WO2008090958A1 - ドメイン交換された遺伝子組換え抗体組成物 - Google Patents

ドメイン交換された遺伝子組換え抗体組成物 Download PDF

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Publication number
WO2008090958A1
WO2008090958A1 PCT/JP2008/050992 JP2008050992W WO2008090958A1 WO 2008090958 A1 WO2008090958 A1 WO 2008090958A1 JP 2008050992 W JP2008050992 W JP 2008050992W WO 2008090958 A1 WO2008090958 A1 WO 2008090958A1
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WO
WIPO (PCT)
Prior art keywords
antibody
domain
antibody composition
recombinant antibody
human igg1
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PCT/JP2008/050992
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English (en)
French (fr)
Inventor
Kenya Shitara
Rinpei Niwa
Akito Natsume
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Kyowa Hakko Kirin Co., Ltd.
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Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Publication of WO2008090958A1 publication Critical patent/WO2008090958A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

　本発明は、ヒトIgG1抗体において、定常領域中のCH1ドメインおよびCH2ドメインを含むポリペプチドが、KabatらによるEUインデックス（以下、EUインデックス）において、それぞれヒトIgG3抗体の同じ位置に相当するアミノ酸配列からなるポリペプチドに置換された、ヒトIgG1抗体およびヒトIgG3抗体よりも高いCDC活性、ならびにヒトIgG1抗体と同等のプロテインA結合活性を有する遺伝子組換え抗体組成物、該遺伝子組換え抗体組成物に含まれる抗体分子または該抗体分子の重鎖定常領域をコードするDNA、該DNAを宿主細胞に導入して得られる形質転換体、該形質転換体を用いた遺伝子組換え抗体組成物の生産方法、ならびに該抗体組成物を有効成分として含有する医薬に関する。
PCT/JP2008/050992 2007-01-24 2008-01-24 ドメイン交換された遺伝子組換え抗体組成物 WO2008090958A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007013642 2007-01-24
JP2007-013642 2007-01-24

Publications (1)

Publication Number Publication Date
WO2008090958A1 true WO2008090958A1 (ja) 2008-07-31

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PCT/JP2008/050992 WO2008090958A1 (ja) 2007-01-24 2008-01-24 ドメイン交換された遺伝子組換え抗体組成物

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WO (1) WO2008090958A1 (ja)

Cited By (19)

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WO2011051351A1 (en) 2009-10-27 2011-05-05 Ucb Pharma S.A. Method to generate antibodies to ion channels
WO2011051349A1 (en) 2009-10-27 2011-05-05 Ucb Pharma S.A. Antibodies to ion channels
WO2011051350A1 (en) 2009-10-27 2011-05-05 Ucb Pharma S.A. Function modifying nav 1.7 antibodies
WO2011118739A1 (ja) 2010-03-26 2011-09-29 協和発酵キリン株式会社 新規修飾部位導入抗体および抗体フラグメント
WO2011123708A2 (en) 2010-03-31 2011-10-06 Ablexis Llc Genetic engineering of non-human animals for the production of chimeric antibodies
JP2012527234A (ja) * 2009-05-20 2012-11-08 ファームアブサイン インコーポレイテッド 新規な形態の二重標的抗体およびその使用
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
US9062105B1 (en) 2014-07-15 2015-06-23 Kymab Limited Precision Medicine by targeting VEGF-A variants for treatment of retinopathy
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US9234037B2 (en) 2009-10-27 2016-01-12 Ucb Biopharma Sprl Method to generate antibodies to ion channels
US9346873B2 (en) 2008-09-30 2016-05-24 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US10618955B2 (en) 2014-07-15 2020-04-14 Kymab Limited Methods for treating neurodegenerative disease using anti-PD-1 antibodies
US10759867B2 (en) 2011-07-06 2020-09-01 Genmab B.V. Antibody variants and uses thereof
US11180572B2 (en) 2012-07-06 2021-11-23 Genmab B.V. Dimeric protein with triple mutations
JP2021534801A (ja) * 2018-08-29 2021-12-16 ユナイテッド バイオファーマ インコーポレイテッド アフコシル化抗体およびその製造法
US11753479B2 (en) 2014-03-04 2023-09-12 Kymab Limited Nucleic acids encoding anti-OX40L antibodies
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods

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US10638736B2 (en) 2008-09-30 2020-05-05 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US10575504B2 (en) 2008-09-30 2020-03-03 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US10561123B2 (en) 2008-09-30 2020-02-18 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US10555506B2 (en) 2008-09-30 2020-02-11 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US10492476B2 (en) 2008-09-30 2019-12-03 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US20160222093A1 (en) * 2008-09-30 2016-08-04 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US20160219850A1 (en) * 2008-09-30 2016-08-04 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
US9346873B2 (en) 2008-09-30 2016-05-24 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
JP2015119705A (ja) * 2009-05-20 2015-07-02 ファームアブサイン インコーポレイテッド 新規な形態の二重標的抗体およびその使用
JP2012527234A (ja) * 2009-05-20 2012-11-08 ファームアブサイン インコーポレイテッド 新規な形態の二重標的抗体およびその使用
US10125194B2 (en) 2009-05-20 2018-11-13 Pharmabcine Inc. Dual targeting antibody of novel form, and use thereof
US10112996B2 (en) 2009-10-27 2018-10-30 Ucb Biopharma Sprl Function modifying NAv1.7 antibodies
US9738710B2 (en) 2009-10-27 2017-08-22 Ucb Biopharma Sprl Method of treating a patient for pain by administering an anti-ion channel antibody
WO2011051349A1 (en) 2009-10-27 2011-05-05 Ucb Pharma S.A. Antibodies to ion channels
WO2011051350A1 (en) 2009-10-27 2011-05-05 Ucb Pharma S.A. Function modifying nav 1.7 antibodies
US9067995B2 (en) 2009-10-27 2015-06-30 Ucb Pharma S.A. Method to generate antibodies to ion channels
WO2011051351A1 (en) 2009-10-27 2011-05-05 Ucb Pharma S.A. Method to generate antibodies to ion channels
US9234037B2 (en) 2009-10-27 2016-01-12 Ucb Biopharma Sprl Method to generate antibodies to ion channels
US8986954B2 (en) 2009-10-27 2015-03-24 Ucb Pharma S.A. DNA encoding function modifying Nav1.7 antibodies
US8926977B2 (en) 2009-10-27 2015-01-06 Ucb Pharma S.A. Antibodies to the E1 extracellular loop of ion channels
US8734798B2 (en) 2009-10-27 2014-05-27 Ucb Pharma S.A. Function modifying NAv 1.7 antibodies
US9956274B2 (en) 2009-10-27 2018-05-01 Ucb Biopharma Sprl Method to generate antibodies to ion channels
WO2011118739A1 (ja) 2010-03-26 2011-09-29 協和発酵キリン株式会社 新規修飾部位導入抗体および抗体フラグメント
KR101830020B1 (ko) 2010-03-31 2018-02-19 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
US10526420B2 (en) 2010-03-31 2020-01-07 Ablexis, Llc Genetic engineering of non-human animals for the production of chimeric antibodies
US10836832B2 (en) 2010-03-31 2020-11-17 Ablexis, Llc Genetic engineering of non-human animals for the production of chimeric antibodies
KR20180018835A (ko) * 2010-03-31 2018-02-21 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
KR20180030942A (ko) * 2010-03-31 2018-03-26 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
KR20180030941A (ko) * 2010-03-31 2018-03-26 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
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US11180572B2 (en) 2012-07-06 2021-11-23 Genmab B.V. Dimeric protein with triple mutations
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US10711059B2 (en) 2014-07-15 2020-07-14 Kymab Limited Methods for treating neurodegenerative diseases using anti-PD-L1 antibodies
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
US10618955B2 (en) 2014-07-15 2020-04-14 Kymab Limited Methods for treating neurodegenerative disease using anti-PD-1 antibodies
US9062105B1 (en) 2014-07-15 2015-06-23 Kymab Limited Precision Medicine by targeting VEGF-A variants for treatment of retinopathy
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
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