WO2008131859A3 - Use of cyclically substituted furopyrimidine derivatives for treating pulmonary arterial hypertonia - Google Patents
Use of cyclically substituted furopyrimidine derivatives for treating pulmonary arterial hypertonia Download PDFInfo
- Publication number
- WO2008131859A3 WO2008131859A3 PCT/EP2008/003008 EP2008003008W WO2008131859A3 WO 2008131859 A3 WO2008131859 A3 WO 2008131859A3 EP 2008003008 W EP2008003008 W EP 2008003008W WO 2008131859 A3 WO2008131859 A3 WO 2008131859A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pulmonary arterial
- hypertonia
- treating pulmonary
- cyclically substituted
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002685134A CA2685134A1 (en) | 2007-04-26 | 2008-04-16 | Use of cyclically substituted furopyrimidine derivatives for treating pulmonary arterial hypertonia |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007019690.5 | 2007-04-26 | ||
DE102007019690A DE102007019690A1 (en) | 2007-04-26 | 2007-04-26 | Use of cyclic substituted furopyrimidine derivatives for the treatment of pulmonary arterial hypertension |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008131859A2 WO2008131859A2 (en) | 2008-11-06 |
WO2008131859A3 true WO2008131859A3 (en) | 2009-07-16 |
Family
ID=39777458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/003008 WO2008131859A2 (en) | 2007-04-26 | 2008-04-16 | Use of cyclically substituted furopyrimidine derivatives for treating pulmonary arterial hypertonia |
Country Status (3)
Country | Link |
---|---|
CA (1) | CA2685134A1 (en) |
DE (1) | DE102007019690A1 (en) |
WO (1) | WO2008131859A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
MX2021005047A (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences Inc | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors. |
EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1817146A1 (en) * | 1968-01-05 | 1969-11-27 | Pfizer & Co C | 4-aminofuro [2,3-d] pyrimidines and their use as relaxants for smooth muscles |
EP1018514A1 (en) * | 1998-07-22 | 2000-07-12 | Suntory Limited | NF-$g(k)B INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT |
WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
EP1132093A1 (en) * | 1999-09-17 | 2001-09-12 | Suntory Limited | Preventives or remedies for myocarditis, dilated cardiomyopathy and cardiac insufficiency containing nf-kappa b inhibitors as the active ingredient |
WO2002092603A1 (en) * | 2001-05-14 | 2002-11-21 | Novartis Ag | Oxazolo-and furopyrimidines and their use in medicaments against tumors |
WO2003022852A2 (en) * | 2001-09-11 | 2003-03-20 | Smithkline Beecham Corporation | Furo-and thienopyrimidine derivatives as angiogenesis inhibitors |
WO2005092896A1 (en) * | 2004-03-12 | 2005-10-06 | Korea Institute Of Science And Technology | Compound for inhibiting tyrosine kinase activity of ddr2 protein |
WO2005121149A1 (en) * | 2004-06-10 | 2005-12-22 | Xention Discovery Limited | Furanopyrimidine compounds effective as potassium channel inhibitors |
WO2006004658A2 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
WO2007079861A1 (en) * | 2005-12-21 | 2007-07-19 | Bayer Healthcare Ag | Novel, cyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseases |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19834044A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | New substituted pyrazole derivatives |
DE19834047A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituted pyrazole derivatives |
DE19943636A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE19943635A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
DE19943634A1 (en) | 1999-09-13 | 2001-04-12 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE19943639A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarboxylic acid derivatives with novel pharmaceutical properties |
AR031176A1 (en) | 2000-11-22 | 2003-09-10 | Bayer Ag | NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE |
DE10110749A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituted aminodicarboxylic acid derivatives |
DE10110750A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
DE10141212A1 (en) | 2001-08-22 | 2003-03-06 | Bayer Ag | New 4-aminofuropyrimidines and their use |
CA2470813A1 (en) | 2001-12-20 | 2003-07-03 | Bayer Healthcare Ag | 1,4-dihydro-1,4-diphenylpyridine derivatives |
DE10220570A1 (en) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamate-substituted pyrazolopyridines |
EP1554246B1 (en) | 2002-08-27 | 2007-08-22 | Bayer HealthCare AG | Dihydropyridinone derivatives as hne inhibitors |
GB0219896D0 (en) | 2002-08-27 | 2002-10-02 | Bayer Ag | Dihydropyridine derivatives |
WO2004024700A1 (en) | 2002-09-10 | 2004-03-25 | Bayer Healthcare Ag | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes |
WO2004024701A1 (en) | 2002-09-10 | 2004-03-25 | Bayer Healthcare Ag | Heterocyclic derivatives |
ES2367699T3 (en) | 2004-02-19 | 2011-11-07 | Bayer Pharma Aktiengesellschaft | DERIVATIVES OF DIHYDROPIRIDINONE. |
EP1730121B1 (en) | 2004-02-26 | 2013-08-07 | Bayer Intellectual Property GmbH | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors |
ES2394177T3 (en) | 2004-02-26 | 2013-01-23 | Bayer Intellectual Property Gmbh | 1,4-diaryl-dihydropyrimidin-2-one and its use as inhibitors of human neutrophil elastase |
-
2007
- 2007-04-26 DE DE102007019690A patent/DE102007019690A1/en not_active Withdrawn
-
2008
- 2008-04-16 WO PCT/EP2008/003008 patent/WO2008131859A2/en active Application Filing
- 2008-04-16 CA CA002685134A patent/CA2685134A1/en not_active Abandoned
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1817146A1 (en) * | 1968-01-05 | 1969-11-27 | Pfizer & Co C | 4-aminofuro [2,3-d] pyrimidines and their use as relaxants for smooth muscles |
EP1018514A1 (en) * | 1998-07-22 | 2000-07-12 | Suntory Limited | NF-$g(k)B INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT |
WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
EP1132093A1 (en) * | 1999-09-17 | 2001-09-12 | Suntory Limited | Preventives or remedies for myocarditis, dilated cardiomyopathy and cardiac insufficiency containing nf-kappa b inhibitors as the active ingredient |
WO2002092603A1 (en) * | 2001-05-14 | 2002-11-21 | Novartis Ag | Oxazolo-and furopyrimidines and their use in medicaments against tumors |
WO2003022852A2 (en) * | 2001-09-11 | 2003-03-20 | Smithkline Beecham Corporation | Furo-and thienopyrimidine derivatives as angiogenesis inhibitors |
WO2005092896A1 (en) * | 2004-03-12 | 2005-10-06 | Korea Institute Of Science And Technology | Compound for inhibiting tyrosine kinase activity of ddr2 protein |
WO2005121149A1 (en) * | 2004-06-10 | 2005-12-22 | Xention Discovery Limited | Furanopyrimidine compounds effective as potassium channel inhibitors |
WO2006004658A2 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
WO2007079861A1 (en) * | 2005-12-21 | 2007-07-19 | Bayer Healthcare Ag | Novel, cyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseases |
Non-Patent Citations (4)
Title |
---|
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; November 2002 (2002-11-01), GALIÈ NAZZARENO ET AL: "Emerging medical therapies for pulmonary arterial hypertension.", XP002528176, Database accession no. NLM12525997 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2006 (2006-09-01), BRESSER PAUL ET AL: "Medical therapies for chronic thromboembolic pulmonary hypertension: an evolving treatment paradigm.", XP002528177, Database accession no. NLM16963540 * |
PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY SEP 2006, vol. 3, no. 7, September 2006 (2006-09-01), pages 594 - 600, ISSN: 1546-3222 * |
PROGRESS IN CARDIOVASCULAR DISEASES 2002 NOV-DEC, vol. 45, no. 3, November 2002 (2002-11-01), pages 213 - 224, ISSN: 0033-0620 * |
Also Published As
Publication number | Publication date |
---|---|
DE102007019690A1 (en) | 2008-10-30 |
WO2008131859A2 (en) | 2008-11-06 |
CA2685134A1 (en) | 2008-11-06 |
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