WO2008124081A3 - Dissolution rapide de produits de combinaison - Google Patents

Dissolution rapide de produits de combinaison Download PDF

Info

Publication number
WO2008124081A3
WO2008124081A3 PCT/US2008/004429 US2008004429W WO2008124081A3 WO 2008124081 A3 WO2008124081 A3 WO 2008124081A3 US 2008004429 W US2008004429 W US 2008004429W WO 2008124081 A3 WO2008124081 A3 WO 2008124081A3
Authority
WO
WIPO (PCT)
Prior art keywords
combination products
rapid dissolution
triptans
nsaids
processes
Prior art date
Application number
PCT/US2008/004429
Other languages
English (en)
Other versions
WO2008124081A2 (fr
Inventor
Ilan Zalit
Uri Zadok
Original Assignee
Teva Pharma
Ilan Zalit
Uri Zadok
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Ilan Zalit, Uri Zadok filed Critical Teva Pharma
Priority to CA002682872A priority Critical patent/CA2682872A1/fr
Priority to EP08742580A priority patent/EP2029117A2/fr
Publication of WO2008124081A2 publication Critical patent/WO2008124081A2/fr
Publication of WO2008124081A3 publication Critical patent/WO2008124081A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des formes de dosage orales pharmaceutiques à dissolution rapide de triptans et de AINS, des procédés de préparation de ceux-ci et des procédés de traitement au moyen de ceux-ci.
PCT/US2008/004429 2007-04-04 2008-04-03 Dissolution rapide de produits de combinaison WO2008124081A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002682872A CA2682872A1 (fr) 2007-04-04 2008-04-03 Dissolution rapide de produits de combinaison
EP08742580A EP2029117A2 (fr) 2007-04-04 2008-04-03 Dissolution rapide de produits de combinaison

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US92203107P 2007-04-04 2007-04-04
US60/922,031 2007-04-04
US93261307P 2007-05-31 2007-05-31
US60/932,613 2007-05-31
US7056308P 2008-03-21 2008-03-21
US61/070,563 2008-03-21

Publications (2)

Publication Number Publication Date
WO2008124081A2 WO2008124081A2 (fr) 2008-10-16
WO2008124081A3 true WO2008124081A3 (fr) 2009-08-06

Family

ID=39530000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/004429 WO2008124081A2 (fr) 2007-04-04 2008-04-03 Dissolution rapide de produits de combinaison

Country Status (3)

Country Link
EP (1) EP2029117A2 (fr)
CA (1) CA2682872A1 (fr)
WO (1) WO2008124081A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2629904C (fr) 2005-11-28 2018-07-10 Imaginot Pty Ltd. Systeme d'administration orale de compose therapeutique
CA3066426A1 (fr) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Compositions pharmaceutiques renfermant un antiemetique et un analgesique opioide
CA2765866C (fr) 2008-06-20 2016-06-21 Alphapharm Pty Ltd Composition pharmaceutique monophasee d'un inhibiteur 5-ht1 et d'un ains
US8906949B2 (en) 2010-05-21 2014-12-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Orally disintegrating tablets of zolmitriptan and process for preparing the same
CN102552423B (zh) * 2012-02-20 2013-07-24 崔新明 一种治疗偏头痛的药物组合物
EP3191093A4 (fr) * 2014-09-09 2018-04-25 Charleston Laboratories, Inc. Compositions pharmaceutiques
CA3055170A1 (fr) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Compositions pharmaceutiques
TR201720429A2 (tr) 2017-12-15 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Flurbi̇profen ve 5-ht1&#8211#&reseptör agoni̇stleri̇ni̇n farmasöti̇k kompozi̇syonlari
TR201921902A1 (tr) * 2019-12-27 2021-07-26 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Flurbiprofen ve eletriptan içeren ağızda dağılan tabletler

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110492A2 (fr) * 2003-06-06 2004-12-23 Glaxo Group Limited Composition pharmaceutique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110492A2 (fr) * 2003-06-06 2004-12-23 Glaxo Group Limited Composition pharmaceutique

Also Published As

Publication number Publication date
WO2008124081A2 (fr) 2008-10-16
CA2682872A1 (fr) 2008-10-16
EP2029117A2 (fr) 2009-03-04

Similar Documents

Publication Publication Date Title
WO2008124081A3 (fr) Dissolution rapide de produits de combinaison
EP2273975B8 (fr) Solutions pharmaceutiques, procédé de préparation et utilisations thérapeutiques
WO2012083017A3 (fr) Formes posologiques pour des médicaments médiocrement solubles administrés par voie orale à libération contrôlée et leurs utilisations
IL199472A0 (en) Non-effervescent, orally disintegrating solid pharmaceutical dosage forms, processes for the preparation of the same and uses thereof
IL199187A (en) Indole history, pharmaceuticals including them and their use in the manufacture of medicines
WO2008040534A3 (fr) Formes pharmaceutiques à base de film non muco-adhésif
HK1138203A1 (en) Method for preparing rapidly disintegrating formulation for oral administration and the products thereof
AP2012006135A0 (en) Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof.
BRPI0816255A2 (pt) Produto farmacêutico, uso do produto, método para a profilaxia ou o tratamento de doenças, e, composição farmaceuticamente aceitável
WO2007050294A3 (fr) Formes posologiques liquides possedant des proprietes enteriques de liberation retardee et ensuite prolongee
IL204887A (en) Acetamide History, Pharmaceuticals Containing Them, Methods of Preparing and Using It in the Preparation of Diabetes Medications
IL207684A (en) Preserved indole history, a method for making these histories, drugs containing these histories, and their use in making drugs
WO2007144169A3 (fr) Dérivés d'entacapone
EP2481739A4 (fr) Dérivés de dihydroptéridinone, leur procédé de préparation et utilisation pharmaceutique
EP2012807A4 (fr) Composition pharmaceutique d'entérosorbant et de prébiotiques, formes galéniques et procédé pour la prévention et le traitement de troubles gastrointestinaux
IL203936A (en) HISTORY 4 - Pyrimidinsulfamide, Process for Preparation, Pharmaceutical Preparations Containing and Using it for Medication Preparation
WO2010127205A3 (fr) Formulations de combinaison de médicament à dose fixe
IL196426A (en) Micro-particles based on amphiphilic copolymer, their preparation processes and their pharmaceutical preparations
WO2009071689A3 (fr) Dérivés d'oxindole substitués par halogène en position 5 et leur utilisation pour traiter des maladies liées à la vasopressine
IL195931A (en) Oral Pharmaceutical Preparation with Controlled Release of Active Ingredient and Methods of Manufacturing
WO2009149056A3 (fr) Combinaisons de niacine et d'un oxicame
WO2012100043A3 (fr) Formes posologiques pharmaceutiques orales à libération contrôlée comprenant de la mgbg
WO2007078271A3 (fr) Comprimes a desintegration orale de lansoprazole
EP2151439A4 (fr) Dérivé d'un cycle aromatique azoté à 6 éléments, et agent pharmaceutique comprenant ledit dérivé
WO2009149058A3 (fr) Formulations de niacine à libération modifiée

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2008742580

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08742580

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2682872

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE