WO2008104847A3 - Procédés de préparation du pramipexole et de ses sels - Google Patents

Procédés de préparation du pramipexole et de ses sels Download PDF

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Publication number
WO2008104847A3
WO2008104847A3 PCT/IB2008/000406 IB2008000406W WO2008104847A3 WO 2008104847 A3 WO2008104847 A3 WO 2008104847A3 IB 2008000406 W IB2008000406 W IB 2008000406W WO 2008104847 A3 WO2008104847 A3 WO 2008104847A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pramipexole
salts
processes
relates
Prior art date
Application number
PCT/IB2008/000406
Other languages
English (en)
Other versions
WO2008104847A2 (fr
Inventor
Aziz Imam Quadri Syed
Mohammad Rafeeq
Mohammed Jaweed Mukarram Siddiqui
Original Assignee
Wockhardt Research Center
Aziz Imam Quadri Syed
Mohammad Rafeeq
Siddiqui Mohammed Jaweed Mukar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Center, Aziz Imam Quadri Syed, Mohammad Rafeeq, Siddiqui Mohammed Jaweed Mukar filed Critical Wockhardt Research Center
Publication of WO2008104847A2 publication Critical patent/WO2008104847A2/fr
Publication of WO2008104847A3 publication Critical patent/WO2008104847A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés de préparation du pramipexole ou de ses sels pharmaceutiquement acceptables. Plus particulièrement, elle concerne un procédé de préparation du dichlorhydrate de pramipexole monohydraté. L'invention concerne également un nouveau composé, la 2-bromo-4-aminocyclohexanone et des procédés destinés à sa préparation. La 2-bromo-4-aminocyclohexanone est un intermédiaire utile dans la préparation du pramipexole ou de ses sels. L'invention concerne en outre un procédé mono-étape de préparation du 2,6-diamino-4,5,6,7-tétrahydrobenzathiazole, un intermédiaire utile dans la préparation du pramipexole ou de ses sels.
PCT/IB2008/000406 2007-02-26 2008-02-25 Procédés de préparation du pramipexole et de ses sels WO2008104847A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN374/MUM/2007 2007-02-26
IN374MU2007 2007-02-26
IN608MU2007 2007-03-30
IN608/MUM/2007 2007-03-30

Publications (2)

Publication Number Publication Date
WO2008104847A2 WO2008104847A2 (fr) 2008-09-04
WO2008104847A3 true WO2008104847A3 (fr) 2009-02-05

Family

ID=39591359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/000406 WO2008104847A2 (fr) 2007-02-26 2008-02-25 Procédés de préparation du pramipexole et de ses sels

Country Status (1)

Country Link
WO (1) WO2008104847A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
ATE537826T1 (de) 2006-05-16 2012-01-15 Knopp Neurosciences Inc Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
EP2137171A4 (fr) * 2007-03-14 2010-05-19 Knopp Neurosciences Inc Synthèse de benzothiazole diamines substituées et purifiées du point de vue chiral
US20110190356A1 (en) 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
RS61539B1 (sr) 2013-07-12 2021-04-29 Knopp Biosciences Llc Lečenje povišenih nivoa eozinofila i/ili bazofila
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
CA2921381A1 (fr) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions et methodes pour le traitement de l'urticaire chronique
CN104496936B (zh) * 2015-01-07 2017-11-28 海南康虹医药科技开发有限公司 一种盐酸普拉克索的制备方法
CN109232471B (zh) * 2018-10-31 2022-05-10 安徽省庆云医药股份有限公司 一种盐酸普拉克索的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060100256A1 (en) * 2002-11-04 2006-05-11 Rao Dharmaraj R Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060100256A1 (en) * 2002-11-04 2006-05-11 Rao Dharmaraj R Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE REGISTRY [online] Chemical Abstracts, Columbus, Ohio; XP002488827, retrieved from STN *
KRANJC A ET AL: "Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 14, no. 12, 21 June 2004 (2004-06-21), pages 3251 - 3256, XP004841384, ISSN: 0960-894X *
SCHNEIDER C S ET AL: "Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and aminothiazole analogue of apomorphine", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 30, no. 3, 1 March 1987 (1987-03-01), pages 494 - 498, XP002186199, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
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