WO2008023027A3 - Méthode de fabrication de comprimés de pramipexole dihydrochlorure - Google Patents

Méthode de fabrication de comprimés de pramipexole dihydrochlorure Download PDF

Info

Publication number
WO2008023027A3
WO2008023027A3 PCT/EP2007/058696 EP2007058696W WO2008023027A3 WO 2008023027 A3 WO2008023027 A3 WO 2008023027A3 EP 2007058696 W EP2007058696 W EP 2007058696W WO 2008023027 A3 WO2008023027 A3 WO 2008023027A3
Authority
WO
WIPO (PCT)
Prior art keywords
storage stability
pramipexole dihydrochloride
high storage
tablets
dihydrochloride tablets
Prior art date
Application number
PCT/EP2007/058696
Other languages
English (en)
Other versions
WO2008023027A2 (fr
Inventor
Hans-Werner Wernersbach
Original Assignee
Boehringer Ingelheim Pharma
Hans-Werner Wernersbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38963081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008023027(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US11/734,041 external-priority patent/US20080254118A1/en
Application filed by Boehringer Ingelheim Pharma, Hans-Werner Wernersbach filed Critical Boehringer Ingelheim Pharma
Priority to JP2009525064A priority Critical patent/JP2010501525A/ja
Priority to MX2009001884A priority patent/MX2009001884A/es
Priority to EP07788511A priority patent/EP2056795A2/fr
Priority to CA002661616A priority patent/CA2661616A1/fr
Priority to AU2007287560A priority patent/AU2007287560A1/en
Priority to BRPI0715835-1A priority patent/BRPI0715835A2/pt
Publication of WO2008023027A2 publication Critical patent/WO2008023027A2/fr
Publication of WO2008023027A3 publication Critical patent/WO2008023027A3/fr
Priority to IL197130A priority patent/IL197130A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une méthode de fabrication de comprimés de pramipexole dihydrochlorure, et en particulier une méthode fabrication permettant d'obtenir des comprimés dotés de propriétés leur conférant une grande stabilité au stockage.
PCT/EP2007/058696 2006-08-24 2007-08-22 Méthode de fabrication de comprimés de pramipexole dihydrochlorure WO2008023027A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009525064A JP2010501525A (ja) 2006-08-24 2007-08-22 プラミペキソールジヒドロクロライド錠剤の調製方法
MX2009001884A MX2009001884A (es) 2006-08-24 2007-08-22 Proceso para preparar comprimidos de dihidrocloruro de pramipexol con elevada estabilidad de conservacion.
EP07788511A EP2056795A2 (fr) 2006-08-24 2007-08-22 Méthode de fabrication de comprimés de pramipexole dihydrochloride à haute stabilité
CA002661616A CA2661616A1 (fr) 2006-08-24 2007-08-22 Methode de fabrication de comprimes de pramipexole dihydrochlorure
AU2007287560A AU2007287560A1 (en) 2006-08-24 2007-08-22 Process for preparing pramipexole dihydrochloride tablets with high storage stability
BRPI0715835-1A BRPI0715835A2 (pt) 2006-08-24 2007-08-22 processo para preparar comprimidos de dicloridrato de pramipexol
IL197130A IL197130A0 (en) 2006-08-24 2009-02-19 Process for preparing pramipexole dihydrochloride tablets

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46705006A 2006-08-24 2006-08-24
US11/467,050 2006-08-24
US11/734,041 2007-04-11
US11/734,041 US20080254118A1 (en) 2007-04-11 2007-04-11 Process for preparing pramipexole dihydrochloride tablets

Publications (2)

Publication Number Publication Date
WO2008023027A2 WO2008023027A2 (fr) 2008-02-28
WO2008023027A3 true WO2008023027A3 (fr) 2008-04-17

Family

ID=38963081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/058696 WO2008023027A2 (fr) 2006-08-24 2007-08-22 Méthode de fabrication de comprimés de pramipexole dihydrochlorure

Country Status (13)

Country Link
EP (1) EP2056795A2 (fr)
JP (1) JP2010501525A (fr)
KR (1) KR20090045943A (fr)
AR (1) AR062509A1 (fr)
AU (1) AU2007287560A1 (fr)
BR (1) BRPI0715835A2 (fr)
CA (1) CA2661616A1 (fr)
CL (1) CL2007002477A1 (fr)
IL (1) IL197130A0 (fr)
MX (1) MX2009001884A (fr)
RU (1) RU2009110253A (fr)
TW (1) TW200816998A (fr)
WO (1) WO2008023027A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
KR20090021169A (ko) 2006-05-16 2009-02-27 크놉 뉴로사이언시스 인코포레이티드 Ｒ(+) 및 ｓ(-) 프라미펙솔을 포함하는 조성물 및 이의 사용 방법
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
WO2008113056A2 (fr) 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthèse de benzothiazole diamines substituées et purifiées du point de vue chiral
US20080254117A1 (en) * 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
EP2334185A4 (fr) 2008-08-19 2011-09-21 Knopp Neurosciences Inc Compositions et procédés employant du (r)-pramipexole
TR200906997A1 (tr) * 2009-09-11 2011-03-21 Sanovel �La� San. Ve T�C. A. �. Pramipeksol farmasötik bileşimleri.
EP2462925A1 (fr) 2010-11-12 2012-06-13 Neuraxpharm Arzneimittel GmbH Granulé de dihydrochlorure de pramipexole
KR101712049B1 (ko) * 2010-11-17 2017-03-03 엘지이노텍 주식회사 발광 소자
WO2013096816A1 (fr) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Synthèse améliorée de composés substitués par amine de 4,5,6,7-tétrahydrobenzothiazole
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
PL3019167T3 (pl) 2013-07-12 2021-06-14 Knopp Biosciences Llc Leczenie podwyższonych poziomów eozynofili i/lub bazofili
HUE055850T2 (hu) 2013-08-13 2022-01-28 Knopp Biosciences Llc Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044353A1 (fr) * 1999-01-29 2000-08-03 Losan Pharma Gmbh Compositions pharmaceutiques
WO2003053402A1 (fr) * 2001-12-20 2003-07-03 Pharmacia Corporation Formes dosifiees a liberation soutenue d'ordre zero et procede de production associe
WO2004100857A2 (fr) * 2003-05-07 2004-11-25 Akina, Inc. Granules a teneur elevee en plastique, destines a la fabrication de comprimes a dissolution rapide
WO2006015943A2 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation d’une pastille à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de cette pastille
WO2006015942A1 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation de comprimé à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de ce comprimé
WO2007070843A2 (fr) * 2005-12-15 2007-06-21 Acusphere, Inc. Procédés de préparation de formulations pharmaceutiques à base de particules destinées à une administration orale

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0998933A1 (fr) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Procédé pour la préparation de compositions pharmaucetiques contenant des diphosphonates pour administration orale
JP4446177B2 (ja) * 2005-01-21 2010-04-07 東和薬品株式会社 耐湿性口腔内崩壊錠の製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044353A1 (fr) * 1999-01-29 2000-08-03 Losan Pharma Gmbh Compositions pharmaceutiques
WO2003053402A1 (fr) * 2001-12-20 2003-07-03 Pharmacia Corporation Formes dosifiees a liberation soutenue d'ordre zero et procede de production associe
WO2004100857A2 (fr) * 2003-05-07 2004-11-25 Akina, Inc. Granules a teneur elevee en plastique, destines a la fabrication de comprimes a dissolution rapide
WO2006015943A2 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation d’une pastille à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de cette pastille
WO2006015942A1 (fr) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Préparation de comprimé à autorisation de sortie élargie, contenant du pramipexole ou un sel de pramipexole pharmaceutiquement acceptable, procédé de fabrication et d’utilisation de ce comprimé
WO2007070843A2 (fr) * 2005-12-15 2007-06-21 Acusphere, Inc. Procédés de préparation de formulations pharmaceutiques à base de particules destinées à une administration orale

Also Published As

Publication number Publication date
AR062509A1 (es) 2008-11-12
BRPI0715835A2 (pt) 2013-07-23
RU2009110253A (ru) 2010-09-27
EP2056795A2 (fr) 2009-05-13
TW200816998A (en) 2008-04-16
IL197130A0 (en) 2009-11-18
CA2661616A1 (fr) 2008-02-28
JP2010501525A (ja) 2010-01-21
CL2007002477A1 (es) 2008-04-18
WO2008023027A2 (fr) 2008-02-28
MX2009001884A (es) 2009-03-06
KR20090045943A (ko) 2009-05-08
AU2007287560A1 (en) 2008-02-28

Similar Documents

Publication Publication Date Title
WO2008023027A3 (fr) Méthode de fabrication de comprimés de pramipexole dihydrochlorure
WO2008046581A3 (fr) Composés tétrahydropyrrolopyrazine substitués et leur utilisation dans des médicaments
EG25151A (en) Process for hydrogen production.
IL204555A0 (en) (carboxylalkylene-phenyl) phenyl-oxalamides, method for the production thereof, and use of same as a medicatment
EP2194093B8 (fr) Composition de résine, composition de résine de moulage préparée à l'aide de celle-ci, stratifiés et procédé de fabrication des stratifiés
WO2008135482A8 (fr) Nouveaux liquides ioniques
TW200716105A (en) Imidazole compounds
EP1908749A4 (fr) Procede de fabrication d'isocyanate, isocyanate fabrique selon ce procede, et utilisation de cet isocyanate
WO2007065942A3 (fr) Composes bis-heterocycliques de l'imidazolyle
WO2010123585A3 (fr) Nouveaux outils améliorés comprenant une combinaison clapet à bille/clapet à battant (blapper) et procédés associés
MX2010003244A (es) Inhibidores de quinasa tipo polo.
WO2006128852A3 (fr) Composes spiro-heterocycliques
PL1877523T3 (pl) Sposób wytwarzania paliwa z biomasy
IL204556A0 (en) (cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
WO2010015657A3 (fr) Nouveaux alcoxypyrazoles
EP1980578A4 (fr) Procédé de production d'un polymère de propylène modifié, polymère de propylène modifié obtenu par ce procédé de production, et composition contenant le polymère de propylène modifié
AP2010005367A0 (en) Process for manufacturing a tea product.
EP2083032A4 (fr) Composition polymérisable, résine réticulable, procédé de production et d'utilisation
IL197708A0 (en) Process for the fabrication of manometric, zonodispersed and stable magnesium hydroxide and product obtained
WO2010076810A3 (fr) Procédé d'élaboration de géfitinibe
EP2116593A4 (fr) Procédé de production de levure sèche contenant de la s-adenosyl-l-méthionine et présentant une excellente stabilité au stockage, produit fabriqué par le procédé et composition moulée de la levure sèche
WO2008122638A3 (fr) Procédé d'élaboration de pastilles de dihydrochlorure de pramipexole
WO2009022327A3 (fr) Nouveau procédé de préparation de lévocétirizine de pureté élevée et de ses sels
PL2089468T3 (pl) Sposób wytwarzania funkcjonalnych kształtek celulozowych
WO2007148102A3 (fr) Hydrochlorure crystallin de duloxétine

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780031523.0

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07788511

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2007788511

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 197130

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 12009500342

Country of ref document: PH

Ref document number: MX/A/2009/001884

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2661616

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2009525064

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 1552/DELNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 575637

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2007287560

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2009110253

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020097006052

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2007287560

Country of ref document: AU

Date of ref document: 20070822

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: PI0715835

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090220