WO2008089044A2 - Dispositif de réparation de valvule mitrale - Google Patents

Dispositif de réparation de valvule mitrale Download PDF

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Publication number
WO2008089044A2
WO2008089044A2 PCT/US2008/050771 US2008050771W WO2008089044A2 WO 2008089044 A2 WO2008089044 A2 WO 2008089044A2 US 2008050771 W US2008050771 W US 2008050771W WO 2008089044 A2 WO2008089044 A2 WO 2008089044A2
Authority
WO
WIPO (PCT)
Prior art keywords
coil
mitral valve
loop
repair device
spoke
Prior art date
Application number
PCT/US2008/050771
Other languages
English (en)
Other versions
WO2008089044A3 (fr
Inventor
Wilmo C. Orejola
Original Assignee
The Trustees Of Columbia University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University filed Critical The Trustees Of Columbia University
Publication of WO2008089044A2 publication Critical patent/WO2008089044A2/fr
Publication of WO2008089044A3 publication Critical patent/WO2008089044A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A61B2017/00783—Valvuloplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body

Definitions

  • This invention relates to devices and methods for repairing a dysfunctional mitral valve without removing or replacing any constituents of the mitral valve. More specifically the invention relates to a support device positionable against the valve leaflets to reduce or eliminate valve flailing and improve coaptation of the valve leaflets thereby correcting regurgitation without unduly restricting the normal flow of blood through the valve orifice from the left atrium to the left ventricle.
  • Mitral regurgitation results in backward flow or reflux of blood from the left ventricle into the left atrium.
  • Mitral regurgitation is usually caused by flailing of the valve leaflets during systole or as a result of annular dilation of the left ventricle during systole, or a combination of valve flailing and annular dilation.
  • the mitral valve In a normal heart, during diastole or relaxation of the heart muscles, the mitral valve opens downwardly from the left atrium to the left ventricle to allow blood to flow downwardly from the left atrium into the left ventricle. When the left ventricle contracts, during systole or contraction of the heart muscles, the mitral valve snaps shut preventing any blood from flowing back up from the left ventricle into the left atrium.
  • the mitral valve In order for the heart to function efficiently, the mitral valve must be in a leak tight closed position during systole. Leakage of blood back through the mitral valve from the left ventricle into the left atrium during systole will cause the left atrium to enlarge because it must accommodate an abnormally large volume of blood. The increased blood volume from the left atrium will be forced into the lungs resulting in shortness of breath and, depending upon the extent of leakage or mitral regurgitation, congestive heart failure can result.
  • Mitral regurgitation thus occurs when there is incomplete closing and upward flailing of the valve leaflets during systole.
  • the valve leaflets move in an upward direction following diastole to a closed condition during systole.
  • the valve leaflets continue to move in an upward direction beyond their normally closed position into an abnormally open or flailing condition in the left atrium following systole. This flailing condition allows blood to flow back or regurgitate into the left atrium through a mitral valve opening or orifice.
  • a well known surgical approach to treating mitral valve regurgitation is to suture an annuloplasty ring around the annulus of the mitral valve to reduce dilation of the left annulus and thereby enable the valve leaflets to more adequately coaptate or close at the appropriate time and thereby moderate the regurgitation.
  • the mitral valve includes anterior and posterior leaflets that spread centrally from anterior and posterior portions of the mitral valve annulus (also referred to as the anterior annulus and the posterior annulus) that surrounds the leaflets.
  • the valve leaflets are thin, pliable flaps, having margins that are tethered to papillary muscles by tendons known as chordae tendinae.
  • Chordal or tendon rupture can occur because of congenital defects, or because of the aging process or as a result of a disease such as rheumatic fever, bacterial endocarditis or coronary artery disease, for example. Heart failure is likely to occur if mitral valve regurgitation is not resolved.
  • U.S. patent 7,070,618 to Streeter shows a mitral shield.
  • the shield are positioned only over the posterior leaflets of the mitral valve.
  • the inventor suggests, with regard to at least one embodiment, that the posterior leaflets maybe excised or left in situ.
  • Two of the Streeter embodiments are positioned over both the anterior and posterior leaflets of the mitral valve.
  • One of these shields includes a circular wire collar surrounding a series of spaced and parallel wires.
  • the other shield is a disc-like structure that includes a solid portion and a portion with spaced openings.
  • both of the shields appear to provide support for the valve leaflets the shield structure partially blocks the valve orifice and is thus likely to impede blood flow from the left atrium to the left ventricle. It is thus desirable to provide a mitral valve repair device that corrects flailing of the valve leaflets, does not unduly restrict blood flow through the valve orifice, does not require removal of any portion of the valve structure and can be installed via open heart surgery or percutaneously transluminally.
  • Fig. 1 is a simplified schematic cross-sectional view of a mitral valve showing the direction of blood flow when there is regurgitation
  • Fig. 2 is a simplified cross-sectional view of a mitral valve repair device incorporating one embodiment of the invention, in an installed position against the mitral valve;
  • Fig. 3 is a simplified plan view of a mitral valve showing an anterior leaflet, a posterior leaflet and the valve orifice;
  • Fig. 4 is a simplified plan view of the mitral valve repair device of
  • Fig. 5 is a simplified plan view of another embodiment of the mitral valve repair device
  • Fig. 6 is a simplified profile view of a catheter for deploying the mitral valve repair device percutaneously
  • Fig. 7 is a simplified view of the catheter in an expanded condition prior to release of the mitral valve repair device from a locked position at the catheter tip;
  • Fig. 8 is a view similar to Fig. 7 showing the mitral valve repair device in an unbent condition and unlocked from the catheter tip prior to implantation of the repair device against the mitral valve as shown in Fig. 2;
  • Fig. 9 is a simplified schematic view showing the deployment catheter in perspective, and the unbending and expansion of the mitral valve repair device after release from the deployment catheter.
  • Corresponding reference numbers indicate corresponding parts throughout the several views of the drawings.
  • a mitral valve repair device incorporating a preferred embodiment of the invention is generally indicated by the reference number 10 in Fig. 5.
  • the mitral valve repair device 10 is intended for implantation via an open heart procedure or by percutaneous deployment.
  • the mitral valve repair device 10 is positioned over a mitral valve 16 (Fig. 5), which is shown in simplified schematic form.
  • the mitral valve 16 includes anterior leaflets 18 and posterior leaflets 20 surrounded by an annulus 26.
  • a mitral valve orifice 28 is shown in an open condition in Fig. 3 and in a closed condition in Figs. 2 and 5.
  • the mitral valve repair device 10 includes an outer loop-like coil 34 of closed periphery.
  • the mitral valve repair device 10 is formed of a non-thrombogenic material such as a biocompatible plastic and/or a bio-compatible metal such as titanium, nitinol wire, stainless steel wire and can be coated with an inert bio-compatible plastic material such as nylon or heparin.
  • the outer loop-like 34 can, for example, be constructed in the same manner as a known annuloplasty ring.
  • the mitral valve repair device 10 also includes an inner loop-like coil 36 of closed periphery, substantially concentric with the outer loop-like coil 34.
  • the outer loop-like coil 34 and the inner loop-like coil 36 are held in a predetermined spaced relationship by spoke-like members 42 that are radially directed from a central axis of the coils 34 and 36.
  • the spoke-like members 42 have an outer end portion 44 connected to the outer coil 34 and an inner end portion 46 connected to the inner coil 36. Under this arrangement the outer coil 34, the inner coil 36 and the spoke-like members 42 are substantially co-planar. Except for the spoke-like members 42 there is completely open space between the outer and inner coils 34 and 36. In addition, there is completely open space within the area defined by the inner coil 36.
  • the inner coil 36 is approximately 1.5 centimeters in circumference.
  • the inner coil 36 is also relatively infexible in comparison to the flexibility of the outer coil 34 and the spoke-like members 42.
  • the mitral valve repair device 10 is flexible and bendable such that the outer coil 34 and the spoke-like members 42 can be flexed, bent or deflected with respect to the inner coil 36 and then restored to the unbent shape. It should be noted that the mitral valve repair device 10 as shown in Fig. 5 is slightly elliptical as is dictated by the shape of the mitral valve that is undergoing repair by the repair device 10.
  • the mitral valve repair device 10 is positioned against the anterior leaflet 18 and the posterior leaflet 20, and held in place by sutures 48 that secure the outer coil 34 to a circumferential area 50 (Fig. 5) of the anterior and posterior annulus of the mitral valve 16.
  • the circumferential area 50 is a peripheral portion of the mitral valve 16 and for purposes of simplification is not demarked with boundaries.
  • the sutures 48 are the only means for securing the mitral valve repair device 10 against the mitral valve 16 when the mitral valve repair device 10 is implanted through an open heart procedure.
  • the inner coil 36, the spoke-like members 42 and the outer coil 34 provide support for the anterior and posterior leaflets 18 and 20 to prevent or moderate any flailing of the leaflets 18 and 20 into the left atrium as shown in Fig. 1.
  • anterior and posterior leaflets 18 and 20 thus can be restored to a greater degree of functionality by remaining in situ and cooperating with the mitral valve repair device 10 to help prevent blood from the left ventricle 62 from being undesirably directed in the left atrium 60. It will also be noted from Fig. 5 that the inner coil 36 does not obstruct the opening of the valve orifice 28 and does not unduly impede the normal flow of blood from the left atrium 60 to the left ventricle 62.
  • the flexibility and bendability of the mitral valve repair device 10 facilitates installation and positioning of the device 10 against the mitral valve 16. Installation of the mitral valve repair device 10 can be accomplished with open heart surgery as well as percutaneously transluminally.
  • the mitral valve repair device 70 includes an outer loop-like coil 74, an inner loop-like coil 76 and spoke-like members 82 joining the outer and inner coils 74 and 76.
  • the spoke-like members 82 include an outer end portion 84 connected to the outer coil 74 and an inner end portion 86 connected to the inner coil 76.
  • Each of the spoke-like members 82 also include a barbed formation
  • the mitral valve repair device 70 is particularly suited for percutaneous transluminal deployment through the groin.
  • the mitral valve repair device 70 is supported in bent condition on a catheter 100.
  • the outer coil 74 and the spoke-like members 82 are bent as folded against an umbrella-like support sleeve 102 having pivot members 104 (Fig. 7) for supporting and unbending the spoke-like members 82 of the repair device 70.
  • a slidable sheath 108 maintains the bent condition of the mitral valve repair device 70 while it is being transported through the femoral artery and advanced intraluminally inside the heart, passing through the interatrial septum and positioned over the mitral valve orifice 28.
  • the sheath or sleeve 102 is pulled back out of the catheter.
  • Pivot members 104 upon which the mitral valve 70 is supported are pivoted to an expanded condition as shown in Fig. 7.
  • a restraining member 110 bears against the inner coil 76 to hold it in a stable position on the catheter 100 until the barbed formations 92 are aligned with the selected circumferential area 50 of the mitral valve 16.
  • restraining member 110 is partially retracted as shown in Fig. 8 to release the inner coil 76 and the mitral valve repair device 10 is pushed toward the mitral valve 16 to cause the barbed formations 92 to embed in the selected circumferential area of the mitral valve.
  • Fig. 9 further shows the umbrella-like support 102 which includes the pivot members 104 that push the mounted mitral valve repair device 70 in place on the mitral orifice 28.
  • the mitral valve repair device 70 is thus affixed to the mitral valve 16 in a desired position without sutures. However if the mitral valve repair device 70 requires sutures a percutaneous transluminal suturing device (not shown) can be used for the suturing operation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un dispositif de réparation de valvule mitrale qui comprend des bobines de type boucle extérieure et intérieure sensiblement concentriques maintenues dans une relation espacée par des organes en rayon dirigés de manière radiale. La bobine extérieure est fixée à une zone circonférentielle sélectionnée de l'anneau antérieur et postérieur de la valvule mitrale, dans l'oreillette gauche pour localiser le dispositif de réparation dans une position souhaitée contre les feuillets de valvule mitrale et permettre ainsi au dispositif de réparation d'éliminer une régurgitation mitrale due à une agitation de la valvule et/ou une dilatation de l'anneau.
PCT/US2008/050771 2007-01-12 2008-01-10 Dispositif de réparation de valvule mitrale WO2008089044A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88464807P 2007-01-12 2007-01-12
US60/884,648 2007-01-12
US94811807P 2007-07-05 2007-07-05
US60/948,118 2007-07-05

Publications (2)

Publication Number Publication Date
WO2008089044A2 true WO2008089044A2 (fr) 2008-07-24
WO2008089044A3 WO2008089044A3 (fr) 2008-12-24

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011033508A1 (fr) * 2009-09-15 2011-03-24 Transcardia Ltd. Remodelage de valvules cardiaques
WO2012143913A3 (fr) * 2011-04-21 2012-12-13 Novogate Medical Ltd Dispositif de fermeture de tissu et procédé de distribution et utilisations de celui-ci
WO2015005690A1 (fr) * 2013-07-11 2015-01-15 주식회사 코스와이어 Cordon de cerclage pour annuloplastie à cerclage de valve mitrale
WO2015194754A1 (fr) * 2014-06-16 2015-12-23 (주)타우피엔유메디칼 Cordon de cerclage pour procédure de cerclage de valve mitrale ayant un protecteur d'artère coronaire arqué formé de façon intégrée à celui-ci
CN105228556A (zh) * 2013-05-06 2016-01-06 釜山大学校产学协力团 心脏瓣膜固定装置
EP2914182A4 (fr) * 2012-11-03 2017-06-28 Novogate Medical Ltd. Système de pose par voie intercostale et méthodes associées
JP2018020199A (ja) * 2011-09-13 2018-02-08 アボット、カーディオバスキュラー、システムズ、インコーポレーテッドＡｂｂｏｔｔ Ｃａｒｄｉｏｖａｓｃｕｌａｒ Ｓｙｓｔｅｍｓ Ｉｎｃ． 組織近置システム用のグリッパ型プッシャ
US10433962B2 (en) 2016-05-06 2019-10-08 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11007059B2 (en) 2016-05-06 2021-05-18 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11039923B2 (en) 2016-05-06 2021-06-22 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11259925B2 (en) 2019-05-02 2022-03-01 University Of Maryland, Baltimore Valve translocation device and method for the treatment of functional valve regurgitation
US11259926B2 (en) 2017-08-26 2022-03-01 Transmural Systems Llc Cardiac annuloplasty and pacing procedures, related devices and methods
US11980545B2 (en) 2016-05-06 2024-05-14 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US12048624B2 (en) 2019-07-15 2024-07-30 Evalve, Inc. Independent proximal element actuation methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050021057A1 (en) * 1999-04-09 2005-01-27 Evalve, Inc. Leaflet structuring
US20050080454A1 (en) * 2003-10-08 2005-04-14 Drews Michael J. Attachment device and methods of using the same
US20060247492A1 (en) * 2000-10-25 2006-11-02 Streeter Richard B Mitral shield

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050021057A1 (en) * 1999-04-09 2005-01-27 Evalve, Inc. Leaflet structuring
US20060247492A1 (en) * 2000-10-25 2006-11-02 Streeter Richard B Mitral shield
US20050080454A1 (en) * 2003-10-08 2005-04-14 Drews Michael J. Attachment device and methods of using the same

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011033508A1 (fr) * 2009-09-15 2011-03-24 Transcardia Ltd. Remodelage de valvules cardiaques
WO2012143913A3 (fr) * 2011-04-21 2012-12-13 Novogate Medical Ltd Dispositif de fermeture de tissu et procédé de distribution et utilisations de celui-ci
US10624640B2 (en) 2011-09-13 2020-04-21 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
JP2019115753A (ja) * 2011-09-13 2019-07-18 アボット カーディオバスキュラー システムズ インコーポレイテッド 組織近置システム用のグリッパ型プッシャ
JP2018020199A (ja) * 2011-09-13 2018-02-08 アボット、カーディオバスキュラー、システムズ、インコーポレーテッドＡｂｂｏｔｔ Ｃａｒｄｉｏｖａｓｃｕｌａｒ Ｓｙｓｔｅｍｓ Ｉｎｃ． 組織近置システム用のグリッパ型プッシャ
US12016561B2 (en) 2011-09-13 2024-06-25 Abbott Cardiovascular Systems Inc. System for fixation of leaflets of a heart valve
US10792039B2 (en) 2011-09-13 2020-10-06 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US10743876B2 (en) 2011-09-13 2020-08-18 Abbott Cardiovascular Systems Inc. System for fixation of leaflets of a heart valve
EP2914182A4 (fr) * 2012-11-03 2017-06-28 Novogate Medical Ltd. Système de pose par voie intercostale et méthodes associées
EP2995279A4 (fr) * 2013-05-06 2017-01-18 Pusan National University Industry - University Cooperation Foundation Dispositif de fixation de valvule cardiaque
CN105228556A (zh) * 2013-05-06 2016-01-06 釜山大学校产学协力团 心脏瓣膜固定装置
KR101589903B1 (ko) * 2013-07-11 2016-01-29 주식회사 코스와이어 승모판막 서클라지 시술용 서클라지 로프
KR20150007557A (ko) * 2013-07-11 2015-01-21 주식회사 코스와이어 승모판막 서클라지 시술용 서클라지 로프
WO2015005690A1 (fr) * 2013-07-11 2015-01-15 주식회사 코스와이어 Cordon de cerclage pour annuloplastie à cerclage de valve mitrale
KR101581025B1 (ko) 2014-06-16 2015-12-29 (주) 타우피엔유메디칼 아치형 관상동맥 보호구가 일체화된 승모판막 서클라지 시술용 서클라지 로프
CN106413573A (zh) * 2014-06-16 2017-02-15 TauPNU医疗有限公司 与拱形冠状动脉保护器一体成型的用于二尖瓣环扎手术的环扎绳
KR20150143992A (ko) * 2014-06-16 2015-12-24 (주) 타우피엔유메디칼 아치형 관상동맥 보호구가 일체화된 승모판막 서클라지 시술용 서클라지 로프
WO2015194754A1 (fr) * 2014-06-16 2015-12-23 (주)타우피엔유메디칼 Cordon de cerclage pour procédure de cerclage de valve mitrale ayant un protecteur d'artère coronaire arqué formé de façon intégrée à celui-ci
US10433962B2 (en) 2016-05-06 2019-10-08 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11007059B2 (en) 2016-05-06 2021-05-18 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11039923B2 (en) 2016-05-06 2021-06-22 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11980545B2 (en) 2016-05-06 2024-05-14 Transmural Systems Llc Annuloplasty procedures, related devices and methods
US11259926B2 (en) 2017-08-26 2022-03-01 Transmural Systems Llc Cardiac annuloplasty and pacing procedures, related devices and methods
US11259925B2 (en) 2019-05-02 2022-03-01 University Of Maryland, Baltimore Valve translocation device and method for the treatment of functional valve regurgitation
US12048624B2 (en) 2019-07-15 2024-07-30 Evalve, Inc. Independent proximal element actuation methods

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