WO2008145830A3 - Nouveaux composes pro-fluorescents - Google Patents
Nouveaux composes pro-fluorescents Download PDFInfo
- Publication number
- WO2008145830A3 WO2008145830A3 PCT/FR2007/052631 FR2007052631W WO2008145830A3 WO 2008145830 A3 WO2008145830 A3 WO 2008145830A3 FR 2007052631 W FR2007052631 W FR 2007052631W WO 2008145830 A3 WO2008145830 A3 WO 2008145830A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- radical
- emission
- activated
- release
- pattern
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 238000000295 emission spectrum Methods 0.000 abstract 2
- 238000000695 excitation spectrum Methods 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- -1 sulphinate Chemical compound 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
- A61K47/556—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells enzyme catalyzed therapeutic agent [ECTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0026—Acridine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0039—Coumarin dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne un composé pro-fluorescent de formule générale (I): A-B-X-F(I) dans laquelle A figure une structure labile activable par un phénomène physique, chimique ou biologique,B figure un bras réactif, activable par libération de A et apte à générer un radical portant un substituant nucléophile, éventuellement anionique, ledit radical étant apte à subir un réarrangement intramoléculaire conduisant à la libération de F,X figure un atome de soufre, d' oxygène, un motif OC(O), OC(O)O, OS(O) ou OP(O), F figure un radical fluorophore compatible avec l'établissement d'une liaison éther, thioéther, ester, carbonate, sulfate, sulfinate, sulfonate, phosphate, phosphonate, phosphinate ou aminophosphonate avec B via le motif X et étant tel que le spectre d'émission et/ou d'excitation de F lié à B est décalé relativement au spectre d'émission et/ou d'excitation de F libre.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0656061 | 2006-12-29 | ||
FR0656061A FR2910897B1 (fr) | 2006-12-29 | 2006-12-29 | Nouveaux composes pro-fluorescents. |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008145830A2 WO2008145830A2 (fr) | 2008-12-04 |
WO2008145830A3 true WO2008145830A3 (fr) | 2009-03-19 |
Family
ID=38542979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2007/052631 WO2008145830A2 (fr) | 2006-12-29 | 2007-12-28 | Nouveaux composes pro-fluorescents |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2910897B1 (fr) |
WO (1) | WO2008145830A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9400273B1 (en) | 2009-12-09 | 2016-07-26 | Life Technologies Corporation | 7-hydroxycoumarin-based cell-tracking reagents |
EP2760844B1 (fr) | 2011-09-29 | 2018-11-21 | Ecole Normale Superieure De Lyon | Substrat de peptidase fluorogene |
FR2994180B1 (fr) | 2012-08-02 | 2014-08-22 | Ecole Norm Superieure Lyon | Substrat de glycosidase fluorogene et procede de detection associe |
CN108623624A (zh) * | 2018-06-12 | 2018-10-09 | 兰州大学 | 一种用探针s-f裸眼鉴别含氟牙膏的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2324529A (en) * | 1997-02-21 | 1998-10-28 | Merck & Co Inc | A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases |
WO2006129036A2 (fr) * | 2005-05-27 | 2006-12-07 | Quidd | Biomarqueur a emission luminescente |
-
2006
- 2006-12-29 FR FR0656061A patent/FR2910897B1/fr not_active Expired - Fee Related
-
2007
- 2007-12-28 WO PCT/FR2007/052631 patent/WO2008145830A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2324529A (en) * | 1997-02-21 | 1998-10-28 | Merck & Co Inc | A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases |
WO2006129036A2 (fr) * | 2005-05-27 | 2006-12-07 | Quidd | Biomarqueur a emission luminescente |
Non-Patent Citations (5)
Title |
---|
CARL P L ET AL: "A NOVEL CONNECTOR LINKAGE APPLICABLE IN PRODRUG DESIGN", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 24, no. 5, May 1981 (1981-05-01), pages 479 - 480, XP009079818, ISSN: 0022-2623 * |
GROOT DE FRANCISCUS M H ET AL: "Elongated Multiple Electronic Cascade and Cyclization Spacer Systems in Activatible Anticancer Prodrugs for Enhanced Drug Release", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 66, 2001, pages 8815 - 8830, XP002212035, ISSN: 0022-3263 * |
JONES ET AL: "An image contrast agent selectively activated by prostate specific antigen", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 14, no. 2, 15 January 2006 (2006-01-15), pages 418 - 425, XP005202852, ISSN: 0968-0896 * |
LAXMAN B ET AL: "Noninvasive real-time imaging of apoptosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 26, 24 December 2002 (2002-12-24), pages 16551 - 16555, XP002333223, ISSN: 0027-8424 * |
WANG Z-Q ET AL: "N-DEVD-N'-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 9, 2 May 2005 (2005-05-02), pages 2335 - 2338, XP004851625, ISSN: 0960-894X * |
Also Published As
Publication number | Publication date |
---|---|
FR2910897B1 (fr) | 2011-05-20 |
WO2008145830A2 (fr) | 2008-12-04 |
FR2910897A1 (fr) | 2008-07-04 |
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