WO2008095263A1 - A dosage form containing two or more active pharmaceutical ingredients in different physical forms - Google Patents
A dosage form containing two or more active pharmaceutical ingredients in different physical forms Download PDFInfo
- Publication number
- WO2008095263A1 WO2008095263A1 PCT/AU2008/000169 AU2008000169W WO2008095263A1 WO 2008095263 A1 WO2008095263 A1 WO 2008095263A1 AU 2008000169 W AU2008000169 W AU 2008000169W WO 2008095263 A1 WO2008095263 A1 WO 2008095263A1
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- WO
- WIPO (PCT)
- Prior art keywords
- tablet
- pharmaceutical composition
- dosage form
- mini
- pharmaceutical
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Definitions
- the present invention relates to formulation of two or more pharmaceutical compositions into a dosage form.
- APIs active pharmaceutical ingredients
- EP 1003503 discloses a pharmaceutical composition containing amlodipine and atorvastatin that can be formulated in a single conventional dosage form or as part of a kit containing separate dosage forms for each API.
- U.S. Pat. No. 6,417,191 discloses the combination of abacavir with lamivudine and optionally also zidovudine through simple admixture of these compounds and formulation with a suitable carrier.
- multiple APIs in a single dosage form can present problems of interaction of one API with another, an API with an excipient and/or different APIs requiring different release characteristics such as release-rate or the proximity of release in the gastrointestinal tract for example in the stomach, large or small intestine, or colon.
- Many APIs exhibit some form of interaction with other APIs and/or with one or more of the many commonly used pharmaceutically acceptable excipients.
- APIs such as omeprazole, pantoprazole and lansoprazole are acid labile compounds that have been provided as enteric coated products to bypass the acidic environment of the stomach and release the API further down the GI tract where the pH is higher and the environment will not degrade the API before it can be absorbed.
- the most common enteric coating polymers are also acidic in nature. Therefore, these APIs contained in the core of the tablet, pellet or bead require additional protection from the acidic enteric coating polymer.
- WO 2004/060355 discloses an example of a multi-layered tablet comprising a triptan in one layer and naproxen in another layer. There is optionally a separating layer between the two layers containing the APIs.
- WO 01/35941 discloses a combination of metformin hydrochloride and a thiazolidinedione ("glitazone") whereby each API is dispersed in its own pharmaceutically acceptable carrier. In one preferred embodiment each of these separate compositions are contained in separate zones in a single dosage form, for example as compressed separate layers of a multi-layered tablet.
- a core optionally containing an API can be sprayed with a layer of API-containing, film- forming polymer. This can subsequently be sprayed with further layers comprising the same or different API and/or with some form of cosmetic, protective or rate-release control polymeric coating.
- cosmetic coatings can be a colour coat for cosmetic appeal, enhanced product presentation, taste-masking and product differentiation.
- Protective coatings can be used such as moisture barriers or protection against acidic environments.
- Rate-release control coatings can be pH solubility specific such as enteric coatings, pH insoluble coatings utilised with an osmotic pump system and a minute hole in the coating to control the release of the API or swellable polymers that control the rate of release of the API substance.
- WO 2004/060355 also discloses an example whereby sumatriptan succinate is included in a film-coat that is applied to a core containing naproxen sodium.
- WO 2004/038428 discloses a formulation containing tramadol hydrochloride and acetaminophen to provide controlled-release of the API in the core and faster release of the API in the coating.
- WO 98/06385 discloses a similar coated core whereby both the core and the coating independently contain at least one API, different from the other.
- U.S. Pat. No. 6,015,577 discloses pellets of dipyridamole encapsulated with an acetylsalicylic acid tablet.
- the acetylsalicylic acid component is not free from acetic acid, which forms by cleavage of acetylsalicylic acid during storage, and acetic acid reacts with dipyridamole to form hygroscopic salts and esters and thereby degrade it. Therefore the tablet is coated with a coating suspension comprising sucrose, gum arabic and talc, the purpose being to separate the two APIs and so prevent degradation of dipyridamole over time in storage.
- U.S. Pat. Appl discloses pellets of dipyridamole encapsulated with an acetylsalicylic acid tablet.
- the acetylsalicylic acid component is not free from acetic acid, which forms by cleavage of acetylsalicylic acid during storage, and ace
- 2006/0062856 discloses a controlled release formulation comprising particles of galantamine wherein the particles are coated by a release rate controlling membrane coating. It further discloses a dosage form wherein part of the galantamine is present as this controlled release formulation and another part is present in an immediate release form, preferably as mini- tablets.
- U.S. Pat. No. 6,514,531 discloses a controlled release dosage form to release Zolpidem according to a biphasic in vitro dissolution profile. The two phases can be achieved by employing a controlled release dosage form comprising pellets spray-coated with a layer of 20% by mass of microcrystalline cellulose or a coated tablet and an immediate release dosage form comprising pellets or tablets incorporated into a larger tablet or capsule.
- This patent also discloses multilayer and multicoated tablets.
- one API or one or more of the excipients used may interfere with the testing of one or both APIs in analytical testing methods.
- HPLC High Performance Liquid Chromatography
- excipient peaks can interfere and/or mask important API peaks in analytical techniques such as Ultra Performance Liquid Chromatography
- NIR Spectroscopy
- XRPD X-Ray Powder Diffractometry
- the present invention relates to a dosage form containing two or more APIs in different physical forms selected from powder form , granules, pellets, beads, mini-tablets and tablets.
- Each API is formulated separately into a discrete pharmaceutical composition and the discrete pharmaceutical compositions are formulated into a dosage form.
- This different physical form of the two compositions serves to minimise interactions between one API and another, or between an API and any of the excipients. This approach gives greater control over rates and/or proximity of release of the APIs and gives greater control of the uniformity of dose as discrete pharmaceutical formulations are employed.
- the present invention allows at least one formulation to remain the same as what may already be manufactured, leading to greater manufacturing and cost efficiencies, and time savings. Furthermore, the present invention allows for analytical testing of products containing two or more APIs to be facilitated through physical separation of the different APIs prior to testing on the basis of the differing size of the units used in the dosage form. This separation of the APIs means that analytical testing can take place on each individual API without interferences from other APIs, related substances and/or excipients .
- a dosage form for administration of two or more active pharmaceutical ingredients to a subject comprising a first pharmaceutical composition comprising a first active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a first physical form selected from the group consisting of powder, granule, pellet, bead or mini-tablet form, and at least a second pharmaceutical composition comprising a second active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a second physical form selected from the group consisting of granule, pellet, bead, mini-tablet or tablet form, wherein the composition is characterised in that said first and second physical forms are selected to be different to minimise interactions between said first and second pharmaceutical compositions and to allow separation of said first and second pharmaceutical compositions for analysis on the basis of size difference.
- a dosage form comprising two or more APIs whereby the dosage form contains a first composition comprising a first API and optionally one or more pharmaceutically acceptable excipients and a second composition comprising a second API with one or more pharmaceutically acceptable excipients wherein the composition is further characterised in that the first and second compositions can be easily separated.
- a method of formulating a dosage form comprising a two or more active pharmaceutical ingredients, comprising: providing a first pharmaceutical composition comprising a first active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a first physical form selected from the group consisting of powder, granule, pellet, bead or mini- tablet form; and providing at least a second pharmaceutical composition comprising a second active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a second physical form selected from the group consisting of granule, pellet, bead, mini- tablet or tablet form; combining said first and second pharmaceutical compositions into said dosage form; wherein said first and second physical forms are selected to be different to minimise interactions between said first and second pharmaceutical compositions and to allow separation of said first and second pharmaceutical compositions for analysis on the basis of size difference.
- a method of preparing a dosage form comprising two or more active pharmaceutical ingredients for analysis of said active pharmaceutical ingredients, said dosage form comprising a first pharmaceutical composition comprising a first active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a first physical form selected from the group consisting of powder, granule, pellet, bead or mini-tablet form, and at least a second pharmaceutical composition comprising a second active pharmaceutical ingredient and optionally one or more pharmaceutically acceptable excipients in a second physical form selected from the group consisting of granule, pellet, bead, mini-tablet or tablet form, wherein separation of said first and second pharmaceutical compositions for analysis on the basis of size difference is undertaken.
- compositions comprising a dosage form according to the invention shall be of such different particle sizes such that separation thereof by physical or other means for analytical testing is a straightforward, simple procedure.
- An example of such a separation is by sieving the product through appropriately sized screens that allow one form to pass through whilst retaining the other, manual separation by hand or by air separation techniques such as winnowing.
- Other separation techniques useful to achieve this aspect of the invention are well known.
- the first and further composition (s) have distinctly different particle sizes .
- the dosage form is such the first composition containing the first API is presented as a powder or granule composition, whilst the or each further composition (s) containing one or more APIs is/are present as a pellet, bead, compressed mini-tablet or conventional tablet composition.
- the inclusion of one API in a powder, granule, pellet or bead form provides excellent separation of that API from the other API (s) and excipients included in the granule, pellets, beads, mini-tablets or tablets.
- This separate presentation form limits any interaction between the first API with any of the excipients or other API (s) in the granule, pellets, beads, mini-tablets or tablets upon storage.
- This presentation also allows for different rates and/or proximities of release of each of the different APIs in the dosage form by the use of different formulations in each dosage unit.
- the invention relates to a pharmaceutical dosage form consisting of a pharmaceutical hard gelatin capsule comprising two or more APIs whereby the capsule contains a first API with one or more pharmaceutically acceptable excipients in a powder, granule, pellet or bead form and at least one other API with one or more pharmaceutically acceptable excipients in a granule pellet, bead, mini-tablet or tablet form.
- the first API is in a powder, granule, pellet or bead form when the other API is in mini-tablet or tablet form only.
- the powder, granules, pellets, beads, mini-tablets, tablets according to the invention may also be coated by conventional means.
- the coating may be of any type including colour coatings, taste masking coatings or modified release coatings such as enteric and other controlled-release type coatings.
- excipient refers to therapeutically inert, pharmaceutically acceptable ingredients that are added to a pharmaceutical formulation to act as, for example, fillers or diluents, binding agents, disintegrants, flow aids or glidants, lubricants or wetting agents. Excipients falling into these and other categories of excipients are well known in pharmaceutical formulation and manufacture.
- tablette refers to coated or uncoated tablets, single layer or multiple layer tablets and any other dosage form which has undergone a process of compression or compaction in order to form a solid dosage unit. While the need for a barrier coating to separate APIs to prevent interactions is overcome, coated tablets may constitute a component of the dosage form of the invention. It will be appreciated that segregation of such compositions from another API in the dosage form still provides the advantage of easy separation of the APIs for analysis .
- mini-tablet refers to a compressed pharmaceutical formulation that has dimensions of length, breadth or diameter of equal to or less than 5mm.
- pellet or “bead” refers to a formulation exhibiting a diameter of about 2mm or less, that has not been compressed but has been made by layering onto non- pareils or extrusion optionally followed by spheronisation or other similar known techniques. Generally pellets and beads are more spherical in appearance than mini-tablets.
- granule refers to a pharmaceutical formulation whereby the ingredients have been mixed together in order to intimately and evenly disperse the
- API within some or all of the other ingredients and to increase the particle size.
- Well known techniques are known in the pharmaceutical industry and can be selected from wet or dry granulation.
- composition may also include preparations of API absent any pharmaceutically acceptable excipients as well as the traditionally understood meaning of a composite of API with pharmaceutically acceptable excipients.
- the API present in the higher dose is designated the first API.
- the formulation of this API as a powder, granule, pellet or bead allows greater possibility to fit into a capsule with the lower dose API presented as a granule, pellet, bead, mini-tablet or tablet.
- the smaller particle size of these dosage presentation forms and the lack of compressional forces during manufacture mean that these formulations require no or reduced amounts of excipients such as binder and disintegrant. This means that of the total formulation being employed, a higher proportion can be API and thus the amount required to be encapsulated is much closer to the dose weight of the API involved.
- the compressed mini-tablet (s) or conventional tablet (s) employed as part of the second or subsequent API compositions require additional excipients, such as release-rate controlling polymers, binders, disintegrants, flow-aids and lubricants. Therefore, these compressed dosage presentation forms lend themselves more towards the lower dose API where the proportion of API to excipient is much lower. Even so, the overall space required for these lower dose APIs is substantially lower than that of the first API. It will of course be understood that notwithstanding the above, the first API composition may also comprise a compressed mini-tablet or conventional tablet.
- first API and second API may be the same compound but the mechanism of delivery may be different.
- first API may be formulated into an immediate release dosage form and the second API may be formulated into an extended, sustained or delayed release dosage form or the like.
- the first and further API(s) can be selected from any compounds having pharmaceutical activity that can be used in combination therapy.
- One embodiment of the invention comprises the API selected from any of the group of compounds comprising fluoxetine, metformin, milnacipran, naproxen, sulphonylureas such as glimepiride, glipizide or glyburide, glitazones such as troglitazone, pioglitazone, rosiglitazone or ciglitazone, diclofenac, acetaminophen (paracetamol) , hydralazine, verapamil, dipyridamole, hydrochlorothiazide, triamterene, the "sartans” such as candesartan, irbesartan, telmisartan, eprosartan, losartan, olmesartan, valsartan, the "prils” such as quinapril, fosinopri
- the first API is preferably fluoxetine hydrochloride or metformin hydrochloride, most preferably fluoxetine hydrochloride.
- the second API is preferably olanzapine, pioglitazone hydrochloride or rosiglitazone maleate, most preferably olanzapine.
- the olanzapine tablets were manufactured by conventional techniques such as wet granulation, drying, crushing, blending and compression using the ingredients set out below.
- the Part A ingredients were granulated and blended as appropriate and well known in the pharmaceutical formulation industry.
- the Part B ingredients were granulated and blended as appropriate and well known in the pharmaceutical formulation industry.
- the subsequent granule was compressed into tablets.
- the Part A ingredients were wet granulated, dried/ crushed and blended as appropriate and well known in the pharmaceutical formulation industry.
- the Part B ingredients were blended as appropriate and well known in the pharmaceutical formulation industry.
- Part B mini-tablets were added.
- Part A ingredients were wet granulated, dried/ crushed and blended as appropriate and well known in the pharmaceutical formulation industry.
- Part B ingredients were wet granulated, dried, crushed and blended as appropriate and well known in the pharmaceutical formulation industry. The subsequent granule was compressed into tablets.
- the Part A ingredients were wet granulated, dried, crushed and blended as appropriate and well known in the pharmaceutical formulation industry.
- the Part B ingredients were blended as appropriate and well known in the pharmaceutical formulation industry.
- Part B mini-tablets were added.
- Part A ingredients were blended as appropriate and well known in the pharmaceutical formulation industry.
- Part B ingredients were blended as appropriate and well known in the pharmaceutical formulation industry.
- the subsequent granule was compressed into tablets.
- Part A The appropriate amount of granule to provide the requisite strength of Part A was filled into an appropriately sized capsule and an appropriate number of Part B mini-tablets were added.
- Part A ingredients were blended as appropriate and well known in the pharmaceutical formulation industry.
- Part B ingredients were blended as appropriate and well known in the pharmaceutical formulation industry.
- the subsequent granule was compressed into tablets.
- Part A The appropriate amount of granule to provide the requisite strength of Part A was filled into an appropriately sized capsule and an appropriate number of Part B mini-tablets were added.
- Part A relates to the first API composition and Part B to the second API composition.
- the word "comprise” or variations such as
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2677623A CA2677623C (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two or more active pharmaceutical ingredients in different physical forms |
JP2009548549A JP5467870B2 (en) | 2007-02-09 | 2008-02-11 | Dosage form containing two or more active pharmaceutical ingredients in different physical forms |
US12/526,326 US9095519B2 (en) | 2007-02-09 | 2008-02-11 | Dosage form containing two or more active pharmaceutical ingredients in different physical forms |
PL08706056T PL2120878T3 (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two active pharmaceutical ingredients in different physical forms |
CN200880004561.1A CN101674811B (en) | 2007-02-09 | 2008-02-11 | The dosage form of the active pharmaceutical ingredient containing two or more different physical aspects |
DK08706056T DK2120878T3 (en) | 2007-02-09 | 2008-02-11 | Dosage form containing two active pharmaceutical ingredients in different physical forms |
AU2008213744A AU2008213744B2 (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two or more active pharmaceutical ingredients in different physical forms |
ES08706056.2T ES2522297T3 (en) | 2007-02-09 | 2008-02-11 | A pharmaceutical form that contains two pharmaceutical active ingredients in different physical forms |
SI200831315T SI2120878T1 (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two active pharmaceutical ingredients in different physical forms |
EP20080706056 EP2120878B1 (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two active pharmaceutical ingredients in different physical forms |
HRP20141008AT HRP20141008T1 (en) | 2007-02-09 | 2014-10-21 | A dosage form containing two active pharmaceutical ingredients in different physical forms |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2007900682 | 2007-02-09 | ||
AU2007900682A AU2007900682A0 (en) | 2007-02-09 | Novel Formulation |
Publications (1)
Publication Number | Publication Date |
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WO2008095263A1 true WO2008095263A1 (en) | 2008-08-14 |
Family
ID=39681201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/AU2008/000169 WO2008095263A1 (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two or more active pharmaceutical ingredients in different physical forms |
Country Status (15)
Country | Link |
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US (1) | US9095519B2 (en) |
EP (1) | EP2120878B1 (en) |
JP (1) | JP5467870B2 (en) |
CN (1) | CN101674811B (en) |
AU (1) | AU2008213744B2 (en) |
CA (1) | CA2677623C (en) |
CY (1) | CY1115652T1 (en) |
DK (1) | DK2120878T3 (en) |
ES (1) | ES2522297T3 (en) |
HR (1) | HRP20141008T1 (en) |
NZ (1) | NZ599031A (en) |
PL (1) | PL2120878T3 (en) |
PT (1) | PT2120878E (en) |
SI (1) | SI2120878T1 (en) |
WO (1) | WO2008095263A1 (en) |
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JP6392355B2 (en) * | 2013-09-13 | 2018-09-19 | アール.ピー.シェーラー テクノロジーズ、エルエルシー | Pellet-containing tablets |
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KR101910901B1 (en) * | 2013-11-29 | 2018-10-24 | 한미약품 주식회사 | Pharmaceutical complex formulation comprising amlodipine, losartan and rosuvastatin |
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- 2008-02-11 AU AU2008213744A patent/AU2008213744B2/en not_active Ceased
- 2008-02-11 PT PT08706056T patent/PT2120878E/en unknown
- 2008-02-11 ES ES08706056.2T patent/ES2522297T3/en active Active
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WO2015022560A1 (en) | 2013-08-16 | 2015-02-19 | Egis Gyógyszergyár Zrt. | Stable pharmaceutical composition containing bisoprolol and ramipril |
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US11918692B2 (en) | 2017-07-17 | 2024-03-05 | Eli Lilly And Company | Pharmaceutical compositions |
Also Published As
Publication number | Publication date |
---|---|
US9095519B2 (en) | 2015-08-04 |
EP2120878A1 (en) | 2009-11-25 |
JP5467870B2 (en) | 2014-04-09 |
PT2120878E (en) | 2014-11-05 |
PL2120878T3 (en) | 2015-01-30 |
AU2008213744B2 (en) | 2013-12-05 |
EP2120878A4 (en) | 2013-05-08 |
SI2120878T1 (en) | 2014-12-31 |
CY1115652T1 (en) | 2017-01-25 |
CN101674811A (en) | 2010-03-17 |
NZ599031A (en) | 2013-11-29 |
EP2120878B1 (en) | 2014-07-30 |
ES2522297T3 (en) | 2014-11-14 |
DK2120878T3 (en) | 2014-11-03 |
HRP20141008T1 (en) | 2015-01-02 |
JP2010518028A (en) | 2010-05-27 |
CN101674811B (en) | 2015-08-19 |
CA2677623C (en) | 2015-04-07 |
AU2008213744A1 (en) | 2008-08-14 |
US20100092549A1 (en) | 2010-04-15 |
CA2677623A1 (en) | 2008-08-14 |
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