WO2008093360A3 - A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride - Google Patents

A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride Download PDF

Info

Publication number
WO2008093360A3
WO2008093360A3 PCT/IN2008/000062 IN2008000062W WO2008093360A3 WO 2008093360 A3 WO2008093360 A3 WO 2008093360A3 IN 2008000062 W IN2008000062 W IN 2008000062W WO 2008093360 A3 WO2008093360 A3 WO 2008093360A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
naphthyloxy
thienyl
methyl
propylamine hydrochloride
Prior art date
Application number
PCT/IN2008/000062
Other languages
French (fr)
Other versions
WO2008093360A2 (en
Inventor
Venkatasubramanian Radhakrishnan Tarur
Nandu Baban Bhise
Dhananjay Govind Sathe
Neeraj Srivastava
Chhayendra Janardan Choudhari
Original Assignee
Usv Ltd
Venkatasubramanian Radhakrishnan Tarur
Nandu Baban Bhise
Dhananjay Govind Sathe
Neeraj Srivastava
Chhayendra Janardan Choudhari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Ltd, Venkatasubramanian Radhakrishnan Tarur, Nandu Baban Bhise, Dhananjay Govind Sathe, Neeraj Srivastava, Chhayendra Janardan Choudhari filed Critical Usv Ltd
Publication of WO2008093360A2 publication Critical patent/WO2008093360A2/en
Publication of WO2008093360A3 publication Critical patent/WO2008093360A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an improved process for preparation of intermediate of Duloxetine base and hydrochloride salt thereof.
PCT/IN2008/000062 2007-01-31 2008-01-31 A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride WO2008093360A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN168/MUM/2007 2007-01-31
IN168MU2007 2007-01-31

Publications (2)

Publication Number Publication Date
WO2008093360A2 WO2008093360A2 (en) 2008-08-07
WO2008093360A3 true WO2008093360A3 (en) 2008-10-02

Family

ID=39535547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000062 WO2008093360A2 (en) 2007-01-31 2008-01-31 A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride

Country Status (1)

Country Link
WO (1) WO2008093360A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009150238A2 (en) * 2008-06-13 2009-12-17 Krka, D.D. Novo Mesto Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives
WO2010079404A2 (en) * 2009-01-06 2010-07-15 Alembic Limited An improved process for the preparation of duloxetine and salts thereof
WO2011033366A2 (en) * 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
WO2006045255A1 (en) * 2004-10-26 2006-05-04 Zentiva, A.S. Method of manufacturing (s)-n-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
WO2006045255A1 (en) * 2004-10-26 2006-05-04 Zentiva, A.S. Method of manufacturing (s)-n-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
F. A. COTTON AND G. WILKINSON: "Advanced Inorganic Chemistry, 3rd Edition", 1972, JOHN WILEY INTERSCIENCE, NEW YORK, US, XP002486191 *

Also Published As

Publication number Publication date
WO2008093360A2 (en) 2008-08-07

Similar Documents

Publication Publication Date Title
HK1199253A1 (en) Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof toblock reuptake of norepinephrine, dopamine, and serotonin
IL184185A0 (en) Pure duloxetine hydrochloride
IL216247A0 (en) Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
EP1746985A4 (en) Method for augmenting the effects of serotonin reuptake inhibitors
IL183245A0 (en) Process for preparing phamaceutically acceptable salts of duloxetine and intermediates thereof
WO2007119114A3 (en) Improved synthesis and preparations of duloxetine salts
EP1976844A4 (en) Improved process for pure duloxetine hydrochloride
ZA200609205B (en) Crystalline forms of duloxetine free base
GB0518612D0 (en) A method of forming conductive tracks
AP2005003467A0 (en) N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline reuptake inhibitors.
EP1819337A4 (en) Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
ZA200702333B (en) Cyclic amine derivative or salt thereof
WO2006081515A3 (en) Duloxetine hydrochloride polymorphs
IL191921A0 (en) A novel process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
DE502005000466D1 (en) Lever-like cam follower
GB0612508D0 (en) Crystalline duloxetine hydrochloride
WO2008093360A3 (en) A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride
GB0612506D0 (en) Crystalline duloxetine hydrochloride
WO2010117979A3 (en) Serotonin and norepinephrine reuptake inhibitor
WO2007134168A3 (en) Process for preparing duloxetine
ZA201201570B (en) A method of crystallization of (s)-n-methyl-3-1(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
SI1937662T1 (en) Process for the preparation of duloxetine
IL184187A0 (en) Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof
WO2007067581A8 (en) 2-(n-methyl-propanamine)-3-(2-naphthol) thiophene, an impurity of duloxetine hydrochloride
WO2007038253A3 (en) Dnt-maleate and methods of preparation thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08720123

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08720123

Country of ref document: EP

Kind code of ref document: A2