WO2008142842A1 - 蛋白質結晶作製装置及び蛋白質結晶作製方法 - Google Patents

蛋白質結晶作製装置及び蛋白質結晶作製方法 Download PDF

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Publication number
WO2008142842A1
WO2008142842A1 PCT/JP2008/001173 JP2008001173W WO2008142842A1 WO 2008142842 A1 WO2008142842 A1 WO 2008142842A1 JP 2008001173 W JP2008001173 W JP 2008001173W WO 2008142842 A1 WO2008142842 A1 WO 2008142842A1
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WO
WIPO (PCT)
Prior art keywords
producing
crystals
protein crystals
protein
light
Prior art date
Application number
PCT/JP2008/001173
Other languages
English (en)
French (fr)
Inventor
Itsuro Motegi
Tetsuo Okutsu
Original Assignee
Panasonic Corporation
National University Corporation Gunma University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panasonic Corporation, National University Corporation Gunma University filed Critical Panasonic Corporation
Publication of WO2008142842A1 publication Critical patent/WO2008142842A1/ja

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0077—Screening for crystallisation conditions or for crystal forms
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus

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  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

　確度の高い蛋白質結晶化条件に効率よく到達して蛋白質結晶を作製することができる蛋白質結晶作製装置及び蛋白質結晶作製方法の提供。容器に設けられた複数のウェルのうちスクリーニング用のウェル内の蛋白質溶液に蛋白質結晶作製用の光を照射し、蛋白質結晶作製用の光が照射された後の蛋白質溶液の濁度を計測して、濁度検出の検出結果に基づいて最も高い確率で結晶化が期待される濁度を与える光の照射条件を求めて、この照射条件を結晶作製用の光の照射条件を結晶化条件として設定する。次いで結晶作製用のウェルに設定された結晶化条件に基づいて結晶作製用の光を照射して、蛋白質溶液内に結晶核を生成させ、この結晶核を成長させて蛋白質結晶作製を行う。
PCT/JP2008/001173 2007-05-10 2008-05-09 蛋白質結晶作製装置及び蛋白質結晶作製方法 WO2008142842A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-125953 2007-05-10
JP2007125953A JP2008280292A (ja) 2007-05-10 2007-05-10 蛋白質結晶作製装置及び蛋白質結晶作製方法

Publications (1)

Publication Number Publication Date
WO2008142842A1 true WO2008142842A1 (ja) 2008-11-27

Family

ID=40031561

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001173 WO2008142842A1 (ja) 2007-05-10 2008-05-09 蛋白質結晶作製装置及び蛋白質結晶作製方法

Country Status (2)

Country Link
JP (1) JP2008280292A (ja)
WO (1) WO2008142842A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019504995A (ja) * 2016-01-28 2019-02-21 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 複数の露光を使用して試料容器及び／又は試料を画像化するための方法及び装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003306497A (ja) * 2002-02-12 2003-10-28 Tetsuo Okutsu 巨大分子結晶の製造方法及びそれに用いる製造装置
JP2004050147A (ja) * 2002-07-24 2004-02-19 Satake Chemical Equipment Mfg Ltd 晶析装置の結晶粒度制御装置
WO2004018744A1 (ja) * 2002-08-26 2004-03-04 Osaka Industrial Promotion Organization 結晶核の製造方法および結晶化条件スクリーニング方法
JP2004532974A (ja) * 2001-01-19 2004-10-28 ケミカル ホロボイス アクティエボラーグ 浮揚させた小滴で分子の核生成傾向をスクリーニングするためのシステム及び方法
JP2005520174A (ja) * 2002-04-10 2005-07-07 ケンドロ ラボラトリィ プロダクツ、 エル ピイ 自動化された蛋白質結晶化の画像化

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532974A (ja) * 2001-01-19 2004-10-28 ケミカル ホロボイス アクティエボラーグ 浮揚させた小滴で分子の核生成傾向をスクリーニングするためのシステム及び方法
JP2003306497A (ja) * 2002-02-12 2003-10-28 Tetsuo Okutsu 巨大分子結晶の製造方法及びそれに用いる製造装置
JP2005520174A (ja) * 2002-04-10 2005-07-07 ケンドロ ラボラトリィ プロダクツ、 エル ピイ 自動化された蛋白質結晶化の画像化
JP2004050147A (ja) * 2002-07-24 2004-02-19 Satake Chemical Equipment Mfg Ltd 晶析装置の結晶粒度制御装置
WO2004018744A1 (ja) * 2002-08-26 2004-03-04 Osaka Industrial Promotion Organization 結晶核の製造方法および結晶化条件スクリーニング方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019504995A (ja) * 2016-01-28 2019-02-21 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 複数の露光を使用して試料容器及び／又は試料を画像化するための方法及び装置
US10928310B2 (en) 2016-01-28 2021-02-23 Siemens Healthcare Diagnostics Inc. Methods and apparatus for imaging a specimen container and/or specimen using multiple exposures

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