WO2008095912A3 - Enantiopure pharmacologically active tricyclic benzimidazoles - Google Patents

Enantiopure pharmacologically active tricyclic benzimidazoles Download PDF

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Publication number
WO2008095912A3
WO2008095912A3 PCT/EP2008/051374 EP2008051374W WO2008095912A3 WO 2008095912 A3 WO2008095912 A3 WO 2008095912A3 EP 2008051374 W EP2008051374 W EP 2008051374W WO 2008095912 A3 WO2008095912 A3 WO 2008095912A3
Authority
WO
WIPO (PCT)
Prior art keywords
enantiopure
pharmacologically active
active tricyclic
tricyclic benzimidazoles
benzimidazoles
Prior art date
Application number
PCT/EP2008/051374
Other languages
French (fr)
Other versions
WO2008095912A2 (en
Inventor
Andreas Palmer
Christian Scheufler
Wilm Buhr
Peter Jan Zimmermann
Christof Brehm
Wolfgang-Alexander Simon
Stefan Postius
Wolfgang Kromer
Original Assignee
Nycomed Gmbh
Andreas Palmer
Christian Scheufler
Wilm Buhr
Peter Jan Zimmermann
Christof Brehm
Wolfgang-Alexander Simon
Stefan Postius
Wolfgang Kromer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh, Andreas Palmer, Christian Scheufler, Wilm Buhr, Peter Jan Zimmermann, Christof Brehm, Wolfgang-Alexander Simon, Stefan Postius, Wolfgang Kromer filed Critical Nycomed Gmbh
Publication of WO2008095912A2 publication Critical patent/WO2008095912A2/en
Publication of WO2008095912A3 publication Critical patent/WO2008095912A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides compounds of the formula (1) in which the substituents and symbols are as de fined in the description. The compounds inhibit the secretion of gastric acid.
PCT/EP2008/051374 2007-02-06 2008-02-05 Enantiopure pharmacologically active tricyclic benzimidazoles WO2008095912A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101836 2007-02-06
EP07101836.0 2007-02-06

Publications (2)

Publication Number Publication Date
WO2008095912A2 WO2008095912A2 (en) 2008-08-14
WO2008095912A3 true WO2008095912A3 (en) 2009-01-15

Family

ID=38268706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/051374 WO2008095912A2 (en) 2007-02-06 2008-02-05 Enantiopure pharmacologically active tricyclic benzimidazoles

Country Status (1)

Country Link
WO (1) WO2008095912A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5802898B2 (en) 2009-07-09 2015-11-04 ラクオリア創薬株式会社 Acid pump antagonists for treating diseases involving gastrointestinal motility disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087701A1 (en) * 2003-04-04 2004-10-14 Altana Pharma Ag Cyclic benzimidazoles
WO2006136552A2 (en) * 2005-06-22 2006-12-28 Nycomed Gmbh Process for the production of intermadiates for the preparation of tricyclic benzimidazoles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087701A1 (en) * 2003-04-04 2004-10-14 Altana Pharma Ag Cyclic benzimidazoles
WO2006136552A2 (en) * 2005-06-22 2006-12-28 Nycomed Gmbh Process for the production of intermadiates for the preparation of tricyclic benzimidazoles

Also Published As

Publication number Publication date
WO2008095912A2 (en) 2008-08-14

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