WO2008114787A1 - 抗ウイルス剤 - Google Patents

抗ウイルス剤 Download PDF

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Publication number
WO2008114787A1
WO2008114787A1 PCT/JP2008/054946 JP2008054946W WO2008114787A1 WO 2008114787 A1 WO2008114787 A1 WO 2008114787A1 JP 2008054946 W JP2008054946 W JP 2008054946W WO 2008114787 A1 WO2008114787 A1 WO 2008114787A1
Authority
WO
WIPO (PCT)
Prior art keywords
antiviral agent
poly
drug
drug carrier
disclosed
Prior art date
Application number
PCT/JP2008/054946
Other languages
English (en)
French (fr)
Inventor
Michinori Kohara
Shin-Ichiro Nakagawa
Original Assignee
Tokyo Metropolitan Organization For Medical Research
Nippon Shinyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Metropolitan Organization For Medical Research, Nippon Shinyaku Co., Ltd. filed Critical Tokyo Metropolitan Organization For Medical Research
Priority to JP2009505221A priority Critical patent/JPWO2008114787A1/ja
Priority to CN200880016543A priority patent/CN101686990A/zh
Priority to US12/531,735 priority patent/US20100152433A1/en
Publication of WO2008114787A1 publication Critical patent/WO2008114787A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明の主な目的は、新規有用な薬理作用を有する抗ウイルス剤を提供することにある。 　本発明者らは、カチオン性リポソームやアテロコラーゲンのような、薬物を細胞内に移送するのに有用な薬物担体に、二本鎖を形成しうるポリＩ及びポリＣといった２つの合成ＲＮＡを包含する複合体が、上記目的を解決することを見出し、本発明を完成した。
PCT/JP2008/054946 2007-03-19 2008-03-18 抗ウイルス剤 WO2008114787A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009505221A JPWO2008114787A1 (ja) 2007-03-19 2008-03-18 抗ウイルス剤
CN200880016543A CN101686990A (zh) 2007-03-19 2008-03-18 抗病毒剂
US12/531,735 US20100152433A1 (en) 2007-03-19 2008-03-18 Antiviral agent

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-070028 2007-03-19
JP2007070028 2007-03-19
JP2008-015713 2008-01-28
JP2008015713 2008-01-28

Publications (1)

Publication Number Publication Date
WO2008114787A1 true WO2008114787A1 (ja) 2008-09-25

Family

ID=39765894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054946 WO2008114787A1 (ja) 2007-03-19 2008-03-18 抗ウイルス剤

Country Status (4)

Country Link
US (1) US20100152433A1 (ja)
JP (1) JPWO2008114787A1 (ja)
CN (1) CN101686990A (ja)
WO (1) WO2008114787A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111041825A (zh) * 2019-12-26 2020-04-21 绍兴博利豪家纺有限公司 一种抗菌涤纶地毯的制备工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048531A1 (fr) * 1998-03-24 1999-09-30 Nippon Shinyaku Co., Ltd. Nouveaux remedes contre l'hepatite

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048531A1 (fr) * 1998-03-24 1999-09-30 Nippon Shinyaku Co., Ltd. Nouveaux remedes contre l'hepatite

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALI S. ET AL.: "Interferon regulatory factor 3-independent double-tranded RNA-induced inhibition of hepatitis C virus replicons in human embryonic kidney 293 cells", JOURNAL OF VIROLOGY, vol. 79, no. 5, May 2005 (2005-05-01), pages 3174 - 3178 *
OKAMOTO H.: "HCV no Idenshigata Bunrui to Bunshi Ekigaku", BUNSHI KAN'EN VIRUS BYOGAKU JOKAN: C-GATA KAN'EN VIRUS HEN, 4 September 1995 (1995-09-04), pages 71 - 79 *
SUGAUCHI F. ET AL.: "B-gata Kan'en Virus no Idenshigata Bunrui to Sono Igi", VIRUS-SEI KAN'EN NO GENKYO TO TENBO, 25 July 2003 (2003-07-25), pages 35 - 40 *
UPRICHARD S.L. ET AL.: "Transcriptional and posttranscriptional control of hepatitis B virus gene expression", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 100, no. 3, 4 February 2003 (2003-02-04), pages 1310 - 1315 *

Also Published As

Publication number Publication date
US20100152433A1 (en) 2010-06-17
JPWO2008114787A1 (ja) 2010-07-08
CN101686990A (zh) 2010-03-31

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