WO2008110809A3 - Dry powder inhalers - Google Patents

Dry powder inhalers Download PDF

Info

Publication number
WO2008110809A3
WO2008110809A3 PCT/GB2008/000886 GB2008000886W WO2008110809A3 WO 2008110809 A3 WO2008110809 A3 WO 2008110809A3 GB 2008000886 W GB2008000886 W GB 2008000886W WO 2008110809 A3 WO2008110809 A3 WO 2008110809A3
Authority
WO
WIPO (PCT)
Prior art keywords
mouthpiece
obstruction
cover
dry powder
inhaler
Prior art date
Application number
PCT/GB2008/000886
Other languages
French (fr)
Other versions
WO2008110809A2 (en
Inventor
Simon James Smith
Lai Chiu Tang
Original Assignee
Cambridge Consultants
Simon James Smith
Lai Chiu Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Consultants, Simon James Smith, Lai Chiu Tang filed Critical Cambridge Consultants
Publication of WO2008110809A2 publication Critical patent/WO2008110809A2/en
Publication of WO2008110809A3 publication Critical patent/WO2008110809A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

A dry powder inhaler comprises a mouthpiece (12) through which in use a user can inhale a powdered medicament. A mouthpiece obstruction or cover (6, 8) is arranged to prevent a user properly inhaling through the mouthpiece. A plurality of medicament doses are provided in individually sealed compartments (24). The inhaler has means (48, 50) for breaching the seal (25) of one of said compartments (24) to establish a pathway between that compartment and the mouthpiece, wherein the mouthpiece obstruction or cover is mechanically coupled to the seal breaching means so as to operate the latter when the mouthpiece obstruction or cover is opened. The inhaler further comprises one or more piercers (52, 54). The piercers are so shaped and arranged that upon penetration of the sealing member they form a hollow tube therewith for communicating with the interior of the compartment.
PCT/GB2008/000886 2007-03-14 2008-03-13 Dry powder inhalers WO2008110809A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0704928.1A GB0704928D0 (en) 2007-03-14 2007-03-14 Dry powder inhalers
GB0704928.1 2007-03-14

Publications (2)

Publication Number Publication Date
WO2008110809A2 WO2008110809A2 (en) 2008-09-18
WO2008110809A3 true WO2008110809A3 (en) 2008-12-31

Family

ID=38008425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000886 WO2008110809A2 (en) 2007-03-14 2008-03-13 Dry powder inhalers

Country Status (2)

Country Link
GB (2) GB0704928D0 (en)
WO (1) WO2008110809A2 (en)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1894591B1 (en) 2002-03-20 2013-06-26 MannKind Corporation Cartridge for an inhalation apparatus
DK1786784T3 (en) 2004-08-20 2011-02-14 Mannkind Corp Catalysis of diketopiperazine synthesis
CN104436170B (en) 2004-08-23 2018-02-23 曼金德公司 Diketopiperazine salt for drug delivery
HUE028623T2 (en) 2005-09-14 2016-12-28 Mannkind Corp Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
IN2015DN00888A (en) 2006-02-22 2015-07-10 Mannkind Corp
EP2534958A1 (en) 2007-12-14 2012-12-19 AeroDesigns, Inc Delivering aerosolizable food products
JP2011507593A (en) 2007-12-20 2011-03-10 アストラゼネカ・アクチエボラーグ Apparatus and method for deagglomerating and disassembling powder 854
WO2009137441A1 (en) 2008-05-05 2009-11-12 Raytheon Company Methods and apparatus for detection/classification of radar targets including birds and other hazards
ES2570400T3 (en) 2008-06-13 2016-05-18 Mannkind Corp A dry powder inhaler and a drug delivery system
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
JP5479465B2 (en) 2008-06-20 2014-04-23 マンカインド コーポレイション Interactive device and method for profiling inhalation efforts in real time
TWI532497B (en) 2008-08-11 2016-05-11 曼凱公司 Use of ultrarapid acting insulin
UA101056C2 (en) 2008-10-08 2013-02-25 Астразенека Аб Inhalation device and method of dispensing medicament
JP5620916B2 (en) * 2008-11-06 2014-11-05 メディスプレイ、ラボラトリーズ、プライベート、リミテッドＭｅｄｉｓｐｒａｙ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ． Ｌｔｄ Inhaler device
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
ES2634111T3 (en) 2009-04-17 2017-09-26 Raytheon Company Method and apparatus for integration of distributed sensors and surveillance radar in airports to mitigate blind spots
KR101875969B1 (en) 2009-06-12 2018-07-06 맨카인드 코포레이션 Diketopiperazine microparticles with defined specific surface areas
EP2448623B1 (en) 2009-07-01 2017-12-20 AstraZeneca AB Dispenser and method for entraining powder in an airflow
US9345848B2 (en) 2009-10-20 2016-05-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
WO2011129789A1 (en) * 2010-04-13 2011-10-20 Mahmut Bilgic Dry powder inhaler mouthpiece button
WO2011129788A1 (en) * 2010-04-13 2011-10-20 Mahmut Bilgic User-friendly dry powder inhaler
JP5784622B2 (en) 2009-11-03 2015-09-24 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
MX359281B (en) 2010-06-21 2018-09-21 Mannkind Corp Dry powder drug delivery system and methods.
ES2535979T3 (en) * 2010-07-21 2015-05-19 Astrazeneca Ab Inhaler
MX353285B (en) 2011-04-01 2018-01-05 Mannkind Corp Blister package for pharmaceutical cartridges.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103945859A (en) 2011-10-24 2014-07-23 曼金德公司 Methods and compositions for treating pain
US9849255B2 (en) 2011-11-25 2017-12-26 Mahmut Bilgic Inhalation device
WO2014012069A2 (en) 2012-07-12 2014-01-16 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
KR102321339B1 (en) 2013-07-18 2021-11-02 맨카인드 코포레이션 Heat-stable dry powder pharmaceutical compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
USD744087S1 (en) 2013-10-01 2015-11-24 Mahmut Bilgic Dry powder inhaler
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001026720A1 (en) * 1999-10-12 2001-04-19 Shl Medical Ab Inhaler
WO2002011800A2 (en) * 2000-08-10 2002-02-14 Meridica Limited Device for delivering physiologically active agent in powdered form
WO2002053216A2 (en) * 2001-01-08 2002-07-11 Cipla Limited An improved device for metered administration of medicament by inhalation
WO2004011071A1 (en) * 2002-07-25 2004-02-05 Glaxo Group Limited Medicament dispenser
GB2407042A (en) * 2003-10-17 2005-04-20 Vectura Ltd Pocket blister inhaler with piercing actuator
WO2006071512A1 (en) * 2004-12-23 2006-07-06 3M Innovative Properties Company Inhalation devices
WO2007012871A1 (en) * 2005-07-28 2007-02-01 Glaxo Group Limited Medicament dispenser

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5921237A (en) * 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
GB0015034D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Inhalation device
GB0209526D0 (en) * 2002-04-26 2002-06-05 Glaxo Group Ltd Medicament dispenser
GB0317374D0 (en) * 2003-07-24 2003-08-27 Glaxo Group Ltd Medicament dispenser

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001026720A1 (en) * 1999-10-12 2001-04-19 Shl Medical Ab Inhaler
WO2002011800A2 (en) * 2000-08-10 2002-02-14 Meridica Limited Device for delivering physiologically active agent in powdered form
WO2002053216A2 (en) * 2001-01-08 2002-07-11 Cipla Limited An improved device for metered administration of medicament by inhalation
WO2004011071A1 (en) * 2002-07-25 2004-02-05 Glaxo Group Limited Medicament dispenser
GB2407042A (en) * 2003-10-17 2005-04-20 Vectura Ltd Pocket blister inhaler with piercing actuator
WO2006071512A1 (en) * 2004-12-23 2006-07-06 3M Innovative Properties Company Inhalation devices
WO2007012871A1 (en) * 2005-07-28 2007-02-01 Glaxo Group Limited Medicament dispenser

Also Published As

Publication number Publication date
GB2447560A (en) 2008-09-17
WO2008110809A2 (en) 2008-09-18
GB0704928D0 (en) 2007-04-25
GB2447560B (en) 2009-10-07
GB0804716D0 (en) 2008-04-16

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