WO2008143880A8 - Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales - Google Patents
Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales Download PDFInfo
- Publication number
- WO2008143880A8 WO2008143880A8 PCT/US2008/006158 US2008006158W WO2008143880A8 WO 2008143880 A8 WO2008143880 A8 WO 2008143880A8 US 2008006158 W US2008006158 W US 2008006158W WO 2008143880 A8 WO2008143880 A8 WO 2008143880A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- brain injury
- traumatic brain
- bryologs
- bryostatins
- therapeutic effects
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention porte: sur l'utilisation de protéines kinases activant ou renforçant le facteur de croissance des nerf (NGF); sur le facteur tiré du cerveau (BDNF); sur d'autres facteurs neurotropes traitant les lésions traumatiques cérébrales (TBI), et spécifiquement, sur des méthodes de traitement des lésions traumatiques cérébrales comprenant les étapes suivantes: identification d'un sujet ayant subi une lésion traumatique cérébrale; administration au sujet d'une quantité efficace d'une préparation pharmaceutique comprenant un activateur de la protéine kinase C (PKC) ou de l'acide 4-méthylcatéchol acétique, dans un excipient ad hoc pour traiter au moins un symptôme de lésion traumatique cérébrale
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92466207P | 2007-05-24 | 2007-05-24 | |
US60/924,662 | 2007-05-24 | ||
USPCT/US2008/001755 | 2008-02-11 | ||
US12/068,742 US9974832B2 (en) | 2007-02-09 | 2008-02-11 | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
PCT/US2008/001755 WO2008100449A2 (fr) | 2007-02-09 | 2008-02-11 | Effets thérapeutiques des bryostatines, de leurs analogues, et d'autres substances connexes sur l'affaiblissement de la mémoire induite par un traumatisme crânien et sur les lésions cérébrales |
US12/068,742 | 2008-02-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008143880A2 WO2008143880A2 (fr) | 2008-11-27 |
WO2008143880A3 WO2008143880A3 (fr) | 2009-06-04 |
WO2008143880A8 true WO2008143880A8 (fr) | 2009-08-13 |
Family
ID=40091420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/006158 WO2008143880A2 (fr) | 2007-05-24 | 2008-05-14 | Effets thérapeutiques des bryostatines, bryologues, et autres substances associées sur des défaillances de mémoire dues ä à des traumatismes crâniens ou à des lésions traumatiques cérébrales |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008143880A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2804789A1 (fr) | 2010-07-08 | 2012-01-12 | Daniel L. Alkon | Activateurs de pkc et anticoagulant dans un regime pour le traitement d'un accident vasculaire cerebral |
RU2470302C1 (ru) * | 2011-09-21 | 2012-12-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера" Министерства здравоохранения и социального развития Российской Федерации | Способ прогнозирования когнитивных нарушений в отдаленном периоде черепно-мозговой травмы |
US20160025704A1 (en) * | 2013-03-15 | 2016-01-28 | Daniel L. Alkon | Methods for identifying neuroprotective pkc activators |
WO2023133230A1 (fr) * | 2022-01-08 | 2023-07-13 | Sohn Joanna | Monoacétyldiglycérides (plag) en tant qu'agent d'atténuation pour lésion cérébrale traumatique et lésion de reperfusion ischémique |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
EP1551387A4 (fr) * | 2002-07-02 | 2007-10-10 | Brni Neurosciences Inst | Activation de la pkc utilisee pour renforcer la secretion de la sapp-a et pour ameliorer la gognition, au moyen de composes du type bryostatine |
US20040229292A1 (en) * | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
CN101541322A (zh) * | 2006-07-28 | 2009-09-23 | 布朗歇特洛克菲勒神经科学研究所 | 刺激细胞生长、突触重塑和巩固长期记忆的方法 |
EP3332797A3 (fr) * | 2007-02-09 | 2018-08-01 | Blanchette Rockefeller Neurosciences Institute | Effets thérapeutiques des bryostatines, bryologues et autres substances apparentées sur les troubles de la mémoire et les lésions cérébrales suite à un traumatisme crânien |
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2008
- 2008-05-14 WO PCT/US2008/006158 patent/WO2008143880A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008143880A2 (fr) | 2008-11-27 |
WO2008143880A3 (fr) | 2009-06-04 |
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