WO2008101943A1 - Formulation pharmaceutique d'hydrochlorure de metformine et comprimé renfermant ladite formulation - Google Patents

Formulation pharmaceutique d'hydrochlorure de metformine et comprimé renfermant ladite formulation Download PDF

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Publication number
WO2008101943A1
WO2008101943A1 PCT/EP2008/052036 EP2008052036W WO2008101943A1 WO 2008101943 A1 WO2008101943 A1 WO 2008101943A1 EP 2008052036 W EP2008052036 W EP 2008052036W WO 2008101943 A1 WO2008101943 A1 WO 2008101943A1
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WO
WIPO (PCT)
Prior art keywords
weight
formulation according
pharmaceutical formulation
pharmaceutically acceptable
metformin
Prior art date
Application number
PCT/EP2008/052036
Other languages
English (en)
Inventor
Maurizio Valleri
Original Assignee
Laboratori Guidotti S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Guidotti S.P.A. filed Critical Laboratori Guidotti S.P.A.
Publication of WO2008101943A1 publication Critical patent/WO2008101943A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • the objective of modifying the original characteristics of the powder can be achieved for example by pre-compression and compaction of the drug.
  • This is commonly applied to drugs such as paracetamol, ranitidine HCI, amoxicillin.
  • this procedure must doubtless be regarded as a procedure additional to the direct compression process.
  • larger sized particles can be used with the purpose of limiting inter-particle friction. This is precisely the case described in US 6,1 17,451 in which the formulation to be directly compressed is strictly confined to the use of metformin HCI of particle size from 400 to 600 micrometres.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur une formulation qui comprend un hydrochlorure de metformine micronisé destiné à la préparation de comprimés pharmaceutiques par simple compression.
PCT/EP2008/052036 2007-02-21 2008-02-20 Formulation pharmaceutique d'hydrochlorure de metformine et comprimé renfermant ladite formulation WO2008101943A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI2007A000042 2007-02-21
IT000042A ITFI20070042A1 (it) 2007-02-21 2007-02-21 Formulazione farmaceutica e compressa comprendente detta formulazione.

Publications (1)

Publication Number Publication Date
WO2008101943A1 true WO2008101943A1 (fr) 2008-08-28

Family

ID=39399182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/052036 WO2008101943A1 (fr) 2007-02-21 2008-02-20 Formulation pharmaceutique d'hydrochlorure de metformine et comprimé renfermant ladite formulation

Country Status (2)

Country Link
IT (1) ITFI20070042A1 (fr)
WO (1) WO2008101943A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011039337A1 (fr) * 2009-10-02 2011-04-07 Boehringer Ingelheim International Gmbh Composition pharmaceutique, forme galénique pharmaceutique, leur procédé de préparation et leurs méthodes de traitement et d'utilisation
WO2013074049A1 (fr) * 2011-11-03 2013-05-23 Mahmut Bilgic Metformine micronisée
WO2013077821A1 (fr) * 2011-11-23 2013-05-30 Mahmut Bilgic Composition homogène contenant un biguanide
US8551957B2 (en) 2007-08-16 2013-10-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivate
US8557782B2 (en) 2006-05-03 2013-10-15 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
WO2014101986A1 (fr) * 2012-12-27 2014-07-03 Zentiva Sağlik Ürünleri San. Ve Tic. A.Ş. Procédé de granulation à sec pour la production de compositions de comprimés de metformine et compositions associées
US8802842B2 (en) 2009-09-30 2014-08-12 Boehringer Ingelheim International Gmbh Method for the preparation of a crystalline form
US9024010B2 (en) 2009-09-30 2015-05-05 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
US9127034B2 (en) 2005-05-10 2015-09-08 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivates and intermediates therein
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9949997B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9949998B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US20180185291A1 (en) 2011-03-07 2018-07-05 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US10406172B2 (en) 2009-02-13 2019-09-10 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2022023213A1 (fr) * 2020-07-31 2022-02-03 Krka, D. D., Novo Mesto Formulation pharmaceutique de metformine ayant une faible teneur en diméthylamine
US11666590B2 (en) 2013-04-18 2023-06-06 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524618B1 (en) * 2001-06-12 2003-02-25 Vijai Kumar Directly compressible extended-release matrix formulation for metformin hydrochloride
WO2006038226A2 (fr) * 2004-10-08 2006-04-13 Rubicon Research Pvt. Ltd. Compositions de metformine fortement compressibles a liberation controlee

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524618B1 (en) * 2001-06-12 2003-02-25 Vijai Kumar Directly compressible extended-release matrix formulation for metformin hydrochloride
WO2006038226A2 (fr) * 2004-10-08 2006-04-13 Rubicon Research Pvt. Ltd. Compositions de metformine fortement compressibles a liberation controlee

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9127034B2 (en) 2005-05-10 2015-09-08 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivates and intermediates therein
US10442795B2 (en) 2005-05-10 2019-10-15 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
US8557782B2 (en) 2006-05-03 2013-10-15 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
US8551957B2 (en) 2007-08-16 2013-10-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivate
US10406172B2 (en) 2009-02-13 2019-09-10 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9873714B2 (en) 2009-09-30 2018-01-23 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
US8802842B2 (en) 2009-09-30 2014-08-12 Boehringer Ingelheim International Gmbh Method for the preparation of a crystalline form
US9024010B2 (en) 2009-09-30 2015-05-05 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
US10610489B2 (en) 2009-10-02 2020-04-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
WO2011039337A1 (fr) * 2009-10-02 2011-04-07 Boehringer Ingelheim International Gmbh Composition pharmaceutique, forme galénique pharmaceutique, leur procédé de préparation et leurs méthodes de traitement et d'utilisation
AP3438A (en) * 2009-10-02 2015-10-31 Boehring Ingelheim Internat Gmbh Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
CN104873974A (zh) * 2009-10-02 2015-09-02 贝林格尔·英格海姆国际有限公司 药物组合物、药物剂型、其制备方法、治疗方法及其用途
EA027181B1 (ru) * 2009-10-02 2017-06-30 Бёрингер Ингельхайм Интернациональ Гмбх Твердая фармацевтическая дозированная форма, включающая ингибитор sglt-2 и гидрохлорид метформина, для лечения
EP3150200A1 (fr) * 2009-10-02 2017-04-05 Boehringer Ingelheim International GmbH Composition pharmaceutique, forme pharmaceutique, procédé pour leur préparation, méthodes de traitement et leurs utilisations
US10596120B2 (en) 2011-03-07 2020-03-24 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US11564886B2 (en) 2011-03-07 2023-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US20180185291A1 (en) 2011-03-07 2018-07-05 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
WO2013074049A1 (fr) * 2011-11-03 2013-05-23 Mahmut Bilgic Metformine micronisée
WO2013077821A1 (fr) * 2011-11-23 2013-05-30 Mahmut Bilgic Composition homogène contenant un biguanide
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2014101986A1 (fr) * 2012-12-27 2014-07-03 Zentiva Sağlik Ürünleri San. Ve Tic. A.Ş. Procédé de granulation à sec pour la production de compositions de comprimés de metformine et compositions associées
RU2647421C2 (ru) * 2012-12-27 2018-03-15 Зентива Саглык Урунлеры Сан. Ве Тыдж. А.Ш. Способ сухого гранулирования для получения композиций метформина в виде таблеток и его композиции
US9949998B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US10258637B2 (en) 2013-04-05 2019-04-16 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11090323B2 (en) 2013-04-05 2021-08-17 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9949997B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11833166B2 (en) 2013-04-05 2023-12-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11918596B2 (en) 2013-04-05 2024-03-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11666590B2 (en) 2013-04-18 2023-06-06 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2022023213A1 (fr) * 2020-07-31 2022-02-03 Krka, D. D., Novo Mesto Formulation pharmaceutique de metformine ayant une faible teneur en diméthylamine

Also Published As

Publication number Publication date
ITFI20070042A1 (it) 2008-08-22

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