WO2008088033A1 - Hiv-protease inhibitor and method for production thereof - Google Patents

Hiv-protease inhibitor and method for production thereof Download PDF

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Publication number
WO2008088033A1
WO2008088033A1 PCT/JP2008/050564 JP2008050564W WO2008088033A1 WO 2008088033 A1 WO2008088033 A1 WO 2008088033A1 JP 2008050564 W JP2008050564 W JP 2008050564W WO 2008088033 A1 WO2008088033 A1 WO 2008088033A1
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
culture
protease inhibitor
mushroom fungus
culturing
Prior art date
Application number
PCT/JP2008/050564
Other languages
French (fr)
Japanese (ja)
Inventor
Sueo Wada
Original Assignee
Sueo Wada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sueo Wada filed Critical Sueo Wada
Publication of WO2008088033A1 publication Critical patent/WO2008088033A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Disclosed are: a novel HIV-protease inhibitor; and a method for producing the HIV-protease inhibitor. An extract having an HIV-protease inhibitory activity can be produced by a method comprising: a first fermentation step for seeding and culturing a lactic acid bacterium and a bacterium Bacillus subtilis in a culture medium; a mushroom fungus culture step for seeding and culturing a mushroom fungus in the culture medium after the first fermentation step; a second fermentation step for adding a Koji mold and water to the mushroom fungus culture produced in the mushroom fungus culture step and culturing the resulting culture; and a solid-liquid separation step for solid-liquid-separating the culture produced in the second fermentation step.
PCT/JP2008/050564 2007-01-19 2008-01-18 Hiv-protease inhibitor and method for production thereof WO2008088033A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007009794A JP2010090030A (en) 2007-01-19 2007-01-19 Hiv-protease inhibitor and method for producing the same
JP2007-009794 2007-01-19

Publications (1)

Publication Number Publication Date
WO2008088033A1 true WO2008088033A1 (en) 2008-07-24

Family

ID=39636033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050564 WO2008088033A1 (en) 2007-01-19 2008-01-18 Hiv-protease inhibitor and method for production thereof

Country Status (2)

Country Link
JP (1) JP2010090030A (en)
WO (1) WO2008088033A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54160787A (en) * 1978-06-05 1979-12-19 Enzamin Kenkiyuushiyo Kk Production of beverage stock containing metabolism controlling factor within live body
JPH02237934A (en) * 1989-03-10 1990-09-20 Noda Shiyokukin Kogyo Kk Immunoactivating agent and production thereof
JPH11103665A (en) * 1997-10-07 1999-04-20 Bunzo Kobayashi Culture medium for culturing agaricus blazei murill and culture of agaricus blazei murill
JP2003210136A (en) * 2002-01-23 2003-07-29 Enzamin Kenkyusho:Kk Method for producing health nutritive food
JP2004057183A (en) * 2002-07-31 2004-02-26 Makoto Yafuji Method for producing agaric mushroom extract
JP3524145B2 (en) * 1994-03-17 2004-05-10 均 伊藤 Orally administered drug for improving AIDS symptoms
JP2004159655A (en) * 2002-10-25 2004-06-10 Oubiken:Kk Edible active oxygen removing composition and functional food product utilizing the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54160787A (en) * 1978-06-05 1979-12-19 Enzamin Kenkiyuushiyo Kk Production of beverage stock containing metabolism controlling factor within live body
JPH02237934A (en) * 1989-03-10 1990-09-20 Noda Shiyokukin Kogyo Kk Immunoactivating agent and production thereof
JP3524145B2 (en) * 1994-03-17 2004-05-10 均 伊藤 Orally administered drug for improving AIDS symptoms
JPH11103665A (en) * 1997-10-07 1999-04-20 Bunzo Kobayashi Culture medium for culturing agaricus blazei murill and culture of agaricus blazei murill
JP2003210136A (en) * 2002-01-23 2003-07-29 Enzamin Kenkyusho:Kk Method for producing health nutritive food
JP2004057183A (en) * 2002-07-31 2004-02-26 Makoto Yafuji Method for producing agaric mushroom extract
JP2004159655A (en) * 2002-10-25 2004-06-10 Oubiken:Kk Edible active oxygen removing composition and functional food product utilizing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EL-MEKKAWY S. ET AL.: "Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum", PHYTOCHEMISTRY, vol. 49, no. 6, 1998, pages 1651 - 1657, XP004321585, DOI: doi:10.1016/S0031-9422(98)00254-4 *
ICHIMURA T. ET AL.: "Inhibition of HIV-1 Protease by Water-Soluble Lignin-Like Substance from an Edible Mushroom, Fuscoporia obliqua", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 62, no. 3, 1998, pages 575 - 577 *

Also Published As

Publication number Publication date
JP2010090030A (en) 2010-04-22

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