WO2008099190A3 - Osteogenic compounds - Google Patents

Osteogenic compounds Download PDF

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Publication number
WO2008099190A3
WO2008099190A3 PCT/GB2008/000529 GB2008000529W WO2008099190A3 WO 2008099190 A3 WO2008099190 A3 WO 2008099190A3 GB 2008000529 W GB2008000529 W GB 2008000529W WO 2008099190 A3 WO2008099190 A3 WO 2008099190A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
compounds
osteogenic compounds
osteogenic
prodrugs
Prior art date
Application number
PCT/GB2008/000529
Other languages
French (fr)
Other versions
WO2008099190A2 (en
Inventor
Bikramjit Chopra
Grahame Mckenzie
Bryn Hardwick
Original Assignee
Inion Ltd
Bikramjit Chopra
Grahame Mckenzie
Bryn Hardwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inion Ltd, Bikramjit Chopra, Grahame Mckenzie, Bryn Hardwick filed Critical Inion Ltd
Publication of WO2008099190A2 publication Critical patent/WO2008099190A2/en
Publication of WO2008099190A3 publication Critical patent/WO2008099190A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to N,N-dimethylacetamide and its pharmaceutically acceptable salts and prodrugs, compositions comprising same and the use of these compounds and compositions as a medicament and in the manufacture of compositions for promoting bone regrowth and repair, and to methods of treating damaged or broken bones.
PCT/GB2008/000529 2007-02-16 2008-02-15 Osteogenic compounds WO2008099190A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0703062.0 2007-02-16
GB0703062A GB2446653A (en) 2007-02-16 2007-02-16 Osteogenic compounds

Publications (2)

Publication Number Publication Date
WO2008099190A2 WO2008099190A2 (en) 2008-08-21
WO2008099190A3 true WO2008099190A3 (en) 2008-10-09

Family

ID=37908777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000529 WO2008099190A2 (en) 2007-02-16 2008-02-15 Osteogenic compounds

Country Status (2)

Country Link
GB (1) GB2446653A (en)
WO (1) WO2008099190A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2187932B1 (en) 2007-08-07 2015-01-28 DePuy Synthes Products, LLC Protein formulations comprising gdf-5 in aqueous acidic solution
WO2009129101A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
WO2016207204A1 (en) * 2015-06-23 2016-12-29 Universität Zürich N-alkylamides for treatment of bromodomain protein related diseases

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201237A1 (en) * 2000-10-26 2002-05-02 Virodene Pharmaceutical Holdings (PTY) Ltd. Composition comprising an amide or a dialkylsulphoxide derivative for the treatment of cancer
WO2003047646A1 (en) * 2001-12-04 2003-06-12 Inion Ltd Resorbable polymer composition, implant and method of making implant
US20040242646A1 (en) * 2001-06-23 2004-12-02 Anderson David M. Treatment using dantrolene
US20050100654A1 (en) * 2003-04-29 2005-05-12 Ast Products, Inc., A Massachusetts Corporation Methods for coating implants
WO2005069837A2 (en) * 2004-01-13 2005-08-04 Royer Biomedical, Inc. Non-aqueous compositions for treatment of orthopedic defects and delivery of bioactive agents
EP1731178A2 (en) * 2005-05-10 2006-12-13 University Of Zurich Resorbable polymer composition, implant and method of making implant
WO2007070983A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE241394T1 (en) * 1994-04-08 2003-06-15 Atrix Lab Inc ASSOCIATED POLYMER SYSTEM FOR USE WITH A MEDICAL DEVICE
ZA9811598B (en) * 1997-09-18 2000-10-11 Cryopreservation Tech Cc A substance or composition for the treatment of cancer.
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201237A1 (en) * 2000-10-26 2002-05-02 Virodene Pharmaceutical Holdings (PTY) Ltd. Composition comprising an amide or a dialkylsulphoxide derivative for the treatment of cancer
US20040242646A1 (en) * 2001-06-23 2004-12-02 Anderson David M. Treatment using dantrolene
WO2003047646A1 (en) * 2001-12-04 2003-06-12 Inion Ltd Resorbable polymer composition, implant and method of making implant
US20050100654A1 (en) * 2003-04-29 2005-05-12 Ast Products, Inc., A Massachusetts Corporation Methods for coating implants
WO2005069837A2 (en) * 2004-01-13 2005-08-04 Royer Biomedical, Inc. Non-aqueous compositions for treatment of orthopedic defects and delivery of bioactive agents
EP1731178A2 (en) * 2005-05-10 2006-12-13 University Of Zurich Resorbable polymer composition, implant and method of making implant
WO2007070983A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents

Also Published As

Publication number Publication date
GB2446653A (en) 2008-08-20
WO2008099190A2 (en) 2008-08-21
GB0703062D0 (en) 2007-03-28

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