WO2008102460A1 - Transplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse destinée à favoriser la récupération fonctionnelle après une blessure de la moelle épinière - Google Patents

Transplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse destinée à favoriser la récupération fonctionnelle après une blessure de la moelle épinière Download PDF

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Publication number
WO2008102460A1
WO2008102460A1 PCT/JP2007/053991 JP2007053991W WO2008102460A1 WO 2008102460 A1 WO2008102460 A1 WO 2008102460A1 JP 2007053991 W JP2007053991 W JP 2007053991W WO 2008102460 A1 WO2008102460 A1 WO 2008102460A1
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WO
WIPO (PCT)
Prior art keywords
nscs
spinal cord
cells
bmsc
bone marrow
Prior art date
Application number
PCT/JP2007/053991
Other languages
English (en)
Inventor
Mari Dezawa
Masao Koda
Keita Mori
Masashi Yamazaki
Original Assignee
Sanbio Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanbio Inc. filed Critical Sanbio Inc.
Priority to PCT/JP2007/053991 priority Critical patent/WO2008102460A1/fr
Publication of WO2008102460A1 publication Critical patent/WO2008102460A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Abstract

L'invention concerne un procédé et une composition pharmaceutique pour la neurotransplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse (BMSC-NSC) destinés à favoriser la récupération fonctionnelle après une blessure de la moelle épinière d'un patient.
PCT/JP2007/053991 2007-02-23 2007-02-23 Transplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse destinée à favoriser la récupération fonctionnelle après une blessure de la moelle épinière WO2008102460A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/053991 WO2008102460A1 (fr) 2007-02-23 2007-02-23 Transplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse destinée à favoriser la récupération fonctionnelle après une blessure de la moelle épinière

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/053991 WO2008102460A1 (fr) 2007-02-23 2007-02-23 Transplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse destinée à favoriser la récupération fonctionnelle après une blessure de la moelle épinière

Publications (1)

Publication Number Publication Date
WO2008102460A1 true WO2008102460A1 (fr) 2008-08-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/053991 WO2008102460A1 (fr) 2007-02-23 2007-02-23 Transplantation de cellules souches neuronales induites par cellules stromales de moelle osseuse destinée à favoriser la récupération fonctionnelle après une blessure de la moelle épinière

Country Status (1)

Country Link
WO (1) WO2008102460A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010036141A1 (fr) * 2008-09-25 2010-04-01 Bryukhovetskiy Andrey Stepanov Système de neuro-endoprothèse implantable, procédé de production de celle-ci, et procédé d’exécution d’une opération de neurochirurgie reconstructrice
EP2530144A3 (fr) * 2011-04-12 2013-05-01 Fujifilm Corporation Composition comprenant un polymère biocompatible et cellulaire
US8785190B2 (en) 2011-04-06 2014-07-22 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
US9326999B2 (en) 2012-10-09 2016-05-03 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration
US9828593B2 (en) 2012-05-16 2017-11-28 Sanbio, Inc. Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells
US10245286B2 (en) 2012-01-27 2019-04-02 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
US10316288B2 (en) 2008-04-30 2019-06-11 Sanbio, Inc. Neural regenerating cells with alterations in DNA methylation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1479767A1 (fr) * 2002-02-06 2004-11-24 Sanbio, Inc. Methode de differenciation/d'induction de cellules interstitielles de moelle osseuse en cellules nerveuses et en cellules musculaires du squelette par transfert du gene notch
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1479767A1 (fr) * 2002-02-06 2004-11-24 Sanbio, Inc. Methode de differenciation/d'induction de cellules interstitielles de moelle osseuse en cellules nerveuses et en cellules musculaires du squelette par transfert du gene notch
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN Y ET AL: "Coaxing bone marrow stromal mesenchymal stem cells towards neuronal differentiation: progress and uncertainties", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 63, no. 14, 19 June 2006 (2006-06-19), pages 1649 - 1657, XP019419179, ISSN: 1420-9071 *
CHOPP MICHAEL ET AL: "Spinal cord injury in rat: Treatment with bone marrow stromal cell transplantation", NEUROREPORT, RAPID COMMUNICATIONS OF OXFORD, OXFORD, vol. 11, no. 13, 11 September 2000 (2000-09-11), pages 3001 - 3005, XP009099725, ISSN: 0959-4965 *
DEZAWA M ET AL: "Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 113, no. 12, 1 June 2004 (2004-06-01), pages 1701 - 1710, XP002311058, ISSN: 0021-9738 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10316288B2 (en) 2008-04-30 2019-06-11 Sanbio, Inc. Neural regenerating cells with alterations in DNA methylation
WO2010036141A1 (fr) * 2008-09-25 2010-04-01 Bryukhovetskiy Andrey Stepanov Système de neuro-endoprothèse implantable, procédé de production de celle-ci, et procédé d’exécution d’une opération de neurochirurgie reconstructrice
US10543234B2 (en) 2011-04-06 2020-01-28 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
US8785190B2 (en) 2011-04-06 2014-07-22 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
US11903972B2 (en) 2011-04-06 2024-02-20 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
USRE46382E1 (en) 2011-04-06 2017-05-02 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
US9655927B2 (en) 2011-04-06 2017-05-23 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
EP2530144A3 (fr) * 2011-04-12 2013-05-01 Fujifilm Corporation Composition comprenant un polymère biocompatible et cellulaire
US11304982B2 (en) 2012-01-27 2022-04-19 Atricure, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
US10245286B2 (en) 2012-01-27 2019-04-02 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
US9828593B2 (en) 2012-05-16 2017-11-28 Sanbio, Inc. Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells
US10626389B2 (en) 2012-05-16 2020-04-21 Sanbio, Inc. Methods and compositions for modulation of migration of neurogenic cells
US9855299B2 (en) 2012-10-09 2018-01-02 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration
US9326999B2 (en) 2012-10-09 2016-05-03 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration

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