WO2008133717A2 - Procédé de contrôle de la transmission du staphylocoque doré résistant à la méthicilline d'origine extra-hospitalière, et prévention ou réduction des infections causées par cet agent - Google Patents

Procédé de contrôle de la transmission du staphylocoque doré résistant à la méthicilline d'origine extra-hospitalière, et prévention ou réduction des infections causées par cet agent Download PDF

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Publication number
WO2008133717A2
WO2008133717A2 PCT/US2007/083584 US2007083584W WO2008133717A2 WO 2008133717 A2 WO2008133717 A2 WO 2008133717A2 US 2007083584 W US2007083584 W US 2007083584W WO 2008133717 A2 WO2008133717 A2 WO 2008133717A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition
mrsa
activated
antibacterial
antimicrobial agent
Prior art date
Application number
PCT/US2007/083584
Other languages
English (en)
Other versions
WO2008133717A3 (fr
Inventor
George E. Fischler
Janice Lynn Fuls
Nancy Day Rodgers
Original Assignee
The Dial Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Dial Corporation filed Critical The Dial Corporation
Publication of WO2008133717A2 publication Critical patent/WO2008133717A2/fr
Publication of WO2008133717A3 publication Critical patent/WO2008133717A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system

Definitions

  • MRSA strain has become resistant to many of the standard antibiotic therapies. MRSA, therefore, is resistant to multiple antibiotics, specifically, all beta-lactams antibiotics, like methicillin, as well as other antibiotics, such as oxacillin, penicillin, and amoxicillin. Vancomycin often is the only drug that successfully treats MRSA infections. MRSA, therefore, is a considerable public health concern.
  • CA-MRSA from an animate or inanimate surface to an animate surface, and particularly to human skin.
  • the present invention also relates to a method of reducing the incidence of infections caused by CA-MRSA.
  • the method provides a rapid and a residual control of CA- MRSA on an animate or inanimate surface.
  • activated hand sanitizer gels typically contain: (a) about 1% to about 75%, by weight, of a disinfecting alcohol, such as ethanol or a combination of lower alcohols, like ethanol and isopropanol, (b) about 0.1% to about 5% of a phenolic antimicrobial agent, (c) water, (d) an optional gelling agent, such as a crosslinked polyacrylate material, and (e) other optional ingredients, such as skin conditioners, fragrances, polyhydric solvents, and the like.
  • a disinfecting alcohol such as ethanol or a combination of lower alcohols, like ethanol and isopropanol
  • a phenolic antimicrobial agent such as ethanol or a combination of lower alcohols, like ethanol and isopropanol
  • water water
  • an optional gelling agent such as a crosslinked polyacrylate material
  • other optional ingredients such as skin conditioners, fragrances, polyhydric solvents, and the like.
  • the hand sanitizer gel also has a
  • the activated antibacterial composition typically is a mild, and preferably mildly acidic to neutral, composition.
  • Preferred activated antibacterial compositions are disclosed, for example, in U.S. Patent Nos. 6,107,261 and 6,136,771, each incorporated herein by reference.
  • An example of a useful commercial neutral to mildly acidic cleansing composition is Dial Complete, available from The Dial Corporation, Scottsdale, AZ.
  • an antimicrobial agent can be present in an activated antibacterial composition in an amount of 0.1% to about 10%, and preferably about 0.1% to about 5%, or about 0.1% to about 2%, and more preferably, about 0.3% to about 1%, by weight of the composition.
  • Activated hand sanitizer gels used in the present method contain about 1 % to about 75%, by weight, of a disinfecting alcohol.
  • Preferred embodiments of the present invention contain about 2% to about 60%, by weight, of a disinfecting alcohol. Most preferred embodiments contain about 5% to about 40%, by weight, of a disinfecting alcohol.
  • the term "disinfecting alcohol” is a water-soluble alcohol containing one to six carbon atoms, i.e., a Ci- ⁇ alcohol. Disinfecting alcohols include, but are not limited to, methanol, ethanol, propanol, and isopropyl alcohol.
  • Exemplary gelling agents present in an activated antibacterial composition include, but are not limited to,
  • the composition was prepared by first admixing the triclosan and dipropylene glycol until homogeneous (about 5 minutes). After the triclosan was completely dissolved, as evidenced by the absence of the undissolved solid material, the sodium xylene sulfonate was added to the solution. The mixture then was stirred to completely dissolve the sodium xylene sulfonate (about 5 minutes). Finally, the ammonium lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about 5 minutes). The composition had a weight ratio of surfactanttriclosan of 2.5:1 and was at least about 90% saturated with triclosan.
  • both animate and inanimate surfaces can be treated in accordance with the method of the present invention.
  • a particularly important surface is mammalian skin, and particularly human skin, to inactivate CA-MRSA, and, in turn, interrupt the transmission of CA-MRSA.
  • the present method also is useful in treating inanimate surfaces of all types.
  • the present method can be used to treat environmental surfaces such as floors, walls, ceilings, and drains.
  • the method can be used to treat equipment such as food processing equipment, dairy processing equipment, brewery equipment, and the like.
  • the compositions can be used to treat a variety of surfaces including food contact surfaces in food, dairy, and brewing facilities, countertops, furniture, sinks, telephones, and the like.
  • the method further can be used to treat tools and instruments, such as medical tools and instruments, dental tools and instruments, as well as equipment used in the healthcare industries and institutional kitchens, including knives, wares (such as pots, pans, and dishes, cutting equipment, and the like).

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cette invention se rapporte à un procédé de lutte contre la transmission du staphylocoque doré résistant à la méthicilline d'origine extra-hospitalière (CA-MRSA), ledit procédé utilisant une composition antibactérienne activée. L'invention a également trait à des procédés de réduction et de prévention des infections causées par CA-MRSA.
PCT/US2007/083584 2006-11-07 2007-11-05 Procédé de contrôle de la transmission du staphylocoque doré résistant à la méthicilline d'origine extra-hospitalière, et prévention ou réduction des infections causées par cet agent WO2008133717A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85744706P 2006-11-07 2006-11-07
US60/857,447 2006-11-07

Publications (2)

Publication Number Publication Date
WO2008133717A2 true WO2008133717A2 (fr) 2008-11-06
WO2008133717A3 WO2008133717A3 (fr) 2009-12-03

Family

ID=39926244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/083584 WO2008133717A2 (fr) 2006-11-07 2007-11-05 Procédé de contrôle de la transmission du staphylocoque doré résistant à la méthicilline d'origine extra-hospitalière, et prévention ou réduction des infections causées par cet agent

Country Status (1)

Country Link
WO (1) WO2008133717A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2566062C2 (ru) * 2011-03-08 2015-10-20 Ска Хайджин Продактс Аб Противомикробная очищающая композиция с низким содержанием спирта
WO2020252131A1 (fr) * 2019-06-12 2020-12-17 Ausubel Frederick M Composés antibiotiques

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07252105A (ja) * 1994-03-15 1995-10-03 Iwao Hishida 液状消毒剤
JPH1087410A (ja) * 1996-09-17 1998-04-07 Kanto Chem Co Inc 殺菌消毒用組成物
EP0937394A1 (fr) * 1998-01-20 1999-08-25 Ethicon, Inc. Composition anti-microbienne
US6136771A (en) * 1999-06-23 2000-10-24 The Dial Corporation Compositions containing a high percent saturation concentration of antibacterial agent
WO2001041567A1 (fr) * 1999-12-13 2001-06-14 Ethicon, Inc. Compositions antimicrobiennes a forte penetration
WO2002078667A1 (fr) * 2001-03-29 2002-10-10 The Dial Corporation Compositions antibacteriennes pour soin cutane
WO2004080179A1 (fr) * 2003-03-10 2004-09-23 Xantech Pharmaceuticals, Inc. Compositions de desinfection superficielle a performance antimicrobienne amelioree

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07252105A (ja) * 1994-03-15 1995-10-03 Iwao Hishida 液状消毒剤
JPH1087410A (ja) * 1996-09-17 1998-04-07 Kanto Chem Co Inc 殺菌消毒用組成物
EP0937394A1 (fr) * 1998-01-20 1999-08-25 Ethicon, Inc. Composition anti-microbienne
US6136771A (en) * 1999-06-23 2000-10-24 The Dial Corporation Compositions containing a high percent saturation concentration of antibacterial agent
US6204230B1 (en) * 1999-06-23 2001-03-20 The Dial Corporation Antibacterial compositions containing a solvent, hydrotrope, and surfactant
WO2001041567A1 (fr) * 1999-12-13 2001-06-14 Ethicon, Inc. Compositions antimicrobiennes a forte penetration
WO2002078667A1 (fr) * 2001-03-29 2002-10-10 The Dial Corporation Compositions antibacteriennes pour soin cutane
WO2004080179A1 (fr) * 2003-03-10 2004-09-23 Xantech Pharmaceuticals, Inc. Compositions de desinfection superficielle a performance antimicrobienne amelioree

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HALEY C E ET AL: "BACTERICIDAL ACTIVITY OF ANTISEPTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS" JOURNAL OF CLINICAL MICROBIOLOGY, vol. 21, no. 6, 1985, pages 991-992, XP002548038 ISSN: 0095-1137 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2566062C2 (ru) * 2011-03-08 2015-10-20 Ска Хайджин Продактс Аб Противомикробная очищающая композиция с низким содержанием спирта
WO2020252131A1 (fr) * 2019-06-12 2020-12-17 Ausubel Frederick M Composés antibiotiques

Also Published As

Publication number Publication date
WO2008133717A3 (fr) 2009-12-03

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