WO2008089257A3 - Drug eluting medical device using polymeric therapeutics with transglutaminase substrates - Google Patents

Drug eluting medical device using polymeric therapeutics with transglutaminase substrates Download PDF

Info

Publication number
WO2008089257A3
WO2008089257A3 PCT/US2008/051195 US2008051195W WO2008089257A3 WO 2008089257 A3 WO2008089257 A3 WO 2008089257A3 US 2008051195 W US2008051195 W US 2008051195W WO 2008089257 A3 WO2008089257 A3 WO 2008089257A3
Authority
WO
WIPO (PCT)
Prior art keywords
medical device
drug eluting
eluting medical
transglutaminase substrates
therapeutics
Prior art date
Application number
PCT/US2008/051195
Other languages
French (fr)
Other versions
WO2008089257A2 (en
Inventor
Shrirang Ranade
Mark Steckel
Rachit Ohri
Original Assignee
Cappella, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cappella, Inc. filed Critical Cappella, Inc.
Publication of WO2008089257A2 publication Critical patent/WO2008089257A2/en
Publication of WO2008089257A3 publication Critical patent/WO2008089257A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/605—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the macromolecule containing phosphorus in the main chain, e.g. poly-phosphazene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed herein are coatings for implantable medical device. The coatings comprise a composition, comprising a polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation (e.g., hydrolysis) of the covalent bond; and transglutaminase substrates.
PCT/US2008/051195 2007-01-16 2008-01-16 Drug eluting medical device using polymeric therapeutics with transglutaminase substrates WO2008089257A2 (en)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US88510507P 2007-01-16 2007-01-16
US88510907P 2007-01-16 2007-01-16
US88509707P 2007-01-16 2007-01-16
US88511207P 2007-01-16 2007-01-16
US60/885,109 2007-01-16
US60/885,112 2007-01-16
US60/885,097 2007-01-16
US60/885,105 2007-01-16
US94230107P 2007-06-06 2007-06-06
US94230907P 2007-06-06 2007-06-06
US60/942,309 2007-06-06
US60/942,301 2007-06-06
US94307707P 2007-06-11 2007-06-11
US60/943,077 2007-06-11

Publications (2)

Publication Number Publication Date
WO2008089257A2 WO2008089257A2 (en) 2008-07-24
WO2008089257A3 true WO2008089257A3 (en) 2009-12-23

Family

ID=39540689

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2008/051196 WO2008089258A2 (en) 2007-01-16 2008-01-16 Drug eluting medical device using polymeric therapeutics
PCT/US2008/051193 WO2008089256A2 (en) 2007-01-16 2008-01-16 Polymeric therapeutics
PCT/US2008/051195 WO2008089257A2 (en) 2007-01-16 2008-01-16 Drug eluting medical device using polymeric therapeutics with transglutaminase substrates

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2008/051196 WO2008089258A2 (en) 2007-01-16 2008-01-16 Drug eluting medical device using polymeric therapeutics
PCT/US2008/051193 WO2008089256A2 (en) 2007-01-16 2008-01-16 Polymeric therapeutics

Country Status (1)

Country Link
WO (3) WO2008089258A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10772993B2 (en) * 2017-02-23 2020-09-15 Medtronic Vascular, Inc. Drug coated medical devices
CN108559086A (en) * 2018-05-21 2018-09-21 武汉工程大学 A kind of vinyl modified star polyphosphate and its synthetic method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085224A1 (en) * 2000-05-12 2001-11-15 The Nottingham Trent University Medical implant materials
US20030073615A1 (en) * 1996-03-12 2003-04-17 Cell Therapeutics, Inc. Water soluble paclitaxel derivatives
WO2003055935A1 (en) * 2001-12-21 2003-07-10 Board Of Regents - The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
US20050025799A1 (en) * 2003-07-30 2005-02-03 Hossainy Syed F. A. Biologically absorbable coatings for implantable devices and methods for fabricating the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
ITPD20020271A1 (en) * 2002-10-18 2004-04-19 Fidia Farmaceutici CHEMICAL-PHARMACEUTICAL COMPOUNDS CONSISTING OF TAXAN DERIVATIVES COVALENTLY LINKED TO HYALURONIC ACID OR ITS DERIVATIVES.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030073615A1 (en) * 1996-03-12 2003-04-17 Cell Therapeutics, Inc. Water soluble paclitaxel derivatives
WO2001085224A1 (en) * 2000-05-12 2001-11-15 The Nottingham Trent University Medical implant materials
WO2003055935A1 (en) * 2001-12-21 2003-07-10 Board Of Regents - The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
US20050025799A1 (en) * 2003-07-30 2005-02-03 Hossainy Syed F. A. Biologically absorbable coatings for implantable devices and methods for fabricating the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOSIO F ET AL: "Preparation, characterization and properties in vitro and in vivo of a paclitaxel-albumin conjugate", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 47, no. 3, 8 September 1997 (1997-09-08), pages 293 - 304, XP004125821, ISSN: 0168-3659 *
HEATH D J ET AL: "Involvement of tissue transglutaminase in the stabilisation of biomaterial/tissue interfaces important in medical devices", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 23, no. 6, 15 March 2002 (2002-03-15), pages 1519 - 1526, XP004348162, ISSN: 0142-9612 *
VERDERIO E ET AL: "Role of the cross-linking enzyme tissue transglutaminase in the biological recognition of synthetic biodegradable polymers", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 200102 US, vol. 54, no. 2, February 2001 (2001-02-01), pages 294 - 304, XP002534469, ISSN: 0021-9304 *

Also Published As

Publication number Publication date
WO2008089258A3 (en) 2009-12-30
WO2008089256A3 (en) 2009-12-30
WO2008089256A2 (en) 2008-07-24
WO2008089258A2 (en) 2008-07-24
WO2008089257A2 (en) 2008-07-24

Similar Documents

Publication Publication Date Title
WO2009055306A3 (en) Coating designs for the tailored release of dual drugs from polymeric coatings
WO2008002586A3 (en) Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2007092583A3 (en) Functionalizing implantable devices with a poly (diol-co-citrate) polymer
EP1832289A3 (en) Compositions and coatings for implantable medical devices
WO2009140421A8 (en) Polymeric carrier
WO2010111232A3 (en) Drug delivery medical device
WO2012009684A3 (en) Drug delivery medical device
WO2011028031A3 (en) In situ-forming hydrogel for tissue adhesives and biomedical use thereof
WO2010005723A3 (en) Drug loaded polymeric nanoparticles and methods of making and using same
WO2007139845A3 (en) Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ
EP2500044A3 (en) Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
WO2007146426A3 (en) Nanoshells for drug delivery
WO2008140482A3 (en) Medical devices having coatings for controlled therapeutic agent delivery
WO2008154143A3 (en) Elastomeric copolymer coatings for implantable medical devices
WO2011079279A3 (en) Nanoconjugates and nanoconjugate formulations
WO2010129381A3 (en) Balloon coating with drug transfer control via coating thickness
WO2008016667A3 (en) Methods to prepare polymer blend implantable medical devices
WO2007100905A3 (en) Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation
TWI370160B (en) Conductive polymer coating composition, method of preparing coating film using the conductive polymer coating composition, and coating film prepared using the method
WO2010084157A3 (en) Multifunctional stealth nanoparticles for biomedical use
WO2007128973A3 (en) Interleukin 1-receptor antagonist composition to treat restenosis
WO2009019477A3 (en) Coating
WO2008137237A3 (en) Method for forming crystallized therapeutic agents on a medical device
WO2008075192A3 (en) Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
WO2009123759A3 (en) Therapeutic uses of biocompatible biogel compositions

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08727753

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08727753

Country of ref document: EP

Kind code of ref document: A2