WO2008117305A3 - Nouveau procédé pour préparer de la prégabaline et ses sels d'addition avec les acides - Google Patents

Nouveau procédé pour préparer de la prégabaline et ses sels d'addition avec les acides Download PDF

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Publication number
WO2008117305A3
WO2008117305A3 PCT/IN2008/000121 IN2008000121W WO2008117305A3 WO 2008117305 A3 WO2008117305 A3 WO 2008117305A3 IN 2008000121 W IN2008000121 W IN 2008000121W WO 2008117305 A3 WO2008117305 A3 WO 2008117305A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid addition
addition salts
novel process
pregabalin
preparing pregabalin
Prior art date
Application number
PCT/IN2008/000121
Other languages
English (en)
Other versions
WO2008117305A2 (fr
Inventor
Venkata Siva Kumar Bobba
Srinivas Reddy Sanikommu
Balasaheb Murlidhar More
Dattatray Shamrao Metil
Pravin Bhalchandra Kulkarni
Koilpillai Joseph Prabahar
Mubeen Khan
Original Assignee
Glenmark Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Limited filed Critical Glenmark Pharmaceuticals Limited
Publication of WO2008117305A2 publication Critical patent/WO2008117305A2/fr
Publication of WO2008117305A3 publication Critical patent/WO2008117305A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention porte sur un procédé pour la préparation de nouveaux intermédiaires de la (S)-Prégabaline. La présente invention porte également sur un procédé pour la préparation de la (S)-Prégabaline ou sur un sel ou un solvate pharmaceutiquement acceptable de celle-ci à l'aide des intermédiaires.
PCT/IN2008/000121 2007-03-28 2008-03-03 Nouveau procédé pour préparer de la prégabaline et ses sels d'addition avec les acides WO2008117305A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN580MU2007 2007-03-28
IN580/MUM/2007 2007-03-28

Publications (2)

Publication Number Publication Date
WO2008117305A2 WO2008117305A2 (fr) 2008-10-02
WO2008117305A3 true WO2008117305A3 (fr) 2009-11-12

Family

ID=39789126

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000121 WO2008117305A2 (fr) 2007-03-28 2008-03-03 Nouveau procédé pour préparer de la prégabaline et ses sels d'addition avec les acides

Country Status (1)

Country Link
WO (1) WO2008117305A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009044409A2 (fr) * 2007-10-01 2009-04-09 Natco Pharma Limited Nouveau procédé de résolution pour la prégabaline
WO2009087650A2 (fr) * 2007-10-15 2009-07-16 V.B. Medicare Pvt. Ltd. Nouveau procédé de synthèse de la prégabaline à partir d'un intermédiaire cyclopropane substitué et procédé pour la résolution enzymatique de la prégabaline racémique
WO2009087674A2 (fr) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Procédé perfectionné pour la préparation de (s)-prégabaline
WO2009125427A2 (fr) * 2008-02-18 2009-10-15 Matrix Laboratories Limited Procédé de fabrication d'acide (s)-3-(aminométhyl)-5-méthylhexanoïque
CA2719892A1 (fr) * 2008-04-04 2009-10-08 Generics [Uk] Limited Nouveau procede
WO2012093411A2 (fr) * 2011-01-07 2012-07-12 Dr Braja Sundar Pradhan Méthode de préparation d'acide r-(-)-3-(carbamoylméthyl)-5-méthylhexanoïque et de ses intermédiaires
EP3154930B1 (fr) 2014-06-12 2018-04-18 Siegfried Ltd. Procédé pour la préparation d'acides gamma-aminocarboxyliques substitués en position bêta
RU2673461C2 (ru) * 2016-12-14 2018-11-27 федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный технический университет" Способ получения 4-метил-1-нитропентена-1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110783A2 (fr) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Procede de fabrication de (s)-pregabaline

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110783A2 (fr) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Procede de fabrication de (s)-pregabaline

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDRUSZKIEWICZ, RYSZARD ET AL.: "A convenient synthesis of 3-alkyl- 4-aminobutanoic acids", SYNTHESIS, vol. 12, 1989, pages 953 - 5 *
DATABASE CASREACT 21 July 2009 (2009-07-21), accession no. STN Database accession no. 113:41285 *
DATABASE CASREACT 21 July 2009 (2009-07-21), accession no. STN Database accession no. 130:311378 *
DATABASE CASREACT 21 July 2009 (2009-07-21), accession no. STN Database accession no. 132:35317 *
JI, JIANGUO ET AL.: "Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 43, 1999, pages 10215 - 10216 *
KANTAM, M. LAKSHMI ET AL.: "One-pot synthesis of conjugated nitroalkenes by diamino-functionalized mesoporous material", CATALYSIS LETTERS, vol. 57, no. 4, 1999, pages 227 - 231, XP002977927, DOI: doi:10.1023/A:1019012019131 *

Also Published As

Publication number Publication date
WO2008117305A2 (fr) 2008-10-02

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