WO2008100534A3 - Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement - Google Patents

Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement Download PDF

Info

Publication number
WO2008100534A3
WO2008100534A3 PCT/US2008/001889 US2008001889W WO2008100534A3 WO 2008100534 A3 WO2008100534 A3 WO 2008100534A3 US 2008001889 W US2008001889 W US 2008001889W WO 2008100534 A3 WO2008100534 A3 WO 2008100534A3
Authority
WO
WIPO (PCT)
Prior art keywords
soft tissue
augmentation
replacement
nanofiber scaffold
phase
Prior art date
Application number
PCT/US2008/001889
Other languages
French (fr)
Other versions
WO2008100534A2 (en
Inventor
Helen H Lu
Kristen L Moffat
William N Levine
Original Assignee
Univ Columbia
Helen H Lu
Kristen L Moffat
William N Levine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Helen H Lu, Kristen L Moffat, William N Levine filed Critical Univ Columbia
Publication of WO2008100534A2 publication Critical patent/WO2008100534A2/en
Publication of WO2008100534A3 publication Critical patent/WO2008100534A3/en
Priority to US12/583,072 priority Critical patent/US8753391B2/en
Priority to US12/806,912 priority patent/US8864843B2/en
Priority to US14/503,053 priority patent/US10265155B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. More particularly, there is provided an implantable device for repair, fixation, augmentation, or replacement of a rotator cuff or a tendon- to-bone interface thereof. In one aspect, this device includes a biphasic, biomimetic, and biodegradable nanofiber scaffold having a first phase that includes nanofibers whose anisotropy mimics that of a tendon and non-mineralized fibrocartilage, which nanofibers are made from a biodegradable polymer and a second phase coupled to the first phase, which second phase includes nanofibers whose anisotropy mimics that of mineralized fibrocartilage and bone, which nanofibers are made from a biodegradable polymer and a biocompatible ceramic, wherein the first and second phases are continuous. Methods of using such devices are also provided
PCT/US2008/001889 2007-02-12 2008-02-12 Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement WO2008100534A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/583,072 US8753391B2 (en) 2007-02-12 2009-08-12 Fully synthetic implantable multi-phased scaffold
US12/806,912 US8864843B2 (en) 2007-02-12 2010-08-24 Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
US14/503,053 US10265155B2 (en) 2007-02-12 2014-09-30 Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90104707P 2007-02-12 2007-02-12
US60/901,047 2007-02-12
US90564907P 2007-03-07 2007-03-07
US60/905,649 2007-03-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/007323 Continuation-In-Part WO2008154030A2 (en) 2006-12-06 2008-06-11 Multi-phased scaffold for fixation of musculoskeletal soft tissue to bone

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/583,072 Continuation-In-Part US8753391B2 (en) 2007-02-12 2009-08-12 Fully synthetic implantable multi-phased scaffold

Publications (2)

Publication Number Publication Date
WO2008100534A2 WO2008100534A2 (en) 2008-08-21
WO2008100534A3 true WO2008100534A3 (en) 2008-10-30

Family

ID=39690688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/001889 WO2008100534A2 (en) 2007-02-12 2008-02-12 Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement

Country Status (1)

Country Link
WO (1) WO2008100534A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2557231C (en) 2004-03-05 2013-12-31 The Trustees Of Columbia University In The City Of New York Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
US8753391B2 (en) 2007-02-12 2014-06-17 The Trustees Of Columbia University In The City Of New York Fully synthetic implantable multi-phased scaffold
US8614189B2 (en) * 2008-09-24 2013-12-24 University Of Connecticut Carbon nanotube composite scaffolds for bone tissue engineering
US20100249924A1 (en) * 2009-03-27 2010-09-30 Allergan, Inc. Bioerodible matrix for tissue involvement
BRPI0906274A8 (en) * 2009-12-22 2018-04-03 Einco Biomaterial Ltda Me PRODUCTION PROCESS, COMPOSITES, SYSTEM AND MEDICAL AND VETERINARY DEVICES BIO-ACTIVE, BIOINTEGRIBLE, CONDUCTIVE, TISSUE INDUCTORS FOR FIXING, REPAIR, RECONSTRUCTION, REMODELING, INTRA, SUPRA TISSUE AND/OR TOTAL, PERMANENT, BIOLOGICAL AND PHYSIOLOGICALLY BIOCOMPATIBLE
CA2798957A1 (en) 2010-05-10 2011-11-17 Lakshmi Sreedharan Nair Lactoferrin-based biomaterials for tissue regeneration and drug delivery
WO2011163328A2 (en) * 2010-06-22 2011-12-29 The Trustees Of Columbia University In The City Of New York Methods for producing tissue scaffold directing differentiation of seeded cells and tissue scaffolds produced thereby
US9487754B2 (en) 2010-10-01 2016-11-08 The Trustees Of Columbia University In The City Of New York Derivation of fibrochondrocytes from progenitor cells
GB201021438D0 (en) * 2010-12-16 2011-02-02 Imp Innovations Ltd Layered fibrous construct
US9211114B1 (en) 2011-02-15 2015-12-15 FM-Nanocoat, LLC Method of coating tissue to promote soft tissue and bone tissue healing, involving nanotechnology, and a photonic curing system for use in repairing tissue
CN102743794B (en) * 2011-04-20 2014-09-24 国家纳米科学中心 Medicinal slow release support and preparation method thereof
US20150064142A1 (en) * 2012-04-12 2015-03-05 Harvard Apparatus Regenerative Technology Elastic scaffolds for tissue growth
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
US10449026B2 (en) 2012-06-26 2019-10-22 Biostage, Inc. Methods and compositions for promoting the structural integrity of scaffolds for tissue engineering
WO2014042736A1 (en) * 2012-06-29 2014-03-20 Allergan, Inc. Textured prosthesis with reduced capsular contracture response and methods for quantifying collagen fiber alignment in periprosthetic tissue
WO2014059378A1 (en) 2012-10-12 2014-04-17 Cayenne Medical, Inc. Systems and methods for repairing soft tissues using nanofiber material
EP2943231A4 (en) 2013-01-09 2016-12-07 Harvard Apparatus Regenerative Tech Inc Synthetic scaffolds
CN103083721B (en) * 2013-01-18 2014-12-10 南方医科大学 Artificial skin graft for genipin immobilized activin B and preparation method thereof
CZ2013913A3 (en) 2013-11-21 2015-06-03 Contipro Biotech S.R.O. Voluminous nanofibrous material based on hyaluronic acid, salts or derivatives thereof, process of its preparation, method of its modification, modified nanofibrous material, nanofibrous formation and use thereof ased .
US20160296336A1 (en) * 2015-04-07 2016-10-13 Gerhard E. Maale Torsionally Stabilized Endoprosthetic Device
JP6820322B2 (en) * 2015-05-22 2021-01-27 ケイエン メディカル，インコーポレイティド Systems and methods for repairing soft tissues
TR201615825A1 (en) * 2016-11-07 2018-05-21 T C Istanbul Medipol Ueniversitesi AN ARTIFICIAL BIOMIMETIC NERVE TISSUE SCAFFOLDING AND PRODUCTION METHOD
JP2020503996A (en) * 2016-12-30 2020-02-06 ザ・ユニバーシティ・オブ・シドニー Synthetic implantable skeleton
CN107469149B (en) * 2017-08-02 2022-05-24 中南大学湘雅医院 Biphase tissue engineering scaffold
CN112661500B (en) * 2021-01-07 2022-06-14 中国科学院上海硅酸盐研究所 Biological ceramic bracket with micro-nano structure on surface and preparation method and application thereof
CN115006598A (en) * 2021-03-03 2022-09-06 上海交通大学医学院附属第九人民医院 Preparation method and application of strontium-doped calcium silicate-fibroin composite material
CN113244451B (en) * 2021-06-02 2022-06-03 青岛大学 Patch material simulating natural tendon-bone gradient interface and preparation method thereof
CN116059441A (en) * 2022-08-29 2023-05-05 广东省科学院生物与医学工程研究所 Anisotropic nanofiber composite natural polysaccharide hydrogel and preparation method and application thereof
CN116059448A (en) * 2022-08-29 2023-05-05 广东省科学院生物与医学工程研究所 Anisotropic silk fibroin/natural polysaccharide/nanofiber composite hydrogel and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20050196425A1 (en) * 2002-08-20 2005-09-08 Biosurface Engineering Technologies, Inc. Positive modulator of bone morphogenic protein-2
US20060067969A1 (en) * 2004-03-05 2006-03-30 Lu Helen H Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050196425A1 (en) * 2002-08-20 2005-09-08 Biosurface Engineering Technologies, Inc. Positive modulator of bone morphogenic protein-2
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20060067969A1 (en) * 2004-03-05 2006-03-30 Lu Helen H Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone

Also Published As

Publication number Publication date
WO2008100534A2 (en) 2008-08-21

Similar Documents

Publication Publication Date Title
WO2008100534A3 (en) Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
US11471266B2 (en) Internal brace for tissue repairs and reinforcements
WO2009120969A3 (en) Bone anchors for orthopedic applications
WO2007092464A3 (en) Methods and devices for rotator cuff repair
EP3372201A3 (en) Tibial bearing component for a knee prosthesis with improved articular characteristics
WO2008130989A3 (en) Prosthetic implants
WO2008111078A3 (en) Soft tissue fixation devices
BRPI0820149A2 (en) '' method for channeling into a bone, method for forming a hole in a bone, method for attaching a suture to the bone, medical kit, medical instrument for forming a hole in a bone, medical instrument for attaching a suture to a bone , medical kit for attaching a suture to a bone particularly in an arthroscopic surgical procedure and method for securing the suture to a bone particularly in an arthroscopic procedure
WO2009109778A3 (en) Implantable prosthetic cord
WO2008109872A3 (en) Systems, methods, and devices for soft tissue attachment to bone
EP2455003A3 (en) Surgical filament snare assemblies
EP2049023A4 (en) Apparatus and method for manipulating or retracting tissue and anatomical structure
BR112012000690A2 (en) suture dowel, set of needles for use in a suture dowel, method for passing suture through tissue and method for treating a hip joint
EP1889575A3 (en) Button and continuous loop for fixation of ligaments
EP3395269A3 (en) Apparatus for performing knee arthroplasty
EP2051641A4 (en) System and method for all-inside suture fixation for implant attachment and soft tissue repair
AU2009289563A8 (en) Device for soft tissue repair or replacement
AU2011232400A1 (en) Mechanically competent scaffold for rotator cuff and tendon augmentation
ATE444035T1 (en) BIOLOGICAL MODULAR TIBIAL AND FEMUR PARTS FOR USE IN TOTAL KNEE JOINT RECONSTRUCTION
WO2010120520A3 (en) Double bundle acl repair
EP2319548A3 (en) Tissue scaffolds
WO2008030668A3 (en) Biocompatible anchoring device for a soft tissue graft, method of making and method of using
EP3308726A3 (en) Devices for knee joint replacement with anterior cruciate ligament substitution
FR2929834B1 (en) SURGICAL CLIP FOR FIXING AND MAINTAINING A HERNIA PROSTHESIS
WO2007100459A3 (en) Surgical slings

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08725513

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08725513

Country of ref document: EP

Kind code of ref document: A2