WO2008100567A3 - Thrombin peptide derivatives for treating fractures in osteopenic patients - Google Patents

Thrombin peptide derivatives for treating fractures in osteopenic patients Download PDF

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Publication number
WO2008100567A3
WO2008100567A3 PCT/US2008/001953 US2008001953W WO2008100567A3 WO 2008100567 A3 WO2008100567 A3 WO 2008100567A3 US 2008001953 W US2008001953 W US 2008001953W WO 2008100567 A3 WO2008100567 A3 WO 2008100567A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide derivatives
thrombin peptide
treating fractures
osteopenic
osteopenic patients
Prior art date
Application number
PCT/US2008/001953
Other languages
French (fr)
Other versions
WO2008100567A2 (en
Inventor
James T Ryaby
Gary M Kiebzak
Original Assignee
Orthologic Corp
James T Ryaby
Gary M Kiebzak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orthologic Corp, James T Ryaby, Gary M Kiebzak filed Critical Orthologic Corp
Publication of WO2008100567A2 publication Critical patent/WO2008100567A2/en
Publication of WO2008100567A3 publication Critical patent/WO2008100567A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is directed to methods of promoting healing of a bone fracture in an osteopenic human patient, comprising administering to the patient a therapeutically effective amount of an non-proteolytically activated thrombin receptor agonist.
PCT/US2008/001953 2007-02-15 2008-02-14 Thrombin peptide derivatives for treating fractures in osteopenic patients WO2008100567A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90144107P 2007-02-15 2007-02-15
US60/901,441 2007-02-15

Publications (2)

Publication Number Publication Date
WO2008100567A2 WO2008100567A2 (en) 2008-08-21
WO2008100567A3 true WO2008100567A3 (en) 2008-11-06

Family

ID=39643035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/001953 WO2008100567A2 (en) 2007-02-15 2008-02-14 Thrombin peptide derivatives for treating fractures in osteopenic patients

Country Status (1)

Country Link
WO (1) WO2008100567A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280722A2 (en) 2008-03-26 2011-02-09 Orthologic Corp. Method of treating degenerative diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005836A2 (en) * 2000-07-19 2002-01-24 The Board Of Regents, The University Of Texas Systems Stimulation of bone growth with thrombin peptide derivatives
WO2003061690A1 (en) * 2002-01-17 2003-07-31 The Board Of Regents, The University Of Texas System Stimulation of bone growth and cartilage formation with thrombing peptide derivatives
WO2004005317A2 (en) * 2002-07-02 2004-01-15 The Board Of Regents, The University Of Texas System Thrombin peptide derivative dimers
WO2004014937A2 (en) * 2002-07-02 2004-02-19 The Board Of Regents, The University Of Texas System Thrombin peptide derivatives
WO2007035406A1 (en) * 2005-09-16 2007-03-29 Orthologic Corp. Antibodies to complementary peptides of thrombin or portions thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005836A2 (en) * 2000-07-19 2002-01-24 The Board Of Regents, The University Of Texas Systems Stimulation of bone growth with thrombin peptide derivatives
WO2003061690A1 (en) * 2002-01-17 2003-07-31 The Board Of Regents, The University Of Texas System Stimulation of bone growth and cartilage formation with thrombing peptide derivatives
WO2004005317A2 (en) * 2002-07-02 2004-01-15 The Board Of Regents, The University Of Texas System Thrombin peptide derivative dimers
WO2004014937A2 (en) * 2002-07-02 2004-02-19 The Board Of Regents, The University Of Texas System Thrombin peptide derivatives
WO2007035406A1 (en) * 2005-09-16 2007-03-29 Orthologic Corp. Antibodies to complementary peptides of thrombin or portions thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI G ET AL: "Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis", JOURNAL OF ORTHOPAEDIC RESEARCH, NEEDHAM, MA, vol. 23, no. 1, 1 January 2005 (2005-01-01), pages 196 - 202, XP004686459, ISSN: 0736-0266 *
WANG H ET AL: "Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis", JOURNAL OF ORTHOPAEDIC RESEARCH, NEEDHAM, MA, vol. 23, no. 3, 1 May 2005 (2005-05-01), pages 671 - 679, XP004882164, ISSN: 0736-0266 *

Also Published As

Publication number Publication date
WO2008100567A2 (en) 2008-08-21

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