WO2008108145A1 - β－ラクタム化合物の製造方法 - Google Patents

β－ラクタム化合物の製造方法 Download PDF

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Publication number
WO2008108145A1
WO2008108145A1 PCT/JP2008/052338 JP2008052338W WO2008108145A1 WO 2008108145 A1 WO2008108145 A1 WO 2008108145A1 JP 2008052338 W JP2008052338 W JP 2008052338W WO 2008108145 A1 WO2008108145 A1 WO 2008108145A1
Authority
WO
WIPO (PCT)
Prior art keywords
lactam compound
beta
reaction
compound
producing beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/052338
Other languages
English (en)
French (fr)
Inventor
Hideo Kawachi
Shingo Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of WO2008108145A1 publication Critical patent/WO2008108145A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、β－ラクタム化合物を製造する方法であって、二重結合を有する化合物とスルホニルイソシアネート類との環化反応を管型反応器を用いて連続的に実施する方法である。本発明によれば、反応操作が容易であり、反応熱による過熱を防止でき、従来の方法と比較して高い温度条件下かつ短い反応時間で、β－ラクタム化合物を高収率で製造することができる。                                                                               
PCT/JP2008/052338 2007-03-06 2008-02-13 β－ラクタム化合物の製造方法 Ceased WO2008108145A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-055373 2007-03-06
JP2007055373 2007-03-06

Publications (1)

Publication Number Publication Date
WO2008108145A1 true WO2008108145A1 (ja) 2008-09-12

Family

ID=39738042

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052338 Ceased WO2008108145A1 (ja) 2007-03-06 2008-02-13 β－ラクタム化合物の製造方法

Country Status (2)

Country Link
TW (1) TW200848405A (ja)
WO (1) WO2008108145A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
CN112939836A (zh) * 2021-03-17 2021-06-11 河南大学 一种β-内酰胺类化合物及制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01172393A (ja) * 1987-12-25 1989-07-07 Kanegafuchi Chem Ind Co Ltd 新規β−ラクタム化合物及びその製造法
JPH02290888A (ja) * 1989-05-01 1990-11-30 Kanegafuchi Chem Ind Co Ltd β―ラクタム化合物の製造法
JPH0320287A (ja) * 1989-06-17 1991-01-29 Kanegafuchi Chem Ind Co Ltd β―ラクタム化合物の製造法
JPH04112867A (ja) * 1990-09-03 1992-04-14 Kanegafuchi Chem Ind Co Ltd β―ラクタム化合物の製造法
JPH11310572A (ja) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd １−クロロスルホニル−３，３，４，４−テトラメチルアゼチジン−２−オンの製造方法
JPH11310571A (ja) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd １−クロロスルホニル−３，３，４，４−テトラメチルアゼチジン−２−オンの製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01172393A (ja) * 1987-12-25 1989-07-07 Kanegafuchi Chem Ind Co Ltd 新規β−ラクタム化合物及びその製造法
JPH02290888A (ja) * 1989-05-01 1990-11-30 Kanegafuchi Chem Ind Co Ltd β―ラクタム化合物の製造法
JPH0320287A (ja) * 1989-06-17 1991-01-29 Kanegafuchi Chem Ind Co Ltd β―ラクタム化合物の製造法
JPH04112867A (ja) * 1990-09-03 1992-04-14 Kanegafuchi Chem Ind Co Ltd β―ラクタム化合物の製造法
JPH11310572A (ja) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd １−クロロスルホニル−３，３，４，４−テトラメチルアゼチジン−２−オンの製造方法
JPH11310571A (ja) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd １−クロロスルホニル−３，３，４，４−テトラメチルアゼチジン−２−オンの製造方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
CN112939836A (zh) * 2021-03-17 2021-06-11 河南大学 一种β-内酰胺类化合物及制备方法

Also Published As

Publication number Publication date
TW200848405A (en) 2008-12-16

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