WO2008143192A1 - アスパラギン酸の化学伝達を司るトランスポーターの同定とその利用 - Google Patents

アスパラギン酸の化学伝達を司るトランスポーターの同定とその利用 Download PDF

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Publication number
WO2008143192A1
WO2008143192A1 PCT/JP2008/059079 JP2008059079W WO2008143192A1 WO 2008143192 A1 WO2008143192 A1 WO 2008143192A1 JP 2008059079 W JP2008059079 W JP 2008059079W WO 2008143192 A1 WO2008143192 A1 WO 2008143192A1
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WO
WIPO (PCT)
Prior art keywords
transporter
aspartic acid
charge
identification
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/059079
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English (en)
French (fr)
Inventor
Yoshinori Moriyama
Hiroshi Omote
Takaaki Miyachi
Miki Hiasa
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Okayama University NUC
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Okayama University NUC
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Application filed by Okayama University NUC filed Critical Okayama University NUC
Priority to JP2008552574A priority Critical patent/JP5317056B2/ja
Publication of WO2008143192A1 publication Critical patent/WO2008143192A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

アスパラギン酸輸送を担うトランスポーターおよびそれをコードする遺伝子を同定し、さらに、そのようなトランスポーターを含む人工膜を用いる、トランスポーターの活性調節剤のスクリーニング法を提供することを、本発明の課題とする。さらに、そのようなスクリーニング法によって、アスパラギン酸代謝が関与する疾患の予防剤・治療剤の候補物質を提供することもまた、本発明の課題である。本発明に従って、アスパラギン酸輸送を担うトランスポーターおよびそれをコードする遺伝子が同定された。さらに、そのようなトランスポーターを用いる、アスパラギン酸トランスポーター活性調節剤のスクリーニング法、ならびにアスパラギン酸代謝が関与する疾患の予防剤・治療剤の候補物質を提供するスクリーニング法が提供される。
PCT/JP2008/059079 2007-05-18 2008-05-16 アスパラギン酸の化学伝達を司るトランスポーターの同定とその利用 Ceased WO2008143192A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008552574A JP5317056B2 (ja) 2007-05-18 2008-05-16 アスパラギン酸の化学伝達を司るトランスポーターの同定とその利用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007133435 2007-05-18
JP2007-133435 2007-05-18

Publications (1)

Publication Number Publication Date
WO2008143192A1 true WO2008143192A1 (ja) 2008-11-27

Family

ID=40031893

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059079 Ceased WO2008143192A1 (ja) 2007-05-18 2008-05-16 アスパラギン酸の化学伝達を司るトランスポーターの同定とその利用

Country Status (2)

Country Link
JP (1) JP5317056B2 (ja)
WO (1) WO2008143192A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021129511A (ja) * 2020-02-19 2021-09-09 学校法人 東洋大学 Ｎａ＋／Ｈ＋アンチポーターの特異的阻害剤スクリーニング方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005375A1 (en) * 1998-07-22 2000-02-03 Vanderbilt University Gbs toxin receptor
EP1069184A1 (en) * 1999-07-16 2001-01-17 Akzo Nobel N.V. Human anion transporter gene implicated in Salla disease and lysosomal sialic acid transport

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005375A1 (en) * 1998-07-22 2000-02-03 Vanderbilt University Gbs toxin receptor
EP1069184A1 (en) * 1999-07-16 2001-01-17 Akzo Nobel N.V. Human anion transporter gene implicated in Salla disease and lysosomal sialic acid transport

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAVELAAR A.C. ET AL.: "Transport of organic anions by the lysosomal sialic acid transporter: a functional approach towards the gene for sialic acid storage disease", FEBS LETT., vol. 446, no. 1, 1999, pages 65 - 68, XP004259321 *
JUGEN N.: "Vesicular glutamate transporter contains two independent transport machineries", J. BIOL. CHEM., vol. 281, no. 51, 22 December 2006 (2006-12-22), pages 39499 - 39506, XP008120904, DOI: doi:10.1074/jbc.M607670200 *
VERHEIJEN F. ET AL.: "A new gene, encoding an anion transporter is mutated in sialic acid storage diseases", NAT. GENET., vol. 23, no. 4, 1999, pages 462 - 465 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021129511A (ja) * 2020-02-19 2021-09-09 学校法人 東洋大学 Ｎａ＋／Ｈ＋アンチポーターの特異的阻害剤スクリーニング方法
JP7593608B2 (ja) 2020-02-19 2024-12-03 学校法人 東洋大学 Ｎａ＋／Ｈ＋アンチポーターの特異的阻害剤スクリーニング方法

Also Published As

Publication number Publication date
JP5317056B2 (ja) 2013-10-16
JPWO2008143192A1 (ja) 2010-08-05

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