ,E] , [-3765 : 2-F-3-
MeO, 2, 3-F2 ,E] , [ -3766 : 2-F-4-MeO, 2 , 3-F2 , E ] , [ -3767 : 2-F-5-
MeO, 2,3-F2 ,E3 , [ -3768 : 2-F-6-MeO, 2 , 3-F2 , E ] , [ -3769 : 3-F-2-
MeO, 2, 3-F2 ,E] , [ -3770 : 3-F-4-MeO, 2, 3-F2 , E ] , [ -3771 : 3-F-5- MeO, 2, 3-F2, E] , [ -3772 : 4-F-2-MeO, 2, 3-F2 , E ] , [ -3773 : 4-F-3-
MeO, 2, 3-F2 ,E] , [-3774 : 2-Cl-3-MeO, 2 , 3-F2 , E] , [-3775 : 2-C1-4-
MeO, 2, 3-F2 ,E] , [-3776 : 2-Cl-5-MeO, 2, 3-F2 , E] , [-3777 : 2-C1-6-
MeO, 2, 3-F2 , E] , [-3778 : 3-Cl-2-MeO, 2, 3-F2 , E] , [-3779 : 3-C1-4-
MeO, 2, 3-F2 ,E] , [-3780 : 3-Cl-5-MeO, 2 , 3-F2 , E] , [-3781:4-01-2- MeO, 2, 3-F2 ,E] , [-3782 : 4-Cl-3-MeO, 2, 3-F2 , E] , [-3783 : 2-Me-3-
MeO, 2, 3-F2 ,E] , [-3784 : 2-Me-4-MeO, 2, 3-F2 , E] , [-3785 : 2-Me-5-
MeO, 2, 3-F2 ,E] , [-3786 : 2-Me-6-MeO, 2, 3-F2 , E] , [-3787 : 3-Me-2-
MeO, 2, 3-F2 ,E] , [-3788 : 3-Me-4-MeO, 2 , 3-F2 , E] , [-3789 : 3-Me-5-
MeO, 2, 3-F2 , E] , [-3790 : 4-Me-2-MeO, 2 , 3-F2 , E] , [-3791 : 4-Me-3- MeO, 2, 3-F2 ,E] , [ -3792 : H, 2 , 4-F2 , E] , [-3793 : 4-F, 2, 4-F2 , E] ,
[-3794:4-F,2,4-F2 ,Z ] , [ -3795 : 4-Cl , 2 , 4-F2 , E ] , [-3796:4-
Cl, 2, 4-F2, Z] , [-3797:4-Br,2,4-F2,E] , [-3798 : 4-1 , 2, 4-F2 , E] ,
[-3799:4-Me,2,4-F2 ,E] , [ -3800 : 4-Me, 2, 4-F2 , Z ] , [-3801:4-
Et, 2, 4-F2, E ] , [ -3802:4-C3H7 ,2,4-F2 ,E ] , [ -3803:4- (Me)2CH, 2, 4-F2 ,E ] , [ -3804 : 4-CF3 , 2, 4-F2 , E ] , [ -3805:4-
CF3, 2, 4-F2 ,Z] , [-3806:4-C2F5 ,2,4-F2,E] , [-3807 : 4-C3 F7 , 2 , 4-
F2, E] , [-3808:4- (CF3 )2CF, 2, 4-F2 ,E] , [-3809 : 4- (CF3 ) 2 CH, 2 , 4-
F2, E] , [-3810:4-CHF2 ,2,4-F2 ,E] , [-3811 : 4-CH2 F, 2 , 4-F2 , E] ,
[ -3812: 4-CF3CH2 ,2,4-F2 ,E ] , [ -3813 : 4-MeO, 2 , 4-F2 , E ] , [ - 3814 :4-MeO,2, 4-F2 ,Z ] , [ -3815 : 4-EtO, 2 , 4-F2 , E ] , [-3816:4-
C3H7O, 2, 4-F2 ,E ] , [ -3817:4-(Me)2CHO,2,4-F2 ,E ] , [-3818:4- NO2 ,2,4-F2 ,E ] , [ -3819:4-NO2 ,2,4-F2 ,Z ] , [ -3820 : 3-F, 2 , 4- F2, E] , [-3821:3-F,2,4-F2,Z] , [ -3822 : 3-Cl, 2, 4-F2 , E ] , [- 3823:3-Cl,2,4-F2 ,Z 3 , [ -3824 : 3-Br, 2, 4-F2 , E ] , [ -3825:3- I, 2, 4-F2, E] , [-3826:3-Me,2,4-F2 ,E] , [-3827 : 3-Me, 2, 4-F2 , z] ,
[-3828:3-Et,2,4-F2 ,E] , [-3829 : 3-C3 H7 , 2, 4-F2 , E] , [-3830:3-
(Me)2CH, 2, 4-F2 ,E ] , [ -3831 : 3-CF3 , 2, 4-F2 , E ] , [ -3832:3-
CF3, 2, 4-F2 ,Z] , [-3833:3-C2F5,2,4-F2 ,E] , [-3834 : 3-C3 F7 , 2 , 4-
F2, E] , [-3835:3- (CF3 )2CF, 2, 4-F2, E] , [-3836 : 3- (CF3 ) 2 CH, 2 , 4- F2, E] , [-3837:3-CHF2 ,2,4-F2 ,E] , [-3838 : 3-CHF2 , 2, 4-F2 , Z] ,
[ -3839:3-CH2F,2,4-F2,E ] , [ -3840 : 3-CH2 F, 2 , 4-F2 , Z ] , C -
3841.3-CF3CH2, 2, 4-F2, E] , [-3842 : 3-MeO, 2 , 4-F2 , E] , (-3843:3-
MeO, 2, 4-F2 ,Z] , [-3844 : 3-EtO, 2 , 4-F2 , E) , [-3845 : 3-C3 H7 O, 2 , 4-
F2, E ) , [ -3846:3-(Me)2CHO,2,4-F2 ,E ) , ( -3847 : 3-NO2 , 2, 4- F2, E] , [-3848:2-F,2,4-F2 ,E3 , [ -3849 : 2-Cl, 2, 4-F2 ,E ] , [-
3850:2-Br,2,4-F2 ,E ) , [ -3851 : 2-1, 2, 4-F2 , E ) , [ -3852:2-
Me, 2, 4-F2, E) , [ -3853 : 2-Et, 2, 4-F2 , E ) , [ -3854 : 2-C3 H7 , 2, 4-
F2, E] , [-3855:2-(Me)2CH,2,4-F2 ,E) , [-3856 : 2-CF3 , 2, 4-F2 , E) ,
[ -3857:2-C2F5,2,4-F2,E ] , [ -3858 : 2-C3 F7 , 2, 4-F2 , E ) , [ - 3859:2- (CF3 )2CF, 2, 4-F2 ,E) , [-3860 : 2- (CF3 ) 2 CH, 2 , 4-F2 , E] , C-
3861:2-CHF2 ,2,4-F2 ,E) , [ -3862 : 2-CH2 F, 2 , 4-F2 , E) , [-3863:2- CF3CH2 ,2,4-F2 ,E ) , [ -3864 : 2-MeO, 2 , 4-F2 , E ) , [ -3865:2- EtO, 2, 4-F2, E ) , ( -3866:2-C3H7O,2,4-F2 ,E ) , [ -3867:2- (Me)2CHO, 2, 4-F2 ,E ) , [ -3868 : 2-NO2 , 2 , 4-F2 , E ) , [-3869:2,3- F2, 2, 4-F2, E) , (-3870:2, 4-F2 ,2,4-F2 ,E) , (-3871 : 2 , 5-F2 , 2 , 4-
F2, E) , (-3872:2, 6-F2, 2, 4-F2 , E) , [ -3873 : 3, 4-F2 , 2 , 4-F2 , E) ,
[ -3874:3, 4-F2, 2, 4-F2, Z ) , [ -3875 : 3, 5-F2 , 2 , 4-F2 , E ) , [ -
3876:3, 5-F2 ,2,4-F2 , Z ) , [ -3877 : 2, 3-Cl2 , 2, 4-F2 , E ) , [ -
3878:2, 3-Cl2 ,2,4-F2 ,Z ) , ( -3879 : 2, 4-Cl2 , 2, 4-F2 , E ) , [ - 3880:2, 4-Cl2, 2, 4-F2 ,Z ) , ( -3881 : 2, 5-Cl2 , 2, 4-F2 , E ) , [ -
3882:2, 5-Cl2 ,2,4-F2 ,Z ) , ( -3883 : 2, 6-Cl2 , 2, 4-F2 , E ) , [ - 3884:3, 4-Cl2 ,2,4-F2 ,E ) , ( -3885 : 3, 5-Cl2 , 2, 4-F2 , E ) , [ - 3886:2, 3-Br2, 2, 4-F2 ,E ) , [ -3887 : 2, 4-Br2 , 2, 4-F2 , E ) , [ - 3888:2, 5-Br2 ,2,4-F2 ,E ) , [ -3889 : 2, 6-Br2 , 2, 4-F2 , E ) , [ - 3890:3, 4-Br2 ,2,4-F2 ,E ) , [ -3891 : 3, 5-Br2 , 2, 4-F2 , E ) , [ -
3892:2, 3-Me2 ,2,4-F2 ,E ] , [ -3893 : 2, 4-Me2 , 2, 4-F2 , E ] , [ - 3894:2, 5-Me2 ,2,4-F2 ,E ] , [ -3895 : 2, 6-Me2 , 2, 4-F2 , E ] , [ - 3896:3, 4-Me2 ,2, 4-F2, E ) , [ -3897 : 3, 5-Me2 , 2, 4-F2 , E ] , ( - 3898:2, 3-Et2, 2, 4-F2 ,E ] , [ -3899 : 2, 4-Et2 , 2, 4-F2 , E ] , C - 3900:2, 5-Et2 ,2,4-F2 ,E ] , [ -3901 : 2, 6-Et2 , 2 , 4-F2 , E ] , [ -
3902:3, 4-Et2 ,2, 4-F2, E ] , [ -3903 : 3, 5-Et2 , 2, 4-F2 , E ] , [ - 3904:2, 3- (CF3 )2, 2, 4-F2 , E.] , [-3905 : 2, 4- (CF3 ) 2 , 2, 4-F2 , E] , [- 3906:2, 5-(CF3 )2 ,2,4-F2 ,E] , [-3907 : 2, 6- (CF3 ) 2 , 2, 4-F2 , E] , [- 3908:3, 4-(CF3)2, 2, 4-F2, E] , [-3909 : 3, 5- (CF3 ) 2 , 2, 4-F2 , E] , [- 3910:2, 3-(CHF2 )2, 2, 4-F2 , E] , [-3911 : 2, 4- (CHF2 ) 2 , 2, 4-F2 , E] ,
[ -3912:2,5-(CHF2)2,2,4-F2,E ] , [ -3913 : 2, 6- (CHF2 ) 2 , 2, 4-
F2, E ] , [ -3914:3, 4- (CHF2 )2 ,2,4-F2 , E ] , [ -3915:3,5-
(CHF2)2, 2, 4-F2, E ] , [ -3916 : 2 , 3- (CH2 F) 2 , 2 , 4-F2 , E ] , [ -
3917:2, 4-(CH2F)2, 2, 4-F2, E] , [ -3918 : 2 , 5- (CH2 F) 2 , 2 , 4-F2 , E] , [ -3919:2, 6- (CH2 F)2 ,2, 4-F2, E ] , [ -3920 : 3, 4- (CH2 F) 2 , 2 , 4-
F2, E ] , [ -3921:3, 5-(CH2F)2, 2, 4-F2 , E ] , [ -3922:2,3- (MeO)2, 2, 4-F2 ,E] , [-3923 : 2, 4- (MeO) 2 , 2, 4-F2 , E] , [-3924:2,5- (MeO)2, 2, 4-F2 , E] , [-3925 : 2, 6- (MeO) 2 , 2 , 4-F2 , E] , [-3926:3,4- (MeO)2, 2, 4-F2 , E] , [-3927 : 3, 5- (MeO) 2 , 2, 4-F2 , E] , [-3928:2,3- (EtO)2, 2, 4-F2 , E] , [-3929 : 2 , 4- (EtO) 2 , 2 , 4-F2 , E] , [-3930:2,5-
(EtO)2, 2, 4-F2 , E] , [-3931:2, 6-(EtO)2 ,2,4-F2 , E] , [-3932:3,4- (EtO)2, 2, 4-F2 ,E] , [-3933:3, 5-(EtO)2 ,2, 4-F2, E] , [-3934:2- Cl-3-F,2,4-F2 ,E] , [-3935:2-Cl-4-F,2,4-F2 ,E] , [-3936.2-C1- 5-F,2,4-F2 ,E] , [-3937:2-Cl-6-F,2,4-F2 ,E] , [ -3938 : 3-C1-2- F, 2, 4-F2, E ] , [ -3939 : 3-C1-4-F, 2 , 4-F2 , E ] , [ -3940 : 3-C1-5-
F, 2, 4-F2, E ] , [ -3941:4-Cl-2-F,2,4-F2 ,E ] , [ -3942 : 4-C1-3- F, 2, 4-F2, E ] , [ -3943:2-F-3-Me,2,4-F2 ,E ] , [ -3944 : 2-F-4- Me, 2, 4-F2 ,E ] , [ -3945 : 2-F-5-Me, 2 , 4-F2 , E ] , [ -3946 : 2-F-6- Me, 2, 4-F2, E ] , [ -3947 : 3-F-2-Me, 2 , 4-F2 , E ] , [ -3948 : 3-F-4- Me, 2, 4-F2, E ] , [ -3949 : 3-F-5-Me, 2, 4-F2 , E ] , [ -3950 : 4-F-2-
Me, 2, 4-F2, E] , [ -3951 : 4-F-3-Me, 2, 4-F2 , E ] , [-3952:2-01-3- Me, 2, 4-F2, E] , C -3953 : 2-Cl-4-Me, 2 , 4-F2 , E ] , ( -3954 : 2-C1-5- Me, 2, 4-F2, E] , [ -3955 : 2-Cl-6-Me, 2, 4-F2 , E ] , [-3956:3-01-2- Me, 2, 4-F2, E] , [ -3957 : 3-Cl-4-Me, 2 , 4-F2 , E ] , [-3958:3-01-5- Me, 2, 4-F2, E] , ( -3959 : 4-Cl-2-Me, 2 , 4-F2 , E ] , (-3960:4-01-3-
Me, 2, 4-F2, E] , [ -3961 : 2-F-3-CF3 , 2 , 4-F2 , E ] , [ -3962 : 2-F-4- CF3, 2, 4-F2 , E] , [-3963:2-F-5-CF3,2,4-F2,E] , [ -3964 : 2-F-6- CF3 ,2,4-F2 ,E] , [-3965:3-F-2-CF3 ,2,4-F2 ,E] , [ -3966 : 3-F-4- CF3, 2, 4-F2, E] , C-3967:3-F-5-CF3,2,4-F2 ,E] , ( -3968 : 4-F-2- CF3 ,2,4-F2 ,E] , [-3969:4-F-3-CF3 ,2,4-F2 ,E] , ( -3970 : 2-C1-3-
CF3, 2, 4-F2 , E] , [-3971:2-Cl-4-CF3,2,4-F2 ,E] , [-3972 : 2-C1-5- CF3, 2, 4-F2 , E] , C-3973:2-Cl-6-CF3,2,4-F2 ,E] , [-3974 : 3-C1-2- CF3 ,2,4-F2 ,E] , (-3975:3-Cl-4-CF3 ,2,4-F2 ,E] , [-3976 : 3-C1-5- CF3, 2, 4-F2, E] , [-3977:4-Cl-2-CF3,2,4-F2 ,E] , [-3978 : 4-C1-3- CF3 ,2,4-F2 ,E] , [-3979:2-Me-3-CF3 ,2,4-F2 ,E] , [-3980 : 2-Me-4-
CF3 ,2,4-F2 ,E] , [-3981:2-Me-5-CF3 ,2,4-F2 ,E] , [-3982 : 2-Me-6- CF3, 2, 4-F2 ,E] , [-3983:3-Me-2-CF3,2,4-F2,E] , (-3984 : 3-Me-4- CF3 ,2,4-F2 ,E] , [-3985:3-Me-5-CF3 ,2,4-F2 ,E] , [-3986 : 4-Me-2- CF3 ,2,4-F2 ,E] , [-3987:4-Me-3-CF3 ,2,4-F2 ,E] , (-3988 : 2-F-3- MeO, 2, 4-F2 ,E] , [ -3989 : 2-F-4-MeO, 2, 4-F2 , E ] , ( -3990 : 2-F-5-
MeO, 2, 4-F2 ,E] , ( -3991 : 2-F-6-MeO, 2, 4-F2 , E ] , [ -3992 : 3-F-2-
MeO, 2, 4-F2 ,E] , [ -3993 : 3-F-4-MeO, 2, 4-F2 , E ] , [ -3994 : 3-F-5-
MeO, 2, 4-F2 ,E) , [ -3995 : 4-F-2-MeO, 2 , 4-F2 , E ) , [ -3996 : 4-F-3-
'MeO, 2, 4-F2 ,E] , [-3997 : 2-Cl-3-MeO, 2 , 4-F2 , E] , [-3998:2-01-4- MeO, 2, 4-F2 ,E] , [-3999 : 2-Cl-5-MeO, 2 , 4-F2 , E] , [-4000:2-01-6-
MeO, 2, 4-F2, E] ,
[-4001:3-Cl-2-MeO,2,4-F2,E] , [-4002 : 3-01-4-MeO, 2 , 4-F2 , E] ,
[-4003:3-Cl-5-MeO,2,4-F2 ,E] , [-4004 : 4-Cl-2-MeO, 2, 4-F2 , E] ,
[-4005:4-Cl-3-MeO,2,4-F2 ,E] , [-4006 : 2-Me-3-MeO, 2 , 4-F2 , E] , [-4007:2-Me-4-MeO,2, 4-F2 ,E] , [-4008 : 2-Me-5-MeO, 2, 4-F2 , E] ,
[-4009:2-Me-6-MeO,2,4-F2 ,E] , [-4010 : 3-Me-2-MeO, 2, 4-F2 , E] ,
[-4011:3-Me-4-MeO,2,4-F2 ,E] , [-4012 : 3-Me-5-MeO, 2, 4-F2 , E] ,
[-4013:4-Me-2-MeO,2, 4-F2 ,E] , [-4014 : 4-Me-3-MeO, 2, 4-F2 , E] ,
[-4015:H,2,5-F2 ,E] , [-4016 : 4-F, 2 , 5-F2 , E] , [-4017 : 4-F, 2 , 5- F2, Z] , [-4018:4-01, 2, 5-F2 , E] , [ -4019 : 4-Cl, 2 , 5-F2 , Z ] , [-
4020:4-Br,2,5-F2 ,E ] , [ -4021 : 4-1, 2, 5-F2 , E ] , [ -4022:4-
Me, 2, 5-F2, E ] , [ -4023 : 4-Me, 2 , 5-F2 , Z ] , [ -4024 : 4-Et, 2, 5-
F2, E ] , [ -4025:4-C3H7 ,2,5-F2 ,E ] , [ -4026 : 4- (Me) 2 CH, 2 , 5-
F2, E] , [-4O27:4-CF3 ,2,5-F2 ,E] , [-4028 : 4-CF3 , 2 , 5-F2 , Z] , [- 4029:4-C2F5,2,5-F2,E] , [-4030 : 4-C3 F7 , 2, 5-F2 , E] , [-4031:4-
(CF3 )2CF,2,5-F2 ,E] , [-4032 : 4- (CF3 ) 2 CH, 2 , 5-F2 , E] , [-4033:4-
CHF2 ,2,5-F2 , E ] , [ -4034:4-CH2F,2,5-F2 ,E ] , [ -4035:4-
CF3CH2 ,2,5-F2 , E ] , [ -4036 : 4-MeO, 2 , 5-F2 , E ] , [ -4037:4-
MeO, 2, 5-F2 ,Z] , [-4038 : 4-EtO, 2, 5-F2 , E] , [-4039 : 4-C3 H7 O, 2, 5- F2, E ] , [ -4040:4- (Me)2CHO, 2, 5-F2 ,E ] , [ -4041 : 4-NO2 , 2, 5-
F2, E] , [-4042:4-NO2 ,2,5-F2 ,Z] , [ -4043 : 3-F, 2, 5-F2 , E ] , C-
4044:3-F,2,5-F2 ,Z ] , C -4045 : 3-Cl, 2, 5-F2 , E ] , [ -4046:3-
Cl, 2, 5-F2, Z] , [-4047:3-Br,2,5-F2 ,E] , [-4048 : 3-1, 2, 5-F2 , E] ,
[-4049:3-Me,2,5-F2 ,E] , [ -4050 : 3-Me, 2, 5-F2 , Z ] , [-4051:3- Et, 2, 5-F2, E ] , [ -4052:3-C3H7 ,2,5-F2 ,E ] , [ -4053:3-
(Me)2CH, 2, 5-F2, E ] , [ -4054 : 3-CF3 , 2, 5-F2 , E ] , [ -4055:3-
CF3 ,2,5-F2 ,Z) , [-4056:3-C2F5 ,2, 5-F2 ,E] , [-4057 : 3-C3 F7 , 2 , 5-
F2, E] , [-4058:3-(CF3 )2CF,2,5-F2 ,E] , [-4059 : 3- (CF3 ) 2 CH, 2 , 5-
F2, E] , [-4060:3-CHF2 ,2,5-F2 ,E] , [-4061 : 3-CHF2 , 2 , 5-F2 , Z ] , [ -4062:3-CH2F,2,5-F2 ,E ] ,' [ -4063 : 3-CH2 F, 2 , 5-F2 , Z ] , [ -
4064:3-CF3CH2 ,2,5-F2 ,E] , [-4065 : 3-MeO, 2 , 5-F2 , E] , [-4066:3- MeO, 2, 5-F2 ,z] , [-4067 : 3-EtO, 2, 5-F2 , E] , [-4068 : 3-C3H7 O, 2, 5- F2, E ] , [ -4069:3-(Me)2CHO,2,5-F2 ,E ] , [ -4070 : 3-NO2 , 2, 5- F2, E] , C-4071:2-F,2,5-F2,E] , [ -4072 : 2-Cl, 2 , 5-F2 , E ] , [- 4073:2-Br,2,5-F2 ,E ] , [ -4074 : 2-1, 2, 5-F2 , E ] , [ -4075:2-
Me, 2, 5-F2, E] , [ -4076 : 2-Et , 2 , 5-F2 , E ] , [ -4077 : 2-C3 H7 , 2, 5- F2, E] , [-4078:2-(Me)2CH,2,5-F2 ,E] , [-4079 : 2-CF3 , 2 , 5-F2 , E] ,
[ -4080:2-C2F5,2,5-F2,E ] , [ -4081 : 2-C3 F7 , 2 , 5-F2 , E ] , [ - 4082:2-(CF3 )2CF,2,5-F2 ,E] , [-4083 : 2- (CF3 ) 2 CH, 2, 5-F2 , E] , [- 4084 :2-CHF2 ,2,5-F2 ,E] , [-4085 : 2-CH2 F, 2, 5-F2 , E] , [-4086:2-
CF3CH2 ,2,5-F2 , E ] , [ -4087 : 2-MeO, 2 , 5-F2 , E ] , [ -4088:2- EtO, 2, 5-F2, E ] , [ -4089:2-C3H7O,2,5-F2 ,E ] , [ -4090:2- (Me)2CHO, 2, 5-F2 ,E ] , [ -4091 : 2-NO2 , 2 , 5-F2 , E ] , [-4092:2,3- F2, 2, 5-F2, E] , [-4093:2, 4-F2 ,2, 5-F2, E] , [ -4094 : 2 , 5-F2 , 2 , 5- F2, E] , [-4095:2, 6-F2, 2, 5-F2, E] , [-4096 : 3, 4-F2 , 2 , 5-F2 , E] ,
[ -4097:3, 4-F2, 2, 5-F2, Z ] , [ -4098 : 3, 5-F2 , 2, 5-F2 , E ] , [ - 4099:3, 5-F2 ,2,5-F2 ,Z ] , [ -4100 : 2 , 3-Cl2 , 2, 5-F2 , E ] , C - 4101:2, 3-Cl2, 2, 5-F2 ,Z ] , [ -4102 : 2, 4-Cl2 , 2, 5-F2 , E ] , [ - 4103:2, 4-Cl2 ,2,5-F2 ,Z ] , [ -4104 : 2, 5-Cl2 , 2, 5-F2 , E ] , [ - 4105:2, 5-Cl2 ,2,5-F2 ,Z ] , [ -4106 : 2, 6-Cl2 , 2 , 5-F2 , E ] , C -
4107:3, 4-Cl2 ,2, 5-F2, E ] , [ -4108 : 3, 5-Cl2 , 2, 5-F2 , E ] , C - 4109:2, 3-Br2, 2, 5-F2, E ] , C -4110 : 2, 4-Br2 , 2/5-F2 , E ] , [ - 4111:2, 5-Br2 ,2,5-F2 ,E ] , C -4112 : 2, 6-Br2 , 2, 5-F2 , E ] , [ - 4113:3, 4-Br2 ,2, 5-F2, E ] , C -4114 : 3, 5-Br2 , 2, 5-F2 , E ] , [ - 4115:2, 3-Me2 ,2,5-F2 ,E ] , C -4116 : 2, 4-Me2 , 2 , 5-F2 , E ] , ( -
4117:2, 5-Me2 ,2,5-F2 ,E ] , C -4118 : 2, 6-Me2 , 2, 5-F2 , E ] , [ - 4119:3, 4-Me2, 2, 5-F2 ,E ] , C -4120 : 3, 5-Me2 , 2, 5-F2 , E ] , C - 4121:2, 3-Et2, 2, 5-F2, E ] , C -4122 : 2 , 4-Et2 , 2 , 5-F2 , E ) , [ - 4123:2, 5-Et2 ,2, 5-F2, E ] , C -4124 : 2, 6-Et2 , 2, 5-F2 , E ] , [ - 4125:3, 4-Et2 ,2,5-F2 ,E ] , C -4126 : 3, 5-Et2 , 2 , 5-F2 , E ] , [ -
4127:2, 3-(CF3)2 ,2,5-F2 ,E] , [-4128 : 2 , 4- (CF3 ) 2 , 2 , 5-F2 , E] , C- 4129:2, 5-(CF3 )2 ,2,5-F2 , E] , C-4130 : 2, 6- (CF3 ) 2 , 2, 5-F2 , E] , [- 4131.3,4-(CFa)2, 2, 5-F2, E] , C-4132 : 3, 5- (CF3 ) 2 , 2, 5-F2 , E] , C- 4133:2, 3-(CHF2 )2, 2, 5-F2, E] , C-4134 : 2 , 4- (CHF2 ) 2 , 2 , 5-F2 , E] , C -4135:2,5-(CHF2)2,2,5-F2,E ] , C -4136 : 2 , 6- (CHF2 ) 2 , 2 , 5-
F2, E ] , C -4137:3,4-(CHF2)2,2,5-F2,E ] , C -4138:3,5-
(CHF2J2, 2, 5-F2, E ] , C -4139:2, 3-(CH2F)2, 2, 5-F2, E ] , [ -
4140:2, 4-(CH2F)2 ,2, 5-F2, E] , C -4141 : 2 , 5- (CH2 F) 2 , 2 , 5-F2 , E] ,
C -4142:2, 6-(CH2F)2, 2, 5-F2, E ] , C -4143 : 3 , 4- (CH2 F) 2 , 2 , 5- F2, E ] , C -4144:3, 5-(CH2F)2 ,2,5-F2 , E ] , C -4145:2,3-
(MeO)2 ,2,5-F2 , E] , [-4146 : 2 , 4- (MeO) 2 , 2 , 5-F2 , E] , [-4147:2,5-
(MeO)2 ,2,5-F2 , E] , [-4148 : 2, 6- (MeO) 2 , 2, 5-F2 , E] , [-4149:3,4-
(MeO)2 ,2, 5-F2, E] , [-4150 : 3, 5- (MeO) 2 , 2 , 5-F2 , E] , [-4151:2,3-
(EtO)2 ,2,5-F2 ,E] , [-4152:2, 4-(EtO)2 ,2,5-F2 ,E] , [-4153:2,5- (EtO)2 ,2,5-F2 ,E] , [-4154:2, 6- (EtO)2 ,2,5-F2 ,E] , [-4155:3,4-
(EtO)2, 2, 5-F2 , E] , [-4156:3, 5-(EtO)2 ,2,5-F2 , E] , [-4157:2-
Cl-3-F,2,5-F2 ,E] , [-4158:2-Cl-4-F,2,5-F2 ,E] , [-4159:2-01-
5-F,2,5-F2,E] , [-4160:2-Cl-6-F,2,5-F2,E] , [-4161:3-01-2-
F, 2, 5-F2, E ] , [ -4162:3-Cl-4-F,2,5-F2 ,E ] , [ -4163:3-01-5- F,2,5-F2,E ] , [ -4164:4-Cl-2-F,2,5-F2 ,E ] , [ -4165:4-01-3-
F, 2, 5-F2, E ] , [ -4166:2-F-3-Me,2,5-F2,E ] , [ -4167 : 2-F-4-
Me, 2, 5-F2, E ] , [ -4168 : 2-F-5-Me, 2, 5-F2 , E ] , [ -4169 : 2-F-6-
Me, 2, 5-F2, E ] , [ -4170 : 3-F-2-Me, 2, 5-F2 , E ] , [ -4171 : 3-F-4-
Me, 2, 5-F2, E ] , [ -4172:3-F-5-Me,2,5-F2 ,E ] , [ -4173 : 4-F-2- Me, 2, 5-F2, E] , [ -4174 : 4-F-3-Me, 2, 5-F2 , E ] , [-4175:2-01-3-
Me, 2, 5-F2, E] , [-4176:2-Cl-4-Me,2,5-F2 ,E] , [-4177:2-01-5-
Me, 2, 5-F2, E] , [-4178:2-Cl-6-Me,2,5-F2 ,E] , [-4179:3-01-2-
Me, 2, 5-F2, E] , [-4180:3-Cl-4-Me,2,5-F2 ,E] , [-4181:3-01-5-
Me, 2, 5-F2, E] , [ -4182 : 4-Cl-2-Me, 2 , 5-F2 , E ] , [-4183:4-01-3- Me, 2, 5-F2, E] , [ -4184 : 2-F-3-CF3 , 2 , 5-F2 , E ] , [ -4185 : 2-F-4-
CF3 ,2,5-F2 ,E] , [-4186:2-F-5-CF3 ,2,5-F2 ,E] , [ -4187 : 2-F-6-
CF3, 2, 5-F2 , E] , [-4188:3-F-2-CF3,2,5-F2,E] , [ -4189 : 3-F-4-
CF3 ,2, 5-F2, E] , [-4190:3-F-5-CF3,2,5-F2,E] , [ -4191 : 4-F-2-
CF3 ,2,5-F2 ,E] , [-4192:4-F-3-CF3 ,2,5-F2 ,E] , [-4193 : 2-C1-3- CF3, 2, 5-F2, E] , [-4194 : 2-Cl-4-CF3 , 2, 5-F2 , E] , [-4195 : 2-C1-5-
CF3 ,2,5-F2 ,E] , [-4196:2-Cl-6-CF3 ,2,5-F2 ,E] , [-4197:3-01-2-
CF3, 2, 5-F2 ,E] , [-4198:3-Cl-4-CF3 ,2,5-F2 ,E] , [-4199:3-01-5-
CF3, 2, 5-F2, E] , C-42OO:4-C1-2-CF3 ,2,5-F2 ,E] , [-4201:4-01-3-
CF3 ,2,5-F2 ,E] , [-4202:2-Me-3-CF3,2,5-F2 ,E] , [-4203 : 2-Me-4- CF3 ,2,5-F2 ,E] , [-4204:2-Me-5-CF3,2,5-F2 ,E] , [-4205 : 2-Me-6-
CF3 ,2,5-F2 ,E] , [-4206:3-Me-2-CF3,2,5-F2 ,E] , [-4207 : 3-Me-4-
CF3, 2, 5-F2 ,E] , [-4208:3-Me-5-CF3 ,2,5-F2 ,E] , [-4209 : 4-Me-2-
CF3, 2, 5-F2 ,E] , [-4210:4-Me-3-CF3 ,2,5-F2 ,E] , [-4211 : 2-F-3-
MeO, 2, 5-F2, E] , [ -4212 : 2-F-4-MeO, 2, 5-F2 , E ] , [ -4213 : 2-F-5- MeO, 2, 5-F2 ,E] , [ -4214 : 2-F-6-MeO, 2, 5-F2 , E ] , [ -4215 : 3-F-2-
MeO, 2, 5-F2 ,E] , [ -4216 : 3-F-4-MeO, 2, 5-F2 , E ] , [ -4217 : 3-F-5-
MeO, 2, 5-F2 ,E] , [ -4218 : 4-F-2-MeO, 2, 5-F2 , E ] , [ -4219: 4-F-3-
MeO, 2, 5-F2 ,E] , [-4220 : 2-Cl-3-MeO, 2, 5-F2 , E] , [-4221:2-01-4-
MeO, 2, 5-F2 , E] , [-4222 : 2-Cl-5-MeO, 2, 5-F2 , E] , [-4223 : 2-C1-6- MeO, 2, 5-F2 ,E] , [-4224 : 3-Cl-2-MeO, 2, 5-F2 , E] , [-4225 : 3-C1-4-
MeO, 2, 5-F2 ,E] , [-4226 : 3-Cl-5-MeO, 2, 5-F2 , E] , [-4227 : 4-C1-2-
MeO, 2, 5-F2 ,E] , [-4228 : 4-Cl-3-MeO, 2 , 5-F2 , E] , [-4229 : 2-Me-3-
MeO, 2, 5-F2 ,E] , [-4230 : 2-Me-4-MeO, 2, 5-F2 , E] , [-4231 : 2-Me-5-
MeO, 2, 5-F2 , E] , [-4232 : 2-Me-6-MeO, 2 , 5-F2 , E] , [-4233 : 3-Me-2- MeO, 2, 5-F2 ,E] , [-4234 : 3-Me-4-MeO, 2 , 5-F2 , E] , [-4235 : 3-Me-5-
MeO, 2, 5-F2 ,E] , [-4236 : 4-Me-2-MeO, 2, 5-F2 , E] , [-4237 : 4-Me-3-
MeO, 2, 5-F2 ,E] , [-4238 : H, 3, 4-F2 , E] , [-4239 : 4-F, 3, 4-F2 , E] ,
[-4240:4-F,3,4-F2 ,Z ] , [ -4241 : 4-Cl, 3, 4-F2 , E ] , [-4242:4-
Cl, 3, 4-F2, Z] , [-4243:4-Br,3,4-F2,E] , [-4244 : 4-1, 3, 4-F2 , E] , [-4245:4-Me,3,4-F2 ,E] , [ -4246 : 4-Me, 3, 4-F2 , Z ] , [-4247:4-
Et, 3, 4-F2, E ] , [ -4248:4-C3H7 ,3, 4-F2 ,E ] , [ -4249:4-
(Me) 2 CH, 3, 4-F2 ,E ) , [ -4250 : 4-CF3 , 3, 4-F2 , E ] , [ -4251:4-
CF3, 3, 4-F2 ,Z] , [-4252:4-C2F5,3,4-F2 ,E] , [-4253 : 4-C3 F7 , 3 , A-
F2, E] , [-4254:4-(CF3)2CF,3,4-F2,E] , [-4255 : 4- (CF3 ) 2 CH, 3, A- F2, E] , [-4256:4-CHF2 ,3,4-F2 ,E] , [ -4257 : 4-CH2 F, 3, 4-F2 , E] ,
[ -4258:4-CF3CH2 ,3,4-F2 ,E ] , [ -4259 : 4-MeO, 3, 4-F2 , E ] , [ -
4260:4-MeO,3,4-F2 ,Z ] , [ -4261 : 4-EtO, 3, 4-F2 , E ] , [-4262:4-
C3H7O, 3, 4-F2 ,E ] , [ -4263:4- (Me)2CHO, 3, 4-F2 ,E ] , [-4264:4-
NO2 ,3,4-F2 ,E ] , [ -4265:4-NO2 ,3,4-F2 ,Z ] , [ -4266 : 3-F, 3, A- F2, E] , [-4267:3-F,3,4-F2,Z] , [ -4268 : 3-Cl, 3, 4-F2 , E ] , [-
4269:3-Cl,3,4-F2 ,Z ] , [ -4270 : 3-Br, 3, 4-F2 , E ] , [ -4271:3-
I, 3, 4-F2, E] , [-4272:3-Me,3,4-F2 ,E] , [-4273 : 3-Me, 3, 4-F2 , Z] ,
[-4274:3-Et,3,4-F2 ,E] , [-4275 : 3-C3 H7 , 3 , 4-F2 , E] , [-4276:3-
(Me)2CH, 3, 4-F2 ,E ] , [ -4277 : 3-CF3 , 3, 4-F2 , E ] , [ -4278:3- CF3, 3, 4-F2, Z] , [-4279:3-C2F5,3,4-F2,E] , [-4280 : 3-C3 F7 , 3, 4-
F2, E] , [-4281.3-(CF3 ) 2 CF, 3, 4-F2 , E] , [-4282 : 3- (CF3 ) 2 CH, 3, A-
F2, E] , [-4283:3-CHF2 ,3,4-F2 ,E] , [ -4284 : 3-CHF2 , 3, 4-F2 , Z ] ,
[ -4285:3-CH2F,3,4-F2 ,E ] , [ -4286 : 3-CH2 F, 3, 4-F2 , Z ] , [ -
4287:3-CF3CH2 ,3,4-F2 ,E] , [-4288 : 3-MeO, 3, 4-F2 , E] , [-4289:3- MeO, 3, 4-F2 , Z] , [-4290 : 3-EtO, 3, 4-F2 , E] , [-4291 : 3-C3 H7 O, 3, 4-
F2, E ] , [ -4292:3- (Me)2CHO, 3, 4-F2 ,E ] , [ -4293 : 3-NO2 , 3, A- F2, E] , [-4294:2-F,3,4-F2 ,E] , [ -4295 : 2-Cl, 3, 4-F2 , E ] , [- 4296:2-Br,3,4-F2,E ] , [ -4297 : 2-1, 3, 4-F2 , E ] , [ -4298:2- Me, 3, 4-F2, E] , [ -4299 : 2-Et , 3, 4-F2 , E ] , [ -4300 : 2-C3 H7 , 3, A- F2, E] , [-4301:2-(Me)2CH,3,4-F2 ,E] , [-4302 : 2-CF3 , 3, 4-F2 , E] ,
C -4303:2-C2F5 ,3,4-F2 ,E ] , C -4304 : 2-C3 F7 , 3, 4-F2 , E ] , [ -
4305:2-(CF3 )2CF,3,4-F2 ,E] , [-4306 : 2- (CF3 ) 2 CH, 3, 4-F2 , E] , C-
4307:2-CHF2 ,3,4-F2 ,E] , [-4308 : 2-CH2 F, 3, 4-F2 , E] , [-4309:2-
CF3CH2 ,3,4-F2 , E ] , [ -4310 : 2-MeO, 3 , 4-F2 , E ] , [ -4311:2- EtO, 3, 4-F2, E ] , [ -4312:2-C3H7O,3,4-F2 ,E ] , [ -4313:2-
(Me)2CHO, 3, 4-F2 ,E ] , [ -4314 : 2-NO2 , 3, 4-F2 , E ] , [-4315:2,3-
F2, 3, 4-F2, E] , [-4316:2, 4-F2, 3, 4-F2 ,E] , [-4317 : 2 , 5-F2 , 3, 4-
F2, E] , [-4318:2, 6-F2, 3, 4-F2 ,E] , [-4319 : 3, 4-F2 , 3, 4-F2 , E] ,
[ -4320:3, 4-F2, 3,4-F2, Z ] , [ -4321 : 3, 5-F2 , 3, 4-F2 , E ] , [ - 4322:3, 5-F2 ,3,4-F2 , Z ] , [ -4323 : 2, 3-Cl2 , 3, 4-F2 , E ] , [ -
4324:2, 3-Cl2, 3, 4-F2, Z ] , [ -4325 : 2, 4-Cl2 , 3, 4-F2 , E ] , [ - 4326:2, 4-Cl2, 3, 4-F2 ,Z ] , [ -4327 : 2, 5-Cl2 , 3, 4-F2 , E ] , [ - 4328:2, 5-Cl2 ,3,4-F2 ,Z ] , [ -4329 : 2 , 6-Cl2 , 3 , 4-F2 , E ] , [ - 4330:3, 4-Cl2 ,3,4-F2 ,E ] , [ -4331 : 3, 5-Cl2 , 3, 4-F2 , E ] , [ - 4332:2, 3-Br2 ,3,4-F2 ,E ] , [ -4333 : 2, 4-Br2 , 3, 4-F2 , E ] , [ -
4334:2, 5-Br2 ,3,4-F2 ,E ] , [ -4335 : 2, 6-Br2 , 3, 4-F2 , E ] , [ - 4336:3, 4-Br2, 3, 4-F2 ,E ] , [ -4337 : 3, 5-Br2 , 3, 4-F2 , E ] , [ - 4338:2, 3-Me2 ,3,4-F2 ,E ] , [ -4339 : 2, 4-Me2 , 3, 4-F2 , E ] , [ - 4340:2, 5-Me2 ,3,4-F2 ,E ] , [ -4341 : 2, 6-Me2 , 3, 4-F2 , E ] , [ - 4342:3, 4-Me2, 3, 4-F2 ,E ] , [ -4343 : 3, 5-Me2 , 3, 4-F2 , E ] , [ -
4344:2, 3-Et2 ,3,4-F2 ,E ] , [ -4345 : 2 , 4-Et2 , 3, 4-F2 , E ] , [ - 4346:2, 5-Et2, 3, 4-F2 ,E ] , [ -4347 : 2, 6-Et2 , 3, 4-F2 , E ] , [ - 4348:3, 4-Et2, 3, 4-F2, E ] , [ -4349 : 3, 5-Et2 , 3, 4-F2 , E ] , [ - 4350:2,3-(CF3)2,3,4-F2,E] , [-4351 : 2, 4- (CF3 ) 2 , 3, 4-F2 , E] , [- 4352:2, 5- (CF3 )2, 3, 4-F2 , E] , [-4353 : 2, 6- (CF3 ) 2 , 3, 4-F2 , E] , [-
4354:3,4-(CF3)2,3,4-F2,E] , [-4355 : 3, 5- (CF3 ) 2 , 3, 4-F2 , E] , [-
4356:2,3- (CHF2 )2 ,3,4-F2 ,E] , [-4357 : 2, 4- (CHF2 ) 2 , 3, 4-F2 , E] ,
[ -4358:2,5- (CHF2 )2 ,3,4-F2 , E ] , [ -4359 : 2 , 6- (CHF2 ) 2 , 3, 4-
F2, E ] , [ -4360:3,4- (CHF2 )2 ,3,4-F2 , E ] , [ -4361:3,5- (CHF2 )2 ,3, 4-F2, E ] , [ -4362 : 2 , 3- (CH2 F) 2 , 3, 4-F2 , E ] , [ -
4363:2, 4-(CH2F)2, 3, 4-F2, E] , [-4364 : 2, 5- (CH2 F) 2 , 3, 4-F2 , E] ,
[ -4365:2, 6-(CH2F)2, 3, 4-F2, E ] , [ -4366 : 3, 4- (CH2 F) 2 , 3, 4-
F2, E ] , [ -4367:3, 5-(CH2F)2, 3, 4-F2 , E ] , [ -4368:2,3-
(.MeO)2 ,3,4-F2 ,E] , [-4369 : 2 , 4- (MeO) 2 , 3, 4-F2 , E] , [-4370:2,5- (MeO)2 ,3,4-F2 ,E] , [-4371 : 2, 6- (MeO) 2 , 3, 4-F2 , E] , [-4372:3,4-
(MeO)2, 3, 4-F2, E] , [-4373 : 3, 5- (MeO) 2 , 3, 4-F2 , E] , [-4374:2,3-
(EtO)2 ,3,4-F2 ,E] , [-4375:2,4- (EtO)2 ,3,4-F2 ,E] , [-4376:2,5-
(EtO)2, 3, 4-F2, E] , [-4377:2, 6-(EtO)2, 3, 4-F2, E] , [-4378:3,4-
(EtO)2 ,3,4-F2 ,E] , [-4379:3,5- (EtO)2 ,3,4-F2 ,E] , [-4380:2- Cl-3-F,3,4-F2 ,E] , [-4381 : 2-C1-4-F, 3, 4-F2 , E] , [-4382.2-C1-
5-F,3,4-F2 ,E] , [-4383:2-Cl-6-F,3,4-F2 ,E] , [ -4384 : 3-C1-2-
F, 3, 4-F2, E ] , [ -4385:3-Cl-4-F,3,4-F2 ,E ] , [ -4386 : 3-C1-5-
F, 3, 4-F2, E ] , [ -4387:4-Cl-2-F,3,4-F2,E ] , [ -4388 : 4-C1-3-
F, 3, 4-F2, E ] , [ -4389:2-F-3-Me,3,4-F2 ,E ] , [ -4390 : 2-F-4- Me, 3, 4-F2, E ] , [ -4391 : 2-F-5-Me, 3, 4-F2 , E ] , [ -4392 : 2-F-6-
Me, 3, 4-F2, E ] , [ -4393 : 3-F-2-Me, 3, 4-F2 , E ] , [ -4394 : 3-F-4-
Me, 3, 4-F2, E ] , [ -4395 : 3-F-5-Me, 3, 4-F2 , E ] , [ -4396 : 4-F-2-
Me, 3, 4-F2, E] , [ -4397 : 4-F-3-Me, 3, 4-F2 , E ] , [ -4398 : 2-C1-3-
Me, 3, 4-F2, E] , [ -4399 : 2-Cl-4-Me, 3, 4-F2 , E ] , [ -4400 : 2-C1-5- Me, 3, 4-F2, E] , [ -4401 : 2-Cl-6-Me, 3, 4-F2 , E ] , [ -4402 : 3-C1-2-
Me, 3, 4-F2, E] , C -4403 : 3-Cl-4-Me, 3, 4-F2 , E ] , [ -4404 : 3-C1-5-
Me, 3, 4-F2, E] , [ -4405 : 4-Cl-2-Me, 3, 4-F2 , E ] , [ -4406 : 4-C1-3-
Me, 3, 4-F2, E] , C -4407 : 2-F-3-CF3 , 3, 4-F2 , E ] , [ -4408 : 2-F-4-
CF3, 3, 4-F2, E] , C-4409:2-F-5-CF3,3,4-F2 ,E] , [ -4410 : 2-F-6- CF3, 3, 4-F2 , E] , C-4411:3-F-2-CF3,3,4-F2 ,E] , [ -4412 : 3-F-4-
CF3 ,3,4-F2 ,E] , [-4413:3-F-5-CF3 ,3,4-F2 ,E] , [ -4414 : 4-F-2-
CF3 ,3,4-F2 ,E] , [-4415:4-F-3-CF3 ,3,4-F2 ,E] , [ -4416 : 2-C1-3-
CF3, 3, 4-F2, E] , (-4417:2-Cl-4-CF3,3,4-F2 ,E] , [-4418 : 2-C1-5-
CF3 ,3,4-F2 ,E] , [-4419:2-Cl-6-CF3 ,3,4-F2 ,E] , [-4420 : 3-C1-2- CF3 ,3,4-F2 ,E] , [-4421:3-Cl-4-CF3 ,3,4-F2 ,E] , [-4422 : 3-C1-5-
CF3, 3, 4-F2, E] , [-4423:4-Cl-2-CF3,3,4-F2 ,E] , [-4424 : 4-C1-3-
CF3 ,3,4-F2 ,E] , [-4425:2-Me-3-CF3 ,3,4-F2 ,E] , [-4426 : 2-Me-4-
CF3 ,3,4-F2 ,E] , [-4427:2-Me-5-CF3 ,3,4-F2 ,E] , [-4428 : 2-Me-6-
CF3 ,3,4-F2 ,E] , [-4429:3-Me-2-CF3 ,3,4-F2 ,E] , [-4430 : 3-Me-4- CF3 ,3,4-F2 ,E] , [-4431:3-Me-5-CF3 ,3,4-F2 ,E] , [-4432 : 4-Me-2-
CF3 ,3,4-F2 ,E] , [-4433:4-Me-3-CF3 ,3,4-F2 ,E] , [-4434 : 2-F-3-
MeO, 3, 4-F2 ,E] , [ -4435 : 2-F-4-MeO, 3, 4-F2 , E ] , [ -4436 : 2-F-5-
MeO, 3, 4-F2 ,E] , [ -4437 : 2-F-6-MeO, 3, 4-F2 , E ] , [ -4438 : 3-F-2-
MeO, 3, 4-F2 ,E] , [ -4439 : 3-F-4-MeO, 3, 4-F2 , E ] , [ -4440 : 3-F-5- MeO, 3, 4-F2 ,E] , [ -4441 : 4-F-2-MeO, 3, 4-F2 , E ] , [ -4442 : 4-F-3-
MeO, 3, 4-F2 , E] , [-4443 : 2-Cl-3-MeO, 3, 4-F2 , E] , [-4444 : 2-C1-4-
MeO, 3, 4-F2 ,E] , [-4445 : 2-Cl-5-MeO, 3, 4-F2 , E] , [-4446 : 2-C1-6-
MeO, 3, 4-F2 ,E] , [-4447 : 3-Cl-2-MeO, 3, 4-F2 , E] , [-4448 : 3-C1-4-
MeO, 3, 4-F2 ,E] , [-4449 : 3-Cl-5-MeO, 3, 4-F2 , E] , [-4450 : 4-C1-2- MeO, 3, 4-F2 ,E] , [-4451 : 4-Cl-3-MeO, 3, 4-F2 , E] , [-4452 : 2-Me-3-
MeO, 3, 4-F2 ,E] , [-4453 : 2-Me-4-MeO, 3, 4-F2 , E] , [-4454 : 2-Me-5-
MeO, 3, 4-F2 , E] , [-4455 : 2-Me-6-MeO, 3, 4-F2 , E] , [-4456 : 3-Me-2-
MeO, 3, 4-F2 ,E] , [-4457 : 3-Me-4-MeO, 3, 4-F2 , E] , [-4458 : 3-Me-5-
MeO, 3, 4-F2 ,E] , [-4459 : 4-Me-2-MeO, 3, 4-F2 , E] , [-4460 : 4-Me-3- MeO, 3, 4-F2 ,EJ , [-4461 :H, 3, 5-Cl2 , E] , [-4462 : 4-F, 3, 5-Cl2 , E] ,
[-4463:4-F,3,5-Cl2 ,Z] , [-4464 : 4-Cl, 3, 5-Cl2 , E] , [-4465:4-
Cl, 3, 5-Cl2 ,Z ] , [ -4466:4-Br,3,5-Cl2 ,E ] , [ -4467:4-1,3,5-
Cl2, E] , [-4468:4-Me,3,5-Cl2 ,E] , [-4469 : 4 -Me, 3, 5-Cl2 , Z] , [-
4470:4-Et,3,5-Cl2 ,E] , [ -4471 : 4-C3 H7 , 3, 5-Cl2 , E] , (-4472:4- (Me)2CH, 3, 5-Cl2 ,E ] , [ -4473 : 4-CF3 , 3, 5-Cl2 , E ] , [ -4474:4-
CF3 ,3,5-Cl2 , Z ] , [ -4475:4-C2F5 ,3,5-Cl2 ,E ] , [ -4476:4-
C3F7 ,3,5-Cl2 ,E] , [-4477:4- (CF3 )2CF, 3, 5-Cl2 ,E] , [-4478:4-
(CF3 )2CH,3,5-C12 ,E] , [-4479:4-CHF2 ,3,5-Cl2 ,E] , [-4480:4-
CH2F, 3, 5-Cl2 ,E ] , [ -4481M-CF3CH2 ,3,5-Cl2 ,E ] , [ -4482:4- MeO, 3, 5-Cl2 ,E] , [-4483 : 4-MeO, 3, 5-Cl2 , z] , [-4484 : 4-EtO, 3, 5-
Cl2, E] , [-4485:4-C3H7O,3,5-Cl2 ,E] , (-4486 : 4- (Me) 2 CHO, 3, 5-
Cl2, E] , [-4487:4-NO2 ,3,5-Cl2 ,E] , [-4488 : 4-NO2 , 3, 5-Cl2 , Z] ,
[-4489:3-F,3,5-Cl2,E] , [ -4490 : 3-F, 3, 5-Cl2 , Z ] , [-4491:3-
Cl, 3, 5-Cl2 , E] , [-4492:3-Cl,3,5-Cl2,Z ] , [ -4493 : 3-Br, 3, 5- Cl2, E] , [-4494:3-1, 3, 5-Cl2 ,E] , [-4495 : 3-Me, 3, 5-Cl2 , E] , [-
4496:3-Me,3,5-Cl2,Z ] , [ -4497 : 3-Et , 3, 5-Cl2 , E ] , [-4498:3- C3H7 ,3,5-Cl2 ,E ] , [ -4499:3- (Me)2CH, 3, 5-Cl2 ,E ] , [-4500:3- CF3 ,3,5-Cl2 , E ] , [ -4501:3-CF3 ,3,5-Cl2 ,Z ] , [ -4502:3- C2F5 ,3,5-Cl2 ,E ] , [ -4503:3-C3F7 ,3,5-Cl2 ,E ] , [ -4504:3- (CF3 )2CF,3,5-C12 ,E ] , [ -4505 : 3- (CF3 ) 2 CH, 3 , 5-Cl2 , E ] , [ -
4506:3-CHF2 ,3,5-Cl2 ,E ) , [ -4507 : 3-CHF2 , 3 , 5-Cl2 , Z ] , [ - 4508:3-CH2F,3,5-Cl2 ,E ) , [ -4509 : 3-CH2 F, 3, 5-Cl2 , Z ] , [ ■ 4510:3-CF3CH2 ,3,5-Cl2 ,E ) , C -4511 : 3-MeO, 3, 5-Cl2 , E ] , [ - 4512:3-MeO,3,5-Cl2 ,z] , [-4513 : 3-EtO, 3, 5-Cl2 , E] , [-4514:3- C3H7O, 3, 5-Cl2 ,E] , [-4515:3- (Me)2CHO, 3, 5-Cl2 ,E] , [-4516:3-
NO2 ,3, 5-Cl2, E ] , [ -4517:2-F,3,5-C12 ,E] , [ -4518.2-Cl, 3, 5- Cl2, E] , [-4519:2-Br,3,5-Cl2 ,E] , [-4520 : 2-1, 3, 5-Cl2 , E] , [- 4521:2-Me,3,5-Cl2 ,E ] , [ -4522 : 2-Et, 3, 5-Cl2 , E ] , [-4523:2- C3H7 ,3,5-Cl2 , E] , [ -4524:2-(Me)2CH,3,5-Cl2 ,E ] , [-4525:2- CF3, 3, 5-Cl2 ,E ] , [ -4526:2-C2F5 ,3,5-Cl2 ,E ] , [ -4527:2-
C3F7 ,3,5-Cl2 ,E] , [-4528:2- (CF3 )2CF, 3, 5-Cl2 ,E] , [-4529:2-
(CF3 )2CH,3,5-C12 ,E] , C-4530:2-CHF2 ,3,5-Cl2 ,E] , [-4531:2-
CH2F, 3, 5-Cl2 ,E ] , [ -4532:2-CF3CH2 ,3,5-Cl2 ,E ] , [ -4533:2-
MeO, 3, 5-Cl2 , E ] , [ -4534 : 2-EtO, 3, 5-Cl2 , E ] , [ -4535:2- C3H7O, 3, 5-Cl2 ,E] , [ -4536 : 2- (Me) 2 CHO, 3 , 5-Cl2 , E] , [-4537:2-
NO2 ,3, 5-Cl2, E ] , [ -4538:2, 3-F2 ,3, 5-Cl2, E ] , [ -4539:2,4- F2, 3, 5-Cl2, E ] , [ -4540:2, 5-F2, 3, 5-Cl2 ,E ] , [ -4541:2,6- F2 ,3,5-Cl2 ,E ] , [ -4542:3, 4-F2 ,3,5-Cl2 ,E ] , [ -4543:3,4- F2, 3, 5-Cl2, Z ] , [ -4544:3, 5-F2, 3, 5-Cl2, E ] , [ -4545:3,5- F2, 3, 5-Cl2, Z ] , [ -4546:2, 3-Cl2 ,3,5-Cl2 , E ], , [ -4547:2,3-
Cl2 ,3,5-Cl2 ,Z ] , [ -4548:2, 4-Cl2 ,3,5-Cl2 ,E ] , [ -4549:2,4- Cl2 ,3, 5-Cl2, Z ] , [ -4550:2, 5-Cl2, 3, 5-Cl2 ,E ] , [ -4551:2,5- Cl2 ,3,5-Cl2 ,Z ] , [ -4552:2, 6-Cl2 ,3,5-Cl2 ,E ] , [ -4553:3,4- Cl2 ,3,5-Cl2 ,E ] , [ -4554:3, 5-Cl2 ,3,5-Cl2 ,E ] , [ -4555:2,3- Br2 ,3,5-Cl2 ,E ] , [ -4556 : 2, 4-Br2 , 3, 5-Cl2 , E ] , [ -4557:2,5-
Br2 ,3, 5-Cl2, E ] , [ -4558 : 2, 6-Br2 , 3, 5-Cl2 , E ] , ( -4559:3,4-
Br2 ,3,5-Cl2 ,E ] , C -4560 : 3, 5-Br2 , 3, 5-Cl2 , E ) , ( -4561:2,3-
Me2 ,3,5-Cl2 ,E ] , ( -4562 : 2 , 4-Me2 , 3, 5-Cl2 , E ] , ( -4563:2,5-
Me2, 3, 5-Cl2, E ] , C -4564 : 2, 6-Me2 , 3, 5-Cl2 , E ] , ( -4565:3,4- Me2 ,3,5-Cl2 ,E ] , ( -4566 : 3, 5-Me2 , 3, 5-Cl2 , E ] , ( -4567:2,3-
Et2 ,3,5-Cl2 ,E ] , ( -4568:2, 4-Et2 ,3,5-Cl2 ,E ] , ( -4569:2,5-
Et2 ,3,5-Cl2 ,E ] , ( -4570:2, 6-Et2 ,3,5-Cl2 ,E ) , ( -4571:3,4-
Et2, 3, 5-Cl2, E ] , ( -4572:3, 5-Et2 ,3,5-Cl2 ,E ] , ( -4573:2,3-
(CF3)2, 3, 5-Cl2, E ] , ( -4574:2, 4-(CF3)2, 3, 5-Cl2, E ] , C - 4575:2, 5-(CF3J2, 3, 5-Cl2, E] , (-4576 : 2, 6- (CF3 ) 2 , 3, 5-Cl2 , E] ,
( -4577:3,4-(CF3)2,3,5-Cl2,E ] , ( -4578 : 3, 5- (CF3 ) 2 , 3, 5-
Cl2, E ] , ( -4579:2,3- (CHF2 )2 ,3,5-Cl2 , E ] , ( -4580:2,4-
(CHF2 )2,3,5-Cl2 ,E ] , ( -4581:2, 5-(CHF2 )2 ,3,5-Cl2 ,E ] , ( -
4582:2, 6- (CHF2 )2 ,3,5-Cl2 ,E] , (-4583 : 3, 4- (CHF2 ) 2 , 3, 5-Cl2 , E] , ( -4584:3,5- (CHF2 )2 ,3,5-Cl2 ,E ] , ( -4585 : 2 , 3- (CH2 F) 2 , 3, 5-
Cl2, E ] , ( -4586:2, 4-(CH2F)2 ,3,5-Cl2 , E ] , ( -4587:2,5-
(CH2F)2 ,3,5-Cl2 ,E ] , ( -4588:2, 6-(CH2F)2, 3, 5-Cl2 ,E ] , ( -
4589:3, 4-(CH2F)2 ,3,5-Cl2 ,E] , (-4590 : 3, 5- (CH2 F) 2 , 3, 5-Cl2 , E] ,
( -4591:2, 3-(MeO)2 ,3,5-Cl2 , E ] , ( -4592 : 2, 4- (MeO) 2 , 3, 5- Cl2, E ] , ( -4593:2, 5-(MeO)2 ,3,5-Cl2 , E ] , ( -4594:2,6-
(MeO)2 ,3,5-Cl2 ,E ] , ( -4595 : 3, 4- (MeO) 2 , 3, 5-Cl2 , E ] , ( -
4596:3, 5-(MeO)2 ,3,5-Cl2 ,E] , (-4597 : 2, 3- (EtO) 2 , 3, 5-Cl2 , E] ,
( -4598:2,4- (EtO)2 ,3,5-Cl2 , E ] , ( -4599 : 2, 5- (EtO) 2 , 3, 5-
Cl2, E ] , ( -4600:2, 6-(EtO)2 ,3,5-Cl2 , E ] , ( -4601:3,4- (EtO)2, 3, 5-Cl2, E] , (-4602 : 3, 5- (EtO) 2 , 3, 5-Cl2 , E] , (-4603:2-
C1-3-F,3,5-C12,E] , [-4604:2-Cl-4-F,3,5-Cl2 ,E] , [-4605:2- Cl-5-F,3,5-Cl2 ,E] , [-460β:2-Cl-β-F,3,5-Cl2 ,E] , [-4607:3- Cl-2-F,3,5-Cl2 ,E] , [-4608:3-Cl-4-F,3,5-Cl2 ,E] , [-4609:3- Cl-5-F,3,5-Cl2 ,E] , [-4610:4-Cl-2-F,3,5-Cl2 ,E] , [-4611:4- Cl-3-F,3,5-Cl2 ,E] , [-4612 : 2-F-3-Me, 3, 5-Cl2 , E] , [-4613.2-F-
4-Me,3,5-Cl2 ,E] , [-4614 : 2-F-5-Me, 3, 5-Cl2 , E] , [-4615 : 2-F-6- Me, 3, 5-Cl2 ,E] , [ -4616 : 3-F-2-Me, 3, 5-Cl2 , E ] , [ -4617 : 3-F-4- Me, 3, 5-Cl2 ,E] , [ -4618 : 3-F-5-Me, 3, 5-Cl2 , E ] , [ -4619 : 4-F-2- Me, 3, 5-Cl2, E] , [-4620 : 4-F-3-Me, 3, 5-Cl2 , E] , [-4621:2-01-3- Me, 3, 5-Cl2, E] , [-4622 : 2-Cl-4-Me, 3, 5-Cl2 , E] , [-4623 : 2-C1-5-
Me, 3, 5-Cl2, E] , [-4624 : 2-Cl-6-Me, 3, 5-Cl2 , E] , [-4625 : 3-C1-2- Me, 3, 5-Cl2 ,E] , [-4626 : 3-Cl-4-Me, 3, 5-Cl2 , E] , [-4627 : 3-C1-5- Me, 3, 5-Cl2 ,E] , [-4628 : 4-Cl-2-Me, 3, 5-Cl2 , E] , [-4629 : 4-C1-3- Me, 3, 5-Cl2 ,E] , [-4630 : 2-F-3-CF3 , 3, 5-Cl2 , E] , [-4631 : 2-F-4- CF3 ,3,5-Cl2 ,E] , [-4632 : 2-F-5-CF3 , 3, 5-Cl2 , E] , [-4633 : 2-F-6-
CF3 ,3,5-Cl2 ,E] , [-4634:3-F-2-CF3 ,3,5-Cl2 , E] , [-4635 : 3-F-4- CF3, 3, 5-Cl2 ,E] , [-4636:3-F-5-CF3 ,3,5-Cl2 ,E] , [-4637 : 4-F-2- CF3 ,3,5-Cl2 ,E] , [-4638:4-F-3-CF3 ,3,5-Cl2 ,E] , [-4639:2-Cl- 3-CF3 ,3,5-Cl2 ,E] , [-4640:2-Cl-4-CF3 ,3,5-Cl2 ,E] , [-4641:2- Cl-5-CF3,3,5-Cl2 ,E 3 , [ -4642 : 2-Cl-6-CF3 , 3, 5-Cl2 , E ] , [ -
4643:3-Cl-2-CF3 ,3,5-Cl2 ,E] , [-4644 : 3-Cl-4-CF3 , 3, 5-Cl2 , E] ,
[ -4645:3-Cl-5-CF3 ,3,5-Cl2 ,E ] , [ -4646 : 4-Cl-2-CF3 , 3, 5-
Cl2, E ] , [ -4647:4-Cl-3-CF3 ,3,5-Cl2 ,E ] , [ -4648 : 2-Me-3-
CF3 ,3,5-Cl2 ,E] , [-4649:2-Me-4-CF3 ,3,5-Cl2 ,E] , [-4650:2-Me- 5-CF3 ,3, 5-Cl2 ,E] , [-4651 : 2-Me-6-CF3 , 3, 5-Cl2 , E] , [-4652:3-
Me-2-CF3 ,3,5-Cl2 ,E ] , [ -4653 : 3-Me-4-CF3 , 3, 5-Cl2 , E ] , [ -
4654:3-Me-5-CF3 ,3,5-Cl2 ,E] , [-4655 : 4-Me-2-CF3 , 3, 5-Cl2 , E] ,
C-4656:4-Me-3-CF3 ,3,5-Cl2 ,E] , [-4657 : 2-F-3-MeO, 3, 5-Cl2 , E] ,
[-4658:2-F-4-MeO,3,5-Cl2 ,E] , [-4659 : 2-F-5-MeO, 3, 5-Cl2 , E] , [-4660:2-F-6-MeO,3,5-Cl2 ,E] , [-4661 : 3-F-2-MeO, 3, 5-Cl2 , E] ,
[-4662:3-F-4-MeO,3,5-Cl2 ,E] , [-4663 : 3-F-5-MeO, 3, 5-Cl2 , E] ,
[-4664:4-F-2-MeO,3,5-Cl2 ,E] , [-4665 : 4-F-3-MeO, 3, 5-Cl2 , E] ,
[ -4666:2-Cl-3-MeO,3,5-Cl2 ,E ] , [ -4667 : 2-01-4-MeO, 3, 5-
Cl2, E ] , [ -4668:2-Cl-5-MeO,3,5-Cl2 ,E ] , [ -4669 : 2-C1-6- MeO, 3, 5-Cl2 ,E] , [-4670 : 3-01-2-MeO, 3, 5-Cl2 , E] , [-4671:3-01-
4-MeO, 3, 5-Cl2 ,E] , [-4672 : 3-Cl-5-MeO, 3, 5-Cl2 , E] , [-4673:4-
Cl-2-MeO,3,5-Cl2 ,E ] , [ -4674 : 4-01-3-MeO, 3, 5-Cl2 , E ] , [ -
4675:2-Me-3-MeO,3,5-Cl2 ,E] , [-4676 : 2-Me-4-MeO, 3, 5-Cl2 , E] ,
[ -4677 :2-Me-5-MeO,3,5-Cl2 ,E ] , [ -4678 : 2-Me-6-MeO, 3, 5- Cl2, E ] , [ -4679:3-Me-2-MeO,3,5-Cl2 ,E ] , [ -4680 : 3-Me-4-
MeO, 3, 5-Cl2 ,E] , [-4681 : 3-Me-5-MeO, 3, 5-Cl2 , E] , [-4682:4-Me-
2-MeO, 3, 5-Cl2 , E ] , [ -4683 : 4-Me-3-MeO, 3, 5-Cl2 , E ] , [ -
4684:H,3-Cl-4-F,E] , [-4685 : 4-F, 3-C1-4-F, E] , [-4686 : 4-F, 3-
C1-4-F, Z] , C -4687:4-01, 3-C1-4-F, E] , [-4688:4-01,3-01-4- F, Z] , [-4689:4-Br,3-Cl-4-F,E] , [-4690 : 4-1, 3-C1-4-F, E] , [-
4691:4-Me,3-Cl-4-F,E] , [-4692 : 4-Me, 3-C1-4-F, Z] , [-4693:4-
Et,3-Cl-4-F,E ] , [ -4694:4-C3H7 ,3-Cl-4-F,E ] , [ -4695:4-
(Me)2CH, 3-Cl-4-F,E] , [ -4696 : 4-CF3 , 3-C1-4-F, E ] , [-4697:4-
CF3 ,3-Cl-4-F,Z ] , [ -4698:4-C2F5 ,3-Cl-4-F,E ] , [ -4699:4- C3F7 ,3-Cl-4-F,E] , [-4700 : 4- (CF3 ) 2 CF, 3-C1-4-F, E] , [-4701:4-
(CF3 )2CH,3-Cl-4-F,E] , C-4702:4-CHF2 ,3-Cl-4-F,E] , [-4703:4-
CH2F,3-Cl-4-F,E] , [-4704:4-CF3CH2 ,3-Cl-4-F,E] , [-4705:4-
MeO,3-Cl-4-F,E] , [-4706 : 4-MeO, 3-C1-4-F, z] , [-4707 : 4-EtO, 3-
Cl-4-F,E ] , [ -4708:4-C3H7O,3-Cl-4-F,E ] , [ -4709:4- (Me)2CHO, 3-Cl-4-F,E] , [-4710 : 4-NO2 , 3-C1-4-F, E] , [-4711:4-
NO2 ,3-Cl-4-F,Z] , [-4712:3-F,3-Cl-4-F,E] , [-4713 : 3-F, 3-C1-
4-F,Z] , [-4714:3-Cl,3-Cl-4-F,E] , [-4715 : 3-Cl, 3-C1-4-F, Z] ,
[ -4716:3-Br,3-Cl-4-F,E ] , [ -4717 : 3-1, 3-C1-4-F, E 3 , [ -
4718:3-Me,3-Cl-4-F,E] , [-4719 : 3-Me, 3-C1-4-F, z] , [-4720:3- Et,3-Cl-4-F,E ] , [ -4721 : 3-C3 H7 , 3-C1-4-F, E ] , [ -4722:3-
(Me)2CH, 3-Cl-4-F,E] , [ -4723 : 3-CF3 , 3-C1-4-F, E ] , [-4724:3-
CF3 ,3-Cl-4-F,Z ] , [ -4725:3-C2F5 ,3-Cl-4-F,E ] , [ -4726:3-
C3F7 ,3-Cl-4-F,E] , [-4727:3- (CF3 ) 2 CF, 3-C1-4-F, E] , [-4728:3-
(CF3 )2CH,3-Cl-4-F,E] , [-4729:3-CHF2 ,3-Cl-4-F,E] , [-4730:3- CHF2 ,3-Cl-4-F,Z ] , [ -4731 : 3-CH2 F, 3-C1-4-F, E ] , [ -4732:3-
CH2F,3-Cl-4-F,z3 , [ -4733 : 3-CF3 CH2 , 3-C1-4-F, E ] , [-4734:3-
MeO,3-Cl-4-F,E] , [-4735 : 3-MeO, 3-C1-4-F, Z] , [-4736 : 3-EtO, 3-
Cl-4-F,E ] , [ -4737:3-C3H7O,3-Cl-4-F,E ] , [ -4738:3-
(Me)2CHO, 3-C1-4-F, E] , [-4739 : 3-NO2 , 3-C1-4-F, E] , [-4740:2- F,3-Cl-4-F,E] , [-4741:2-Cl,3-Cl-4-F,E] , [-4742 : 2-Br, 3-C1-
4-F,E] , [-4743:2-1, 3-C1-4-F, E] , [-4744 : 2-Me, 3-C1-4-F, E] ,
[ -4745:2-Et,3-Cl-4-F,E ] , [ -4746 : 2-C3 H7 , 3-C1-4-F, E ] , [-
4747:2- (Me)2CH, 3-Cl-4-F,E] , [ -4748 : 2-CF3 , 3-C1-4-F, E ] , [-
4749:2-C2F5 ,3-Cl-4-F,E ] , [ -4750 : 2-C3 F7 , 3-C1-4-F, E ] , [ - 4751.2-(CF3 ) 2 CF, 3-C1-4-F, E] , [-4752 : 2- (CF3 ) 2 CH, 3-C1-4-F, E] ,
[-4753:2-CHF2 ,3-Cl-4-F,E] , C -4754 : 2-CH2 F, 3-C1-4-F, E] , C- 4755:2-CF3CH2 ,3-Cl-4-F,E ] , C -4756 : 2-MeO, 3-C1-4-F, E ) , C- 4757:2-EtO,3-Cl-4-F,E ] , C -4758 : 2-C3 H7 O, 3-C1-4-F, E ] , [ - 4759:2- (Me)2CHO, 3-Cl-4-F,E] , [-4760 : 2-NO2 , 3-C1-4-F, E] , C- 4761:2, 3-F2 ,3-Cl-4-F,E ] , C -4762 : 2 , 4-F2 , 3-C1-4-F, E ] , [ -
4763:2, 5-F2 ,3-Cl-4-F,E ] , C -4764 : 2, 6-F2 , 3-C1-4-F, E ) , C - 4765:3, 4-F2 ,3-Cl-4-F,E ] , C -4766 : 3, 4-F2 , 3-C1-4-F, Z ] , C - 4767:3, 5-F2 ,3-Cl-4-F,E ] , C -4768 : 3, 5-F2 , 3-C1-4-F, Z ] , [ - 4769:2, 3-Cl2 ,3-Cl-4-F, E] , C -4770 : 2, 3-Cl2 , 3-C1-4-F, Z ] , C- 4771:2, 4-Cl2 ,3-Cl-4-F,E] , C -4772 : 2, 4-Cl2 , 3-C1-4-F, Z ] , C-
4773:2, 5-Cl2 ,3-Cl-4-F, E] , C -4774 : 2, 5-Cl2 , 3-C1-4-F, Z ] , C- 4775:2, 6-Cl2 ,3-Cl-4-F, E] , C -4776 : 3, 4-Cl2 , 3-C1-4-F, E ] , [- 4777:3, 5-Cl2 ,3-Cl-4-F,E] , C -4778 : 2 , 3-Br2 , 3-C1-4-F, E ] , [- 4779:2, 4-Br2 ,3-Cl-4-F, E] , C -4780 : 2, 5-Br2 , 3-C1-4-F, E ] , [ - 4781:2, 6-Br2, 3-C1-4-F, E] , C -4782 : 3, 4-Br2 , 3-C1-4-F, E ] , C-
4783:3, 5-Br2, 3-C1-4-F, E] , C -4784 : 2, 3-Me2 , 3-C1-4-F, E ] , [- 4785:2, 4-Me2, 3-C1-4-F, E] , C -4786 : 2, 5-Me2 , 3-C1-4-F, E ] , C- 4787:2, 6-Me2 ,3-Cl-4-F,E] , C -4788 : 3, 4-Me2 , 3-C1-4-F, E ] , [- 4789:3, 5-Me2 ,3-Cl-4-F, E] , C -4790 : 2, 3-Et2 , 3-C1-4-F, E ] , [- 4791:2, 4-Et2 ,3-Cl-4-F, E] , C -4792 : 2 , 5-Et2 , 3-C1-4-F, E ] , [-
4793:2, 6-Et2 ,3-Cl-4-F, E] , C -4794 : 3, 4-Et2 , 3-C1-4-F, E ] , [ -
4795:3, 5-Et2 ,3-Cl-4-F, E] , C -4796 : 2 , 3- (CF3 ) 2 , 3-C1-4-F, E ] ,
[ -4797:2, 4-(CF3)2 ,3-C1-4-F,E ] , C -4798 : 2 , 5- (CF3 ) 2 , 3-C1-4-
F, E] , C-4799:2,6-(CF3 ) 2 , 3-C1-4-F, E] , [-4800 : 3, 4- (CF3 ) 2 , 3- Cl-4-F,E ] , C -4801:3, 5-(CF3)2 ,3-Cl-4-F,E ] , C -4802:2,3-
(CHF2 )z ,3-Cl-4-F,E ) , C -4803 : 2 , 4- (CHF2 ) 2 , 3-C1-4-F, E ] , C-
4804:2,5- (CHF2 )2 ,3-Cl-4-F, E ] , [ -4805 : 2 , 6- (CHF2 ) 2 , 3-C1-4-
F, E ] , C -4806:3, 4- (CHF2 )2,3-Cl-4-F, E ] , C -4807:3,5-
(CHF2 )2,3-Cl-4-F, E] , [ -4808 : 2 , 3- (CH2 F) 2 , 3-C1-4-F, E ] , [- 4809:2, 4-(CH2F)2 , 3-C1-4-F, E ] , [ -4810 : 2, 5- (CH2 F) 2 , 3-C1-4-
F, E ] , ( -4811:2, 6- (CH2F)2 , 3-C1-4-F, E ] , [ -4812:3,4-
(CH2F)2, 3-C1-4-F, E] , [ -4813 : 3, 5- (CH2 F) 2 , 3-C1-4-F, E ] , [-
4814:2,3- (MeO)2 ,3-Cl-4-F,E] , [-4815 : 2, 4- (MeO) 2 , 3-C1-4-F, E] ,
[ -4816:2, 5-(MeO)2 ,3-Cl-4-F, E ] , C -4817 : 2, 6- (MeO) 2 , 3-C1-4- F, E] , [-4818:3, 4-(MeO)2, 3-C1-4-F, E] , [-4819 : 3, 5- (MeO) 2 , 3-
Cl-4-F,E ] , [ -4820:2,3- (EtO)2 ,3-Cl-4-F, E ] , [ -4821:2,4-
(EtO)2, 3-C1-4-F, E ] , [ -4822:2,5- (EtO)2 ,3-Cl-4-F, E ] , [ -
4823:2, 6-(EtO)2 ,3-Cl-4-F, E] , [-4824 : 3, 4- (EtO) 2 , 3-C1-4-F, E] ,
[ -4825:3, 5-(EtO)2 , 3-C1-4-F, E ] , [ -4826 : 2-C1-3-F, 3-C1-4- F,E] , [-4827:2-Cl-4-F,3-Cl-4-F,E] , [-4828 : 2-C1-5-F, 3-C1-4-
F, E] , [-4829:2-Cl-6-F,3-Cl-4-F,E] , [-4830 : 3-C1-2-F, 3-C1-4-
F, E] , [-4831:3-Cl-4-F,3-Cl-4-F,E] , [-4832 : 3-C1-5-F, 3-C1-4-
F, E] , [-4833:4-Cl-2-F,3-Cl-4-F,E] , [-4834 : 4-C1-3-F, 3-C1-4-
F, E] , [-4835:2-F-3-Me,3-Cl-4-F,E] , [-4836 : 2-F-4-Me, 3-C1-4- F,E] , [-4837:2-F-5-Me,3-Cl-4-F,E] , [-4838 : 2-F-6-Me, 3-C1-4-
F, E] , [-4839:3-F-2-Me,3-Cl-4-F,E] , [-4840 : 3-F-4-Me, 3-C1-4-
F, E] , [-4841:3-F-5-Me,3-Cl-4-F,E] , [-4842 : 4-F-2-Me, 3-C1-4-
F, E] , [-4843:4-F-3-Me,3-Cl-4-F,E] , [-4844 : 2-Cl-3-Me, 3-C1-
4-F,E] , [-4845:2-Cl-4-Me,3-Cl-4-F,E] , [-4846 : 2-Cl-5-Me, 3- Cl-4-F,E] , [ -4847:2-Cl-6-Me,3-Cl-4-F,E] , [ -4848 : 3-C1-2-
Me,3-Cl-4-F,E] , [-4849 : 3-Cl-4-Me, 3-C1-4-F, E] , [-4850.3-C1- 5-Me,3-Cl-4-F,E] , [-4851 : 4-Cl-2-Me, 3-C1-4-F, E] , [-4852:4- Cl-3-Me,3-Cl-4-F,E ] , [ -4853 : 2-F-3-CF3 , 3-C1-4-F, E ] , [ - 4854:2-F-4-CF3 ,3-Cl-4-F,E] , [-4855 : 2-F-5-CF3 , 3-C1-4-F, E] , [ -4856:2-F-6-CF3,3-Cl-4-F,E ] , [ -4857 : 3-F-2-CF3 , 3-C1-4-
F, E] , [-4858:3-F-4-CF3,3-Cl-4-F,E] , [-4859 : 3-F-5-CF3 , 3-C1- 4-F,E] , [-4860:4-F-2-CF3 ,3-Cl-4-F,E] , [-4861 : 4-F-3-CF3 , 3- Cl-4-F,E] , [-4862:2-Cl-3-CF3 ,3-Cl-4-F,E] , [ -4863 : 2-C1-4- CF3 ,3-Cl-4-F,E] , [-4864:2-Cl-5-CF3,3-Cl-4-F,E] , [-4865:2- Cl-6-CF3 ,3-Cl-4-F,E] , [ -4866 : 3-Cl-2-CF3 , 3-C1-4-F, E ] , [-
4867:3-Cl-4-CF3 ,3-Cl-4-F,E] , [-4868 : 3-Cl-5-CF3 , 3-C1-4-F, E] ,
[ -4869:4-Cl-2-CF3 ,3-Cl-4-F,E ] , [ -4870 : 4-Cl-3-CF3 , 3-C1-4- F, E] , [-4871:2-Me-3-CF3 ,3-Cl-4-F,E] , [ -4872 : 2-Me-4-CF3 , 3- Cl-4-F,E] , [-4873:2-Me-5-CF3 ,3-Cl-4-F,E] , [ -4874 : 2-Me-6- CF3 ,3-Cl-4-F,E] , [ -4875 : 3-Me-2-CF3 , 3-C1-4-F, E] , [-4876:3-
Me-4-CF3 ,3-Cl-4-F,E ] , [ -4877 : 3-Me-5-CF3 , 3-C1-4-F, E ] , C- 4878:4-Me-2-CF3,3-Cl-4-F,E] , [-4879 : 4-Me-3-CF3 , 3-C1-4-F, E] ,
[ -4880:2-F-3-MeO,3-Cl-4-F,E ] , [ -4881 : 2-F-4-MeO, 3-C1-4- F,E] , [-4882:2-F-5-MeO,3-Cl-4-F,E] , [-4883 : 2-F-6-MeO, 3-C1- 4-F,E] , [-4884:3-F-2-MeO,3-Cl-4-F,E] , [-4885 : 3-F-4-MeO, 3-
Cl-4-F,E ] , [ -4886:3-F-5-MeO,3-Cl-4-F,E ] , [ -4887 : 4-F-2- MeO,3-Cl-4-F,E] , [ -4888 : 4-F-3-MeO, 3-C1-4-F, E ] , [-4889:2- Cl-3-MeO,3-Cl-4-F,E ] , [ -4890 : 2-Cl-4-MeO, 3-C1-4-F, E ] , [- 4891:2-Cl-5-MeO,3-Cl-4-F,E] , [-4892 : 2-Cl-6-MeO, 3-C1-4-F, E] , [ -4893:3-Cl-2-MeO,3-Cl-4-F,E ] , [ -4894 : 3-Cl-4-MeO, 3-C1-4-
F, E] , [-4895:3-Cl-5-MeO,3-Cl-4-F,E] , [-4896 : 4-Cl-2-MeO, 3- Cl-4-F,E] , [-4897:4-Cl-3-MeO,3-Cl-4-F,E] , [ -4898 : 2-Me-3- MeO,3-Cl-4-F,E] , [-4899 : 2-Me-4-MeO, 3-C1-4-F, E] , [-4900:2- Me-5-MeO,3-Cl-4-F,E ] , [ -4901 : 2-Me-6-MeO, 3-C1-4-F, E ] , [- 4902:3-Me-2-MeO, 3-Cl-4-F,E] , [-4903 : 3-Me-4-MeO, 3-C1-4-F, E] ,
[ -4904:3-Me-5-MeO,3-Cl-4-F,E ] , [ -4905 : 4-Me-2-MeO, 3-C1-4- F, E] , [-4906:4-Me-3-MeO,3-Cl-4-F,E] , [-4907 :H, 4-C1-3-F, E] ,
[-4908:4-F,4-Cl-3-F,E] , [-4909 : 4-F, 4-C1-3-F, z] , [-4910:4-
Cl,4-Cl-3-F,E] , [-4911:4-Cl,4-Cl-3-F,Z] , [-4912 : 4-Br, 4-C1- 3-F,E] , [-4913:4-1, 4-Cl-3-F,E] , [-4914 : 4-Me, 4-C1-3-F, E) ,
[ -4915:4-Me,4-Cl-3-F,Z ] , [ -4916 : 4-Et, 4-C1-3-F, E ] , [ -
4917:4-C3H7 ,4-Cl-3-F,E] , [-4918 : 4- (Me) 2 CH, 4-C1-3-F, E] , [-
4919:4-CF3 ,4-Cl-3-F,E ] , [ -4920 : 4-CF3 , 4-C1-3-F, Z ] , [ -
4921:4-C2F5 ,4-Cl-3-F,E ] , [ -4922 : 4-C3 F7 , 4-C1-3-F, E ] , [ - 4923:4- (CF3 ) 2 CF, 4-C1-3-F, E] , [-4924 : 4- (CF3 ) 2 CH, 4-C1-3-F, E] ,
[-4925:4-CHF2 ,4-Cl-3-F,E] , [ -4926 : 4-CH2 F, 4-C1-3-F, E ] , [- 4927:4-CF3CH2 ,4-Cl-3-F,E ] , [ -4928 : 4-MeO, 4-C1-3-F, E ] , [- 4929:4-MeO,4-Cl-3-F,Z ] , [ -4930 : 4-EtO, 4-C1-3-F, E ] , [ - 4931:4-C3H7O,4-Cl-3-F,E] , [ -4932 : 4- (Me) 2 CHO, 4-C1-3-F, E ] , [ -4933:4-NO2 ,4-Cl-3-F,E ] , [ -4934 : 4-NO2 , 4-C1-3-F, Z ] , [-
4935:3-F,4-Cl-3-F,E] , [ -4936 : 3-F, 4-C1-3-F, Z ] , [-4937:3- Cl,4-Cl-3-F,E] , [-4938:3-Cl,4-Cl-3-F,z] , [-4939 : 3-Br, 4-C1- 3-F,E] , [-4940:3-1, 4-Cl-3-F,E] , [-4941 : 3-Me, 4-C1-3-F, E] ,
[ -4942:3-Me,4-Cl-3-F,Z ] , [ -4943 : 3-Et, 4-C1-3-F, E ] , [ - 4944:3-C3H7 ,4-Cl-3-F,E] , [-4945 : 3- (Me) 2 CH, 4-C1-3-F, E] , [-
4946:3-CF3,4-Cl-3-F,E ] , [ -4947 : 3-CF3 , 4-C1-3-F, Z ] , C - 4948:3-C2F5 ,4-Cl-3-F,E ] , C -4949 : 3-C3 F7 , 4-C1-3-F, E ] , [ - 4950:3-(CF3 ) 2 CF, 4-C1-3-F, E] , [-4951 : 3- (CF3 ) 2 CH, 4-C1-3-F, E] ,
C-4952:3-CHF2 ,4-Cl-3-F,E] , C-4953 : 3-CHF2 , 4-C1-3-F, Z ] , [- 4954:3-CH2F,4-Cl-3-F,E ] , C -4955 : 3-CH2 F, 4-C1-3-F, Z ] , C -
4956:3-CF3CH2 ,4-Cl-3-F,E) , C -4957 : 3-MeO, 4-C1-3-F, E ] , [-
4958:3-MeO,4-Cl-3-F,Z ] , C -4959 : 3-EtO, 4-C1-3-F, E ] , [ -
4960:3-C3H7O,4-Cl-3-F,E] , C -4961 : 3- (Me) 2 CHO, 4-C1-3-F, E ] ,
C -4962:3-NO2 ,4-Cl-3-F,E ) , C -4963 : 2-F, 4-C1-3-F, E ] , C - 4964:2-Cl,4-Cl-3-F,E] , C-4965 : 2-Br, 4-C1-3-F, E] , [-4966:2-
I, 4-C1-3-F,E] , [-4967:2-Me,4-Cl-3-F,E] , [-4968 : 2-Et , 4-C1-
3-F,E] , C-4969:2-C3H7 ,4-Cl-3-F,E] , [-4970 : 2- (Me) 2 CH, 4-C1-
3-F,E] , [ -4971.2-CF3 ,4-Cl-3-F,E ] , [ -4972 : 2-C2 F5 , 4-C1-3-
F, E] , [-4973:2-C3F7 ,4-Cl-3-F,E] , [-4974 : 2- (CF3 ) 2 CF, 4-C1-3- F, E] , [-4975:2-(CF3)2CH,4-Cl-3-F,E] , [-4976 : 2-CHF2 , 4-C1-3-
F, E] , [-4977:2-CH2F,4-Cl-3-F,E] , [ -4978 : 2-CF3 CH2 , 4-C1-3-
F, E] , [-4979:2-MeO,4-Cl-3-F,E] , [-4980 : 2-EtO, 4-C1-3-F, E] ,
[-4981:2-C3H7O,4-Cl-3-F,E] , [-4982 : 2- (Me) 2 CHO, 4-C1-3-F, E] ,
[-4983:2-NO2 ,4-Cl-3-F,E] , [ -4984 : 2, 3-F2 , 4-C1-3-F, E ] , [- 4985:2, 4-F2 ,4-Cl-3-F,E ] , [ -4986 : 2 , 5-F2 , 4-C1-3-F, E ] , [ -
4987:2, 6-F2 ,4-Cl-3-F,E ] , [ -4988 : 3 , 4-F2 , 4-C1-3-F, E ] , [ -
4989:3, 4-F2 ,4-Cl-3-F,Z ] , [ -4990 : 3, 5-F2 , 4-C1-3-F, E ] , [ -
4991:3, 5-F2 ,4-Cl-3-F,Z ] , [ -4992 : 2, 3-Cl2 , 4-C1-3-F, E ] , [-
4993:2, 3-Cl2 ,4-Cl-3-F,z] , [ -4994 : 2 , 4-Cl2 , 4-C1-3-F, E ] , [- 4995:2, 4-Cl2 ,4-Cl-3-F,Z] , [ -4996 : 2, 5-Cl2 , 4-C1-3-F, E ] , [-
4997:2, 5-Cl2 ,4-Cl-3-F,Z] , [ -4998 : 2, 6-Cl2 , 4-C1-3-F, E ] , [- 4999:3, 4-Cl2 ,4-Cl-3-F,E) , C -5000 : 3, 5-Cl2 , 4-C1-3-F, E ] , [- 5001:2, 3-Br2, 4-Cl-3-F,E] , [ -5002 : 2, 4-Br2 , 4-C1-3-F, E ] , [- 5003:2, 5-Br2 ,4-Cl-3-F, E] , [ -5004 : 2, 6-Br2 , 4-C1-3-F, E ] , (- 5005:3, 4-Br2 ,4-Cl-3-F,E) , C -5006 : 3, 5-Br2 , 4-C1-3-F, E ) , [-
5007: 2, 3-Me2 ,4-Cl-3-F,E] , [ -5008 : 2, 4-Me2 , 4-C1-3-F, E ] , [- 5009:2, 5-Me2 ,4-Cl-3-F,E] , [ -5010 : 2, 6-Me2 , 4-C1-3-F, E ] , [- 5011:3, 4-Me2, 4-C1-3-F, E] , [ -5012 : 3, 5-Me2 , 4-C1-3-F, E ] , [- 5013:2, 3-Et2, 4-C1-3-F, E] , ( -5014 : 2, 4-Et2 , 4-C1-3-F, E ] , [- 5015:2, 5-Et2, 4-C1-3-F, E] , [ -5016 : 2, 6-Et2 , 4-C1-3-F, E ] , [-
5017:3, 4-Et2, 4-C1-3-F, E] , [ -5018 : 3, 5-Et2 , 4-C1-3-F, E ] , [- 5019:2,3- (CF3 J2 ,4-Cl-3-F,E] , [-5020 : 2, 4- (CF3 ) 2 , 4-C1-3-F, E] ,
[-5021:2, 5-(CF3J2, 4-C1-3-F, E] , [ -5022 : 2 , 6- (CF3 ) 2 , 4-C1-3- F, E] , [-5023:3, 4- (CF3 )2 , 4-C1-3-F, E] , [ -5024 : 3 , 5- (CF3 ) 2 , 4- Cl-3-F,E ] , [ -5025:2, 3-(CHF2 )2,4-Cl-3-F, E ] , [ -5026:2,4-
(CHF2 )2,4-Cl-3-F, E] , [ -5027 : 2 , 5- (CHF2 ) 2 , 4-C1-3-F, E ] , [- 5028:2,6- (CHF2 )2 , 4-C1-3-F, E ] , [ -5029 : 3, 4- (CHF2 ) 2 , 4-C1-3- F, E ] , [ -5030:3, 5-(CHF2 )2,4-Cl-3-F, E ] , [ -5031:2,3- (CH2F)2, 4-C1-3-F, E] , [ -5032 : 2 , 4- (CH2 F) 2 , 4-C1-3-F, E ] , [- 5033:2,5- (CH2F)2 , 4-C1-3-F, E ] , [ -5034 : 2, 6- (CH2 F) 2 , 4-C1-3-
F, E ] , [ -5035:3,4- (CH2F)2 , 4-C1-3-F, E ] , [ -5036:3,5-
(CH2F)2, 4-C1-3-F, E ] , [ -5037 : 2 , 3- (MeO) 2 , 4-C1-3-F, E ] , [ -
5038:2,4- (MeO)2 ,4-Cl-3-F,E] , [-5039 : 2, 5- (MeO) 2 , 4-C1-3-F, E] ,
[ -5040:2, 6- (MeO)2 , 4-C1-3-F, E ] , [ -5041 : 3, 4- (MeO) 2 , 4-C1-3- F, E] , [-5042:3, 5-(MeO)2 , 4-C1-3-F, E] , [-5043 : 2 , 3- (EtO) 2 , 4-
Cl-3-F,E ) , [ -5044:2, 4-(EtO)2 , 4-C1-3-F, E ] , [ -5045:2,5- (EtO)2 , 4-C1-3-F, E ] , [ -5046:2, 6- (EtO)2 ,4-Cl-3-Ff E ] , [ - 5047:3, 4-(EtO)2 , 4-C1-3-F, E] , [-5048 : 3, 5- (EtO) 2 , 4-C1-3-F, E] ,
[-5049:2-C1-3-F,4-C1-3-F,E] , [-5050 : 2-C1-4-F, 4-C1-3-F, E] , C-5051:2-Cl-5-Ff 4-Cl-3-FfE] , [-5052 : 2-C1-6-F, 4-C1-3-F, E] ,
[-5053.3-C1-2-F, 4-Cl-3-F,E] , [-5054 : 3-C1-4-F, 4-C1-3-F, E] ,
[-505513-Cl-S-FM-Cl-S-F7E] , [-5056 : 4-C1-2-F, 4-C1-3-F, E] ,
[-505714-Cl-S-FM-Cl-S-F7E] , [-5058 : 2-F-3-Me, 4-C1-3-F, E] ,
[-5059:2-F-4-Me,4-Cl-3-F,E] , [-5060 : 2-F-5-Me, 4-C1-3-F, E] , [-5061:2-F-6-Me,4-Cl-3-F,E] , [-5062 : 3-F-2-Me,4-Cl-3-F, E] ,
[-5063:3-F-4-Me,4-Cl-3-F,E] , [-5064 : 3-F-5-Me, 4-C1-3-F, E] ,
[-5065:4-F-2-Me,4-Cl-3-F,E] , [-5066 : 4-F-3-Me, 4-C1-3-F, E] ,
[ -5067:2-Cl-3-Me,4-Cl-3-F,E ] , [ -5068 : 2-Cl-4-Me, 4-C1-3-
F, E] , [-5069:2-Cl-5-Me,4-Cl-3-F,E] , [-5070 : 2-Cl-6-Me,4-Cl- 3-F,E] , C-5071:3-Cl-2-Me,4-Cl-3-F,E] , [-5072 : 3-Cl-4-Me, 4-
Cl-3-F,E] , [ -5073:3-Cl-5-Me,4-Cl-3-F,E ] , [-5074:4-01-2-
Me,4-Cl-3-F,E] , [-5075 : 4-Cl-3-Me, 4-C1-3-F, E] , [-5076:2-F-
3-CF3 , 4-C1-3-F,E] , [-5077:2-F-4-CF3 ,4-C1-3-F,E] , [-5078:2-
F-5-CF3 ,4-Cl-3-F,E ] , [ -5079:2-F-6-CF3 ,4-Cl-3-F,E ] , [ - 5080:3-F-2-CF3 ,4-Cl-3-F,E] , [-5081 : 3-F-4-CF3 ,4-Cl-3-F, E] ,
[ -5082:3-F-5-CF3 ,4-Cl-3-F,E ] , [ -5083 : 4-F-2-CF3 M-Cl-3-
F, E] , [-5084:4-F-3-CF3 ,4-Cl-3-F,E] , [ -5085 : 2-Cl-3-CF3 , 4-
Cl-3-F,E] , [-5086:2-Cl-4-CF3 ,4-Cl-3-F,E] , [-5087:2-01-5-
CF3,4-Cl-3-F,E] , [-5088:2-Cl-6-CF3,4-Cl-3-F,E] , [-5089:3- 01-2-CF3 ,4-Cl-3-F,E ] , [ -5090 : 3-01-4-CF3 , 4-C1-3-F, E ] , [-
5091:3-Cl-5-CF3 ,4-Cl-3-F,E] , [-5092 : 4-Cl-2-CF3 , 4-C1-3-F, E] ,
[-5093:4-Cl-3-CF3,4-Cl-3-F,E] , C -5094 : 2-Me-3-CF3 , 4-C1-3-
F, E] , [-5095:2-Me-4-CF3 ,4-Cl-3-F,E] , [-5096 : 2-Me-5-CF3 , 4-
Cl-3-F,E] , [-5097:2-Me-6-CF3 ,4-Cl-3-F,E] , [ -5098 : 3-Me-2- CF3 ,4-Cl-3-F,E] , [-5099:3-Me-4-CF3 ,4-Cl-3-F,E] , [-5100:3-
Me-5-CF3 ,4-Cl-3-F,E ] , [ -5101 : 4-Me-2-CF3 , 4-C1-3-F, E ] , [-
5102:4-Me-3-CF3 ,4-C1-3-F,E3 , [-5103 : 2-F-3-MeO, 4-C1-3-F, E] ,
[ -5104:2-F-4-MeO,4-Cl-3-F,E ] , [ -5105 : 2-F-5-MeO, 4-C1-3-
F, E] , [-5106:2-F-6-MeO,4-Cl-3-F,E] , [-5107 : 3-F-2-MeO, 4-C1- 3-F,E] , [-5108:3-F-4-MeO,4-Cl-3-F,E] , [-5109 : 3-F-5-MeO, 4- Cl-3-F,E] , [ -5110:4-F-2-MeO,4-Cl-3-F,E ] , [ -5111 : 4-F-3- MeO,4-Cl-3-F,E] , [ -5112 : 2-Cl-3-MeO, 4-C1-3-F, E] , [-5113:2- Cl-4-MeO,4-Cl-3-F,E ] , [ -5114 : 2-Cl-5-MeO, 4-C1-3-F, E ] , [- 5115:2-Cl-6-MeO, 4-Cl-3-F,E] , [-5116 : 3-Cl-2-MeO, 4-C1-3-F, E] , [ -5117:3-Cl-4-MeO,4-Cl-3-F,E ] , [ -5118 : 3-Cl-5-MeO, 4-C1-3- F, E] , C-5119:4-Cl-2-MeO,4-Cl-3-F,E] , [-5120 : 4-Cl-3-MeO, 4- Cl-3-F,E] , [-5121:2-Me-3-MeO,4-Cl-3-F,E] , [ -5122 : 2-Me-4- MeO,4-Cl-3-F,E] , [-5123 : 2-Me-5-MeO, 4-C1-3-F, E] , [-5124:2- Me-6-MeO,4-Cl-3-F,E 3 , [ -5125 : 3-Me-2-MeO, 4-C1-3-F, E ] , [- 5126:3-Me-4-MeO,4-Cl-3-F,E] , [-5127 : 3-Me-5-MeO, 4-C1-3-F, E] ,
[ -5128:4-Me-2-MeO,4-Cl-3-F,E ] , [ -5129 : 4-Me-3-MeO, 4-C1-3-
F, E ] , [ -5130:H,3-F-4- (Me)3CO, E ] , [ -5131 : 4-F, 3-F-4-
(Me)3CO, E] , [-5132:4-F,3-F-4- (Me)3CO, Z] , [ -5133 : 4-Cl, 3-F-
4-(Me)3CO, E] , [-5134:4-Cl,3-F-4- (Me)3CO, Z] , [-5135 : 4-Br, 3- F-4- (Me)3CO, E ] , [ -5136 : 4-1, 3-F-4- (Me) 3 CO, E ] , [-5137:4-
Me, 3-F-4- (Me)3CO, E ] , [ -5138 : 4-Me, 3-F-4- (Me) 3 CO, Z ] , C -
5139:4-Et,3-F-4-(Me)3CO,E] , [-5140 : 4-C3 H7 , 3-F-4- (Me) 3 CO, E] ,
( -5141:4- (Me)2CH, 3-F-4- (Me)3CO, E ] , [ -5142 : 4-CF3 , 3-F-4-
(Me)3CO, E ] , [ -5143:4-CF3 ,3-F-4- (Me)3CO, Z ] , ( -5144:4- C2F5 ,3-F-4- (Me)3CO, E] , [ -5145 : 4-C3 F7 , 3-F-4- (Me) 3 CO, E ] , [-
5146:4-(CF3 )2CF,3-F-4- (Me)3CO, E] , [-5147 : 4- (CF3 ) 2 CH, 3-F-4-
(Me)3CO, E ] , [ -5148:4-CHF2 ,3-F-4- (Me)3CO, E ] , [ -5149:4-
CH2F, 3-F-4- (Me)3CO, E] , [ -5150 : 4-CF3 CH2 , 3-F-4- (Me) 3 CO, E ] ,
[ -5151:4-MeO,3-F-4-(Me)3CO,E ] , [ -5152 : 4-MeO, 3-F-4- (Me)3CO, Z ) , ( -5153:4-EtO,3-F-4- (Me)3CO, E ] , [ -5154:4-
C3H7O, 3-F-4- (Me)3CO, E] , [-5155 : 4- (Me) 2 CHO, 3-F-4- (Me) 3 CO, E] ,
[ -5156:4-NO2 , 3-F-4- (Me) 3 CO, E ] , [ -5157 : 4-NO2 , 3-F-4-
(Me)3CO, Z] , [-5158:3-F,3-F-4- (Me)3CO, E] , [-5159 : 3-F, 3-F-4-
(Me)3CO, z] , [-5160:3-Cl,3-F-4- (Me)3CO, E] , [-5161 : 3-Cl, 3-F- 4-(Me)3CO, z] , [-5162 : 3-Br, 3-F-4- (Me) 3 CO, E] , [-5163:3-1,3-
F-4- (Me)3CO, E ] , [ -5164 : 3-Me, 3-F-4- (Me) 3 CO, E ] , [-5165:3-
Me, 3-F-4- (Me)3CO, Z ] , ( -5166 : 3-Et, 3-F-4- (Me) 3 CO, E ] , [ -
5167:3-C3H7 , 3-F-4- (Me) 3 CO, E ] , [ -5168 : 3- (Me) 2 CH, 3-F-4-
(Me)3CO, E] , [-5169:3-CF3 ,3-F-4- (Me)3CO, E] , [-5170 : 3-CF3 , 3- F-4- (Me)3CCZ] , [-5171 : 3-C2 F5 , 3-F-4- (Me) 3 CO, E] , [-5172:3-
C3F7 ,3-F-4- (Me)3C0,E] , [-5173 : 3- (CF3 ) 2 CF, 3-F-4- (Me) 3 CO, E] ,
[ -5174:3- (CF3 )2CH,3-F-4- (Me)3CCE ] , [ -5175 : 3-CHF2 , 3-F-4-
(Me)3CO, E ] , [ -5176:3-CHF2 , 3-F-4- (Me) 3 CO, Z ] , [ -5177:3-
CH2F, 3-F-4- (Me)3CO, E] , ( -5178 : 3-CH2 F, 3-F-4- (Me) 3 CO, Z ] , [- 5179:3-CF3CH2 ,3-F-4- (Me)3CO, E ] , [ -5180 : 3-MeO, 3-F-4-
(Me)3CO, E] , [-5181: 3-MeO, 3-F-4- (Me)3CO, Z] , [-5182 : 3-EtO, 3- F-4- (Me)3CO, E] , [-5183 : 3-C3 H70, 3-F-4- (Me) 3 CO, E] , [-5184:3- (Me)2CHO, 3-F-4- (Me)3CO, E] , [-5185 : 3-NO2 , 3-F-4- (Me) 3 CO, E] ,
[-5186:2-F,3-F-4-(Me)3CO,E] , [-5187 : 2-Cl, 3-F-4- (Me) 3 CO, E] , [-5188:2-Br,3-F-4-(Me)3CO,E] , [-5189 : 2-1, 3-F-4- (Me) 3 CO, E) ,
[ -5190:2-Me,3-F-4- (Me)3CO, E ] , [ -5191 : 2-Et , 3-F-4- (Me)3CO,E ] , [ -5192:2-C3H7 ,3-F-4- (Me)3CO, E ] , [ -5193:2- (Me)2CH, 3-F-4- (Me)3CO, E] , [ -5194 : 2-CF3 , 3-F-4- (Me) 3 CO, E ] ,
[ -5195:2-C2 F5 ,3-F-4- (Me)3CO, E ] , [ -5196 : 2-C3 F7 , 3-F-4- (Me)3CO, E] , [-5197:2- (CF3 )2CF,3-F-4- (Me)3CO, E] , [-5198:2-
(CF3 )2CH,3-F-4- (Me)3CO,E] , [-5199 : 2-CHF2 , 3-F-4- (Me) 3 CO, E] ,
[ -5200:2-CH2F,3-F-4-(Me)3CO,E ] , [ -5201 : 2-CF3 CH2 , 3-F-4-
(Me)3CO, E] , [-5202:2-MeO,3-F-4- (Me)3CO, E] , [-5203 : 2-EtO, 3-
F-4- (Me)3CO, E] , [-5204 : 2-C3 H7 O, 3-F-4- (Me) 3 CO, E] , [-5205:2- (Me)2CHO, 3-F-4- (Me)3CO, E] , [-5206 : 2-NO2 , 3-F-4- (Me) 3 CO, E] ,
[ -5207:2, 3-F2 ,3-F-4- (Me)3CO, E ] , [ -5208 : 2, 4-F2 , 3-F-4-
(Me)3CO, E] , [ -5209:2, 5-F2 ,3-F-4- (Me)3CO, E ] , [-5210:2,6-
F2 ,3-F-4- (Me)3CO, E ] , [ -5211 : 3, 4-F2 , 3-F-4- (Me) 3 CO, E ] , [-
5212:3, 4-F2 , 3-F-4- (Me) 3 CO, Z ] , [ -5213 : 3, 5-F2 , 3-F-4- (Me)3CCE] , [ -5214:3, 5-F2 ,3-F-4- (Me)3CO, Z ] , [-5215:2,3-
Cl2 ,3-F-4-(Me)3CO,E] , [-5216 : 2 , 3-Cl2 , 3-F-4- (Me) 3 CO, Z] , [-
5217:2, 4-Cl2 ,3-F-4- (Me)3CO, E ] , [ -5218 : 2, 4-Cl2 , 3-F-4-
(Me)3CO, Z] , [-5219:2, 5-Cl2 ,3-F-4- (Me)3CO, E] , [-5220:2,5-
Cl2 , 3-F-4- (Me)3CO, z] , [-5221 : 2, 6-Cl2 , 3-F-4- (Me) 3 CO, E] , [- 5222:3, 4-Cl2 , 3-F-4- (Me)3CO, E ] , [ -5223 : 3, 5-Cl2 , 3-F-4-
(Me)3CO, E] , [-5224:2, 3-Br2 ,3-F-4- (Me)3CO, E] , [-5225:2,4-
Br2 ,3-F-4- (Me)3CO, E] , [-5226 : 2 , 5-Br2 , 3-F-4- (Me) 3 CO, E] , [-
5227:2, 6-Br2 ,3-F-4- (Me)3CO, E ] , [ -5228 : 3, 4-Br2 , 3-F-4-
(Me)3CO, E] , [-5229:3, 5-Br2 ,3-F-4- (Me)3CO, E] , [-5230:2,3- Me2 ,3-F-4- (Me)3CO, E] , [-5231 : 2, 4-Me2 , 3-F-4- (Me) 3 CO, E] , [-
5232:2, 5-Me2 ,3-F-4- (Me)3CO, E ] , [ -5233 : 2, 6-Me2 , 3-F-4-
(Me)3CO, E] , [-5234:3, 4-Me2 ,3-F-4- (Me)3CO, E] , [-5235:3,5-
Me2 ,3-F-4- (Me)3CO, E] , [-5236 : 2, 3-Et2 , 3-F-4- (Me) 3 CO, E] , [-
5237:2, 4-Et2 , 3-F-4- (Me) 3 CO, E ] , [ -5238 : 2, 5-Et2 , 3-F-4- (Me)3CO, E] , [-5239:2, 6-Et2 ,3-F-4- (Me)3CO, E] , [-5240:3,4-
Et2 ,3-F-4- (Me) 3CO,E] , [-5241 : 3 , 5-Et2 , 3-F-4- (Me) 3 CO, E] , [- 5242:2,3- (CF3 )2 ,3-F-4- (Me)3CO, E] , [ -5243 : 2, 4- (CF3 ) 2 , 3-F-4- (Me)3C0,E ] , [ -5244:2, 5- (CF3 ) 2 , 3-F-4- (Me) 3 CO, E ] , C - 5245:2,6- (CF3 )2 , 3-F-4- (Me)3CO, E] , [ -5246 : 3, 4- (CF3 ) 2 , 3-F-4- (Me)3CO, E ] , [ -5247 : 3, 5- (CF3 ) 2 , 3-F-4- (Me) 3 CO, E ] , [ -
5248:2,3- (CHF2 )2 , 3-F-4- (Me) 3 CO, E] , [ -5249 : 2, 4- (CHF2 ) 2 , 3-F- 4-(Me)3CO, E ] , [ -5250:2,5- (CHF2 )2 , 3-F-4- (Me)3CO, E ] , [ - 5251:2, 6- (CHF2 )2 , 3-F-4- (Me)3CO, E] , [ -5252 : 3, 4- (CHF2 ) 2 , 3-F- 4-(Me)3CO, E ] , [ -5253:3,5- (CHF2 )2 ,3-F-4- (Me)3CO, E ] , [ - 5254:2,3- (CH2F)2 , 3-F-4- (Me) 3 CO, E] , [-5255 : 2 , 4- (CH2 F) 2 , 3-F-
4-(Me)3CO, E ] , [ -5256:2,5- (CH2 F)2 ,3-F-4- (Me)3CO, E ] , C - 5257:2, 6- (CH2F)2 ,3-F-4- (Me)3CO, E] , [ -5258 : 3, 4- (CH2 F) 2 , 3-F- 4-(Me)3CO, E ] , [ -5259:3, 5-(CH2F)2 , 3-F-4- (Me) 3 CO, E ] , [ - 5260:2,3- (MeO)2 ,3-F-4- (Me) 3CO,E] , [-5261 : 2 , 4- (MeO) 2 , 3-F-4- (Me)3CO, E ] , [ -5262:2, 5-(MeO)2 , 3-F-4- (Me) 3 CO, E ] , [ -
5263:2,6- (MeO)2 ,3-F-4- (Me)3CO, E] , (-5264 : 3, 4- (MeO) 2 , 3-F-4- (Me)3CO, E ] , C -5265:3, 5-(MeO)2 , 3-F-4- (Me) 3 CO, E ] , [ - 5266:2,3- (EtO)2 , 3-F-4- (Me) 3C0, E] , [-5267 : 2 , 4- (EtO) 2 , 3-F-4- (Me)3CO, E ] , [ -5268:2,5- (EtO)2 ,3-F-4- (Me)3CO, E ] , ( - 5269:2, 6- (EtO)2 ,3-F-4- (Me)3CO, E] , (-5270 : 3, 4- (EtO) 2 , 3-F-4-
(Me)3CO, E] , [-5271:3,5- (EtO)2 , 3-F-4- (Me) 3 CO, E] , [-5272:2- Cl-3-F,3-F-4-(Me)3CO,E] , (-5273 : 2-C1-4-F, 3-F-4- (Me) 3 CO, E] ,
[ -5274:2-Cl-5-F,3-F-4- (Me)3CO7E ] , [ -5275 : 2-C1-6-F, 3-F-4- (Me)3CO, E] , [-5276:3-Cl-2-F,3-F-4-(Me)3CO,E] , [-5277 :3-Cl- 4-F,3-F-4-(Me)3CO,E] , [-5278 : 3-C1-5-F, 3-F-4- (Me) 3 CO, E] , [-
5279:4-Cl-2-F,3-F-4- (Me)3CO, E ] , [ -5280 : 4-C1-3-F, 3-F-4- (Me)3CO, E] , C-5281:2-F-3-Me,3-F-4-(Me)3CO,E] , [-5282:2-F- 4-Me,3-F-4- (Me)3CO, E ] , [ -5283 : 2-F-5-Me, 3-F-4- (Me) 3 CO, E ] ,
( -5284:2-F-6-Me,3-F-4- (Me)3CO, E] , [ -5285 : 3-F-2-Me, 3-F-4- (Me)3CO7E] , [-5286 : 3-F-4-Me, 3-F-4- (Me) 3 CO, E] , [-5287:3-F-
5-Me,3-F-4- (Me)3CO, E] , [ -5288 : 4-F-2-Me, 3-F-4- (Me) 3 CO, E ] ,
[-5289:4-F-3-Me,3-F-4- (Me)3CO, E] , [ -5290 : 2-Cl-3-Me, 3-F-4-
(Me)3CO, E] , [-5291:2-Cl-4-Me,3-F-4- (Me)3CO, E] , (-5292:2-
Cl-5-Me,3-F-4- (Me)3CO, E ] , [ -5293 : 2-Cl-6-Me, 3-F-4- (Me)3CO, E] , (-5294:3-Cl-2-Me,3-F-4- (Me) 3CO,E] , [-5295:3-
Cl-4-Me,3-F-4-(Me)3CO,E ] , [ -5296 : 3-Cl-5-Me, 3-F-4-
(Me)3CO, E] , [-5297:4-Cl-2-Me,3-F-4- (Me)3CO, E] , (-5298:4-
Cl-3-Me,3-F-4- (Me) 3CO,E ] , [ -5299 : 2-F-3-CF3 , 3-F-4-
(Me)3CO, E] , [-5300:2-F-4-CF3,3-F-4-(Me)3CO,E] , [-5301.2-F- 5-CF3 ,3-F-4-(Me)3CO,E] , [-5302 : 2-F-6-CF3 , 3-F-4- (Me) 3 CO, E] ,
[-5303:3-F-2-CF3 ,3-F-4- (Me)3CO, E) , [-5304 : 3-F-4-CF3 , 3-F-4-
(Me)3CO, E] , [-5305:3-F-5-CF3 , 3-F-4- (Me) 3 CO, E] , [-5306:4-F-
2-CF3 ,3-F-4- (Me)3CO, E) , [-5307 : 4-F-3-CF3 , 3-F-4- (Me) 3 CO, E] ,
[-5308:2-Cl-3-CF3 ,3-F-4- (Me)3CO, E) , [-5309 : 2-Cl-4-CF3 , 3-F- 4-(Me)3CO, E ] , [ -5310 : 2-Cl-5-CF3 , 3-F-4- (Me) 3 CO, E ) , [ -
5311:2-Cl-6-CF3 ,3-F-4- (Me)3CO, E] , [-5312 : 3-Cl-2-CF3 , 3-F-4-
(Me)3CO, E] , [-5313:3-Cl-4-CF3 , 3-F-4- (Me) 3 CO, E) , [-5314:3-
Cl-5-CF3 ,3-F-4-(Me)3CO,E ) , [ -5315 : 4-Cl-2-CF3 , 3-F-4-
(Me)3CO, E] , [-5316:4-Cl-3-CF3 , 3-F-4- (Me)3CO, E] , [-5317:2- Me-3-CF3 ,3-F-4- (Me)3CO, E ] , [ -5318 : 2-Me-4-CF3 , 3-F-4-
(Me)3CO, E) , [-5319:2-Me-5-CF3 ,3-F-4- (Me) 3CO,E) , [-5320:2-
Me-6-CF3 ,3-F-4- (Me)3CO, E ) , [ -5321 : 3-Me-2-CF3 , 3-F-4-
(Me)3CO, E) , [-5322:3-Me-4-CF3 , 3-F-4- (Me)3CO, E) , [-5323:3-
Me-5-CF3 ,3-F-4- (Me)3CO, E ) , [ -5324 : 4-Me-2-CF3 , 3-F-4- (Me)3CO, E) , [-5325:4-Me-3-CF3 ,3-F-4- (Me) 3CO,E) , [-5326:2-
F-3-MeO,3-F-4- (Me)3CO, E ) , [ -5327 : 2-F-4-MeO, 3-F-4-
(Me)3CO, E) , [-5328:2-F-5-MeO,3-F-4- (Me)3CO, E) , [-5329:2-F-
6-MeO,3-F-4- (Me) 3CO,E) , [-5330 : 3-F-2-MeO, 3-F-4- (Me) 3 CO, E) ,
[-5331:3-F-4-MeO,3-F-4- (Me)3CO, E) , [-5332 : 3-F-5-MeO, 3-F-4- (Me)3CO, E] , [-5333 : 4-F-2-MeO, 3-F-4- (Me) 3 CO, E) , [-5334:4-F-
3-MeO,3-F-4- (Me) 3CO,E) , [-5335 : 2-Cl-3-MeO, 3-F-4- (Me) 3 CO, E) ,
[-5336:2-Cl-4-MeO,3-F-4- (Me)3CO, E) , [-5337 : 2-Cl-5-MeO, 3-F-
4-(Me)3CO, E ) , [ -5338:2-Cl-β-MeO,3-F-4- (Me)3CO, E ) , [ -
5339:3-Cl-2-MeO,3-F-4- (Me) 3CO,E) , [-5340 : 3-Cl-4-MeO, 3-F-4- (Me)3C0,E) , [-5341 : 3-Cl-5-MeO, 3-F-4- (Me) 3 CO, E] , [-5342:4-
Cl-2-MeO,3-F-4- (Me)3CO, E ] , C -5343 : 4-Cl-3-MeO, 3-F-4-
(Me)3CO, E] , [-5344:2-Me-3-MeO,3-F-4- (Me)3CO, E] , [-5345:2-
Me-4-MeO,3-F-4- (Me)3CO, E ] , [ -5346 : 2-Me-5-MeO, 3-F-4-
(Me)3CO, E] , [-5347 : 2-Me-6-MeO, 3-F-4- (Me)3CO, E] , [-5348:3- Me-2-MeO,3-F-4- (Me)3CO, E ] , [ -5349 : 3-Me-4-MeO, 3-F-4-
(Me)3CO, E] , [-5350:3-Me-5-MeO,3-F-4-(Me)3CO,E] , [-5351:4-
Me-2-MeO,3-F-4- (Me) 3C0,E ] , [ -5352 : 4-Me-3-MeO, 3-F-4-
(Me) 3 CO, E ] , C -5353 : H, 4 -Me, E ] , C -5354 : 4 -F, 4 -Me, E ] , [-5355:4-
F,4-Me,Z], [-5356:4-Cl,4-Me,E], [-5357 : 4-Cl, 4 -Me, Z] , [-5358:4- Br, 4 -Me, E], [-5359 : 4-1, 4 -Me, E] , [-5360 : 4 -Me, 4 -Me, E] , [-5361:4-
Me, 4 -Me, Z ] , [ -5362 : 4 -Et, 4 -Me, E ] , [ -5363: 4-C3 H7 , 4 -Me, E ] , [ -
5364:4- (Me) 2 CH, 4 -Me, E] , [-5365 : 4-CF3 , 4 -Me, E] , [-5366: 4-CF3 ,4-
Me, Z], [-5367: 4-C2 F5 ,4-Me, E], [-5368 : 4-C3 F7 ,4-Me, E], [-5369:4-
(CF3 )2CF,4-Me,E], [-5370 : 4- (CF3 ) 2 CH, 4-Me, E] , [-5371 : 4-CHF2 ,4- Me, E ] , [ -5372: 4-CH2 F, 4-Me, E ] , [ -5373 : 4-CF3 CH2 ,4-Me, E ) , ( -
5374:4-MeO,4-Me,E ] , [ -5375 : 4-MeO, 4-Me, Z ] , [ -5376 : 4-EtO, 4- Me, E ] , [ -5377: 4-C3 H70, 4-Me, E ] , [-5378:4- (Me) 2 CHO, 4-Me, E ] , [- 5379: 4-NO2 ,4-Me, E], [-5380: 4-NO2 ,4-Me,z], [-5381 : 3-F, 4-Me, E] , [-5382 :3-F, 4-Me, Z], [-5383 : 3-Cl, 4-Me, E] , [-5384 : 3-Cl, 4-Me, Z] , [-5385 :3-Br, 4-Me, E], [-5386 : 3-1, 4-Me, E] , [-5387 : 3-Me, 4-Me, E] ,
[ -5388: 3-Me, 4-Me, Z ] , [ -5389 : 3-Et , 4-Me, E ] , [ -5390: 3-C3 H7 ,4- Me, E ] , [ -5391: 3- (Me)2 CH, 4 -Me, E ] , [ -5392: 3-CF3 ,4-Me, E ] , [ - 5393: 3-CF3 ,4-Me, Z ] , [ -5394 : 3-C2 F5 ,4-Me,E] , [ -5395: 3-C3 F7 , 4- Me, E], [-5396:3- (CF3 ) 2 CF, 4-Me, E] , [-5397 : 3- (CF3 ) 2 CH, 4-Me, E], [- 5398: 3-CHF2 ,4-Me,E] , [ -5399 : 3-CHF2 ,4-Me,Z] , [ -5400 : 3-CH2 F, 4-
Me, E ] , C -5401: 3-CH2 F, 4 -Me, Z ] , C -5402 : 3-CF3 CH2 ,4-Me, E ] , C - 5403:3-MeO,4-Me,E ] , C -5404 : 3-MeO, 4 -Me, Z ] , C -5405 : 3-EtO, 4- Me, E ] , [ -5406 : 3-C3 H70,4-Me, E ] , [-5407:3- (Me) 2 CHO, 4 -Me, E ] , [■ 5408: 3-NO2 , 4 -Me, E], [-5409 : 2-F, 4 -Me, E], [-5410 : 2-Cl, 4 -Me, E], [- 5411:2-Br,4-Me,E], [-5412 : 2-1, 4 -Me, E] , [-5413 : 2 -Me, 4 -Me, E] , C-
5414:2-Et,4-Me,E], [-5415 : 2-C3 H7 ,4-Me, E], [-5416 : 2- (Me) 2 CH, 4- Me, E] , [-5417: 2-CF3 ,4-Me, E ] , [-5418 : 2-C2 F5 , 4-Me,E], [-5419:2- C3F7 ,4-Me, E], [ -5420 : 2- (CF3 ) 2 CF, 4 -Me, E] , [-5421 : 2- (CF3 ) 2 CH, 4- Me, E], [-5422: 2-CHF2 , 4-Me,E], [-5423 : 2-CH2 F, 4 -Me, E] , [-5424:2- CF3CH2 ,4-Me, E], [-5425 : 2-MeO, 4 -Me, E] , [-5426 : 2-EtO, 4 -Me, E] , C-
5427: 2-C3 H7 O, 4 -Me, E ] , [ -5428 : 2- (Me) 2 CHO, 4 -Me, E ] , [ -5429:2- NO2 ,4-Me,E] , [ -5430 : 2, 3-F2 ,4-Me,E] , [-5431:2, 4-F2 ,4-Me,E] , [- 5432: 2, 5-F2 ,4-Me, E ] , [-5433:2, 6-F2 ,4-Me, E ] , [ -5434 : 3, 4-F2 ,4- Me, E ] , [ -5435:3,4-F2,4-Me,Z ] , [ -5436 : 3, 5-F2 , 4 -Me, E ] , [ - 5437:3, 5-F2 ,4-Me, Z ] , [ -5438 : 2 , 3-Cl2 , 4 -Me, E ] , [ -5439:2,3-
Cl2 ,4-Me, z], [-5440 : 2, 4-Cl2 , 4 -Me, E], [-5441 : 2, 4-Cl2 ,4-Me, z], C- 5442:2, 5-Cl2 ,4-Me, E 3 , [ -5443 : 2, 5-Cl2 , 4 -Me, Z ] , [ -5444:2,6- Cl2 , 4-Me,E],C-5445:3,4-Cl2 , 4 -Me, E], [-5446 : 3, 5-Cl2 ,4-Me,E],[- 5447 :2, 3-Br2 ,4-Me, E ] , [ -5448 : 2, 4-Br2 , 4 -Me, E ] , [ -5449:2,5- Br2 , 4-Me,E],C-5450:2, 6-Br2 , 4 -Me, E] , [-5451 : 3, 4-Br2 ,4-Me,E], [-
5452: 3, 5-Br2 ,4-Me, E ] , [ -5453 : 2, 3-Me2 ,4-Me, E ] , [ -5454:2,4- Me2 , 4-Me,E],C-5455:2,5-Me2 , 4 -Me, E] , [-5456 : 2 , 6-Me2 , 4-Me,E], C- 5457: 3, 4-Me2 , 4 -Me, E ] , [ -5458 : 3, 5-Me2 , 4 -Me, E ] , [ -5459:2, 3- Et2 ,4-Me, E], [-5460:2, 4-Et2 , 4 -Me, E], [-5461 : 2, 5-Et2 , 4-Me,E], C- 5462:2, 6-Et2 ,4-Me, E ] , [ -5463 : 3, 4-Et2 ,4-Me, E ] , [ -5464:3,5-
Et2 ,4-Me, E] , [-5465:2,3- (CF3 )2 , 4-Me,E] , [-5466:2,4- (CF3 )2 , 4-- Me, E], [-5467: 2, 5- (CF3 ) 2 , 4 -Me, E], [-5468 : 2, 6- (CF3 )2 , 4-Me,E], C- 5469:3,4- (CF3 )2 ,4-Me, E ] , C -5470 : 3, 5- (CF3 ) 2 , 4 -Me, E ] , [ - 5471:2,3- (CHF2 )2 , 4 -Me, E ] , [ -5472 : 2, 4- (CHF2 ) 2 , 4 -Me, E ] , [ - 5473:2, 5- (CHF2 )2 ,4-Me, E ] , [ -5474 : 2, 6- (CHF2 ) 2 , 4 -Me, E ] , [ -
5475:3, 4-(CHF2 )2 ,4-Me, E ] , [ -5476 : 3, 5- (CHF2 ) 2 , 4 -Me, E ] , [ - 5477:2, 3-(CH2F)2 ,4-Me, E ] , [ -5478 : 2, 4- (CH2 F) 2 , 4 -Me, E ] , [ - 5479:2, 5-(CH2F)2 ,4-Me, E ] , [ -5480 : 2, 6- (CH2 F) 2 , 4 -Me, E ] , [ - 5481:3,4- (CH2F)2 , 4 -Me, E ] , [ -5482 : 3, 5- (CH2 F) 2 , 4 -Me, E ] , [ - 5483:2,3- (MeO)2 ,4-Me, E ] , [ -5484 : 2, 4- (MeO) 2 , 4 -Me, E ] , [ -
5485:2, 5-(MeO)2 ,4-Me, E ] , [ -5486 : 2, 6- (MeO) 2 , 4 -Me, E ] , [ - 5487:3, 4-(MeO)2 ,4-Me, E ] , [ -5488 : 3, 5- (MeO) 2 , 4 -Me, E ] , [ - 5489:2, 3-(EtO)2 ,4-Me, E ] , [ -5490 : 2, 4- (EtO) 2 , 4 -Me, E ] , [ - 5491:2, 5-(EtO)2 ,4-Me, E ] , [ -5492 : 2, 6- (EtO) 2 , 4 -Me, E ] , [ - 5493: 3, 4- (EtO)2 ,4-Me, E], [-5494 : 3, 5- (EtO) 2 ,4-Me, E], [-5495:2-
Cl-3-F,4-Me,E] , [ -5496 : 2-C1-4-F, 4-Me, E ] , [ -5497 : 2-C1-5-F, 4- Me, E] , [ -5498 :2-Cl-6-F, 4-Me, E] , [ -5499 : 3-C1-2-F, 4-Me, E ] , C- 5500:3-Cl-4-F,4-Me,E] , [ -5501 : 3-C1-5-F, 4-Me, E ] , C-5502.4-C1- 2-F,4-Me,E], [-5503 : 4-C1-3-F, 4-Me, E] , [-5504 : 2-F-3-Me, 4-Me, E] , [-5505 : 2-F-4 -Me, 4-Me, E], [-5506 : 2-F-5-Me, 4-Me, E] , [-5507 :2-F-
6-Me,4-Me,E ] , [ -5508 : 3-F-2-Me, 4-Me, E ] , [ -5509 : 3-F-4-Me, 4- Me, E] , [ -5510:3-F-5-Me,4-Me,E] , [ -5511 : 4-F-2-Me, 4-Me, E ] , [ - 5512:4-F-3-Me, 4-Me,E], [-5513 : 2-Cl-3-Me, 4-Me, E] , [-5514 :2-Cl- 4-Me,4-Me,E] , [ -5515 : 2-Cl-5-Me, 4-Me, E ] , [ -5516 : 2-Cl-6-Me, 4- Me, E], [-5517 :3-Cl-2-Me, 4-Me, E], [-5518 : 3-C1-4 -Me, 4-Me, E] , [-
5519:3-Cl-5-Me,4-Me,E] , [ -5520 : 4-Cl-2-Me, 4-Me, E ] , [-5521:4- Cl-3-Me, 4-Me,E ] , [ -5522 : 2-F-3-CF3 , 4-Me, E ] , [ -5523:2-F-4- CF3 ,4-Me, E ] , C -5524 : 2-F-5-CF3 ,4-Me, E ] , [ -5525 : 2-F-6-CF3 ,A- Me, E], C-5526:3-F-2-CF3 ,4-Me,E], [-5527 : 3-F-4-CF3 ,4-Me,E], [- 5528:3-F-5-CF3 , 4-Me,E], [-5529 : 4-F-2-CF3 ,4-Me,E], [-5530: 4-F- 3-CF3, 4-Me, E ] , [ -5531 : 2-Cl-3-CF3 , 4-Me, E ] , [ -5532 : 2-C1-4- CF3 ,4-Me, E D , [ -5533 : 2-Cl-5-CF3 , 4-Me, E] , [ -5534 : 2-Cl-6-CF3 ,4- Me,E],[-5535:3-Cl-2-CF3 , 4-Me, E] , [-5536 : 3-C1-4-CF3 , 4-Me,E],[- 5537:3-Cl-5-CF3 , 4-Me,E], [-5538 : 4-Cl-2-CF3 , 4-Me,E], [-5539:4- Cl-3-CF3 ,4-Me, E ] , [ -5540 : 2-Me-3-CF3 ,4-Me, E 3 , [ -5541 : 2-Me-4- CF3 ,4-Me, E ] , [ -5542 : 2-Me-5-CF3 , 4-Me,E] , [ -5543 : 2-Me-6-CF3 , A- Me,E],[-5544:3-Me-2-CF3 ,4-Me,E], [-5545 : 3-Me-4-CF3 , 4-Me,E], [- 5546:3-Me-5-CF3 , 4-Me,E], [-5547 : 4-Me-2-CF3 ,4-Me, E], [-5548:4- Me-3-CF3 , 4-Me, E ] , [ -5549 : 2-F-3-MeO, 4-Me, E ] , [ -5550:2-F-4- MeO, 4-Me, E ] , [ -5551 : 2-F-5-MeO, 4-Me, E ] , [ -5552 : 2-F-6-MeO, 4- Me, E] , [-5553 :3-F-2-MeO, 4-Me, E], [ -5554 : 3-F-4-MeO, 4-Me, E] , [- 5555 :3-F-5-MeO, 4-Me, E], [-5556 : 4-F-2-MeO, 4-Me, E] , [-5557:4-F- 3-MeO, 4-Me, E ] , [ -5558 : 2-Cl-3-MeO, 4-Me, E ] , [ -5559 : 2-C1-4- MeO, 4-Me, E ] , [ -5560 : 2-Cl-5-MeO, 4-Me, E ] , [ -5561 : 2-Cl-6-MeO, A- Me, E], [-5562: 3-Cl-2-MeO, 4-Me, E], [-5563: 3-Cl-4-MeO, 4-Me, E], [- 5564 :3-Cl-5-MeO, 4-Me, E], [-5565 : 4-Cl-2-MeO, 4-Me, E] , [-5566:4- Cl-3-MeO, 4-Me, E ] , [ -5567 : 2-Me-3-MeO, 4-Me, E ] , [ -5568 : 2-Me-A- MeO, 4-Me, E ] , [ -5569 : 2-Me-5-MeO, 4-Me, E ] , [ -5570 : 2-Me-6-MeO, A- Me,E],[-5571:3-Me-2-MeO,4-Me,E],C-5572:3-Me-4-MeO,4-Me,E], [- 5573 : 3-Me-5-MeO, 4-Me, E], [-5574 : 4-Me-2-MeO, 4-Me,E], [-5575:4-
Me-3-MeO,4-Me,E ] , C-5576:H, 3-Me,E ] , C -5577 : 4 -F, 3 -Me, E ] , [ -
5578:4-F,3-Me,Z], [-5579 : 4 -Cl, 3-Me, E] , [-5580 : 4 -Cl, 3-Me, z] , [- 5581 :4-Br, 3-Me, E], [-5582 : 4-1, 3-Me, E] , [-5583 : 4 -Me, 3-Me, E] , C-
5584 :4-Me, 3-Me, Z], [-5585 : 4 -Et, 3-Me, E] , [-5586 : 4-C3 H7 , 3-Me,E], [ -5587:4- (Me) 2 CH, 3-Me, E ] , [ -5588: 4-CF3 ,3-Me, E ] , [ -5589:4-
CF3 , 3-Me,z], [-5590: 4-C2 F5 ,3-Me, E], [-5591 : 4-C3 F7 , 3-Me,E], C- 5592:4- (CF3 ) 2 CF, 3-Me, E] , [-5593 : 4- (CF3 ) 2 CH, 3-Me, E] , [-5594:4- CHF2 ,3-Me, E], [-5595 : 4-CH2 F, 3-Me, E] , [-5596 : 4-CF3 CH2 ,3-Me, E], [ -5597: 4-MeO, 3-Me, E ] , [ -5598 : 4-MeO, 3-Me, Z ] , [ -5599 : 4-EtO, 3- Me,E] , [ -5600: 4-C3 H7 O, 3-Me, E ] , [-5601:4- (Me)2CHO, 3-Me, E ] , C-
5602: 4-NO2 , 3-Me,E], [-5603: 4-NO2 , 3-Me,Z], [-5604 : 3-F, 3-Me, E] , [-5605 :3-F, 3-Me, z], [-5606 : 3-Cl, 3-Me, E] , [-5607 : 3-Cl, 3-Me, Z] , [-5608 :3-Br, 3-Me, E], [-5609 : 3-1, 3-Me, E] , [-5610 : 3-Me, 3-Me, E] , [ -5611: 3-Me, 3-Me, Z ] , [ -5612 : 3-Et , 3-Me, E ] , [ -5613: 3-C3 H7 , 3- Me, E ] , C -5614: 3- (Me)2 CH, 3-Me, E ] , [ -5615: 3-CF3 ,3-Me, E ] , C -
5616: 3-CF3 ,3-Me, Z ] , [ -5617: 3-C2 F5 ,3-Me, E] , [ -5618: 3-C3 F7 , 3- Me, E], [-5619: 3- (CF3 ) 2 CF, 3-Me, E], [-5620:3- (CF3 ) 2 CH, 3-Me, E], C- 5621: 3-CHF2 ,3-Me,E] , [ -5622 : 3-CHF2 ,3-Me, Z] , C -5623 : 3-CH2 F, 3- Me, E ] , [ -5624:3-CH2F,3-Me,Z ] , [ -5625 : 3-CF3 CH2 ,3-Me, E ] , C - 5626:3-MeO,3-Me,E ] , [ -5627 : 3-MeO, 3-Me, Z 3 , [ -5628 : 3-EtO, 3-
Me, E ] , [-5629: 3-C3 H7 O, 3-Me, E ] , [-5630:3- (Me) 2 CHO, 3-Me, E ] , [- 5631: 3-NO2 , 3-Me, E], [-5632 : 2-F, 3-Me, E], [-5633 : 2-Cl, 3-Me, E], [- 5634 :2-Br, 3-Me, E], [-5635 : 2-1, 3-Me, E] , [-5636 : 2 -Me, 3-Me, E] , [- 5637 :2-Et, 3-Me, E], [-5638 : 2-C3 H7 ,3-Me, E], [-5639 : 2- (Me) 2 CH, 3- Me, E], [-5640: 2-CF3 ,3-Me, E], [ -5641 : 2-C2 F5 ,3-Me, E] , [-5642:2-
C3F7 ,3-Me, E], C -5643: 2- (CF3 ) 2 CF, 3-Me, E] , [-5644 : 2- (CF3 ) 2 CH, 3- Me, E], [-5645: 2-CHF2 ,3-Me, E], [-5646 : 2-CH2 F, 3-Me, E] , [-5647:2- CF3CH2 ,3-Me,E], [-5648 : 2-MeO, 3-Me, E] , [-5649 : 2-EtO, 3-Me, E] , [■ 5650: 2-C3 H7 O, 3-Me, E ] , [ -5651:2- (Me) 2 CHO, 3-Me, E ] , [ -5652:2- NO2 ,3-Me, E], [ -5653 : 2, 3-F2 ,3-Me, E] , [-5654 : 2, 4-F2 ,3-Me,E], C-
5655: 2, 5-F2 , 3-Me,E] , [ -5656 : 2, 6-F2 , 3-Me,E] , [ -5657 : 3, 4-F2 , 3- Me, E ] , [ -5658 :3, 4-F2 ,3-Me, Z ] , [ -5659 : 3, 5-F2 , 3-Me, E ] , C - 5660:3, 5-F2 ,3-Me, Z ] , [ -5661 : 2 , 3-Cl2 , 3-Me, E ] , [ -5662:2,3- Cl2 , 3-Me, z], [-5663: 2, 4-Cl2 ,3-Me, E], [-5664 : 2, 4-Cl2 , 3-Me, Z], C- 5665: 2, 5-Cl2 ,3-Me, E ] , [ -5666 : 2 , 5-Cl2 ,3-Me, Z ] , [ -5667:2, 6-
Cl2 ,3-Me, E], [-5668: 3, 4-Cl2 , 3-Me, E] , [-5669 : 3, 5-Cl2 , 3-Me,E], C- 5670:2, 3-Br2 ,3-Me, E ] , [ -5671 : 2, 4-Br2 ,3-Me, E ] , [ -5672:2,5- Br2 ,3-Me,E], [-5673:2, 6-Br2 , 3-Me,E], [-5674 : 3, 4-Br2 , 3-Me,E], C- 5675: 3, 5-Br2 ,3-Me, E ] , [ -5676 : 2 , 3-Me2 ,3-Me, E ] , [ -5677:2,4- Me2 ,3-Me,E], [-5678 : 2, 5-Me2 , 3-Me,E], [-5679:2, 6-Me2 ,3-Me,E], [-
5680: 3, 4-Me2 ,3-Me, E ] , [ -5681 : 3, 5-Me2 ,3-Me, E ] , [ -5682:2,3- Et2 , 3-Me, E], [-5683: 2, 4-Et2 ,3-Me, E], [-5684 : 2, 5-Et2 , 3-Me, E], C- 5685:2, 6-Et2 ,3-Me, E ] , [ -5686 : 3, 4-Et2 ,3-Me, E ] , [ -5687:3,5- Et2 ,3-Me, E] , [ -5688: 2, 3- (CF3 )2 , 3-Me,E] , [ -5689 : 2, 4- (CF3 ) 2 , 3- Me, E], [-5690: 2, 5- (CF3J2, 3-Me, E], [-5691: 2, 6- (CF3 ) 2 , 3-Me, E] , C-
5692:3, 4-(CF3 )2 ,3-Me, E ] , [ -5693 : 3, 5- (CF3 ) 2 , 3-Me, E ] , [ - 5694:2,3- (CHF2 )2 ,3-Me, E ] , [ -5695 : 2, 4- (CHF2 ) 2 , 3-Me, E ] , [ - 5696:2,5- (CHF2 )2 ,3-Me, E ] , [ -5697 : 2, 6- (CHF2 ) 2 , 3-Me, E ] , C - 5698 :3, 4- (CHF2 )2 ,3-Me, E ] , [ -5699 : 3, 5- (CHF2 ) 2 , 3-Me, E ] , [ - 5700:2, 3-(CH2 F)2 ,3-Me, E ] , [ -5701 : 2, 4- (CH2 F) 2 , 3-Me, E ] , C -
5702:2,5- (CH2F)2 ,3-Me, E ] , C -5703 : 2, 6- (CH2 F) 2 , 3-Me, E ] , C - 5704:3,4- (CH2F)2 , 3 -Me, E ] , C -5705 : 3, 5- (CH2 F) 2 , 3-Me, E ] , [ - 5706:2,3- (MeO)2 ,3-Me, E ] , C -5707 : 2, 4- (MeO) 2 , 3-Me, E ] , [ - 5708:2,5- (MeO)2 ,3-Me, E ] , [ -5709 : 2, 6- (MeO) 2 , 3-Me, E ] , [ - 5710:3, 4-(MeO)2 ,3-Me, E ] , C -5711 : 3, 5- (MeO) 2 , 3-Me, E ] , [ -
5712:2,3- (EtO)2 ,3-Me, E ] , C -5713 : 2, 4- (EtO) 2 , 3-Me, E ] , [ - 5714:2,5- (EtO)2 ,3-Me, E ] , C -5715 : 2, 6- (EtO) 2 , 3-Me, E ] , C - 5716:3,4- (EtO)2 , 3-Me,E], [-5717:3,5- (EtO)2 , 3-Me,E], [-5718:2- Cl-3-F,3-Me,E] , [ -5719 : 2-C1-4-F, 3-Me, E ] , [ -5720 : 2-C1-5-F, 3- Me, E] , [ -5721 :2-Cl-6-F, 3-Me, E] , [ -5722 : 3-C1-2-F, 3-Me, E ] , [-
5723 :3-Cl-4-F, 3-Me, E] , [ -5724 : 3-C1-5-F, 3-Me, E ] , C-5725: 4-C1- 2-F, 3-Me,E], [-5726 : 4-C1-3-F, 3-Me, E] , [-5727 : 2-F-3-Me, 3-Me, E] , C-5728:2-F-4-Me,3-Me,E], [-5729 : 2-F-5-Me, 3-Me, E] , [-5730:2-F- 6-Me,3-Me,E ] , [ -5731 : 3-F-2-Me, 3-Me, E ] , [ -5732 : 3-F-4-Me, 3- Me, E] , [ -5733 :3-F-5-Me, 3-Me, E] , [ -5734 : 4-F-2-Me, 3-Me, E ] , [-
5735 :4-F-3-Me, 3-Me, E], [-5736 : 2-Cl-3-Me, 3-Me, E] , C-5737.2-C1- 4-Me,3-Me,E] , [ -5738 : 2-Cl-5-Me, 3-Me, E ] , [ -5739 : 2-Cl-6-Me, 3- Me, E], [-5740 :3-Cl-2-Me, 3-Me, E], [-5741 : 3-Cl-4-Me, 3-Me, E] , [- 5742:3-Cl-5-Me,3-Me,E] , [ -5743 : 4-Cl-2-Me, 3-Me, E ] , [-5744:4- Cl-3-Me,3-Me,E ] , [ -5745 : 2-F-3-CF3 , 3-Me, E ] , [ -5746:2-F-4-
CF3 ,3-Me, E ] , [ -5747 : 2-F-5-CF3 ,3-Me, E ] , [ -5748 : 2-F-6-CF3 , 3- Me, E], [-5749:3-F-2-CF3 ,3-Me,E], [-5750 : 3-F-4 -CF3 , 3-Me,E], C- 5751:3-F-5-CF3 , 3-Me,E], [-5752 : 4-F-2-CF3 , 3-Me,E], [ -5753: 4 -F- 3-CF3, 3-Me, E ] , [ -5754 : 2-Cl-3-CF3 , 3-Me, E ] , [ -5755 : 2-C1-4- CF3 ,3-Me, E] , [ -5756 : 2-Cl-5-CF3 , 3-Me,E] , [ -5757 : 2-Cl-6-CF3 , 3-
Me,E],C-5758:3-Cl-2-CF3 , 3-Me, E] , [-5759 : 3-Cl-4-CF3 , 3-Me,E], C- 5760:3-Cl-5-CF3 , 3-Me,E], [-5761 : 4-Cl-2-CF3 , 3-Me,E], [-5762:4- CI-3-CF3 ,3-Me7E] , [ -5763:2-Me-3-CF3 ,3-Me,E] , [ -5764 : 2-Me-4- CF3 ,3-Me, E] , [ -5765 : 2-Me-5-CF3 ,3-Me,E] , [ -5766 : 2 -Me- 6-CF3 , 3- Me,E],[-5767:3-Me-2-CF3 , 3-Me, E] , [-5768 : 3-Me-4-CF3 ,3-Me, E], C-
5769:3-Me-5-CF3 , 3-Me,E], [-5770 : 4-Me-2-CF3 ,3-Me,E], [-5771:4- Me-3-CF3 ,3-Me, E ] , [ -5772 : 2-F-3-MeO, 3-Me, E ] , [ -5773:2-F-4- MeO, 3-Me, E ] , [ -5774 : 2-F-5-MeO, 3-Me, E ] , [ -5775 : 2-F-6-MeO, 3- Me, E], [-5776: 3-F-2-MeO, 3-Me, E], [ -5777 : 3-F-4 -MeO, 3-Me, E] , [- 5778 :3-F-5-MeO, 3-Me, E], [-5779 : 4-F-2-MeO, 3-Me, E] , [-5780 :4-F-
3-MeO, 3-Me, E ] , [ -5781 : 2-Cl-3-MeO, 3-Me, E ] , [ -5782 : 2-C1-4- MeO, 3-Me, E] , [ -5783 : 2-Cl-5-MeO, 3-Me, E ] , [ -5784 : 2-Cl-6-MeO, 3- Me,E],[-5785:3-Cl-2-MeO,3-Me,E], [-5786 : 3-C1-4 -MeO, 3-Me, E], [- 5787 :3-Cl-5-MeO, 3-Me, E], [-5788 : 4-Cl-2-MeO, 3-Me, E] , [-5789:4- Cl-3-MeO, 3-Me, E ] , [ -5790 : 2-Me-3-MeO, 3-Me, E ] , [ -5791 : 2 -Me- 4-
MeO, 3-Me, E ] , [ -5792 : 2-Me-5-MeO, 3-Me, E ] , [ -5793 : 2-Me- 6-MeO, 3- Me, E], [-5794: 3-Me-2-MeO, 3-Me, E], [-5795: 3-Me-4-MeO, 3-Me, E], C-
5796 :3-Me-5-MeO, 3-Me, E], [-5797 : 4-Me-2-MeO, 3-Me, E] , [-5798:4- Me-3-MeO,3-Me,E ] , [ -5799 :H, 2 -Me, E ] , [ -5800 : 4 -F, 2 -Me, E ] , [ - 5801:4-F,2-Me,Z], [-5802 : 4 -Cl, 2 -Me, E] , [-5803 : 4 -Cl, 2 -Me, z] , [-
5804:4-Br,2-Me,E], [-5805 : 4-1, 2 -Me, E] , [-5806 : 4 -Me, 2 -Me, E] , C- 5807:4-Me,2-Me,z], [-5808 : 4 -Et, 2 -Me, E] , [-5809 : 4-C3 H7 ,2-Me, E], [ -5810:4-(Me)2CH,2-Me,E ] , [ -5811 : 4-CF3 , 2 -Me, E ] , [ -5812:4- CF3 ,2-Me, Z ] , [-5813: 4-C2 F5 ,2-Me,E], [-5814 : 4-C3 F7 ,2-Me, E ] , C- 5815:4- (CF3 ) 2 CF, 2 -Me, E] , [-5816:4- (CF3 ) 2 CH, 2 -Me, E] , [-5817:4-
CHF2 ,2-Me, E], [-5818 : 4-CH2 F, 2 -Me, E] , [-5819 : 4-CF3 CH2 ,2-Me, E], [ -5820: 4-MeO, 2-Me, E ] , [ -5821 : 4-MeO, 2 -Me, Z ] , [ -5822 : 4-EtO, 2- Me, E ] , [ -5823: 4-C3 H70,2-Me, E ] , [-5824:4- (Me) 2 CHO, 2 -Me, E ] , C- 5825: 4-NO2 ,2-Me, E], [-5826: 4-NO2 ,2-Me, Z], [-5827 : 3-F, 2 -Me, E] , [-5828: 3-F, 2-Me,Z], [-5829 : 3-Cl, 2 -Me, E] , [-5830 : 3-Cl, 2 -Me, Z] ,
[-5831 :3-Br, 2-Me, E], [-5832 : 3-1, 2 -Me, E 3 , [-5833 : 3-Me, 2 -Me, E] , [ -5834:3-Me,2-Me,Z ] , [ -5835 : 3-Et , 2 -Me, E ] , [ -5836: 3-C3 H7 ,2- Me, E ] , [ -5837:3-(Me)2CH,2-Me,E ] , [ -5838: 3-CF3 ,2-Me, E ] , C - 5839: 3-CF3 ,2-Me, Z ] , [ -5840: 3-C2 F5 ,2-Me, E ] , [ -5841 : 3-C3 F7 ,2- Me, E], [-5842:3- (CF3 ) 2 CF, 2 -Me, E], [-5843 : 3- (CF3 ) 2 CH, 2 -Me, E], [-
5844 :3-CHF2 ,2-Me, E ] , [ -5845 : 3-CHF2 ,2-Me,z] , [ -5846 : 3-CH2 F, 2- Me, E ] , [ -5847:3-CH2F,2-Me,Z ] , [ -5848 : 3-CF3 CH2 ,2-Me, E ] , [ - 5849:3-MeO,2-Me,E ] , [ -5850 : 3-MeO, 2 -Me, Z ] , [ -5851 : 3-EtO, 2- Me, E] , [ -5852: 3-C3 H70,2-Me, E ] , [-5853:3- (Me) 2 CHO, 2 -Me, E ] , C- 5854: 3-NO2 , 2 -Me, E], [-5855 : 2-F, 2 -Me, E], [-5856 : 2-Cl, 2-Me, E], [-
5857:2-Br,2-Me,E], [-5858 : 2-1, 2-Me, E] , [-5859 : 2-Me, 2-Me, E] , C- 5860 :2-Et, 2-Me, E], [-5861 : 2-C3H7 ,2-Me,E], [-5862 : 2- (Me) 2 CH, 2- Me, E], C -5863: 2-CF3, 2-Me, E], [-5864 : 2-C2 F5 ,2-Me,E], [-5865:2- C3F7 ,2-Me, E], [-5866 : 2- (CF3 ) 2 CF, 2-Me, E] , [-5867 : 2- (CF3 )2CH,2- Me, E], [-5868: 2-CHF2 ,2-Me,E], [-5869 : 2-CH2 F, 2-Me, E] , [-5870:2-
CF3CH2 ,2-Me,E], [-5871 : 2-MeO, 2-Me, E] , [-5872 : 2-EtO, 2-Me, E] , [- 5873: 2-C3 H7 O, 2-Me, E ] , [ -5874 : 2- (Me) 2 CHO, 2-Me, E ] , [ -5875:2- NO2 ,2-Me, E] , [ -5876 : 2, 3-F2 ,2-Me,E], [ -5877 : 2, 4-F2 ,2-Me,E], [- 5878: 2, 5-F2 ,2-Me,E] , [-5879:2, 6-F2 , 2-Me,E] , [-5880:3, 4-F2, 2- Me, E ] , [ -5881:3, 4-F2, 2-Me, Z ] , [ -5882 : 3, 5-F2 , 2-Me, E ] , [ -
5883:3, 5-F2 , 2-Me,Z ] , C -5884 : 2 , 3-Cl2 , 2 -Me, E ] , [ -5885:2,3- Cl2 ,2-Me,z], [-5886:2, 4-Cl2 , 2 -Me, E], [-5887 : 2, 4-Cl2 , 2-Me,z],[- 5888: 2, 5-Cl2 ,2-Me, E ] , [ -5889 : 2, 5-Cl2 ,2-Me, Z ] , C -5890:2, 6- Cl2 ,2-Me, E], [-5891:3, 4-Cl2 , 2 -Me, E], [-5892 : 3, 5-Cl2 ,2-Me,E], C- 5893: 2, 3-Br2 ,2-Me, E ] , [ -5894 : 2, 4-Br2 ,2-Me, E ] , [ -5895:2,5-
Br2 ,2-Me, E], [-5896:2, 6-Br2 , 2 -Me, E], [-5897 : 3, 4-Br2 ,2-Me,E], [- 5898: 3, 5-Br2 ,2-Me, E ] , [ -5899 : 2 , 3-Me2 ,2-Me, E ] , [ -5900:2,4- Me2 ,2-Me,E],[-5901:2,5-Me2 , 2 -Me, E] , [-5902 : 2, 6-Me2 ,2-Me,E], [- 5903: 3, 4-Me2 ,2-Me, E ] , [ -5904 : 3, 5-Me2 ,2-Me, E ] , [ -5905:2,3- Et2 ,2-Me, E], [-5906 : 2, 4-Et2 ,2-Me,E], [-5907 : 2, 5-Et2 , 2-Me, E], C-
5908: 2, 6-Et2 ,2-Me, E ] , [ -5909 : 3, 4-Et2 ,2-Me, E ] , [ -5910:3,5- Et2,2-Me,E] , [-5911:2,3- (CF3 )2 ,2-Me, E ] , [ -5912 : 2, 4- (CF3 )2,2- Me, E], [-5913: 2, 5- (CF3 )2 , 2 -Me, E], [-5914 : 2, 6- (CF3 )2 ,2-Me,E], C- 5915:3, 4-(CF3)2 ,2-Me, E ] , [ -5916 : 3, 5- (CF3 ) 2 , 2-Me, E ] , C - 5917:2, 3-(CHF2 )2 ,2-Me, E ] , [ -5918 : 2 , 4- (CHF2 ) 2 , 2-Me, E ] , C -
5919:2, 5-(CHF2 )2 ,2-Me, E ] , [ -5920 : 2 , 6- (CHF2 ) 2 , 2-Me, E ] , C - 5921:3,4- (CHF2 )2 ,2-Me, E ] , [ -5922 : 3, 5- (CHF2 ) 2 , 2-Me, E ] , C - 5923:2, 3-(CH2F)2 ,2-Me, E ] , [ -5924 : 2, 4- (CH2 F) 2 , 2-Me, E ] , C - 5925:2,5- (CH2F)2 ,2-Me, E ] , [ -5926 : 2, 6- (CH2 F) 2 , 2-Me, E ] , C - 5927:3, 4-(CH2F)2, 2-Me, E ] , [ -5928 : 3, 5- (CH2 F) 2 , 2-Me, E ] , [ -
5929:2,3- (MeO)2 ,2-Me, E ] , [ -5930 : 2 , 4- (MeO) 2 , 2-Me, E ] , [ - 5931:2,5- (MeO)2 ,2-Me, E ] , [ -5932 : 2 , 6- (MeO) 2 , 2-Me, E ] , [ - 5933:3,4- (MeO)2 ,2-Me, E ] , [ -5934 : 3, 5- (MeO) 2 , 2-Me, E ] , [ - 5935:2,3- (EtO)2 ,2-Me, E ] , [ -5936 : 2, 4- (EtO) 2 , 2-Me, E ] , [ - 5937:2,5- (EtO)2 ,2-Me, E ] , [ -5938 : 2, 6- (EtO) 2 , 2-Me, E ] , [ -
5939:3,4- (EtO)2 ,2-Me, E], [-5940:3,5- (EtO)2 ,2-Me, E], [-5941:2- Cl-3-F,2-Me,E] , [ -5942 : 2-C1-4-F, 2 -Me, E ] , [ -5943 : 2-C1-5-F, 2- Me, E ] , [ -5944:2-Cl-6-F,2-Me, E] , [ -5945 : 3-C1-2-F, 2-Me, E ] , [ - 594β:3-Cl-4-F,2-Me,E] , [ -5947 : 3-C1-5-F, 2-Me, E ] , [-5948:4-01- 2-F,2-Me,E], [-5949 : 4-C1-3-F, 2-Me, E] , [-5950 : 2-F-3-Me, 2-Me, E] ,
[-5951:2-F-4-Me,2-Me,E], [-5952 : 2-F-5-Me, 2-Me, E] , [-5953:2-F- β-Me,2-Me,E } , [ -5954 : 3-F-2-Me, 2-Me, E ] , [ -5955 : 3-F-4-Me, 2- Me, E ] , [ -5956:3-F-5-Me,2-Me,E] , [ -5957 : 4-F-2-Me, 2-Me, E ] , [- 5958:4-F-3-Me,2-Me,E], [-5959 : 2-Cl-3-Me, 2-Me, E] , [-5960: 2 -Cl- 4-Me,2-Me,E] , [ -5961 : 2-Cl-5-Me, 2-Me, E ] , [ -5962 : 2-Cl-6-Me, 2-
Me, E], [-5963:3-Cl-2-Me,2-Me,E] , [ -5964 : 3-Cl-4-Me, 2-Me, E] , [- 5965:3-Cl-5-Me,2-Me,E] , [ -5966 : 4-Cl-2-Me, 2-Me, E ] , [ -5967: 4- Cl-3-Me,2-Me,E ] , [ -5968 : 2-F-3-CF3 , 2-Me, E ] , [ -5969:2-F-4- CF3 ,2-Me, E ] , [ -5970 : 2-F-5-CF3 ,2-Me, E ] , [ -5971 : 2-F- 6-CF3 ,2- Me,E] , [-5972:3-F-2-CF3 ,2-Me,E] , [ -5973 : 3-F-4 -CF3 ,2-Me,E] , [-
5974:3-F-5-CF3 ,2-Me,E], [-5975 : 4-F-2-CF3 ,2-Me,E], [-5976:4-F- 3-CF3, 2-Me, E ] , [ -5977 : 2-Cl-3-CF3 , 2-Me, E ] , [ -5978 : 2-C1-4- CF3 ,2-Me,E] , [ -5979 : 2-Cl-5-CF3 ,2-Me,E] , [ -5980 : 2-01-6-CF3 ,2- Me, E], [-5981: 3-01-2-CF3 , 2-Me, E] , [-5982 : 3-C1-4 -CF3 f 2-Me, E], C- 5983:3-Cl-5-CF3 ,2-Me,E], [-5984 : 4-Cl-2-CF3 ,2-Me,E], [-5985:4-
Cl-3-CF3 ,2-Me, E ] , [ -5986 : 2-Me-3-CF3 ,2-Me, E] , [ -5987 : 2-Me-4- CF3 ,2-Me, E] , [ -5988 : 2-Me-5-CF3 , 2-Me,E] , [ -5989 : 2-Me-6-CF3 ,2- Me,E],[-5990:3-Me-2-CF3 , 2-Me, E], [-5991 : 3-Me-4 -CF3 ,2-Me,E], [- 5992 :3-Me-5 -CF3 ,2-Me,E], [-5993 : 4-Me-2-CF3 , 2-Me,E], [-5994:4- Me-3-CF3 ,2-Me, E ] , [ -5995 : 2-F-3-MeO, 2-Me, E ] , [ -5996:2-F-4-
MeO,2-Me,E ] , [ -5997 : 2-F-5-MeO, 2-Me, E ] , C -5998 : 2-F-β-MeO, 2- Me, E] , [ -5999 :3-F-2-MeO, 2-Me, E] , C -6000 : 3-F-4-MeO, 2-Me, E] , C- 6001 :3-F-5-MeO, 2-Me, E], [-6002 : 4-F-2-MeO, 2-Me, E] , [-6003:4-F- 3-MeO, 2-Me, E ] , C -6004 : 2-Cl-3-MeO, 2-Me, E ] , C -6005 : 2-C1-4- MeO, 2-Me, E] , C -6006 : 2-Cl-5-MeO, 2-Me, E ] , [ -6007 : 2-Cl-6-MeO, 2-
Me, E], [- 6008 :3-Cl-2-MeO, 2-Me, E],[- 6009 :3-Cl-4 -MeO, 2-Me, E], [- 6010:3-Cl-5-MeO,2-Me,E], [-6011 : 4-Cl-2-MeO, 2-Me, E] , [-6012:4- Cl-3-MeO,2-Me,E] , [ -6013 : 2-Me-3-MeO, 2-Me, E ] , [ -6014 : 2-Me-4- MeO, 2-Me, E] , [ -6015 : 2-Me-5-MeO, 2-Me, E ] , [ -6016 : 2 -Me- 6-MeO, 2- Me,E],[-6017:3-Me-2-MeO,2-Me,E],[-6018:3-Me-4-MeO,2-Me,E],[-
6019 : 3-Me-5-MeO, 2-Me, E] , [-6020 : 4-Me-2-MeO, 2-Me, E] , [-6021 : 4- Me-3-MeO,2-Me,E], [-6022:H,3, 4-Me2 ,E], [-6023 : 4 -F, 3, 4-Me2 ,E], [ -6024:4-F,3,4-Me2 ,Z ] , [ -6025 : 4-Cl, 3, 4-Me2 , E ] , [ -6026:4- Cl, 3, 4-Me2 , Z], [-6027 : 4 -Br, 3, 4-Me2 ,E], [-6028:4-1,3, 4-Me2 ,E], [ -6029:4-Me,3,4-Me2 , E ] , [ -6030 : 4 -Me, 3, 4-Me2 , z ] , [ - 6031:4-
Et, 3, 4-Me2, E ] , [ -6032 : 4-C3 H7 , 3, 4-Me2 , E ] , [ -6033:4-
(Me)2CH, 3, 4-Me2 , E ] , [ -6034 : 4-CF3 , 3, 4-Me2 , E ] , [ -6035:4-
CF3 ,3,4-Me2 , z] , [ -6036 : 4-C2 F5 ,3,4-Me2 , E] , [ -6037 : 4-C3 F7 ,3,4-
Me2 ,E] , [-6038: 4- (CF3) 2 CF, 3, 4-Me2 , E ] , [ -6039 : 4- (CF3 ) 2 CH, 3, 4- Me2 , E], [-6040: 4-CHF2 ,3,4-Me2 ,E], [-6041 : 4-CH2 F, 3, 4-Me2 , E], [-
6042: 4-CF3 CH2 ,3,4-Me2 , E] , [ -6043 : 4-MeO, 3, 4-Me2 ,E], [-6044:4- MeO, 3, 4-Me2 , Z] , [ -6045 : 4-EtO, 3, 4-Me2 , E] , [ -6046 : 4-C3 H7 O, 3, 4- Me2 , E], [-6047:4- (Me)2CHO, 3, 4-Me2 ,E], [-6048: 4-NO2 ,3, 4-Me2 ,E], [ -6049: 4-NO2 ,3,4-Me2 , Z ] , [ -6050 : 3-F, 3, 4-Me2 , E ] , [ -6051:3- F, 3, 4-Me2 ,Z], [-6052 : 3-Cl, 3, 4-Me2 , E] , [-6053 : 3-Cl, 3, 4-Me2 ,Z],
C -6054:3-Br,3,4-Me2 ,E ] , C -6055 : 3-1, 3, 4-Me2 , E ] , [ -6056:3-
Me, 3,4-Me2 , E], [-6057 : 3-Me, 3, 4-Me2 , Z], C-6058:3-Et, 3,4-Me2 , E],
[ -6059: 3-C3 H7 ,3,4-Me2 , E ] , [ -6060 : 3- (Me) 2 CH, 3, 4-Me2 , E ] , C -
6061: 3-CF3, 3, 4 -Me2 , E ] , [ -6062: 3-CF3 ,3,4-Me2 , Z ] , [ -6063 : 3- C2F5 ,3,4-Me2 , E ] , C -6064 : 3-C3 F7 , 3, 4-Me2 , E ] , C -6065:3-
(CF3 )2CF,3, 4-Me2 , E] , [-6066:3- (CF3 )2CH,3, 4-Me2 , E] , [-6067:3-
CHF2 ,3,4-Me2 ,E], [-6068 : 3-CHF2 ,3,4-Me2 , z], [-6069 : 3-CH2 F, 3, 4 -
Me2 ,E], [-6070: 3-CH2 F, 3, 4-Me2 ,Z], [-6071 : 3-CF3 CH2 ,3,4-Me2 , E],
[ -6072: 3-MeO, 3, 4-Me2 , E] , [ -6073 : 3-MeO, 3, 4-Me2 , Z] , [-6074:3- EtO, 3, 4-Me2 , E ] , [ -6075 : 3-C3 H7 O, 3, 4-Me2 , E ] , [ -6076:3-
(Me)2 CHO, 3, 4-Me2 , E], [-6077: 3-NO2 ,3,4-Me2 , E], [-6078 : 2-F, 3, A-
Me2 ,E ] , [ -6079:2-Cl,3,4-Me2 , E ] , [ -6080 : 2-Br, 3, 4-Me2 ,E ] , C-
6081: 2-1, 3, 4-Me2 , E], [-6082 : 2 -Me, 3, 4-Me2 ,E], [-6083 : 2 -Et , 3, 4-
Me2 , E], [-6084: 2-C3 H7 , 3, 4-Me2 , E], [-6085 : 2- (Me) 2 CH, 3, 4-Me2 , E], [-6086: 2-CF3 ,3,4-Me2 ,E) , [ -6087 : 2-C2 F5 ,3,4-Me2 ,E], [-6088:2-
C3F7 ,3,4-Me2 , E } , [ -6089 : 2- (CF3 ) 2 CF, 3, 4-Me2 , E ] , [ -6090:2-
(CF3 )2CH,3, 4-Me2 ,E ] , [ -6091 : 2-CHF2 , 3, 4-Me2 , E D , [ -6092:2-
CH2 F, 3, 4-Me2 , E ] , [ -6093 : 2-CF3 CH2 , 3, 4-Me2 , E ] , [ -6094:2-
MeO, 3,4-Me2 , E ] , [ -6095 : 2-EtO, 3, 4-Me2 , E] , [ -6096 : 2-C3 H7 O, 3, A- Me2 ,E], [-6097: 2- (Me) 2 CHO, 3, 4 -Me2 , E], [-6098 : 2-NO2 ,3,4-Me2 ,E],
[ -6099:2, 3-F2 ,3,4-Me2 , E ] , [ -6100 : 2, 4-F2 , 3, 4-Me2 , E ] , [ - 6101: 2, 5-F2 ,3,4-Me2 , E] , [-6102 : 2, 6-F2 ,3,4-Me2 , E], [-6103:3, 4- F2 ,3,4-Me2 , E ] , [ -6104 : 3, 4-F2 ,3,4-Me2 , Z ] , [ -6105: 3, 5-F2 ,3,4- Me2 ,E], [-6106:3, 5-F2 ,3,4-Me2 , Z] , [-6107 : 2, 3-Cl2 ,3,4-Me2 ,E],[- 6108:2, 3-Cl2 ,3,4-Me2 , Z ] , [ -6109 : 2, 4-Cl2 , 3, 4-Me2 , E ] , [ -
6110:2, 4-Cl2, 3, 4-Me2, Z ] , [ -6111:2, 5-Cl2 , 3, 4-Me2 , E ] , [ - 6112:2, 5-Cl2 ,3,4-Me2 , Z 3 , C -6113 : 2 , 6-Cl2 , 3, 4-Me2 , E ] , C - 6114:3, 4-Cl2 ,3,4-Me2 , E 3 , C -6115 : 3, 5-Cl2 , 3, 4-Me2 , E ] , C - 6116:2, 3-Br2 ,3,4-Me2 , E ] , C -6117 : 2, 4-Br2 , 3, 4-Me2 , E 3 , [ - 6118:2, 5-Br2 ,3,4-Me2 , E ] , C -6119 : 2, 6-Br2 , 3, 4-Me2 , E ] , C -
6120:3, 4-Br2 ,3,4-Me2 , E ] , C -6121 : 3, 5-Br2 , 3, 4-Me2 , E ] , [ - 6122:2, 3-Me2 ,3,4-Me2 , E ] , C -6123 : 2, 4-Me2 , 3, 4-Me2 , E ] , C - 6124:2, 5-Me2 ,3,4-Me2 , E ] , [ -6125 : 2, 6-Me2 , 3, 4-Me2 , E ] , C - 6126:3, 4-Me2 ,3,4-Me2 , E 3 , C -6127 : 3, 5-Me2 , 3, 4-Me2 , E 3 , [ - 6128:2, 3-Et2 ,3,4-Me2 , E ] , C -6129 : 2, 4-Et2 , 3, 4-Me2 , E ] , C -
6130:2, 5-Et2 ,3, 4-Me2, E 3 , [ -6131 : 2 , 6-Et2 , 3, 4-Me2 , E 3 , C - 6132:3, 4-Et2 ,3,4-Me2 , E 3 , C -6133 : 3, 5-Et2 , 3, 4-Me2 , E 3 , C - 6134:2, 3- (CF3 )2,3,4-Me2 ,E3 , C -6135 : 2, 4- (CF3 ) 2 , 3, 4-Me2 , E 3 , C- 6136:2, 5- (CF3 ) 2 , 3, 4-Me2 , E 3 , C -6137 : 2, 6- (CF3 ) 2 , 3, 4-Me2 , E 3 , C- 6138:3,4- (CF3 )2 ,3,4-Me2 ,E3 , C -6139 : 3, 5- (CF3 ) 2 ,3,4-Me2 ,E3 , C-
6140: 2, 3- (CHF2 )2,3,4-Me2 ,E] , [ -6141 : 2, 4- (CHF2 ) 2 , 3, 4-Me2 , E 3 , [-6142:2,5- (CHF2 )2 ,3,4-Me2 , E 3 , [-6143 : 2 , 6- (CHF2 )2 ,3,4-Me2 ,E3, [-6144: 3, 4- (CHF2 ) 2 , 3, 4-Me2 , E 3 , [-6145 : 3, 5- (CHF2 )2 ,3,4-Me2,E3, [ -6146: 2, 3- (CH2 F) 2, 3, 4-Me2, E], [-6147 : 2, 4- (CH2 F) 2 ,3,4-Me2,E3, [ -6148: 2, 5- (CH2 F) 2, 3, 4-Me2, E], [-6149 : 2, 6- (CH2 F) 2 ,3,4-Me2 ,E],
[-6150: 3, 4- (CH2 F) 2 ,3,4-Me2 ,E], [-6151 : 3, 5- (CH2 F) 2 ,3,4-Me2 ,E], [-6152:2,3- (MeO)2 ,3,4-Me2 , E], [-6153 : 2, 4- (MeO) 2 ,3,4-Me2 ,E3, [- 6154:2,5- (MeO)2 ,3,4-Me2 ,E] , [-6155:2, 6- (MeO)2 ,3,4-Me2 , E] , [- 6156:3,4- (MeO)2 ,3,4-Me2 ,E], [ -6157 : 3, 5- (MeO) 2 , 3, 4-Me2 , E 3 , C- 6158:2, 3- (EtO) 2 ,3,4-Me2 ,E] , C -6159: 2, 4- (EtO) 2 ,3, 4-Me2, E 3 , C-
6160:2,5- (EtO)2 ,3,4-Me2 ,E] , [-6161:2, 6- (EtO) 2 ,3,4-Me2,E] , [ 6162:3,4- (EtO)2 ,3,4-Me2 ,E] , [-6163:3, 5- (EtO) 2 ,3,4-Me2 ,E] , [ 6164:2-Cl-3-F,3,4-Me2 ,E 3 , [ -6165 : 2-C1-4-F, 3, 4-Me2 , E ] , [ 6166:2-Cl-5-F,3,4-Me2 ,E ] , [ -6167 : 2-C1-6-F, 3, 4-Me2 , E 3 , [ 6168:3-Cl-2-F,3,4-Me2 ,E 3 , [ -6169 : 3-C1-4-F, 3, 4-Me2 , E 3 , [
6170:3-Cl-5-F,3,4-Me2 ,E ] , [ -6171 : 4-C1-2-F, 3, 4-Me2 , E ] , [ 6172:4-Cl-3-F,3,4-Me2 ,E ] , [ -6173 : 2-F-3-Me, 3, 4-Me2 , E 3 , [ 6174:2-F-4-Me,3,4-Me2 ,E ] , [ -6175 : 2-F-5-Me, 3, 4-Me2 , E 3 , [ 6176:2-F-6-Me,3,4-Me2 ,E 3 , [ -6177 : 3-F-2-Me, 3, 4-Me2 , E ] , [ 6178:3-F-4-Me,3,4-Me2 ,E 3 , C -6179 : 3-F-5-Me, 3, 4-Me2 , E 3 , [ ■
6180:4-F-2-Me,3,4-Me2 ,E 3 , C -6181 : 4-F-3-Me, 3, 4-Me2 , E 3 , [ 6182:2-Cl-3-Me,3,4-Me2 ,E 3 , [ -6183 : 2-Cl-4-Me, 3, 4-Me2 ,E 3 , [ 6184 :2-Cl-5-Me,3, 4-Me2 , E 3 , [ -6185 : 2-Cl-6-Me, 3, 4-Me2 , E 3 , [ 6186:3-Cl-2-Me,3,4-Me2 , E 3 , C -6187 : 3-Cl-4-Me, 3, 4-Me2 ,E 3 , [ • 6188:3-Cl-5-Me,3,4-Me2 , E 3 , C -6189 : 4-Cl-2-Me, 3, 4-Me2 , E 3 , [
6190:4-Cl-3-Me,3,4-Me2 , E 3 , C -6191 : 2-F-3-CF3 ,3,4-Me2 , E 3 , [ 6192:2-F-4-CF3 ,3,4-Me2 , E 3 , [ -6193 : 2-F-5-CF3 ,3,4-Me2 , E 3 , [ ■ 6194 :2-F- 6-CF3 ,3,4-Me2 , E 3 , [ -6195 : 3-F-2-CF3 ,3,4-Me2 , E 3 , [ 6196:3-F-4-CF3 ,3,4-Me2 , E 3 , [ -6197 : 3-F-5-CF3 ,3, 4-Me2 , E 3 , [ ■ 6198:4-F-2-CF3 ,3,4-Me2 ,E ] , [ -6199 : 4-F-3-CF3 ,3,4-Me2 ,E ] , [ ■
6200:2-Cl-3-CF3 ,3,4-Me2 ,E3 , [ -6201 : 2-Cl-4-CF3 ,3, 4-Me2, E 3 , [• 6202:2-Cl-5-CF3 ,3,4-Me2 ,E3 , [ -6203 : 2-Cl-6-CF3 ,3,4-Me2 ,E3 , [■ 6204:3-Cl-2-CF3 ,3,4-Me2 ,E3 , [ -6205 : 3-C1-4 -CF3 ,3,4-Me2 ,E] , [• 6206:3-Cl-5-CF3,3,4-Me2 ,E] , [ -6207 : 4-Cl-2-CF3 ,3,4-Me2 ,E] , [■ 6208:4-Cl-3-CF3 ,3,4-Me2 ,E3 , [ -6209 : 2-Me-3-CF3 ,3,4-Me2 , E 3 , [■
6210:2-Me-4-CF3 ,3,4-Me2 ,E] , C -6211 : 2-Me-5-CF3 ,3,4-Me2 , E] , C- 6212: 2 -Me- 6-CF3 ,3,4-Me2 , E] , C -6213 : 3-Me-2-CF3 ,3, 4-Me2 , E] , C- 6214 :3-Me-4 -CF3 ,3,4-Me2 , E] , C -6215 : 3-Me-5-CF3 ,3,4-Me2 , E] , C- 6216:4-Me-2-CF3 ,3,4-Me2 , E] , C -6217 : 4-Me-3-CF3 ,3,4-Me2 , E] , C- 6218:2-F-3-MeO,3,4-Me2 , E ] , C -6219 : 2-F-4-MeO, 3, 4-Me2 , E ] , C -
6220:2-F-5-MeO,3,4-Me2 ,E ] , C -6221 : 2-F-6-MeO, 3, 4-Me2 ,E D , C - 6222:3-F-2-MeO,3,4-Me2 , E ] , C -6223 : 3-F-4-MeO, 3, 4-Me2 , E ] , C- 6224 :3-F-5-MeO,3, 4-Me2 , E ] , C -6225 : 4-F-2-MeO, 3, 4-Me2 , E ] , C-
6226:4-F-3-MeO,3,4-Me2-,E] , C -6227 : 2-Cl-3-MeO, 3, 4-Me2 , E ] , C- 6228:2-Cl-4-MeO,3,4-Me2 , E] , C -6229 : 2-Cl-5-MeO, 3, 4-Me2 ,E] , C-
6230:2-Cl-6-MeO,3,4-Me2 , E] , C -6231 : 3-Cl-2-MeO, 3, 4-Me2 , E] , C- 6232:3-Cl-4-MeO,3,4-Me2 , E] , C -6233 : 3-Cl-5-MeO, 3, 4-Me2 , E] , C- 6234:4-Cl-2-MeO,3,4-Me2 , E] , C -6235 : 4-Cl-3-MeO, 3, 4-Me2 , E] , C-
6236:2-Me-3-MeO,3,4-Me2 , E] , C -6237 : 2 -Me- 4 -MeO, 3, 4-Me2 , E] , C- 6238:2-Me-5-MeO,3,4-Me2 , E] , C -6239 : 2-Me- 6-MeO, 3, 4-Me2 , E] , C-
6240:3-Me-2-MeO,3,4-Me2 , E] , C -6241 : 3-Me-4-MeO, 3, 4-Me2 , E] , C- 6242:3-Me-5-MeO,3,4-Me2 ,E] , C -6243 : 4-Me-2-MeO, 3, 4-Me2 , E] , C- 6244:4-Me-3-MeO,3,4-Me2 , E ] , C -6245 :H, 3-F-4-Me, E ] , C- 6246:4- F,3-F-4-Me,E ] , C -6247 : 4-F, 3-F-4-Me, Z ] , C -6248 : 4-Cl, 3-F-4- Me, E] , C -6249:4-Cl,3-F-4-Me,Z] , C -6250 : 4-Br, 3-F-4-Me, E ] , C-
6251:4-1, 3-F-4-Me,E], C -6252 : 4 -Me, 3-F-4-Me, E] , C -6253 : 4 -Me, 3- F-4-Me,z], C-6254:4-Et,3-F-4-Me,E], C -6255 : 4-C3 H7 , 3-F-4-Me, E] , C -6256:4- (Me) 2 CH, 3-F-4-Me, E ] , C -6257: 4-CF3 ,3-F-4-Me,E ] , C - 6258 :4-CF3 ,3-F-4-Me,z] , C -6259 : 4-C2 F5 , 3-F-4-Me, E ] , C -6260: 4- C3F7 , 3- F- 4 -Me, E ] , C -6261:4- (CF3 ) 2 CF, 3-F-4-Me, E ] , C -6262:4-
(CF3 )2CH,3-F-4-Me,E ] , C -6263: 4-CHF2 , 3-F-4-Me,E ] , C -6264:4- CH2F,3-F-4-Me,E ] , C -6265 : 4-CF3 CH2 , 3-F-4-Me, E ] , [ -6266:4- MeO,3-F-4-Me,E] , [ -6267 : 4-MeO, 3-F-4-Me, Z ] , [ -6268 : 4-EtO, 3-F- 4 -Me, E], C-6269:4-C3H7O,3-F-4-Me,E], [-6270:4- (Me) 2 CHO, 3-F-4- Me, E], C -6271: 4-NO2 ,3-F-4-Me,E] , C -6272: 4-NO2 , 3-F-4-Me, Z] , C-
6273:3-F,3-F-4-Me,E] , C -6274 : 3-F, 3-F-4-Me, Z ] , [ -6275 : 3-Cl, 3- F-4-Me,E],C-6276:3-Cl,3-F-4-Me,Z],C-6277:3-Br,3-F-4-Me,E],C- 6278: 3-1, 3-F-4-Me,E], [-6279 : 3-Me, 3-F-4-Me, E] , [-6280 : 3-Me, 3- F-4-Me,z], C-6281:3-Et,3-F-4-Me,E], [-6282 : 3-C3 H7 , 3-F-4-Me, E] , [ -6283:3-(Me)2CH,3-F-4-Me,E ] , [ -6284: 3-CF3 , 3-F-4-Me,E ] , C -
6285: 3-CF3 , 3-F-4-Me,z] , [ -6286 : 3-C2 F5 , 3-F-4-Me,E] , [-6287:3- C3F7 , 3-F-4-Me,E ] , [ -6288 : 3- (CF3 ) 2 CF, 3-F-4-Me, E ] , [ -6289:3- (CF3 )2CH,3-F-4-Me,E ] , [ -6290:3-CHF2 ,3-F-4-Me,E 3 , C -6291:3- CHF2 ,3-F-4-Me,Z], [-6292 : 3-CH2 F, 3-F-4-Me, E] , [-6293 : 3-CH2 F, 3- F-4-Me,Z ] , [ -6294 : 3-CF3 CH2 , 3-F-4-Me,E] , C -6295 : 3-MeO, 3-F-4-
Me, E], C-6296:3-MeO,3-F-4-Me,Z], C -6297 : 3-EtO, 3-F-4-Me, E] , C- 6298:3-C3H7O,3-F-4-Me,E] , [ -6299 : 3- (Me) 2 CHO, 3-F-4-Me, E ] , [- 6300:3-NO2 ,3-F-4-Me,E ] , [ -6301 : 2-F, 3-F-4-Me, E ] , [ -6302:2- Cl,3-F-4-Me,E ] , [ -6303 : 2-Br, 3-F-4-Me, E ] , [ -6304 : 2-1, 3-F-4- Me, E ] , [ - 6305 : 2 -Me, 3-F- 4 -Me, E ] , [ -6306:2-Et, 3-F-4-Me,E] , [ -
6307: 2-C3 H7 ,3-F-4-Me,E ] , [ -6308 : 2- (Me) 2 CH, 3-F-4-Me, E ] , C - 6309:2-CF3,3-F-4-Me,E] , [ -6310 : 2-C2 F5 , 3-F-4-Me, E ] , [-6311:2- C3F7 ,3-F-4-Me,E ] , [ -6312: 2- (CF3 ) 2 CF, 3-F-4-Me, E ] , [ -6313:2- (CF3 )2CH,3-F-4-Me,E ] , [ -6314: 2-CHF2 ,3-F-4-Me,E ] , C - 6315:2- CH2F,3-F-4-Me,E ] , [ -6316 : 2-CF3 CH2 , 3-F-4-Me, E ] , [ -6317:2-
MeO,3-F-4-Me,E] , [ -6318 : 2-EtO, 3-F-4-Me, E ] , [ -6319 : 2-C3 H70, 3- F-4-Me,E], [-6320:2-(Me)2CHO,3-F-4-Me,E], [-6321: 2-NO2 , 3-F-4- Me, E], [-6322: 2, 3-F2 , 3-F-4-Me, E], [-6323 : 2, 4-F2 , 3-F-4-Me, E], C- 6324:2,5-F2,3-F-4-Me,E ] , [ -6325 : 2, 6-F2 , 3-F-4-Me, E ] , [ - 6326:3, 4-F2 ,3-F-4-Me,E ] , [ -6327 : 3, 4-F2 , 3-F-4-Me, Z ] , [ -
6328:3, 5-F2 , 3-F-4-Me, E 3 , [ -6329 : 3, 5-F2 , 3-F-4-Me, Z ] , [ - 6330:2, 3-Cl2 ,3-F-4-Me, E ] , [ -6331 : 2, 3-Cl2 , 3-F-4-Me, Z ] , C - 6332:2, 4-Cl2 ,3-F-4-Me, E ] , [ -6333 : 2, 4-Cl2 , 3-F-4-Me, Z ] , C - 6334:2, 5-Cl2 ,3-F-4-Me, E ] , [ -6335 : 2 , 5-Cl2 , 3-F-4-Me, Z ] , [ - 6336:2, 6-Cl2 ,3-F-4-Me, E ] , [ -6337 : 3, 4-Cl2 , 3-F-4-Me, E ] , C -
6338:3, 5-Cl2 ,3-F-4-Me, E ] , [ -6339 : 2, 3-Br2 , 3-F-4-Me, E ] , [ - 6340:2, 4-Br2 ,3-F-4-Me, E ] , [ -6341 : 2, 5-Br2 , 3-F-4-Me, E ] , [ - 6342:2, 6^Br2 ,3-F-4-Me, E ] , [ -6343 : 3, 4-Br2 , 3-F-4-Me, E ] , [ - 6344:3, 5-Br2 ,3-F-4-Me, E ] , [ -6345 : 2, 3-Me2 , 3-F-4-Me, E ] , C - 6346:2, 4-Me2 ,3-F-4-Me, E ] , [ -6347 : 2, 5-Me2 , 3-F-4-Me, E ] , C -
6348:2, 6-Me2 ,3-F-4-Me, E ] , [ -6349 : 3, 4-Me2 , 3-F-4-Me, E ] , [ - 6350:3, 5-Me2 ,3-F-4-Me, E ] , [ -6351 : 2, 3-Et2 , 3-F-4-Me, E ] , C - 6352:2, 4-Et2, 3-F-4-Me, E ] , [ -6353 : 2 , 5-Et2 , 3-F-4-Me, E ] , C - 6354:2, 6-Et2 ,3-F-4-Me, E ] , [ -6355 : 3, 4-Et2 , 3-F-4-Me, E ] , C - 6356: 3, 5-Et2 , 3-F-4-Me,E] , [ -6357:2,3- (CF3 )2 , 3-F-4-Me,E] , C -
6358:2, 4- (CF3 )2 , 3-F-4-Me,E ] , [ -6359 : 2, 5- (CF3 )2 ,3-F-4-Me,E] , [-6360:2,6- (CF3 ) 2 , 3-F-4-Me, E] , [-6361 : 3, 4- (CF3 ) 2 , 3-F-4-Me, E] , [ -6362:3,5- (CF3 )2 ,3-F-4-Me, E ] , [ -6363 : 2 , 3- (CHF2 ) 2 , 3-F-4- Me, E] , [-6364:2,4- (CHF2 )2 ,3-F-4-Me,E] , [-6365:2,5- (CHF2 ) 2 , 3- F-4-Me,E ] , [ -6366 : 2 , 6- (CHF2 ) 2 , 3-F-4-Me, E ] , [ -6367:3,4-
(CHF2 )2 ,3-F-4-Me,E ] , C -6368 : 3, 5- (CHF2 ) 2 , 3-F-4-Me, E ] , C - 6369:2,3- (CH2F)2 , 3-F-4-Me, E] , [-6370 : 2, 4- (CH2 F) 2 , 3-F-4-Me, E] , [ -6371:2, 5-(CH2 F)2, 3-F-4-Me, E ] , C -6372 : 2, 6- (CH2 F) 2 , 3-F-4- Me, E ] , C -6373: 3, 4- (CH2 F) 2 , 3-F-4-Me, E ] , [-6374:3,5- (CH2F)2 , 3- F-4-Me,E ] , [ -6375 : 2 , 3- (MeO) 2 , 3-F-4-Me, E ] , [ -6376:2,4-
(MeO)2 ,3-F-4-Me, E ] , [ -6377 : 2 , 5- (MeO) 2 , 3-F-4-Me, E ] , [ - 6378:2, 6-(MeO)2 , 3-F-4-Me,E] , [-6379:3,4- (MeO)2 ,3-F-4-Me,E] , [-6380:3,5- (MeO)2 , 3-F-4-Me, E] , [-6381:2,3- (EtO)2 , 3-F-4-Me, E] , [-6382: 2, 4- (EtO) 2 , 3-F-4-Me, E] , [-6383:2,5- (EtO)2 , 3-F-4-Me, E] , [-6384:2, 6-(EtO)2 , 3-F-4-Me, E] , [-6385:3,4- (EtO)2 , 3-F-4-Me, E] ,
[-6386:3,5- (EtO)2 , 3-F-4-Me, E ] , [ -6387 : 2-C1-3-F, 3-F-4-Me, E ] , [-6388:2-Cl-4-F,3-F-4-Me,E] , [ -6389 : 2-C1-5-F, 3-F-4-Me, E ] , [-
6390:2-Cl-6-F,3-F-4-Me,E ] , [ -6391 : 3-C1-2-F, 3-F-4-Me, E ] , [ - 6392:3-Cl-4-F,3-F-4-Me,E ] , [ -6393 : 3-C1-5-F, 3-F-4-Me, E ] , [ - 6394:4-Cl-2-F,3-F-4-Me,E ] , [ -6395 : 4-C1-3-F, 3-F-4-Me, E ] , [ - 6396:2-F-3-Me,3-F-4-Me,E ] , [ -6397 : 2-F-4-Me, 3-F-4-Me, E ] , [ - 6398:2-F-5-Me,3-F-4-Me,E ] , [ -6399 : 2-F-6-Me, 3-F-4-Me,E ] , [ - 6400:3-F-2-Me,3-F-4-Me,E ] , [ -6401 : 3-F-4-Me, 3-F-4-Me, E ] , [ -
6402:3-F-5-Me,3-F-4-Me,E ] , [ -6403 : 4-F-2-Me, 3-F-4-Me, E ), [- 6404:4-F-3-Me,3-F-4-Me,E] , [ -6405 : 2-Cl-3-Me, 3-F-4-Me, E ] , [-
6406:2-Cl-4-Me,3-F-4-Me,E] , [ -6407 : 2-Cl-5-Me, 3-F-4-Me, E ] , [- 6408:2-Cl-6-Me,3-F-4-Me,E] , [ -6409 : 3-Cl-2-Me, 3-F-4-Me, E ] , C- 6410:3-Cl-4-Me,3-F-4-Me,E] , [ -6411 : 3-Cl-5-Me, 3-F-4-Me, E ] , [- 6412:4-Cl-2-Me,3-F-4-Me,E] , [ -6413 : 4-Cl-3-Me, 3-F-4-Me, E] , C- 6414:2-F-3-CF3 ,3-F-4-Me,E] , [ -6415 : 2-F-4-CF3 ,3-F-4-Me,E] , [-
6416:2-F-5-CF3 , 3-F-4-Me,E] , C -6417 : 2-F-6-CF3 , 3-F-4-Me,E] , C- 6418:3-F-2-CF3 , 3-F-4-Me, E ] , C -6419 : 3-F-4-CF3 , 3-F-4-Me, E ] , C- 6420:3-F-5-CF3 , 3-F-4-Me, E ] , C -6421 : 4-F-2-CF3 , 3-F-4-Me,E] , C- 6422:4-F-3-CF3 , 3-F-4-Me, E] , C-6423 : 2-Cl-3-CF3 , 3-F-4-Me, E] , C- 6424 :2-Cl-4-CF3 , 3-F-4-Me,E] , C -6425 : 2-Cl-5-CF3 , 3-F-4-Me, E ] , C-6426:2-Cl-6-CF3 , 3-F-4-Me, E] , C-6427 : 3-Cl-2-CF3 , 3-F-4-Me, E] , C-6428:3-Cl-4-CF3 , 3-F-4-Me, E] , C-6429 : 3-Cl-5-CF3 , 3-F-4-Me, E] , C-6430:4-Cl-2-CF3 , 3-F-4-Me, E] , C -6431 : 4-Cl-3-CF3 , 3-F-4-Me, E] , C-6432:2-Me-3-CF3 , 3-F-4-Me, E] , C -6433 : 2-Me-4-CF3 , 3-F-4-Me, E] , C-6434:2-Me-5-CF3 , 3-F-4-Me, E] , C-6435 : 2-Me-6-CF3 , 3-F-4-Me, E] , C-6436:3-Me-2-CF3 , 3-F-4-Me,E] , C -6437 : 3-Me-4-CF3 , 3-F-4-Me, E] , C-6438:3-Me-5-CF3 , 3-F-4-Me, E] , C -6439 : 4-Me-2-CF3 , 3-F-4-Me, E] , C-6440:4-Me-3-CF3 , 3-F-4-Me, E] , C-6441 : 2-F-3-MeO, 3-F-4-Me, E] , C-6442:2-F-4-MeO,3-F-4-Me,E] , C -6443 : 2-F-5-MeO, 3-F-4-Me, E ] , C-6444:2-F-6-MeO,3-F-4-Me,E] , C -6445 : 3-F-2-MeO, 3-F-4-Me, E ] , C-6446:3-F-4-MeO,3-F-4-Me,E] , C -6447 : 3-F-5-MeO, 3-F-4-Me, E ] , C-6448:4-F-2-MeO,3-F-4-Me,E] , C -6449 : 4-F-3-MeO, 3-F-4-Me, E ] , C-6450:2-Cl-3-MeO,3-F-4-Me,E], C-6451 : 2-Cl-4-MeO, 3-F-4-Me, E] , C-6452:2-Cl-5-MeO,3-F-4-Me,E], C-6453 : 2-Cl-6-MeO, 3-F-4-Me, E] , C-6454:3-Cl-2-MeO,3-F-4-Me,E], C-6455 : 3-Cl-4-MeO, 3-F-4-Me, E] , C-6456:3-Cl-5-MeO,3-F-4-Me,E], C-6457 : 4-Cl-2-MeO, 3-F-4-Me, E] , C-6458:4-Cl-3-MeO,3-F-4-Me,E], C -6459 : 2-Me-3-MeO, 3-F-4-Me, E] , C-6460:2-Me-4-MeO,3-F-4-Me,E], C -6461 : 2-Me-5-MeO, 3-F-4-Me, E] , C-6462:2-Me-6-MeO,3-F-4-Me,E], C-6463 : 3-Me-2-MeO, 3-F-4-Me, E] , C-6464:3-Me-4-MeO,3-F-4-Me,E], C-6465 : 3-Me-5-MeO, 3-F-4-Me, E] ,
[-6466:4-Me-2-MeO,3-F-4-Me,E], [-6467 : 4 -Me -3 -MeO, 3-F-4-Me,E], C-6468:H,4-F-3-Me,E], [-6469 : 4 -F, 4-F-3-Me, E] , [-6470 : 4 -F, 4 -F- 3-Me,Z], C-6471:4-Cl,4-F-3-Me,E], [-6472 : 4 -Cl, 4-F-3-Me, Z] , C- 6473:4-Br,4-F-3-Me,E], [-6474:4-1, 4-F-3-Me,E], [-6475:4-Me, A- F-3-Me,E],[-6476:4-Me, 4-F-3-Me, z], [-6477:4-Et, 4-F-3-Me,E], C-
6478:4-C3H7 ,4-F-3-Me,E ] , [ -6479 : 4- (Me) 2 CH, 4-F-3-Me, E ] , C - 6480: 4-CF3 ,4-F-3-Me,E ] , C -6481: 4-CF3 , 4-F-3-Me,Z] , [-6482:4- C2F5 ,4-F-3-Me,E ] , [ -6483 : 4-C3 F7 , 4-F-3-Me, E ] , [ -6484:4- (CF3 )2CF,4-F-3-Me,E ] , [ -6485 : 4- (CF3 ) 2 CH, 4-F-3-Me, E ] , [ - 6486: 4-CHF2 , 4-F-3-Me, E] , [-6487 : 4-CH2 F, 4-F-3-Me, E] , [-6488:4-
CF3CH2 , 4-F-3-Me,E], [-6489 : 4-MeO, 4-F-3-Me,E], [-6490 : 4-MeO, 4- F-3-Me,Z ] , [ -6491:4-EtO,4-F-3-Me,E ] , [ -6492 : 4-C3 H7 O, 4-F-3- Me, E ] , [ -6493:4- (Me)2CHO, 4-F-3-Me, E ] , [ -6494 : 4-NO2 , 4-F-3- Me, E ] , [-6495: 4-NO2 ,4-F-3-Me,Z] , [ -6496 : 3-F, 4-F-3-Me, E ] , [- 6497: 3-F, 4-F-3-Me,z], [-6498 : 3-Cl, 4-F-3-Me, E] , [-6499 : 3-Cl, 4-
F-3-Me,z], [-6500:3-Br,4-F-3-Me,E], [-6501 : 3-1, 4-F-3-Me, E] , [- 6502:3-Me,4-F-3-Me,E ] , C -6503 : 3-Me, 4-F-3-Me, Z ] , [ -6504:3- Et,4-F-3-Me,E ] , [ -6505 : 3-C3 H7 , 4-F-3-Me, E ] , [ -6506:3- (Me)2CH, 4-F-3-Me, E ] , [ -6507 : 3-CF3 , 4-F-3-Me, E ] , [ -6508:3- CF3 ,4-F-3-Me,z] , [ -6509 : 3-C2 F5 ,4-F-3-Me,E] , [ -6510 : 3-C3 F7 ,4-
F-3-Me,E J , [ -6511:3- (CF3 ) 2 CF, 4-F-3-Me, E ] , [ -6512:3- (CF3 )2CH,4-F-3-Me,E ] , [ -6513: 3-CHF2 ,4-F-3-Me,E ] , [ -6514: 3- CHF2 ,4-F-3-Me,Z], [-6515 : 3-CH2 F, 4-F-3-Me, E] , [-6516 : 3-CH2 F, 4- F-3-Me,Z ] , [ -6517: 3-CF3 CH2 ,4-F-3-Me,E] , [ -6518 : 3-MeO, 4-F-3- Me, E], C-6519:3-MeO,4-F-3-Me,Z], C -6520 : 3-EtO, 4-F-3-Me, E] , [-
6521:3-C3H7O,4-F-3-Me,E) , [-6522:3- (Me) 2 CHO, 4-F-3-Me, E ] , [ ■
6523:3-NO2,4-F-3-Me,E ] , C -6524 : 2-F, 4-F-3-Me, E ] , C -6525:2-
Cl,4-F-3-Me,E ] , [ -6526 : 2-Br, 4-F-3-Me, E ] , C -6527 : 2-1, 4-F-3-
Me, E D , C -6528:2-Me,4-F-3-Me,E] , C -6529 : 2-Et , 4-F-3-Me, E ] , C - 6530: 2-C3 H7 ,4-F-3-Me,E ] , C -6531:2- (Me) 2 CH, 4-F-3-Me, E ) , ( ■
6532: 2-CF3 , 4-F-3-Me,E] , C -6533 : 2-C2 F5 ,4-F-3-Me,E] , C -6534: 2-
C3F7 ,4-F-3-Me,E ] , C -6535:2- (CF3 ) 2 CF, 4-F-3-Me, E ] , [ -6536:2-
(CF3 )2CH,4-F-3-Me,E ] , [ -6537: 2-CHF2 , 4-F-3-Me,E ] , C -6538:2-
CH2F, 4-F-3-Me,E ] , C -6539 : 2-CF3 CH2 , 4-F-3-Me, E ] , [ -6540:2- MeO,4-F-3-Me,E] , C -6541 : 2-EtO, 4-F-3-Me, E ] , [ -6542 : 2-C3 H7 O, 4-
F-3-Me,E], [-6543:2- (Me) 2 CHO, 4-F-3-Me, E] , [-6544: 2-NO2 , 4-F-3- Me, E], [-6545:2, 3-F2 , 4-F-3-Me, E], [-6546 : 2 , 4-F2 , 4-F-3-Me, ED, [- 6547:2, 5-F2 ,4-F-3-Me,E ] , [ -6548 : 2, 6-F2 , 4-F-3-Me, E ] , [ - 6549:3, 4-F2 ,4-F-3-Me,E ] , [ -6550 : 3, 4-F2 , 4-F-3-Me, Z ] , [ - 6551:3, 5-F2 ,4-F-3-Me,E ] , [ -6552 : 3, 5-F2 , 4-F-3-Me, Z ] , [ -
6553:2, 3-Cl2 ,4-F-3-Me, E ] , [ -6554 : 2, 3-Cl2 , 4-F-3-Me, Z ] , [ - 6555:2, 4-Cl2 ,4-F-3-Me, E ] , [ -6556 : 2 , 4-Cl2 , 4-F-3-Me, Z } , [ - 6557:2, 5-Cl2 ,4-F-3-Me, E ] , [ -6558 : 2, 5-Cl2 , 4-F-3-Me, Z ] , [ - 6559:2, 6-Cl2 ,4-F-3-Me, E ] , [ -6560 : 3, 4-Cl2 , 4-F-3-Me, E ] , [ - 6561:3, 5-Cl2 ,4-F-3-Me, E ] , [ -6562 : 2 , 3-Br2 , 4-F-3-Me, E ] , [ -
6563:2, 4-Br2 ,4-F-3-Me, E ] , [ -6564 : 2 , 5-Br2 , 4-F-3-Me, E ] , [ - 6565:2, 6-Br2 , 4 -F- 3 -Me, E ] , [ -6566 : 3, 4-Br2 , 4-F-3-Me, E ] , [ - 6567:3, 5-Br2 ,4-F-3-Me, E ] , [ -6568 : 2, 3-Me2 , 4-F-3-Me, E ] , [ - 6569:2, 4-Me2 ,4-F-3-Me, E ] , [ -6570 : 2 , 5-Me2 , 4-F-3-Me, E ] , [ - 6571:2, 6-Me2 ,4-F-3-Me, E ] , [ -6572 : 3, 4-Me2 , 4-F-3-Me, E ] , [ -
6573:3, 5-Me2 , 4-F-3-Me, E ] , [ -6574 : 2, 3-Et2 , 4-F-3-Me, E ] , C - 6575:2, 4-Et2 , 4-F-3-Me, E ] , [ -6576 : 2, 5-Et2 , 4-F-3-Me, E ] , C - 6577:2, 6-Et2 , 4-F-3-Me, E ] , C -6578 : 3, 4-Et2 , 4-F-3-Me, E ] , C - 6579:3,5-Et2,4-F-3-Me,E] , C -6580 : 2, 3- (CF3 ) 2 , 4-F-3-Me,E] , [- 6581 : 2, 4- (CF3 )2 ,4-F-3-Me,E] , C -6582 : 2, 5- (CF3 ) 2 , 4-F-3-Me, E 3 ,
[-6583:2, 6- (CF3 )2 , 4-F-3-Me, E] , [-6584 : 3, 4- (CF3 ) 2 , 4-F-3-Me, E J , [ -6585:3,5- (CF3 )2 ,4-F-3-Me, E ] , [ -6586 : 2, 3- (CHF2 ) 2 , 4-F-3- Me, E] , [-6587: 2, 4- (CHF2 )2 , 4-F-3-Me,E] , [ -6588 : 2, 5- (CHF2 )2 ,4- F-3-Me,E ] , [ -6589:2, 6- (CHF2 )2 ,4-F-3-Me, E ] , [ -6590:3,4- (CHF2 )2 ,4-F-3-Me,E ] , [ -6591 : 3, 5- (CHF2 ) 2 , 4-F-3-Me, E ] , [ -
6592:2,3- (CH2F)2 , 4-F-3-Me, E] , [-6593 : 2, 4- (CH2 F) 2 , 4-F-3-Me, E] , [ -6594:2,5- (CH2F)2 ,4-F-3-Me, E ] , [ -6595 : 2 , 6- (CH2 F) 2 , 4-F-3- Me, E 3, [-6596:3, 4- (CH2 F) 2 ,4-F-3-Me,E] , [ -6597 : 3, 5- (CH2 F) 2 , 4- F-3-Me,E ] , [ -6598:2,3- (MeO)2 ,4-F-3-Me, E ] , [ -6599:2,4- (MeO)2 ,4-F-3-Me, E ] , [ -6600 : 2, 5- (MeO) 2 , 4-F-3-Me, E ] , [ -
6601:2,6- (MeO)2 ,4-F-3-Me,E] , [-6602:3,4- (MeO)2 ,4-F-3-Me,E] , [-6603:3,5- (MeO)2 , 4-F-3-Me, E] , [-6604:2,3- (EtO)2 , 4-F-3-Me, E] , [-6605:2, 4- (EtO)2 , 4-F-3-Me, E] , [-6606:2,5- (EtO)2 , 4-F-3-Me, E] , [-6607:2,-6- (EtO) 2 , 4-F-3-Me, E] , [-6608 : 3, 4- (EtO) 2 , 4-F-3-Me, E] , [-6609: 3, 5- (EtO) 2 ,4-F-3-Me,Ej , [ -6610 : 2-C1-3-F, 4-F-3-Me, E ] ,
[-6611:2-Cl-4-F,4-F-3-Me,E] , [ -6612 : 2-C1-5-F, 4-F-3-Me, E ] , C- 6613:2-Cl-6-F,4-F-3-Me,E ] , [ -6614 : 3-C1-2-F, 4-F-3-Me, E ) , (- 6615:3-Cl-4-F,4-F-3-Me,E ] , [ -6616 : 3-C1-5-F, 4-F-3-Me, E ] , [ - 6617:4-Cl-2-F,4-F-3-Me,E ] , [ -6618 : 4-C1-3-F, 4-F-3-Me, E ] , [ - 6619:2-F-3-Me,4-F-3-Me,E ] , [ -6620 : 2-F-4-Me, 4-F-3-Me, E ] , [ -
6621:2-F-5-Me,4-F-3-Me,E ] , C -6622 : 2-F-6-Me, 4-F-3-Me, E ] , C - 6623:3-F-2-Me,4-F-3-Me,E ] , C -6624 : 3-F-4-Me, 4-F-3-Me, E ] , C - 6625:3-F-5-Me,4-F-3-Me,E ] , [ -6626 : 4-F-2-Me, 4-F-3-Me, E ] , C - 6627:4-F-3-Me,4-F-3-Me,E] , C -6628 : 2-Cl-3-Me, 4-F-3-Me, E ] , C - 6629:2-Cl-4-Me,4-F-3-Me,E] , C -6630 : 2-Cl-5-Me, 4-F-3-Me, E J , C- 6631:2-Cl-6-Me,4-F-3-Me,E] , C -6632 : 3-Cl-2-Me, 4-F-3-Me, E ] , C- 6633:3-Cl-4-Me,4-F-3-Me,E] , C -6634 : 3-Cl-5-Me, 4-F-3-Me, E ] , C- 6635:4-Cl-2-Me,4-F-3-Me,E] , C -6636 : 4-Cl-3-Me, 4-F-3-Me, E ] , C- 6637:2-F-3-CF3 , 4-F-3-Me,E] , C -6638 : 2-F-4-CF3 , 4-F-3-Me, E ] , C- 6639:2-F-5-CF3,4-F-3-Me,E], C -6640 : 2-F-6-CF3 , 4-F-3-Me, E ] , C- 6641:3-F-2-CF3 , 4-F-3-Me,E] , C -6642 : 3-F-4-CF3 , 4-F-3-Me,E] , C- 6643:3-F-5-CF3 , 4-F-3-Me,E] , C -6644 : 4-F-2-CF3 , 4-F-3-Me, E ] , C- 6645:4-F-3-CF3 , 4-F-3-Me, E] , C-6646 : 2-Cl-3-CF3 , 4-F-3-Me, E] , C- 6647:2-Cl-4-CF3 ,4-F-3-Me,E] , C -6648 : 2-Cl-5-CF3 , 4-F-3-Me, E ] , C-6649:2-Cl-6-CF3 , 4-F-3-Me, E] , C -6650 : 3-Cl-2-CF3 , 4-F-3-Me, E] , C-6651:3-Cl-4-CF3 , 4-F-3-Me, E] , C--6652 : 3-Cl-5-CF3 , 4-F-3-Me, E] , C-6653:4-Cl-2-CF3 , 4-F-3-Me, E] , C -6654 : 4-Cl-3-CF3 , 4-F-3-Me, E3 , C-6655:2-Me-3-CF3 , 4-F-3-Me, E] , C -6656 : 2-Me-4-CF3 , 4-F-3-Me, E] , C-6657:2-Me-5-CF3 , 4-F-3-Me, E] , C -6658 : 2-Me-6-CF3 , 4-F-3-Me, E] , C-6659:3-Me-2-CF3 , 4-F-3-Me, E] , C-6660 : 3-Me-4-CF3 , 4-F-3-Me, E] , C-6661:3-Me-5-CF3 , 4-F-3-Me, E] , C-6662 : 4-Me-2-CF3 , 4-F-3-Me, E] , C-6663:4-Me-3-CF3 , 4-F-3-Me, E] , C-6664 : 2-F-3-MeO, 4-F-3-Me, E] , C -6665: 2-F-4-MeO, 4-F-3-Mef E] , C -6666 : 2-F-5-MeO, 4-F-3-Me, E ] , C-6667:2-F-6-MeO,4-F-3-Me,E] , C -6668 : 3-F-2-MeO, 4-F-3-Me, E ] , C-6669:3-F-4-MeO,4-F-3-Me,E] , C -6670 : 3-F-5-MeO, 4-F-3-Me, E ] ,
C-6671:4-F-2-MeO,4-F-3-Me,E] , C -6672 : 4-F-3-MeO, 4-F-3-Me, E 3 , [-6673:2-Cl-3-MeO,4-F-3-Me,E3, [-6674 : 2-C1-4 -MeO, 4-F-3-Me, E3 , [-6675:2-Cl-5-MeO,4-F-3-Me,E3, [-6676 : 2-Cl-6-MeO, 4-F-3-Me,E], [-6677:3-Cl-2-MeO,4-F-3-Me,E], [-6678 : 3-Cl-4-MeO, 4-F-3-Me, E] , [-6679:3-Cl-5-MeO,4-F-3-Me,E], [-6680 : 4-Cl-2-MeO, 4-F-3-Me, E3 , [-6681:4-Cl-3-MeO,4-F-3-Me,E3, [-6682 : 2-Me-3-MeO, 4-F-3-Me,E], [-6683:2-Me-4-MeO,4-F-3-Me,E3, [-6684 : 2-Me-5-MeO, 4-F-3-Me,E3, [-6685:2-Me-6-MeO,4-F-3-Me,E], [-6686 : 3-Me-2-MeO, 4-F-3-Me, E3 , [-6687:3-Me-4-MeO,4-F-3-Me,E], [-6688 : 3-Me-5-MeO, 4-F-3-Me, E3 , [-6689:4-Me-2-MeO, 4-F-3-Me,E3, [-6690 : 4-Me-3-MeO, 4-F-3-Me,E3.
In the above "combination G", for example, (X) m being "H" denotes m = 0, (X) m being "4-F" denotes m = 1 and that X is a fluorine atom substituting at 4-position, (X)m being "2, 3- (CF3) 2" denotes m = 2 and that one X is a trifluoromethyl group substituting at 2-position and the other X is a trifluoromethyl group substituting at 3- position; (Z)n being "H" denotes n = 0, (Z)n being "4-MeO" denotes n=l and that Z is a methoxy group substituting at 4-position, (Z)n being "3-F-4- (Me) 3CO" denotes n = 2 and that one Z is a fluorine atom substituting at 3-position and the other Z is a t-butoxy group substituting at A- position; geometric isomerism at a double bond of CH=CH being "E" denotes that the isomerism at a double bond of CH=CH is E (entgegen) isomer in the formula (I), and geometric
isomerism at a double bond of CH=CH being "Z" denotes that the isomerism at a double bond of CH=CH is Z (zusaπtmen) isomer in the formula (I) .
Example 1
Compound 2-94: Bicyclo [4.4.0] -3-decyl 3- (3, 5- dichlorophenylthio) -N- (phenyl) thioacrylimidate
Bicyclo [4.4.0] -3-decyl N- (phenyl) thiopropynimidate
(0.11 g) was dissolved in methanol (10 mL) , and 3,5- dichlorothiophenol (0.05 g) was added thereto at room temperature, followed by stirring for 4 hours. The reaction mixture was concentrated under reduced pressure. The resultant residue was subjected to silica gel column chromatography (hexane/ethyl acetate = 30/1), followed by medium pressure preparative HPLC (hexane/ethyl acetate = 99.2/0.8) to give bicyclo [4.4.0] -3-decyl 3-(3,5- dichlorophenylthio) -N- (phenyl) thioacrylimidate (0.07 g) . 1HNMR (CDCl3) δ (ppm) : 1.23-2.16 (16H, m) , 3.67-3.74 (0.7H, m) , 3.95 (0.2H, br) , 4.31 (0.1H, br) , 6.14 (IH, d, J= 15.5 Hz), 6.72-6.74 (2H, m) , 7.03-7.07 (IH, m) , 7.20-7.34 ( 6H, m) Example 2
Compound 2-4: Bicyclo [4.4.0] -3-decyl 3- (4- chlorophenylthio) -N- (phenyl) thioacrylimidate
Compound 2-4
Bicyclo[4.4.0]-3-decyl N- (phenyl) -3-
(trimethylsilyl) thiopropynimidate (0.40 g) was dissolved in methanol (10 mL) , and a small amount of potassium carbonate was added thereto at room temperature, followed by stirring for one hour. Then, 4-chlorothiophenol (0.087 g) was added to the mixture at room temperature, and the mixture was stirred for 4 hours. The reaction mixture was concentrated under reduced pressure, and then subjected to silica gel column chromatography (hexane/ethyl acetate = 30/1), followed by medium pressure preparative HPLC (hexane/ethyl acetate = 99.2/0.8) to give bicyclo [4.4.0] -3-decyl 3-(4- chlorophenylthio) -N- (phenyl) thioacrylimidate (0.10 g) . 1HNMR (CDCl3) δ (ppm) : 1.22-2.15 (16H, m) , 3.65-3.73 (0.7H, m) , 3.94 (0.2H, br) , 4.30 (0.1H, br) , 6.02 (IH, d, J= 15.2 Hz), 6.69-6.71 (2H, m) , 7.01-7.05 (IH, m) , 7.23-7.28 (7H, m)
The following compounds were prepared in the same manner as in Example 2. Compound 2-8: Bicyclo [4.4.0] -3-decyl 3- (4- methylphenylthio) -N- (phenyl) thioacrylimidate
Compound 2-8 1HNMR (CDCl3 ) δ (ppm) : 1 . 21-2 . 14 ( 16H, m) , 2 . 31 ( 3H, s ]
3.64-3.72 (0.7H, m) , 3.93 (0.2H, br) , 4.28 (0.1H, br) , 5.97 (IH, d, J= 15.4 Hz), 6.69-6.71 (2H, m) , 6.98-7.09 (3H, m) , 7.21-7.25 (4H, m) , 7.32 (IH, d, J= 15.4 Hz) Compound 2-22: Bicyclo [4.4.0] -3-decyl 3- (4- methoxyphenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) δ (ppm) : 1.21-2.14 (16H, m) , 3.63-3.71 (0.7H, m) , 3.77 (3H, s), 3.92 (0.2H, br) , 4.28 (0.1H, br) , 5.86 (IH, d, J= 15.4 Hz), 6.67-6.69 (2H, m) , 6.78-6.80 (2H, m) , 6.97-7.01 (IH, m) , 7.20-7.33 (5H, m) Compound 2-31: Bicyclo [4.4.0] -3-decyl 3- (3- chlorophenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) δ (ppm): 1.26-2.15 (16H, m) , 3.67-3.73 (0.7H, m) , 3.94 (0.2H, br) , 4.30 (0.1H, br) , 6.10 (IH, d, J= 15.4Hz), 6.72-6.73 (2H, m) , 7.01-7.05 (IH, m) , 7.21-7.34
( 7H , m)
Compound 2-35: Bicyclo [4.4.0] -3-decyl 3- (3- methylphenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) δ (ppm) : 1.22-2.14 (16H, m) , 2.30 (3H, s), 3.65-3.72 (0.7H, m) , 3.93 (0.2H, br) , 4.29 (0.1H, br) , 6.05 (IH, d, J= 15.6 Hz), 6.71-6.73 (2H, m) , 7.00-7.39 (8H, m) Compound 2-36: Bicyclo [4.4.0] -3-decyl 3- (3- methylphenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) δ (ppm): 1.20-2.00 (16H, m) , 2.34 (3H, s), 3.18 (0.6H, br), 3.40 (0.2H, br) , 3.81 (0.2H, br) , 6.39- 6.41 (IH, m) , 6.97-7.33 (1OH, m) Compound 2-29: Bicyclo [4.4.0] -3-decyl 3- (3- fluorophenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) δ (ppm): 1.22-2.02 (16H, m) , 3.66-3.74 (0.7H,
m) , 3.94 (0.2H, br) , 4.30 (0.1H, br) , 6.11 (IH, d, J= 15.6 Hz) , 6.72-6.74 (2H, in) , 6.94-7.12 (4H, m) , 7.23-7.35 (4H, m)
Compound 2-27: Bicyclo [4.4.0] -3-decyl 3- (4- nitrophenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) 'δ (ppm): 1.22-2.15 (16H, m) , 3.67-3.74 (0.7H, m) , 3.95 (0.2H, br) , 4.31 (0.1H, br) , 6.08 (IH, d, J= 15.4 Hz), 6.70-6.72 (2H, m) , 7.00-7.04 (IH, m) , 7.23-7.61 (7H, m)
Compound 2-13: Bicyclo [4.4.0] -3-decyl N-phenyl-3- (4- trifluoromethylphenylthio) thioacrylimidate
Compound 2-13
1HNMR (CDCl3) δ (ppm) : 1.23-2.14 (16H, m) , 3.68-3.75 (0.7H, m) , 3.96 (0.2H, br) , 4.31 (0.1H, br) , 6.15 (IH, d, J= 15.6Hz), 6.72-6.73 (2H, m) , 7.02-7.06 (IH, m) , 7.24-7.55 (7H, m)
Example 3
Compound 2-5354: Bicyclo [4.4.0] -3-decyl 3-(.4- f luorophenylthio) -N- (4-methylphenyl) thioacrylimidate
Ethynyltrimethylsilane (0.7 πiL) was dissolved in dry THF (10 inL) , a solution of n-butyl lithium in hexane (1.57 mol/L: 3.4 mL) was added dropwise thereto at -78°C, and the resultant mixture was heated up to 00C. A solution of 4- methylphenyl isothiocyanate (0.75 mL) in THF (3 mL) was added dropwise to the mixture, followed by stirring with ice-cooling for 30 minutes. Then, a solution of bicyclo [4.4.0] -3-decyl methanesulfonate (1.3 g) in THF (2 mL) was added to the reaction mixture, and it was stirred under heat-refluxing conditions for 6 hours. An aqueous
saturated sodium chloride solution (15 mL) and water (10 mL) were added to the reaction mixture, followed by extraction twice with t-butyl methyl ether (20 mL) . The resultant organic layer was washed with an aqueous saturated sodium chloride solution (20 mL) , dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give a brown oily matter (2.07 g) . The oily matter was subjected to florisil column chromatography (hexane/ethyl acetate = 30/1) to give bicyclo [4.4.0] -3- decyl N- (4-methylphenyl) -3-
(trimethylsilyl) thiopropynimidate (0.8βg) .
The resultant bicyclo [4.4.0] -3-decyl N- (4- methylphenyl) -3- (trimethylsilyl) thiopropynimidate was dissolved in methanol (10 mL) , a small amount of potassium carbonate was added to the solution at room temperature, followed by stirring for 30 minutes. Then, 4- fluorothiophenol (0.08 mL) was added thereto at room temperature, followed by stirring for 2 hours. The reaction mixture was concentrated under reduced pressure. The resultant residue was subjected to silica gel column chromatography (hexane/ethyl acetate = 30/1), followed by medium pressure preparative HPLC (hexane/ethyl acetate = 99.2/0.8) to give bicyclo [4.4.0] -3-decyl 3-(4- fluorohenylthio) -N- (4-methylphenyl) thioacrylimidate (0.16 g) .
1HNMR (CDCl3) δ (ppm) : 1.20-2.14 (16H, m) , 2.30 (3H, s) , 3.64-3.72 (0.7H, m) , 3.93 (0.2H, br) , 4.30 (0.1H, br) , 5.94 (IH, d, J= 15.5 Hz) , 6.59 (2H, d, J= 8.0 Hz) , 6.95-6.99 (2H, m) , 7.03 (2H, d, J= 8.0 Hz) , 7.24 (IH, d, J= 15.5 Hz) , 7.28-7.33 (2H, m)
The following compounds were prepared in the same manner as in Example 3.
Compound 2-2: Bicyclo [4.4.0] -3-decyl 3- (4- fluorophenylthio) -N- (phenyl) thioacrylimidate
1HNMR (CDCl3) δ (ppm): 1.22-2.16 (16H, m) , 3.64-3.72 (0.8H, m) , 4.29 (0.2H, br) , 5.92 (IH, d, J= 15.4 Hz), 6.68-6.70 (2H, m) , 6.96-7.04 (3H, m) , 7.22-7.34 (5H, m) Compound 2-448: Bicyclo [4.4.0] -3-decyl N- (4-chlorophenyl) - 3- (4-fluorophenylthio) thioacrylimidate
1HNMR (CDCl3) δ(ppm): 1.21-2.11 (16H, m) , 3.61-3.69 (0.7H, m) , 3.90 (0.2H, br) , 4.26 (0.1H, br) , 5.82 (IH, d, J= 15.4 Hz), 6.62 (2H, d, J= 8.5 Hz), 6.98-7.02 (2H, m) , 7.19 (2H, d, J= 8.5 Hz), 7.24-7.33 (3H, m)
Compound 2-894: Bicyclo [4.4.0] -3-decyl 3- (4- fluorophenylthio) -N- (4-methoxylphenyl) thioacrylimidate
1HNMR(CDCl3) δ (ppm) : 1.18-1.89 (16H, m) , 3.64-3.71 (IH, m) , 3.80 (3H, s), 5.98 (IH, d, J = 15.4Hz), 6.65 (2H, d, J = 8.5Hz), 6.80 (2H, d, J = 8.5Hz), 6.96-7.03 (2H, m) , 7.25 (IH, d, J = 15.4Hz), 7.33-7.37 (2H, m) Compound 2-1786: Bicyclo [4.4.0] -3-decyl 3- (4- fluorophenylthio) -N- (3- trifluoromethylphenyl ) thioacrylimidate
1HNMR(CDCl3) δ (ppm) : 1.22-1.85 (16H, m) , 3.63-3.68 (IH, m) , 5.64 (IH, d, J = 15.4Hz) , 6.82-6.98 (4H, m) , 7.26-7.33 (5H, m
Compound 2-6023: Bicyclo [4.4.0] -3-decyl N- (3,4- dimethylphenyl) -3- (4-fluorophenylthio) thioacrylimidate
Next, Production Examples of starting compounds of the compound (I) will be illustrated. Production Example 1
Bicyclo [4.4.0] -3-decyl N- (phenyl) -3- (trimethylsilyl ) thiopropynimidate
Ethynyltrimethylsilane (4.1 iriL) was dissolved in dry THF (80 mL) , a solution of n-butyl lithium in hexane (1.57 mol/L: 20 mL) was added dropwise thereto at -78°C, and the temperature of the resultant mixture was elevated to 00C. A solution of phenyl isothiocyanate (3.7 mL) in THF (5 mL) was added dropwise to the reaction mixture, followed by stirring with ice-cooling for 30 minutes. A solution of bicyclo [4.4.0] -3-decyl methanesulfonate (7.74 g) in THF (3 mL) was added to the reaction mixture, and it was stirred under heat-refluxing conditions for 6 hours. An aqueous saturated sodium chloride solution (80 mL) and water (20 mL) were added to the reaction mixture, followed by extraction with t-butyl methyl ether (80 mL and 40 mL) .
The resultant organic layer was washed with an aqueous saturated sodium chloride solution (80 rtiL) , dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give a black oily matter (11.99 g) . The oily matter was subjected to alumina column chromatography
(hexane/ethyl acetate = 30/1) to give bicyclo [4.4.0] -3- decyl N- (phenyl) -3- (trimethylsilyl) thiopropynimidate (4.22 g) •
1HNMR (CDCl3) δ(ppm): 0.09 (5H, s), 0.29 (4H, s), 1.19-1.90 (16H, m) , 3.50-3.58 (0.4H, m) , 3.70-3.77 (0.6H, m) , 6.88- 6.91 (IH, m) , 7.02-7.05 (IH, m) , 7.08-7.14 (IH, m) , 7.28- 7.36 (2H, m) . Production Example 2 Bicyclo [4.4.0]-3-decyl N- (phenyl) thiopropynimidate
Bicyclo [4.4.0] -3-decyl N- (phenyl) -3-
( trimethylsilyl) thiopropynimidate (0.18 g) was dissolved in methanol (10 mL) , a small amount of potassium carbonate was added thereto at room temperature, followed by stirring for one hour. The reaction solution was concentrated under reduced pressure, and extracted with water (10 mL) and chloroform (10 mL) . The organic layer was dried, and the solvent was distilled off to give bicyclo [4.4.0] -3-decyl N-
(phenyl) thiopropynimidate (0.13 g) .
1HNMR (CDCl3) δ (ppm) : 1.24-1.86 (16H, m) , 3.21 (0.7H, s) , 3.38 (0.3H, s) , 3.53-3.61 (0.3H, m) , 3.72-3.80 (0.7H, m) , 6.90-7.14 (3H, m) , 7.31-7.37 (2H, m) Next, Formulation Examples will be illustrated. Parts are by weight. Formulation Example 1
Ten (10) parts of each of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354 is dissolved in a mixture of 35 parts of xylene and 35 parts of N, N-dimethylformamide . Fourteen (14) parts of polyoxyethylene stylylphenyl ether and 6 parts of calcium dodecylbenzenesulfonate are added thereto, and the mixture is thoroughly mixed with stirring to give a 10% emulsifiable concentrate. Formulation Example 2
Twenty (20) parts of each of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354 is added to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfate, 20 parts of synthetic hydrous silicon oxide fine powder and 54
parts of diatomite. The mixture is thoroughly mixed with stirring to give a 20% wettable powder. Formulation Example 3
One (1) part of synthetic hydrous silicon oxide fine powder, 2 parts of calcium ligninsulfate, 30 parts of bentonite and 65 parts of kaolin clay are added to 2 parts of each of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354. The mixture is thoroughly mixed with stirring. An appropriate amount of water is added to the mixture. The obtained mixture is further stirred, granulated with a granulator, and dried through circulation drying with air to give a 2% granular formulation of each. Formulation Example 4
One (1) part of each of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27 , compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354 is dissolved in an appropriate amount of acetone. Five (5) parts of synthetic hydrous silicon oxide fine powder, 0.3 part of PAP and 93.7 parts of Fubasami clay are added thereto. The mixture is thoroughly mixed with stirring, and then acetone is removed by evaporation to
give a 1% powder formulation of each. Formulation Example 5
Ten (10) parts of each of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354, 35 parts of white carbon that contains 50 parts of ammonium polyoxyethylenealkyl ether sulfate, and 55 parts of water are mixed, and pulverized by a wet milling method to give a 10% flowable concentrate of each. Formulation Example 6
Each (0.1 part) of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354 is dissolved in 5 parts of xylene and 5 parts of trichloroethane . The mixture is mixed in 89.9 parts of deodorized kerosene to give a 0.1% oil formulation. Formulation Example 7 Ten (10) mg of each of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27 , compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448 and compound 2-5354 is dissolved in 0.5mL of acetone. The solution is added to 5 g of a solid feed powder for animals (Breeding
Solid Feed Powder CE-2, trade name by JAPAN CLEA CO., LTD.) and uniformly mixed. Then, acetone is evaporated to give a poison bait.
Group A: As insecticides:
(1) Organic phosphorus compounds aluminium phosphide, butathiofos, cadusafos, chlorethoxyfos, chlorfenvinphos, chlorpyrifos, chlorpyrifos-methyl, cyanophos (CYAP) , diazinon, DCIP (dichlorodiisopropyl ether) , dichlofenthion (ECP) , dichlorvos (DDVP), dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, etrimfos, fenthion (MPP), fenitrothion (MEP) , fosthiazate, formothion, hydrogen phosphide, isofenphos, isoxathion, malathion, mesulfenfos, methidathion (DMTP) , monocrotophos, naled (BRP) , oxydeprofos (ESP) , parathion, phosalone, phosmet (PMP) , pirimiphos-methyl, pyridafenthion, quinalphos, phenthoate
(PAP), profenofos, propaphos, prothiofos, pyraclorfos, salithion, sulprofos, tebupirimfos, temephos, tetrachlorvinphos, terbufos, thiometon, trichlorphon (DEP) , and vamidothion;
(2) Carbameta compounds alanycarb, bendiocarb, benfuracarb, BPMC, carbaryl, carbofuran, carbosulfan, cloethocarb, ethiofencarb, fenobucarb, fenothiocarb, fenoxycarb, furathiocarb,
isoprocarb (MIPC) , metolcarb, methomy1, methiocarb, NAC, oxamyl, pirimicarb, propoxur (PHC) , XMC, thiodicarb, and xylylcarb;
(3) Synthetic pyrethroid compounds acrinathrin, allethrin, benfluthrin, beta-cyfluthrin, bifenthrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, deltamethrin, esfenvalerate, ethofenprox, fenpropathrin, fenvalerate, flucythrinate, flufenoprox, flumethrin, fluvalinate, halfenprox, imiprothrin, permethrin, prallethrin, pyrethrins, resmethrin, sigma- cypermethrin, silafluofen, tefluthrin, tralomethrin, transfluthrin, 2,3,5,6-tetrafluoro-4- (methoxymethyl) benzyl (EZ) - (IRS, 3RS; IRS, 3SR) -2 , 2-dimethyl-3-prop-l- enylcyclopropanecarboxylate, 2,3,5, 6-teterafluoro-4- methylbenzyl (EZ) - ( IRS, 3RS; IRS, 3SR) -2, 2-dimethyl-3-prop-l- enylcyclopropanecarboxylate, and 2, 3, 5, 6-tetrafluoro-4- (methoxymethyl) benzyl (IRS, 3RS; IRS, 3SR) -2, 2-dimethyl-3- (2- methyl-1-propenyl) cyclopropanecarboxylate;
(4) Nereisetoxin compounds cartap, bensultap, thiocyclam, monosultap, and bisultape;
(5) Neonicotinoid compounds imidacloprid, nitenpyram, acetamiprid, thiamethoxam, thiacloprid, clothianidin, and dinotefuran; (6) Benzoylurea compounds
chlorfluazuron, bistrifluron, diafenthiuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, and triflumuron; (7) Phenylpyrazzole compounds acetoprole, fipronil, vaniliprole, pyriprole, and pyrafluprole;
(8) Bt toxin insecticides living spores derived from Bacillus thuringiensis and crystalline toxin produced therefrom, as well as a mixture thereof;
(9) Hydrazine compounds chromafenozide, halofenozide, methoxyfenozide, and tebufenozide; (10) Organic chlorine-based compounds aldrin, dieldrin, dienochlor, endosulfan, and methoxychlor;
(11) Natural insecticides machine oil and nicotine-sulfate; (12) Other insecticides avermectin-B, bromopropylate, buprofezin, chlorphenapyr, cyromazine, 1, 3-dichloropropene, emamectin- benzoate, fenazaquin, flupyrazofos, hydroprene, indoxacarb, metoxadiazone, milbemycin-A, pymetrozine, pyridalyl, pyriproxyfen, spinosad, sulfluramide, tolfenpyrad,
triazamate, flubendiamide, SI-0009, cyfluinetofen, arsenic acid, benclothiaz, calcium cyanamide, calcium polysulfide, chlordane, DDT, DSP, flufenerim, flonicamide, flurimfen, formethanate, metarn-ammonium, metam-sodium, methyl bromide, nidinotefuran, potassium oleate, protrifenbute, spiromesifen, lepimectin, sulfur, metaflumizone, spirotetramat , NNI-OlOl, chlorantraniliprole, and a compound represented by the formula (A) : Formula (A) :
As arcaricides (active components of arcaricides) : acequinocyl, amitraz, benzoximate, bifenazate, bromopropylate, chinomethionat , chlorobenzilate, CPCBS
(chlorfenson) , clofentezine, cyflumetofen, dicofol, etoxazole, fenbutatin oxide, fenothiocarb, fenpyroximate, fluacrypyrim, fluproxyfen, hexythiazox, propargite (BPPS) , polynactins, pyridaben, pyrimidifen, tebufenpyrad, tetradifon, spirodiclofen, and amidoflumet.
As nematocides (active components of nematocides) : DCIP, fosthiazate, levamisol, methyisothiocyanate, morantel tartarate, imicyafos, and the like.
As fungicides : acibenzolar-S-methyl, amobam, ampropylfos, anilazine, azoxystrobin, benalaxyl, benodanil, benomyl, benthiavalicarb, benthiazole, bethoxazin, bitertanol, blasticidin-S, Bordeaux mixture, boscalid, bromuconazole, buthiobate, calcium hypochlorite, calcium polysulfide, captan, carbendazol, carboxin, carpropamid, chlobenthiazone, chloroneb, chloropicrin, chlorothalonil (TPN) , chlorthiophos, cinnamaldehyde, clozylacon, CNA (2,6- dichloro-4-nitroaniline) , copper hydroxide, copper sulfate, cyazofamid, cyfluphenamid, cymoxanil, cyproconazole, cyprodinil, cyprofuram, dazomet, debacarb, dichlofluanid,
D-D (1, 3-dichloropropene) , diclocymet, diclomezine, diethofencarb, difenoconazole, diflumetorim, dimefluazole, dimethirimol, dimethomorph, • M (diniconazole-M) , dinocap, edifenphos, epoxiconazole, nickel dithiocarbamate, etaconazole, ethaboxam, ethirimol, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fendazosulam, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fentiazon, fentin hydroxide, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, fluoroimide, fluotrimazole, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, fosetyl-Al, fthalide, fuberidazole, furalaxyl, furametpyr, furcarbanil, furconazole-cis, hexaconazole, hymexazol, IBP, imazalil, imibenconazole, iminoctadine-albesilate, iminoctadine- triacetate, iodocarb, ipconazole, iprodione, iprovalicarb, isoprothiolane, kasugamycin, kresoxim-methyl, mancozeb, maneb, mepanipyrim, mepronil, metalaxyl, metalaxyl-M, metam-sodium, methasulfocarb, methyl bromide, metconazole, methfuroxam, metominostrobin, metrafenone, metsulfovax, mildiomycin, milneb, myclobutanil, myclozolin, nabam, orysastrobin, ofurace, oxadixyl, oxolinic acid, oxpoconazole, oxycarboxin, oxytetracycline, pefurazoate, penconazole, pencycuron, picoxystrobin, polycarbamate, polyoxin, potassium hydrogen carbonate, probenazole, prochloraz, procymidone, propamocarb-hydrochloride,
propiconaole, propineb, proquinazid, prothiocarb, prothioconazole, pyracarbolid, pyraclostrobin, pyrazophos, pyributicarb, pyrifenox, pyrimethanil, pyroquilon, quinoxyfen, quintozene (PCNB) , silthiopham, simeconazole, sipconazole, sodium bibarbonate, sodium hypochlorite, spiroxamine, SSF-129 ( (E) -2- [2- (2, 5- dimethylphenoxymethyl) phenyl] -2-methoxyimino-N- methylacetamide) , streptomycin, sulfur, tebuconazole, tecloftalam, tetraconazole, thiabendazole, thiadinil, thiram (TMTD) , thifluzamide, thiophanate-methyl, tolclofos- methyl, TPN, triadimefon, triadimenol, triazoxide, triclamide, tricyclazole, tridemorph, triflumizole, trifloxystrobin, triforine, tr-iticonazole, validamycin, vinclozolin, viniconazole, zineb, ziram, and zoxamide . As herbicides, plant hormone agents and plant growth regulators : abscisic acid, acetochlor, acifluorfen-sodium, alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, aminoethoxyvinylglycine, aminopyralid, AC94 , 377, amiprofos-methyl, ancymidol, asulam, atrazine, aviglycine, azimsulfuron, beflubutamid, benfluralin, benfuresate, bensulfuron-methyl, bensulide (SAP) , bentazone, benthiocarb, benzamizole, benzfendizone, benzobicyclon, benzofenap, benzyl adenine, benzylaminopurine, bialaphos, bifenox, Brassinolide, bromacil, bromobutide, butachlor, butafenacil,
butamifos, butylate, cafenstrole, calcium carbonate, calcium peroxide, carbaryl, chlomethoxynil, chloridazon, chlorimuron-ethyl, chlorphthalim, chlorpropham, chlorsulfuron, chlorthal-dimethyl, chlorthiamid (DCBN) , choline chloride, cinidon-ethyl, cinmethylin, cinosulfuron, clethodim, clomeprop, cloxyfonac-sodium, chlormequat chloride, 4-CPA (4-chlorophenoxyacetic acid) , cliprop, clofencet, cumyluron, cyanazine, cyclanilide, cyclosulfamron, cyhalofop-butyl, 2, 4-Dichlorophenoxyacetic acid salts, dichlorprop (2, 4-DP), daimuron, dalapon (DPA), dimethenamid-P, daminozide, dazomet, n-decyl alcohol, dicamba-sodium (MDBA) , dichlobenil (DBN) , diflufenican, dikegulac, dimepiperate, dimethametryn, dimethenamid, diquat, dithiopyr, diuron, endothal, epocholeone, esprocarb, ethephon, ethidimuron, ethoxysulfuron, ethychlozate, etobenzanid, fenarimol, fenoxaprop-ethyl, fentrazamide, flazasulfuron, florasulam, fluazifop-butyl, fluazolate, flucarbazone, flufenacet, flufenpyr, flumetralin, flumioxazin, flupropanate-sodium, flupyrsulfuron-methyl- sodium, flurprimidol, fluthiacet-methyl, foramsulfuron, forchlorfenuron, formesafen, gibberellin, glufosinate, glyphosate, halosulfuron-methyl, hexazinone, imazamox, imazapic, imazapyr, imazaquin, imazosulfuron, inabenfide, indole acetic acid (IAA), indole butyric acid, iodosulfuron, ioxynil-octanoate, isouron, isoxachlortole, isoxadifen,
karbutilate, lactofen, lenacil, linuron, LGC-42153, maleic hydrazide, mecoprop (MCPP) , 2-methyl-4-chlorophenoxyacetic acid - salts, MCPA-thioethyl, 2-methyl-4- chlorophenoxybutanoic acid ethyl ester, mefenacet, mefluidide, mepiquat, mesosulfuron, mesotrione, methyl daimuron, metolachlor, metribuzin, metsulfuron-methyl, molinate, naphthylacetic acid, 1-naphthaleneacetamide, naproanilide, napropamide, n-decyl alcohol, nicosulfuron, n-phenylphthalamic acid, orbencarb, oxadiazon, oxaziclomefone, oxine-sulfate, paclobutrazol, paraquat, pelargonic acid, pendimethalin, penoxsulam, pentoxazone, pethoxamide, phenmedipham, picloram, picolinafen, piperonyl butoxide, piperophos, pretilachlor, primisulfuron-methyl, procarbazone, prodiamine, profluazol, profoxydim, prohexadione-calcium, prohydrojasmon, prometryn, propanil, propoxycarbazone, propyzamide, pyraflufen-ethyl, pyrazolate, pyrazosulfuron-ethyl, pyrazoxyfen, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac- methyl, pyrithiobac, quiclorac, quinoclamine, quizalofop- ethyl, rimsulfuron, sethoxydim, siduron, simazine, simetryn, sodium chlorate, sulfosulfuron, swep (MCC) , tebuthiuron, tepraloxydim, terbacil, terbucarb (MBPMC) , thenylchlor, thiazafluron, thiziazuron, thifensulfuron-methyl, triaziflam, tribufos, triclopyr, tridiphane, trifloxysulfuron, trifluralin, trinexapac-ethyl,
tritosulfuron, uniconazole-P, and vemolate (PPTC) .
As synergists: piperonyl butoxide, sesamex, N- (2-ethylhexyl) -8 , 9, 10- trinorborn-5-ene-2, 3-dicarboxyimide (MGK 264), WARF- antiresistant, and diethylmaleate .
As safeners: benoxacor, cloquintocet-mexyl, cyometrinil, daimuron, dichlormid, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, mefenpyr-diethyl, MG191, naphthalic anhydride, and oxabetrinil. Formulation Example 8
Ten (10) parts of the compound 2-2, and 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above Group A are added to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder. Formulation Example 9
Ten (10) parts of the compound 2-13, and 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above group A are added
to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder. Formulation Example 10
Ten (10) parts of the compound 2-29, and of 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above group A are added to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder. Formulation Example 11
Ten (10) parts of the compound 2-40, and 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above group A are added to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder.
Formulation Example 12
Ten (10) parts of the compound 2-5354, and 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above group A are added to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder. Formulation Example 13
Ten (10) parts of the compound 2-22, and 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above group A are added to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder. Formulation Example 14
Ten (10) parts of the compound 2-36, and 10 parts of the insecticide, acaricide, nematocide, fungicide, herbicide, plant hormone agent, plant growth regulator, synergist or safener listed in the above group A are added
to a mixture of 4 parts of sodium laurylsulfate, 2 parts of calcium ligninsulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of diatomite. The resultant mixture is thoroughly stirred and mixed to give a mixed wettable powder.
The following Test Examples will illustrate that the present invention is effective for control of pests.
In Test Examples 1 to 8, the formulation obtained by mixing 10 parts of the compound (I), 35 parts of white carbon containing 50 parts of ammonium polyoxyethylenealkyl ether sulfate and 55 parts of water, and pulverizing the mixture by a wet milling method was diluted with water so that the concentration of the active component was 500ppm. The resultant solution was used as a test solution. Test Example 1 (Spodoptera litura)
On the bottom of a polyethylene cup of 5.5 cm in diameter, filter paper of the same size was placed. Insecta LF (NIHON NOSAN KOGYO CO.) sliced into 6 mm in thickness and further cut into half was placed thereon, and 2 mL of the above test solution was impregnated. ' After air drying, five Spodoptela litura larvae in forth instar were released, and the cup was closed. The number of dead larvae was counted after 6 days .
The mortality rate was calculated by the following equation:
Mortality rate (%) = (Number of dead larvae/Number of test larvae) x 100 and evaluated by the following indexes:
4: 100%, 3: 80-99%, 2: 60-79%, 1: 30-59% and 0: 0-29% in mortality rate.
Any of the compound 2-2, compound 2-4, compound 2-8, compound 2-22, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-448, compound 2-
894, compound 2-5354 and compound 2-6023 was evaluated as index 3 or greater.
Test Example 2 (Adoxophyes orana)
On the bottom of a polyethylene cup of 5.5 cm in diameter, filter paper of the same size was placed.
Silkmate 2S (NIHON NOSAN KOGYO CO.) sliced into 2 mm in thickness was placed thereon, and 1 mL of the above test solution was impregnated. After air drying, filter paper of 5.5 cm in diameter was placed thereon, and thirty
Adoxophyes orana larvae in first instar were released. The cup was closed. The number of dead larvae was counted after 7 days.
The mortality rate was calculated by the following equation:
Mortality rate (%) = (Number of dead larvae/Number of test larvae) x 100 and evaluated by the following indexes:
4: 100%, 3: 80-99%, 2: 60-79%, 1: 30-59% and 0: 0-29% in mortality rate.
Any of the compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27 , compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448, compound 2-894, compound 2-
5354 and compound 2-6023 was evaluated as index 3 or greater .
Test Example 3 (Aphis gossypii) On the leaves of cucumber at a one-leaf stage raised in a one ounce cup, thirty Aphis gossypii larvae in first instar were released. Twenty (20) mL of the above test solution was sprayed next day. The number of survived larvae was counted after 6 days. The survival rate relative to an untreated cup was calculated by the following equation:
Survival rate (%) = (Number of survived larvae in test cup/Number of survived larvae in untreated cup) x 100 and evaluated by the following indexes: 4: 0%, 3: 1-10%, 2: 11-40%, 1: 41-70% and 0: > 70% in survival rate.
Any of the compound 2-2, compound 2-4, compound 2-8, compound 2-22, compound 2-31, compound 2-35, compound 2-894, compound 2-5354 and compound 2-6023 was evaluated as index 3 or greater.
Test Example 4 (Nilaparvata lugens)
Rice was raised in a 90 mL plastic cup, and 5 cm or more of the rice at a two- or three-leaves stage was cut from the top of the root. Twenty (20) mL/pot of the above test solution was sprayed. After air drying, thirty
Nilaparvata lugens larvae in first to second instar were released. The cup was closed. After 6 days, the number of survived larvae was counted.
The survival rate relative to an untreated cup was calculated by the following equation:
Survival rate (%) = (Number of survived larvae in test cup/Number of survived larvae in untreated cup) x 100 and evaluated by the following indexes: 4: 0%, 3: 1-10%, 2: 11-40%, 1: 41-70% and 0: >70% in survival rate.
Any of the compound 2-2, compound 2-13, compound 2-22, compound 2-29, compound 2-31, compound 2-35, compound 2-448, compound 2-894, compound 2-5354 and compound 2-6023 was evaluated as index 3 or greater. Test Example 5 (Musca domestica)
On the bottom of a polyethylene cup of 5.5 cm in diameter, filter paper of the same size was placed. The above test solution (0.7 mL) was added dropwise onto the filter paper, and 30 mg of sucrose was uniformly placed as bait. Ten Musca domestica female imagoes were released.
The cup was closed. The number of dead imagoes was counted after 24 hours.
The mortality rate was calculated by the following equation : Mortality rate (%) = (Number of dead larvae/Number of test larvae) x 100 and evaluated by the following indexes:
4: 100%, 3: 70-99%, 2: 40-69%, 1: 10-39% and 0: 0-9% in mortality rate. The compound 2-2 was evaluated as index 3 or greater.
Test Example 6 (Blattalla germanica)
On the bottom of a polyethylene cup of 5.5 cm in diameter, filter paper of the same size was placed. The above test solution (0.7 mL) was added dropwise onto the filter paper, and 30 mg of sucrose was uniformly placed as bait. Two Blattalla germanica male imagoes were released.
The cup was closed. The number of dead imagoes was counted after 6 days.
The mortality rate was calculated by the following equation:
Mortality rate (%) = (Number of dead larvae/Number of test larvae) x 100 and evaluated by the following indexes:
4: 100%, 2: 50%, and 0: 0% in mortality rate. The compound 2-2 was evaluated as index 4.
Test Example 7 (Culex pipiens pallens)
The above test solution (0.7 mL) was added to 100 mL of ion exchange water (concentration of the active component: 3.5 ppm) . In the solution, twenty Culex pipiens pallens larvae in last instar were released, and the number of dead larvae was counted after 1 day.
The mortality rate was calculated by the following equation :
Mortality rate (%) = (Number of dead larvae/Number of test larvae) x 100 and evaluated by the following indexes :
4: 91-100%, 2: 11-90%, and 0: 0-10% in mortality rate.
The compound 2-2, compound 2-4, compound 2-8, compound 2-22, compound 2-27 , compound 2-29, compound 2-31, compound 2-35, compound 2-40, compound 2-894 were evaluated as index 4. Test Example 8 (Plutella xylostella)
Thirty (30) mg of the compound (I) was dissolved in
0.075 mL of a mixture of xylene and N, N-dimethylformamide (DMF) (mixing ratio by volume being xylene : N, N- dimethylformamide = 1 : 1) . 0.04 mL of a mixture of xylene and Sorpol 3005X (trademark; manufactured by TOHO CHEMICAL
INDUSTRY CO., LTD.) (mixing ration by volume being xylene :
Sorpol 3005X = 1 : 9) was added thereto. The mixture was diluted with ion exchange water to prepare a test solution
(500 ppm) of the test compound.
Twenty (20) mL of the test solution was sprayed over Brassicae oleracea at a four leaves stage. After the test solution was dry, the terrestrial portion was cut out and placed in a polyethylene cup (100 mL volume) together with five Plutella xylostella larvae in second instar. The cup was stored at 25°C. The number of dead larvae was counted after 5 days.
The mortality rate was calculated by the following equation:
Mortality rate (%) = (Number of dead larvae/Number of test larvae) x 100 and evaluated by the following indexes:
4: 100%, 3: 80-99%, 2: 60-79%, 1: 30-59% and 0: 0-29% in mortality rate.
The compound 2-2, compound 2-4, compound 2-8, compound 2-13, compound 2-22, compound 2-27, compound 2-29, compound 2-31, compound 2-35, compound 2-36, compound 2-40, compound 2-94, compound 2-448, compound 2-894, compound 2-5354 and compound 2-6023 were evaluated as index 3 or greater. Test Example 9 (Bemisia tabaci)
Forty (40) mg of the compound (I) was dissolved in 0.1 mL of an organic solvent (xylene : DMF = 1 : 1) and 0.04 mL of a mixture of xylene and Sorpol 3005X (registered trademark; manufactured by TOHO CHEMICAL INDUSTRY CO.,
LTD.) (mixing ratio by volume being xylene : Sorpol 3005X = 1 : 9). The mixture was diluted with 80 mL of ion exchange water to prepare a 500 ppm compound solution. Thirty (30) mL of this solution was diluted with 45 mL of ion exchange water to prepare a 200 ppm compound solution. Twenty (20) mL of the 200 ppm compound solution was diluted with 60 mL of ion exchange water to prepare a 50 ppm compound solution, and 20 mL of the 50 ppm compound solution was further diluted with 60 mL of ion exchange water to prepare a 12.5 ppm compound solution. Dine (registered trademark; manufactured by TAKEDA PHARMACEUTICAL CO., LTD.) was added to each compound solution so that Dine was diluted by 3,000 times to prepare a test solution.
Cymbidium kanran was raised in a three ounce cup for about 3 weeks. All leaves except for a second true leaf were removed. Bemisia tabaci imagoes were released on the Cymbidium kanran and allowed to lay eggs for 3 days. The imagoes were removed, and the cup was stored in a green house for 8 days to incubate the eggs. Twenty (20) mL of the above test solution was sprayed, and the mortality rate of each pot was investigated after 7 days. The effect was evaluated by a five-point rating according to the following indexes . Index 4: mortality rate of 100%, index 3: mortality rate of 90-99% (attachment area of larvae being 1 to 10% of that in
an untreated group), index 2: mortality rate of 60-89% (attachment area of larvae being 11 to 40% of that of an untreated group), index 1: mortality rate of 30-59% (attachment area of larvae being 41 to 70% of that of an untreated group), and index 0: mortality rate of 0-29%
(attachment area of larvae being 71% or more of that of an untreated group)
The compound 2-2, compound 2-4, compound 2-31, compound 2-894, compound 2-5354 and compound 2-6023 were evaluated as index 3 or greater, in the case of 12.5 ppm. Test Example 10 (Haemaphysalis longicornis)
The compound (I) (0.5 mg) was dissolved in 1 mL of acetone, and uniformly applied on one side of filter paper (TOYO No.2; 5 x 10 cm) . After drying, the filter paper was folded in two, and the sides were clipped to make a pouch. Test ticks (Haemaphysalis longicornis, non-blood sucking nymphal ticks, ten ticks in a group) were placed therein. The open part of the pouch was clipped and sealed. Fatal ratio was observed after 2 days. The compound 2-22 and compound 2-29 showed a mortality rate of 90% or greater.
Industrial Applicability
As described hereinabove, the compound (I) has an excellent control efficacy against pests, and is useful as
an active component of a pest control preparation.
Claims
1. A thioimidate compound represented by the formula (D :
2. The thioimidate compound according to claim 1, wherein R in the formula (I) represents a C6-12 bicycloalkyl group .
3. The thioimidate compound according to claim 1, wherein R in the formula (I) represents a bicyclo [ 4.4.0] decyl group.
4. A pest control preparation comprising the compound according to any one of claims 1 to 3 as an active component .
5. Use of the compound according to any one of claims 1 to 3 for controlling pests.
6. Use of the compound according to any one of claims 1 to 3 for production of a pest control preparation.
7. A pest control method which comprises applying the compound according to any one of claims 1 to 3 to pests or habitats of pests.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007-142830 | 2007-05-30 | ||
| JP2007142830 | 2007-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2008149962A1 true WO2008149962A1 (en) | 2008-12-11 |
Family
ID=39768509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2008/060407 WO2008149962A1 (en) | 2007-05-30 | 2008-05-30 | Thioimidate compound and use thereof for controlling pests |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5304026B2 (en) |
| AR (1) | AR066755A1 (en) |
| TW (1) | TW200901876A (en) |
| WO (1) | WO2008149962A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012072489A1 (en) | 2010-11-29 | 2012-06-07 | Bayer Cropscience Ag | Alpha,beta-unsaturated imines |
| US8920846B2 (en) | 2009-09-10 | 2014-12-30 | Sumitomo Chemical Company, Limited | Microcapsule and production method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016029022A (en) * | 2012-12-21 | 2016-03-03 | 日本曹達株式会社 | 1-aryl-1-heterodiene compounds and pest control agents |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0317266A2 (en) * | 1987-11-17 | 1989-05-24 | Ici Americas Inc. | Novel thioimidate and amidine insecticides |
| EP0656352A1 (en) * | 1993-12-03 | 1995-06-07 | BASF Aktiengesellschaft | Thioimidates as agents against animal pests and pest fungi |
| JPH09202766A (en) * | 1996-01-24 | 1997-08-05 | Kuraray Co Ltd | Production of unsaturated thioimidate |
| US5691333A (en) * | 1995-04-07 | 1997-11-25 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole-3-carboximidothoic acid esters |
| WO2007063702A2 (en) * | 2005-12-01 | 2007-06-07 | Sumitomo Chemical Company, Limited | Iminopropene compound and use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5239148B2 (en) * | 2005-12-01 | 2013-07-17 | 住友化学株式会社 | 3-Iminopropene compound, pest control agent containing it, and its use for pest control |
-
2008
- 2008-05-19 TW TW097118336A patent/TW200901876A/en unknown
- 2008-05-28 JP JP2008139139A patent/JP5304026B2/en not_active Expired - Fee Related
- 2008-05-29 AR ARP080102252A patent/AR066755A1/en unknown
- 2008-05-30 WO PCT/JP2008/060407 patent/WO2008149962A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0317266A2 (en) * | 1987-11-17 | 1989-05-24 | Ici Americas Inc. | Novel thioimidate and amidine insecticides |
| EP0656352A1 (en) * | 1993-12-03 | 1995-06-07 | BASF Aktiengesellschaft | Thioimidates as agents against animal pests and pest fungi |
| US5691333A (en) * | 1995-04-07 | 1997-11-25 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole-3-carboximidothoic acid esters |
| JPH09202766A (en) * | 1996-01-24 | 1997-08-05 | Kuraray Co Ltd | Production of unsaturated thioimidate |
| WO2007063702A2 (en) * | 2005-12-01 | 2007-06-07 | Sumitomo Chemical Company, Limited | Iminopropene compound and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| DATABASE WPI Week 199741, Derwent World Patents Index; AN 1997-444077, XP002497867 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8920846B2 (en) | 2009-09-10 | 2014-12-30 | Sumitomo Chemical Company, Limited | Microcapsule and production method thereof |
| WO2012072489A1 (en) | 2010-11-29 | 2012-06-07 | Bayer Cropscience Ag | Alpha,beta-unsaturated imines |
| US9055743B2 (en) | 2010-11-29 | 2015-06-16 | Bayer Intellectual Property Gmbh | Alpha, beta-unsaturated imines |
Also Published As
| Publication number | Publication date |
|---|---|
| AR066755A1 (en) | 2009-09-09 |
| TW200901876A (en) | 2009-01-16 |
| JP2009007343A (en) | 2009-01-15 |
| JP5304026B2 (en) | 2013-10-02 |
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