WO2008089256A3 - Polymeric therapeutics - Google Patents
Polymeric therapeutics Download PDFInfo
- Publication number
- WO2008089256A3 WO2008089256A3 PCT/US2008/051193 US2008051193W WO2008089256A3 WO 2008089256 A3 WO2008089256 A3 WO 2008089256A3 US 2008051193 W US2008051193 W US 2008051193W WO 2008089256 A3 WO2008089256 A3 WO 2008089256A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymers
- disclosed
- covalent bond
- chemical moiety
- therapeutics
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/605—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the macromolecule containing phosphorus in the main chain, e.g. poly-phosphazene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
Abstract
Disclosed herein are polymers comprising a chemical moiety linked through a covalent bond, where the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond. The polymers can be chosen from star polymers, dendrimers, and hyperbranched polymers. Also disclosed are coatings for implantable medical device comprising such polymers.
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88510507P | 2007-01-16 | 2007-01-16 | |
US88510907P | 2007-01-16 | 2007-01-16 | |
US88509707P | 2007-01-16 | 2007-01-16 | |
US88511207P | 2007-01-16 | 2007-01-16 | |
US60/885,109 | 2007-01-16 | ||
US60/885,112 | 2007-01-16 | ||
US60/885,097 | 2007-01-16 | ||
US60/885,105 | 2007-01-16 | ||
US94230107P | 2007-06-06 | 2007-06-06 | |
US94230907P | 2007-06-06 | 2007-06-06 | |
US60/942,309 | 2007-06-06 | ||
US60/942,301 | 2007-06-06 | ||
US94307707P | 2007-06-11 | 2007-06-11 | |
US60/943,077 | 2007-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008089256A2 WO2008089256A2 (en) | 2008-07-24 |
WO2008089256A3 true WO2008089256A3 (en) | 2009-12-30 |
Family
ID=39540689
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/051196 WO2008089258A2 (en) | 2007-01-16 | 2008-01-16 | Drug eluting medical device using polymeric therapeutics |
PCT/US2008/051193 WO2008089256A2 (en) | 2007-01-16 | 2008-01-16 | Polymeric therapeutics |
PCT/US2008/051195 WO2008089257A2 (en) | 2007-01-16 | 2008-01-16 | Drug eluting medical device using polymeric therapeutics with transglutaminase substrates |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/051196 WO2008089258A2 (en) | 2007-01-16 | 2008-01-16 | Drug eluting medical device using polymeric therapeutics |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/051195 WO2008089257A2 (en) | 2007-01-16 | 2008-01-16 | Drug eluting medical device using polymeric therapeutics with transglutaminase substrates |
Country Status (1)
Country | Link |
---|---|
WO (3) | WO2008089258A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10772993B2 (en) * | 2017-02-23 | 2020-09-15 | Medtronic Vascular, Inc. | Drug coated medical devices |
CN108559086A (en) * | 2018-05-21 | 2018-09-21 | 武汉工程大学 | A kind of vinyl modified star polyphosphate and its synthetic method |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030073615A1 (en) * | 1996-03-12 | 2003-04-17 | Cell Therapeutics, Inc. | Water soluble paclitaxel derivatives |
WO2003055935A1 (en) * | 2001-12-21 | 2003-07-10 | Board Of Regents - The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
WO2004035629A2 (en) * | 2002-10-18 | 2004-04-29 | Fidia Farmaceutici S.P.A. | Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4328204A (en) * | 1977-03-02 | 1982-05-04 | Ethicon, Inc. | Absorbable polymer-drug compounds and method for making same |
GB0011356D0 (en) * | 2000-05-12 | 2000-06-28 | Univ Nottingham Trent | Medical implant materials |
US7169404B2 (en) * | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
-
2008
- 2008-01-16 WO PCT/US2008/051196 patent/WO2008089258A2/en active Application Filing
- 2008-01-16 WO PCT/US2008/051193 patent/WO2008089256A2/en active Application Filing
- 2008-01-16 WO PCT/US2008/051195 patent/WO2008089257A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030073615A1 (en) * | 1996-03-12 | 2003-04-17 | Cell Therapeutics, Inc. | Water soluble paclitaxel derivatives |
WO2003055935A1 (en) * | 2001-12-21 | 2003-07-10 | Board Of Regents - The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
WO2004035629A2 (en) * | 2002-10-18 | 2004-04-29 | Fidia Farmaceutici S.P.A. | Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
Non-Patent Citations (2)
Title |
---|
ACHARYA G ET AL: "Mechanisms of controlled drug release from drug-eluting stents", ADVANCED DRUG DELIVERY REVIEWS 20060603 NL, vol. 58, no. 3, 3 June 2006 (2006-06-03), pages 387 - 401, XP002533859, ISSN: 0169-409X * |
COMMANDEUR S ET AL: "Polymers, drug release, and drug-eluting stents", JOURNAL OF INTERVENTIONAL CARDIOLOGY 200612 US, vol. 19, no. 6, December 2006 (2006-12-01), pages 500 - 506, XP002533860, ISSN: 0896-4327 1540-8183 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008089258A3 (en) | 2009-12-30 |
WO2008089256A2 (en) | 2008-07-24 |
WO2008089258A2 (en) | 2008-07-24 |
WO2008089257A3 (en) | 2009-12-23 |
WO2008089257A2 (en) | 2008-07-24 |
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