WO2008114577A3 - Antibacterial peptide - Google Patents

Antibacterial peptide Download PDF

Info

Publication number
WO2008114577A3
WO2008114577A3 PCT/JP2008/053211 JP2008053211W WO2008114577A3 WO 2008114577 A3 WO2008114577 A3 WO 2008114577A3 JP 2008053211 W JP2008053211 W JP 2008053211W WO 2008114577 A3 WO2008114577 A3 WO 2008114577A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
integer
gly
amino acid
lys
Prior art date
Application number
PCT/JP2008/053211
Other languages
French (fr)
Japanese (ja)
Other versions
WO2008114577A2 (en
Inventor
Masao Tanihara
Keiko Ida
Original Assignee
Nat Univ Corp Nara Inst
Phg Corp
Masao Tanihara
Keiko Ida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Corp Nara Inst, Phg Corp, Masao Tanihara, Keiko Ida filed Critical Nat Univ Corp Nara Inst
Priority to JP2009505105A priority Critical patent/JP5354206B2/en
Publication of WO2008114577A2 publication Critical patent/WO2008114577A2/en
Publication of WO2008114577A3 publication Critical patent/WO2008114577A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

Disclosed is a peptide having high safety and an excellent antibacterial activity or a salt of the peptide. Specifically disclosed is a peptide selected from the following peptides (1) and (2) or a salt of the peptide. (1) A peptide comprising an amino acid sequence represented by the general formula (I). (Pro Hyp Gly)n-[(Lys x Gly)m-(Pro Hyp Gly)l-(Lys X Gly)p]α- (Pro Hyp Gly)r (I) [wherein n represents an integer of 1 to 6; m represents an integer of 1 to 4; l represents an integer of 0 to 7; p represents an integer of 1 to 4; r represents an integer of 1 to 6; α represents an integer of 1 to 6; and X represents an amino acid residue selected from Ile, Leu and Hyp, provided that the (m+p) pieces of X's may be the same as or different from each other, n+m+l+p+r = 4 to 15, m+p≥2 when l=0, and m=1, l=0 and p=1 when α≥2.] (2) A peptide which comprises an amino acid sequence having the substitution, deletion or addition of 1 to 3 amino acid residues other than Lys, Gly and X in the amino acid sequence represented by the general formula (I), and which has an antibacterial activity.
PCT/JP2008/053211 2007-02-26 2008-02-25 Antibacterial peptide WO2008114577A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009505105A JP5354206B2 (en) 2007-02-26 2008-02-25 Antibacterial peptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-045490 2007-02-26
JP2007045490 2007-02-26

Publications (2)

Publication Number Publication Date
WO2008114577A2 WO2008114577A2 (en) 2008-09-25
WO2008114577A3 true WO2008114577A3 (en) 2008-11-27

Family

ID=39766594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053211 WO2008114577A2 (en) 2007-02-26 2008-02-25 Antibacterial peptide

Country Status (2)

Country Link
JP (1) JP5354206B2 (en)
WO (1) WO2008114577A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015091760A (en) * 2012-01-23 2015-05-14 学校法人早稲田大学 Drug carrier consisting of collagen-like peptide
CN110079531B (en) * 2019-04-26 2022-09-20 安阳工学院 Antibacterial peptide and application thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11215983A (en) * 1998-01-30 1999-08-10 Agriculture Forestry And Fisheries Technical Information Society Antifungal agent with peptide as active component
JPH11335396A (en) * 1998-03-25 1999-12-07 Seikagaku Kogyo Co Ltd New antimicrobial peptide
JP2000319300A (en) * 1999-05-14 2000-11-21 Meiji Milk Prod Co Ltd Antibicrobial peptide
JP2003321500A (en) * 2002-02-28 2003-11-11 Sentomedo:Kk New polypeptide and method for producing the same
JP2005060550A (en) * 2003-08-13 2005-03-10 Masao Tanihara Film-forming composition
JP2005206542A (en) * 2004-01-23 2005-08-04 Masao Tanihara New polypeptide and method for producing the same
JP2006045214A (en) * 2004-07-06 2006-02-16 Juntendo Antibacterial peptide
WO2007010623A1 (en) * 2005-07-22 2007-01-25 Phg Corporation Novel polypeptide and method for producing the same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11215983A (en) * 1998-01-30 1999-08-10 Agriculture Forestry And Fisheries Technical Information Society Antifungal agent with peptide as active component
JPH11335396A (en) * 1998-03-25 1999-12-07 Seikagaku Kogyo Co Ltd New antimicrobial peptide
JP2000319300A (en) * 1999-05-14 2000-11-21 Meiji Milk Prod Co Ltd Antibicrobial peptide
JP2003321500A (en) * 2002-02-28 2003-11-11 Sentomedo:Kk New polypeptide and method for producing the same
JP2005060550A (en) * 2003-08-13 2005-03-10 Masao Tanihara Film-forming composition
JP2005206542A (en) * 2004-01-23 2005-08-04 Masao Tanihara New polypeptide and method for producing the same
JP2006045214A (en) * 2004-07-06 2006-02-16 Juntendo Antibacterial peptide
WO2007010623A1 (en) * 2005-07-22 2007-01-25 Phg Corporation Novel polypeptide and method for producing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TANIHARA M. ET AL.: "Sanju Rasen Kozo o Keisei suru Kokinsei Peptide no Sekkei to Gosei", DAI 127 PROCEEDINGS OF THE ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2007 (2007-03-05), pages 79 + ABSTR. NO. 28P1-PM040 *

Also Published As

Publication number Publication date
JPWO2008114577A1 (en) 2010-07-01
WO2008114577A2 (en) 2008-09-25
JP5354206B2 (en) 2013-11-27

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