WO2008099912A1 - ５ｈｔ４受容体拮抗薬 - Google Patents

５ｈｔ４受容体拮抗薬 Download PDF

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Publication number
WO2008099912A1
WO2008099912A1 PCT/JP2008/052494 JP2008052494W WO2008099912A1 WO 2008099912 A1 WO2008099912 A1 WO 2008099912A1 JP 2008052494 W JP2008052494 W JP 2008052494W WO 2008099912 A1 WO2008099912 A1 WO 2008099912A1
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WO
WIPO (PCT)
Prior art keywords
receptor antagonist
receptor
creosote
serotonin
binding
Prior art date
Application number
PCT/JP2008/052494
Other languages
English (en)
French (fr)
Inventor
Koji Ataka
Takashi Shibata
Hitoshi Shibata
Original Assignee
Taiko Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiko Pharmaceutical Co., Ltd. filed Critical Taiko Pharmaceutical Co., Ltd.
Priority to JP2008558143A priority Critical patent/JPWO2008099912A1/ja
Priority to KR1020097015847A priority patent/KR20090110320A/ko
Priority to CNA2008800048925A priority patent/CN101610779A/zh
Publication of WO2008099912A1 publication Critical patent/WO2008099912A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　セロトニン５ＨＴ４受容体に結合する５ＨＴ４受容体拮抗薬であって、クレオソートからなることを特徴とする５ＨＴ４受容体拮抗薬。
PCT/JP2008/052494 2007-02-16 2008-02-15 ５ｈｔ４受容体拮抗薬 WO2008099912A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008558143A JPWO2008099912A1 (ja) 2007-02-16 2008-02-15 ５ｈｔ４受容体拮抗薬
KR1020097015847A KR20090110320A (ko) 2007-02-16 2008-02-15 5ｈｔ4 수용체 길항약
CNA2008800048925A CN101610779A (zh) 2007-02-16 2008-02-15 5ht4受体拮抗药

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007036470 2007-02-16
JP2007-036470 2007-02-16
JP2007-067177 2007-03-15
JP2007067177 2007-03-15
JP2007-283628 2007-10-31
JP2007283628 2007-10-31

Publications (1)

Publication Number Publication Date
WO2008099912A1 true WO2008099912A1 (ja) 2008-08-21

Family

ID=39690137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052494 WO2008099912A1 (ja) 2007-02-16 2008-02-15 ５ｈｔ４受容体拮抗薬

Country Status (4)

Country Link
JP (1) JPWO2008099912A1 (ja)
KR (1) KR20090110320A (ja)
CN (1) CN101610779A (ja)
WO (1) WO2008099912A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020202601A1 (ja) * 2019-03-29 2020-10-08 大幸薬品株式会社 アセチルコリンエステラーゼ阻害剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106619670A (zh) * 2016-12-17 2017-05-10 郑州郑先医药科技有限公司 一种治疗胃痛的西药组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1017466A (ja) * 1996-07-01 1998-01-20 Taiko Yakuhin Kk 腸液吸収促進剤
JP2003128538A (ja) * 2001-10-15 2003-05-08 Taiko Pharmaceutical Co Ltd ストレス起因性下痢治療剤、及びマルチタイプ下痢治療剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1017466A (ja) * 1996-07-01 1998-01-20 Taiko Yakuhin Kk 腸液吸収促進剤
JP2003128538A (ja) * 2001-10-15 2003-05-08 Taiko Pharmaceutical Co Ltd ストレス起因性下痢治療剤、及びマルチタイプ下痢治療剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ATAKA K. ET AL.: "Creosote wa, Ishikika Mukosoku Rat ni Oite CRF Noshitsunai Toyo ni yoru Ketcho Undo Koshin o Kin'i Ketcho dewa 5-HT3 Juyotai, En'i Ketcho dewa 5-HT4 Juyotai o Kaishite Yokusei suru", JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 103, 2006, pages A705 *
DATABASE CAPLUS [online] KOJI A. ET AL.: "Wood creosote prevents CRF-induced motility via 5-HT3 receptors in proximal and 5-HT4 receptors in distal colon in rats", accession no. STN Database accession no. (2007:449628) *
KUGE T. ET AL.: "Stress-induced breakdown of intestinal barrier function in the rat: Reversal by wood creosote", LIFE SCI., vol. 79, no. 9, 2006, pages 913 - 918, XP005544809 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020202601A1 (ja) * 2019-03-29 2020-10-08 大幸薬品株式会社 アセチルコリンエステラーゼ阻害剤
JP2020164463A (ja) * 2019-03-29 2020-10-08 大幸薬品株式会社 アセチルコリンエステラーゼ阻害剤

Also Published As

Publication number Publication date
KR20090110320A (ko) 2009-10-21
JPWO2008099912A1 (ja) 2010-05-27
CN101610779A (zh) 2009-12-23

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