WO2008099913A1 - ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 - Google Patents
ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 Download PDFInfo
- Publication number
- WO2008099913A1 WO2008099913A1 PCT/JP2008/052500 JP2008052500W WO2008099913A1 WO 2008099913 A1 WO2008099913 A1 WO 2008099913A1 JP 2008052500 W JP2008052500 W JP 2008052500W WO 2008099913 A1 WO2008099913 A1 WO 2008099913A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hmgb
- antibody
- active ingredient
- therapeutic agent
- antibody capable
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 206010002022 amyloidosis Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008558144A JP5225109B2 (ja) | 2007-02-15 | 2008-02-15 | ヒトhmgb−1に特異的に結合する抗体を有効成分として含有する治療剤 |
EP08711330A EP2123297A4 (en) | 2007-02-15 | 2008-02-15 | THERAPEUTIC AGENT COMPRISING AN ANTIBODY CAPABLE OF BINDING SPECIFICALLY TO HMGB-1 AS ACTIVE INGREDIENT |
US12/449,543 US8470325B2 (en) | 2007-02-15 | 2008-02-15 | Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007034325 | 2007-02-15 | ||
JP2007-034325 | 2007-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008099913A1 true WO2008099913A1 (ja) | 2008-08-21 |
Family
ID=39690138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/052500 WO2008099913A1 (ja) | 2007-02-15 | 2008-02-15 | ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8470325B2 (ja) |
EP (1) | EP2123297A4 (ja) |
JP (1) | JP5225109B2 (ja) |
TW (1) | TW200902063A (ja) |
WO (1) | WO2008099913A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020059847A1 (ja) | 2018-09-21 | 2020-03-26 | 国立大学法人 東京医科歯科大学 | ヒトhmgb1に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物 |
US10730937B2 (en) | 2016-08-09 | 2020-08-04 | National University Corporation Tokyo Medical And Dental University | Antibodies against HMB1, and composition comprising same for treating or preventing alzheimer's disease |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5285437B2 (ja) * | 2007-02-15 | 2013-09-11 | 学校法人福岡大学 | 抗hmgb−1抗体を含む臓器移植拒絶抑制剤 |
EP2123299A4 (en) * | 2007-02-15 | 2011-10-05 | Univ Kyushu Nat Univ Corp | THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY |
FI20105715A0 (fi) | 2010-06-18 | 2010-06-18 | Helsingin Yliopisto | Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine |
WO2014110225A1 (en) * | 2013-01-09 | 2014-07-17 | The Feinstein Institute For Medical Research | Hmgb1-binding beads and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003534351A (ja) * | 2000-05-22 | 2003-11-18 | ニュー・ヨーク・ユニヴァーシティー | アミロイドβ及びアミロイド沈着物に対する免疫応答誘導のための、アミロイドβと相同的な、合成の、免疫原性だが非アミロイド原性ペプチド |
JP2004107260A (ja) * | 2002-09-18 | 2004-04-08 | Takeda Chem Ind Ltd | 脳アミロイドーシス予防・治療薬のスクリーニング方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62166897A (ja) | 1986-01-20 | 1987-07-23 | Toyo Soda Mfg Co Ltd | 核内非ヒストン蛋白質に対するモノクロ−ナル抗体 |
EP0727487A1 (en) | 1995-02-17 | 1996-08-21 | K.U. Leuven Research & Development | Multiple-tumor aberrant growth genes |
EP1577671A1 (en) * | 1996-07-17 | 2005-09-21 | Kaneka Corporation | Diagnostic drugs for autoimmune diseases |
JP3267893B2 (ja) | 1997-05-15 | 2002-03-25 | 鐘淵化学工業株式会社 | 自己免疫疾患の診断薬 |
US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US6794132B2 (en) * | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
US7754217B2 (en) | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7220723B2 (en) * | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
BR0209689A (pt) * | 2001-05-15 | 2006-02-07 | Long Island Jewish Res Inst | Uso de fragmento de hmg como agente anti-inflamatório |
JP4823465B2 (ja) | 2001-07-13 | 2011-11-24 | 株式会社シノテスト | ヒトhmg−1に特異的に結合する抗体並びにこの抗体を用いるヒトhmg−1の免疫学的測定方法及び免疫学的測定試薬 |
ITMI20011986A1 (it) | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
DE50212280D1 (de) | 2001-12-19 | 2008-06-26 | Alcedo Biotech Gmbh | Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren |
CN1671742A (zh) | 2002-07-03 | 2005-09-21 | 塔博尔山圣拉弗尔基金中心 | Hmgb1在治疗组织损伤和/或促进组织修复中的用途 |
GB0226251D0 (en) | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
US20060121047A1 (en) | 2002-11-20 | 2006-06-08 | Tracey Kevin J | Use of hmgb polypetides for increasing immune responses |
US20040141948A1 (en) * | 2002-11-20 | 2004-07-22 | Critical Therapeutics, Inc. | Use of HMGB fragments as anti-inflammatory agents |
WO2004046345A2 (en) | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
WO2005026209A2 (en) | 2003-09-11 | 2005-03-24 | Critical Therapeutics, Inc. | Monoclonal antibodies against hmgb1 |
ITRM20040058A1 (it) | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
CA2585043A1 (en) | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | High affinity antibodies against hmgb1 and methods of use thereof |
US20100040607A1 (en) | 2005-05-13 | 2010-02-18 | Tracey Kevin J | Combination Therapy with Inhibitors of HMGB and Caspase for the Treatment of Inflammatory Diseases |
EP2364998A1 (en) | 2005-06-16 | 2011-09-14 | The Feinstein Institute for Medical Research | Antibodies against HMGB1 and fragments thereof |
NZ571692A (en) * | 2006-05-05 | 2012-01-12 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
JP5285437B2 (ja) * | 2007-02-15 | 2013-09-11 | 学校法人福岡大学 | 抗hmgb−1抗体を含む臓器移植拒絶抑制剤 |
EP2123299A4 (en) * | 2007-02-15 | 2011-10-05 | Univ Kyushu Nat Univ Corp | THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY |
-
2008
- 2008-02-15 EP EP08711330A patent/EP2123297A4/en not_active Withdrawn
- 2008-02-15 JP JP2008558144A patent/JP5225109B2/ja not_active Expired - Fee Related
- 2008-02-15 TW TW097105308A patent/TW200902063A/zh unknown
- 2008-02-15 US US12/449,543 patent/US8470325B2/en not_active Expired - Fee Related
- 2008-02-15 WO PCT/JP2008/052500 patent/WO2008099913A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003534351A (ja) * | 2000-05-22 | 2003-11-18 | ニュー・ヨーク・ユニヴァーシティー | アミロイドβ及びアミロイド沈着物に対する免疫応答誘導のための、アミロイドβと相同的な、合成の、免疫原性だが非アミロイド原性ペプチド |
JP2004107260A (ja) * | 2002-09-18 | 2004-04-08 | Takeda Chem Ind Ltd | 脳アミロイドーシス予防・治療薬のスクリーニング方法 |
Non-Patent Citations (1)
Title |
---|
See also references of EP2123297A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10730937B2 (en) | 2016-08-09 | 2020-08-04 | National University Corporation Tokyo Medical And Dental University | Antibodies against HMB1, and composition comprising same for treating or preventing alzheimer's disease |
WO2020059847A1 (ja) | 2018-09-21 | 2020-03-26 | 国立大学法人 東京医科歯科大学 | ヒトhmgb1に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
EP2123297A4 (en) | 2011-10-12 |
EP2123297A1 (en) | 2009-11-25 |
TW200902063A (en) | 2009-01-16 |
US20110229487A1 (en) | 2011-09-22 |
JP5225109B2 (ja) | 2013-07-03 |
JPWO2008099913A1 (ja) | 2010-05-27 |
US8470325B2 (en) | 2013-06-25 |
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