WO2008129307A1 - Milieux contenant de l'acide nucléique - Google Patents

Milieux contenant de l'acide nucléique Download PDF

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Publication number
WO2008129307A1
WO2008129307A1 PCT/GB2008/001441 GB2008001441W WO2008129307A1 WO 2008129307 A1 WO2008129307 A1 WO 2008129307A1 GB 2008001441 W GB2008001441 W GB 2008001441W WO 2008129307 A1 WO2008129307 A1 WO 2008129307A1
Authority
WO
WIPO (PCT)
Prior art keywords
coating composition
nucleic acid
human
composition according
human animal
Prior art date
Application number
PCT/GB2008/001441
Other languages
English (en)
Inventor
Bryan Clifford Sykes
Original Assignee
Oxford Ancestors Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Ancestors Limited filed Critical Oxford Ancestors Limited
Publication of WO2008129307A1 publication Critical patent/WO2008129307A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/65—Additives macromolecular

Definitions

  • the present invention relates to nucleic acid-containing media.
  • DNA is the chemical embodiment of the genetic code which instructs cells how to build and run our bodies. However, in recent years it has acquired a new meaning in the popular imagination. DNA has become synonymous with our essential essence. "It's in my DNA” is now the mantra not only for individuals looking to understand their own actions, but also for corporations and brands seeking to define themselves. Mercedes
  • Benz® for example, announces that "Obsession. It's something that's buried deep within the DNA of our company. Something that drives everyone that works here.”
  • Mitochondrial DNA is passed exclusively down the female line.
  • the mtDNA of an individual is the same as that of his or her matrilineal ancestor unless there has been a mutation in the mtDNA at one or more points in the intervening generations between the ancestor and the living individual.
  • mtDNA is inherited down the maternal line because human eggs contain large numbers of mitochondria, whereas sperm mitochondria are both much fewer in number and are actively destroyed in the fertilised egg.
  • males and females inherit mtDNA only females pass it on to their children (through their eggs).
  • Different clades are referred to either by an alphanumeric sequence (A, B, C, D; Hl, H2, etc.) or, in popular accounts, by an invented name for the founder of each clade, or 'clan mother'.
  • the seven clans in Europe are thus named Helena, Ursula, Xenia, Velda, Tara, Katrine and Jasmine, collectively referred to as 'The Seven Daughters of Eve'.
  • Surveys of the sequence variation of large samples of individuals within each clade have been used, along with a generally accepted mutation rate, to estimate how long ago the clan mothers lived. They are, in ascending order, 45,000 years (Ursula), 25,000 years (Xenia), 20,000 years (Helena), 17,000 years (Velda and Tara), 15,000 years (Katrine) and 10,000 years (Jasmine).
  • the 36 clan mothers are as follows: Ai/Aiyana, Chie/Chochmingwu, Djigonese/Sachi, Emiko, Fufei, Gaia, Helena, Ina, Jasmine, Katrine, Lamia, Lalamika, Lara, Latasha, Latifa, Layla, LiIa, Limber, Lingaire, Lubaya, Makeda, Malaxshmi, Vietnamese, Nene, Sachi, Tara, Ulaana, UlIa, Ulrike, Uma, Una, Ursula, Uta, Velda, Yumi and Xenia. With reference to the Helena sequence, the sequence variants for the other major clan mothers are shown in Table
  • XENIA 16223C-T All of the clan mothers are descended from Mitochondrial Eve, whose sequence variants (relative to the reference sequence of Helena) are: 16129G-A, 16148C-T, 16187C-T, 16188C-T, 16189T-C, 16223C-T, 16230A-G, 16278C-T, 1631 IT-C, 16320C-T. Since the publication of this research in The Seven Daughters of Eve (W.W.
  • the present invention combines the two features of DNA, the biological and the psychological, by its physical incorporation into various media and by so doing enhances the properties of the modified medium.
  • the present invention relates to the incorporation of a nucleic acid into a solid or liquid medium which comprises, or forms the basis for, an article of commerce.
  • the present invention may broadly be considered a method of enhancing a solid or liquid medium which comprises, or forms the basis for, an article of commerce, said method comprising incorporating a nucleic acid into the medium.
  • the present invention may broadly be considered the use of a nucleic acid to enhance a solid or liquid medium which comprises, or forms the basis for, an article of commerce.
  • Said enhancement may include enhancement of the psychological impact of the medium and/or article of commerce, in other words the perception of the article in the mind of a consumer or user, which in turn improves the commercial appeal of said article of commerce.
  • the medium is a non-medical medium.
  • the nucleic acid is DNA.
  • Any form of DNA may be used.
  • the DNA may be mitochondrial DNA, nuclear DNA or chromosomal DNA, in particular Y-chromosomal DNA. Any length of DNA may be used.
  • the DNA may be at least one fragment of predetermined or initially unknown length or a mixture of different fragments of predetermined or unknown length. For example, if the DNA is synthesised by polymerase chain reaction (PCR) amplification between two primers which are complementary to unique sequences in the template DNA, the length(s) of the product or products will generally be known. If the DNA is synthesised by PCR amplification between two primers which are complementary to non-unique sequences in the template
  • PCR polymerase chain reaction
  • DNA the length(s) of the product or products will generally not be known, at least initially. If the DNA is synthesised by chemical, enzymatic or mechanical fragmentation of template DNA, the length(s) of the product or products will generally not be known, at least initially. Of course, the characteristics of the DNA may be determined subsequently.
  • the sequence of the nucleic acid may correspond to a nucleic acid sequence of any individual organism.
  • the nucleic acid may be a nucleic acid of predetermined sequence.
  • the nucleic acid sequence may be selected from a database of known sequences.
  • the nucleic acid may be isolated from a sample of blood or tissue using conventional techniques. Alternatively, the nucleic acid may be synthesised or reconstructed using known techniques. For safety, the nucleic acid may be modified to prevent incorporation into the genetic material of a human or non-human animal.
  • the nucleic acid sequence may correspond to a nucleic acid sequence of a living human or non-human animal, for instance a sequence determined by analysis of a blood or tissue sample from said human or non-human animal.
  • the nucleic acid sequence may correspond to a nucleic acid sequence of a dead human or non-human animal, which may be determined by direct analysis of a blood or tissue sample or alternatively may be selected from a database of known sequences.
  • the nucleic acid sequence may comprise a sequence of an ancestor, or probable ancestor, of an individual human or non-human animal.
  • WO 01/77381 describes a method of determining probable ancestry of an individual to a dead female ancestor ('clan mother'). The contents of WO 01/77381 are incorporated herein by reference.
  • DNA from the clan mothers can be reconstructed in different ways.
  • the founding sequence of a clan mother is determined by phylogenetic analysis of the complete mtDNA sequences, or a segment or segments thereof, of a sample of members of the clan and the determination of the root.
  • the mtDNA segment comprises 400 bases of the first hypervariable segment of the control region
  • the DNA segment is chemically synthesised by standard methods.
  • the mtDNA segment is synthesised by polymerase chain reaction from DNA extracted from an individual in whom DNA tests have determined that he or she possesses the root sequence.
  • ancestry may be determined by analysis of the Y-chromosome of a male individual.
  • WO 00/43542 describes the use of DNA analysis to haplotype the Y-chromosome. The contents of WO 00/43542 are incorporated herein by reference.
  • most Y-chromosomes can be assigned to one of five genetically related phylogenetic clades on the basis of shared features of their haplotypes. These shared features may be their allelic state at one or more genetic marker loci. These marker loci may be dimorphic sequence variants revealed as single nucleotide polymorphisms (SNPs) or length variation due to differences in the number of tandem DNA repeats (STRs).
  • SNPs single nucleotide polymorphisms
  • STRs tandem DNA repeats
  • the major worldwide patrilineal clades and subclades defined by Y-chromosome variants include A, B, C, D, E3a, E3b, G2, G5, H, Ha, lib, J, K, L, N, Q, RIa and RIb.
  • the major clades and sub-clades are known either by their alphanumeric notation as E3a, E3b, Ha, lib, J, RIa and Rlb_or, in popular accounts, by an invented name for the founder of each clade, or 'clan father', for example NASAd, Oisin, Wodan, Re and Eshu.
  • the features as hereinbefore described may apply to any of the aspects of the present invention.
  • a coating composition containing a nucleic acid containing a nucleic acid.
  • the coating composition may comprise a coating composition for coating any type of surface.
  • the coating composition may be any form of solid or liquid composition.
  • a further aspect of the present invention provides a method of manufacturing a coating composition, wherein the method includes the step of introducing a nucleic acid into a carrier coating composition.
  • a further aspect of the present invention provides a method of coating a surface by applying thereto a coating composition, wherein the coating composition contains a nucleic acid.
  • a further aspect of the present invention provides the use of a coating composition containing a nucleic acid for coating a surface to be coated.
  • the nucleic acid sequence may correspond to a nucleic acid sequence of an individual, such that a coating composition may be provided that is tailored to that individual or a group of individuals sharing the same nucleic acid sequence. This may be achieved using conventional techniques of nucleic acid isolation, analysis and synthesis.
  • the nucleic acid sequence may correspond to a sequence of a nucleic acid sequence of a third party, in particular a known third party, such as a celebrated or noted person.
  • the nucleic acid sequence may correspond to a sequence of an ancestor, or probable ancestor, of an individual, whose ancestry may be determined using any of the known analyses.
  • the coating composition is for coating a body surface.
  • the coating composition may comprise a cosmetic composition.
  • the coating composition may comprise a skin care composition.
  • a cream or lotion may be provided, although it is to be understood that any form of coating composition may be provided.
  • the coating composition may comprise a fragrance or perfume, which may be applied to the body in any conventional manner.
  • a coating composition containing a nucleic acid wherein the coating composition is for coating a surface of the body of a human or non-human animal.
  • a further aspect of the present invention provides a method of manufacturing a coating composition, wherein the coating composition is for coating a surface of the body of a human or non-human animal, and wherein the method includes the step of introducing a nucleic acid into a carrier coating composition.
  • a further aspect of the present invention provides a method of coating a surface of the body of a human or non-human animal by applying thereto a coating composition, wherein the coating composition contains a nucleic acid.
  • a further aspect of the present invention provides the use of a coating composition containing a nucleic acid for coating a surface of the body of a human or non-human animal.
  • the coating composition may be absorbed into the body, typically via the skin.
  • the 3' and 5' ends of DNA may be chemically blocked in such a way as to prevent incorporation of the DNA into the genetic material of the user.
  • the nucleic acid may therefore be incorporated into a vector so as to assist its assimilation into the genetic material of the user's cells.
  • the incorporation of nucleic acids into skin care products may afford a certain degree of protection by blocking ultra-violet radiation which is known to damage DNA within the cells of the dermis.
  • DNA damage occurs when UVA cross-links adjacent T bases in the DNA sequence to produce stable thymine dimers. DNA segments containing these dimers cannot be replicated and, if not repaired by intrinsic mechanisms, will inhibit proper cell division. Nucleic acids applied to the outside of the skin will be damaged by the incident radiation and will thereby reduce its effects before it can penetrate to live cells within the dermis. It is known that DNA damage is an important factor in shortening the life of cells.
  • a basic skin care composition containing an amount of 'carrier' DNA may be provided.
  • a particular nucleic acid which may be selected as described herein.
  • the nucleic acid sequence incorporated into the cosmetic or other coating composition may comprise a nucleic acid sequence of an ancestor.
  • different coating compositions may be provided that contain reconstructed DNA of the seven women who are the maternal ancestors of most Europeans (the clan mothers).
  • the a cosmetic or other coating composition incorporates the DNA from her (or his) clan mother
  • its presence within the composition enhances the connection between the user and the benign and protective spirit of her or his ancestor. This in turn enhances the psychologically beneficial properties of the product. It is known that psychological impact is an important factor in the commercial success of cosmetic products, such as skin care compositions.
  • the invention is not limited to this embodiment, as other ancestral nucleic acid sequences may equally be used.
  • the enhanced psychological effects of the presence of the DNA of a user's clan mother within a skin care composition, and its direct protective biological effect due to the reduction of DNA damage within the dermal cells, increases the appeal of products that incorporate the composition.
  • the coating composition comprises a protective and/or decorative coating composition.
  • the coating composition may comprise paint or the like (including, but not limited to, any varnish, stain, ink, dye, colouring, glaze or wax).
  • a protective and/or decorative coating composition containing a nucleic acid.
  • a further aspect of the present invention provides a method of manufacturing a protective and/or decorative coating composition, wherein the method includes the step of introducing a nucleic acid into a carrier coating composition.
  • a further aspect of the present invention provides a method of coating a surface by applying thereto a protective and/or decorative coating composition, wherein the protective and/or decorative coating composition contains a nucleic acid.
  • a further aspect of the present invention provides the use of a protective and/or decorative coating composition containing a nucleic acid for coating a surface to be coated. It will be appreciated that the protective and/or decorative coating composition may be applied to the surface in any suitable manner, and that any surface may be coated.
  • the protective and/or decorative coating composition comprises a paint containing a nucleic acid, and may be used to paint a likeness, depiction or representation of a human or non-human animal, wherein the sequence of the nucleic acid corresponds to a nucleic acid sequence of said human or non-human animal.
  • a subject may sit for a painted portrait, wherein the subject's DNA is incorporated into the paint.
  • the incorporation of the sitter's DNA enhances the connection between the portrait and the subject, and endures after the sitter's death.
  • the nucleic acid sequence incorporated into the paint may comprise a nucleic acid sequence of an ancestor, or a third party such as a celebrated or noted person.
  • DNA is incorporated into paint applied to the canvas of seven portraits.
  • the portraits are of the seven women who are the maternal ancestors of most Europeans (the clan mothers). These portraits are intended to capture the essence or the spirit of these women, who are the ancestors of at least 400 million people living today.
  • the presence of the reconstructed DNA of the seven women in the paint of their respective portraits enhances their connection within the portraits, particularly in the eyes of those individuals whose clan mother has been determined.
  • the invention is not limited to this embodiment, as other ancestral nucleic acid sequences may equally be used.
  • nucleic acids into a solid or liquid medium, which comprises, or forms the basis for, an article of commerce
  • a solid or liquid medium which comprises, or forms the basis for, an article of commerce
  • the present invention provides for enhanced connection between the medium and an individual and/or his or her relatives or ancestors.
  • a DNA-containing skin cream preparation was made by adding DNA solution to readily available proprietary skin cream, as follows.
  • 200mg of salmon sperm DNA was added to 20ml of distilled water in an inert vessel then heated to 100°C for 5 minutes to assist with its solution at a concentration of lOmg per ml.
  • the DNA solution was then cooled to 55°C.
  • 0.1 ml of this warm solution was added to 10ml of a proprietary aqueous skin cream at room temperature.
  • the skin cream contained, as its main non-aqueous ingredients, 6% w/w Liquid Paraffin BP, 15% w/w white Soft Paraffin BP, 0.1% w/w chlorocresol and emulsifying wax. The mixture was stirred thoroughly and left to stand at room temperature for twelve hours.
  • the mixture was applied topically to the skin on the forearm of five volunteers. In no case was an adverse reaction observed.
  • the addition of the carrier DNA to the skin cream preparations gave relatively high concentrations of DNA.
  • the DNA acts as an effective UV block for a reduction in thymine dimer formation within the DNA of skin cells.
  • These preparations were then used as bases to which were added small amounts of specifically prepared nucleic products, for example amplified mtDNA from the ancestral clan mothers.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne l'incorporation d'un acide nucléique dans un milieu solide ou liquide qui comprend un article de commerce ou lui sert de base. L'acide nucléique renforce le milieu solide ou liquide. Ledit renforcement peut consister à renforcer l'impact psychologique du milieu et/ou de l'article de commerce, en d'autres termes la perception de l'article par le consommateur ou l'utilisateur, ce qui améliore à son tour l'attrait commercial dudit article de commerce. Les modes de réalisation de l'invention comprennent : une composition de revêtement renfermant un acide nucléique, cette dernière servant à recouvrir la surface du corps d'un animal humain ou non humain; et une composition de revêtement protecteur et/ou décoratif contenant un acide nucléique. La composition de revêtement protecteur et/ou décoratif peut contenir de la peinture ou un autre élément semblable (y compris, mais sans s'y limiter, tout type de vernis, vernis coloré, encre, teinture, colorant, glacis ou cire).
PCT/GB2008/001441 2007-04-23 2008-04-23 Milieux contenant de l'acide nucléique WO2008129307A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0707790.2A GB0707790D0 (en) 2007-04-23 2007-04-23 Nucleic acid-containing media
GB0707790.2 2007-04-23

Publications (1)

Publication Number Publication Date
WO2008129307A1 true WO2008129307A1 (fr) 2008-10-30

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PCT/GB2008/001441 WO2008129307A1 (fr) 2007-04-23 2008-04-23 Milieux contenant de l'acide nucléique

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GB (1) GB0707790D0 (fr)
WO (1) WO2008129307A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015050903A3 (fr) * 2013-10-02 2015-06-04 Fabric Media Compositions à base de composants de produits améliorés grâce à du matériel génétique de synthèse

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1603826A (en) * 1968-12-09 1971-06-07 Dna-and rna-contg cosmetic prods
FR2511243A1 (fr) * 1980-12-02 1983-02-18 Geskis Denise Gamme de produits cosmetiques et solaires a base d'a.d.n. hautement polymerise
DE19815090A1 (de) * 1998-04-06 1999-10-14 Henkel Kgaa Kosmetische Mittel
WO2001068048A2 (fr) * 2000-03-17 2001-09-20 Unilever Plc Fragments d'adn non-physiologiques permettant le bronzage de la peau
WO2001077381A2 (fr) * 2000-04-11 2001-10-18 Isis Innovation Limited Analyse d'adn
WO2004005306A2 (fr) * 2002-07-04 2004-01-15 Technische Universität Dresden Objet metallique recouvert d'acides nucleiques et de derives d'acides nucleiques, son procede de production et d'utilisation
JP2005168331A (ja) * 2003-12-08 2005-06-30 Ltt Bio-Pharma Co Ltd Ｄｎａを配合した塗料による車両の識別方法
US20050181378A1 (en) * 2004-02-18 2005-08-18 Applera Corporation Polyelectrolyte-coated size-exclusion ion-exchange particles
JP2005293531A (ja) * 2004-04-05 2005-10-20 Shiro Gounai Ｄｎａラベル
WO2006053435A1 (fr) * 2004-11-17 2006-05-26 Forensink Corporation Inc. Compositions pour marquer des objets à l’adn et procédés pour marquer et lier un objet à son propriétaire
JP2006169338A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 情報化核酸含有固形油脂組成物
JP2006167558A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 補修塗膜及び補修塗装方法
WO2007001658A2 (fr) * 2005-06-21 2007-01-04 Boston Scientific Scimed, Inc. Pâtes thérapeutiques pour revêtement de matériel médical

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1603826A (en) * 1968-12-09 1971-06-07 Dna-and rna-contg cosmetic prods
FR2511243A1 (fr) * 1980-12-02 1983-02-18 Geskis Denise Gamme de produits cosmetiques et solaires a base d'a.d.n. hautement polymerise
DE19815090A1 (de) * 1998-04-06 1999-10-14 Henkel Kgaa Kosmetische Mittel
WO2001068048A2 (fr) * 2000-03-17 2001-09-20 Unilever Plc Fragments d'adn non-physiologiques permettant le bronzage de la peau
WO2001077381A2 (fr) * 2000-04-11 2001-10-18 Isis Innovation Limited Analyse d'adn
WO2004005306A2 (fr) * 2002-07-04 2004-01-15 Technische Universität Dresden Objet metallique recouvert d'acides nucleiques et de derives d'acides nucleiques, son procede de production et d'utilisation
JP2005168331A (ja) * 2003-12-08 2005-06-30 Ltt Bio-Pharma Co Ltd Ｄｎａを配合した塗料による車両の識別方法
US20050181378A1 (en) * 2004-02-18 2005-08-18 Applera Corporation Polyelectrolyte-coated size-exclusion ion-exchange particles
JP2005293531A (ja) * 2004-04-05 2005-10-20 Shiro Gounai Ｄｎａラベル
WO2006053435A1 (fr) * 2004-11-17 2006-05-26 Forensink Corporation Inc. Compositions pour marquer des objets à l’adn et procédés pour marquer et lier un objet à son propriétaire
JP2006169338A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 情報化核酸含有固形油脂組成物
JP2006167558A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 補修塗膜及び補修塗装方法
WO2007001658A2 (fr) * 2005-06-21 2007-01-04 Boston Scientific Scimed, Inc. Pâtes thérapeutiques pour revêtement de matériel médical

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DATABASE WPI Week 200646, Derwent World Patents Index; AN 2006-454505, XP002492059 *
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OXFORD ANCESTORS: "Your paternal ancestry: putting the genes in geneaology", 5 January 2007 (2007-01-05), XP002492024, Retrieved from the Internet <URL:http://web.archive.org/web/20070105132748/http://www.oxfordancestors.com/your-paternal.html> [retrieved on 20080812] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015050903A3 (fr) * 2013-10-02 2015-06-04 Fabric Media Compositions à base de composants de produits améliorés grâce à du matériel génétique de synthèse

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