WO2008126517A1 - 哺乳動物における新規ｓｌｃ１７型トランスポータータンパク質およびその利用 - Google Patents

哺乳動物における新規ｓｌｃ１７型トランスポータータンパク質およびその利用 Download PDF

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Publication number
WO2008126517A1
WO2008126517A1 PCT/JP2008/053878 JP2008053878W WO2008126517A1 WO 2008126517 A1 WO2008126517 A1 WO 2008126517A1 JP 2008053878 W JP2008053878 W JP 2008053878W WO 2008126517 A1 WO2008126517 A1 WO 2008126517A1
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WO
WIPO (PCT)
Prior art keywords
slc17
mammal
novel
transporter protein
type transporter
Prior art date
Application number
PCT/JP2008/053878
Other languages
English (en)
French (fr)
Inventor
Yoshinori Moriyama
Hiroshi Omote
Keisuke Sawada
Original Assignee
National University Corporation Okayama University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Okayama University filed Critical National University Corporation Okayama University
Priority to US12/594,149 priority Critical patent/US7951595B2/en
Priority to EP08721298A priority patent/EP2159281B1/en
Priority to JP2008526701A priority patent/JP5219146B2/ja
Publication of WO2008126517A1 publication Critical patent/WO2008126517A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

ＡＴＰ輸送を担うトランスポーターおよびそれをコードする遺伝子を単離することを本発明の課題とする。さらに、そのようなトランスポーターを用いる、中枢神経における疼痛や血小板由来のＡＴＰによる血液凝固などを処置および／または調節するための薬剤のスクリーニング法を提供することを、本発明の課題とする。本発明に従って、ＡＴＰ輸送を担うトランスポーターおよびそれをコードする遺伝子が単離された。さらに、そのようなトランスポーターを用いる、中枢神経における疼痛や血小板由来のＡＴＰによる血液凝固などを処置および／または調節するための薬剤のスクリーニング法が提供される。
PCT/JP2008/053878 2007-03-30 2008-03-04 哺乳動物における新規ｓｌｃ１７型トランスポータータンパク質およびその利用 WO2008126517A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/594,149 US7951595B2 (en) 2007-03-30 2008-03-04 Methods for screening modulators of SLC17-type anion transport activity
EP08721298A EP2159281B1 (en) 2007-03-30 2008-03-04 Novel slc17-type transporter protein in mammal and use thereof
JP2008526701A JP5219146B2 (ja) 2007-03-30 2008-03-04 哺乳動物における新規ｓｌｃ１７型トランスポータータンパク質およびその利用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007095055 2007-03-30
JP2007-095055 2007-03-30

Publications (1)

Publication Number Publication Date
WO2008126517A1 true WO2008126517A1 (ja) 2008-10-23

Family

ID=39863675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053878 WO2008126517A1 (ja) 2007-03-30 2008-03-04 哺乳動物における新規ｓｌｃ１７型トランスポータータンパク質およびその利用

Country Status (4)

Country Link
US (1) US7951595B2 (ja)
EP (1) EP2159281B1 (ja)
JP (1) JP5219146B2 (ja)
WO (1) WO2008126517A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017126700A1 (ja) * 2016-01-20 2017-07-27 芳則 森山 小胞型ヌクレオチドトランスポーター活性阻害剤
CN116803424A (zh) * 2023-08-24 2023-09-26 上海懿贝瑞生物医药科技有限公司 Slc17a5基因抑制剂及其用途

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017126700A1 (ja) * 2016-01-20 2017-07-27 芳則 森山 小胞型ヌクレオチドトランスポーター活性阻害剤
CN116803424A (zh) * 2023-08-24 2023-09-26 上海懿贝瑞生物医药科技有限公司 Slc17a5基因抑制剂及其用途
CN116803424B (zh) * 2023-08-24 2023-11-28 上海懿贝瑞生物医药科技有限公司 Slc17a5基因抑制剂及其用途

Also Published As

Publication number Publication date
JPWO2008126517A1 (ja) 2010-07-22
EP2159281A1 (en) 2010-03-03
EP2159281A4 (en) 2010-12-15
EP2159281B1 (en) 2012-09-26
US7951595B2 (en) 2011-05-31
US20100167411A1 (en) 2010-07-01
JP5219146B2 (ja) 2013-06-26

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