WO2008086400A3 - Sirtuin-activating compounds of enhanced bioavailability - Google Patents

Sirtuin-activating compounds of enhanced bioavailability Download PDF

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Publication number
WO2008086400A3
WO2008086400A3 PCT/US2008/050588 US2008050588W WO2008086400A3 WO 2008086400 A3 WO2008086400 A3 WO 2008086400A3 US 2008050588 W US2008050588 W US 2008050588W WO 2008086400 A3 WO2008086400 A3 WO 2008086400A3
Authority
WO
WIPO (PCT)
Prior art keywords
solubility
sac
sirtuin
organic material
solvent
Prior art date
Application number
PCT/US2008/050588
Other languages
French (fr)
Other versions
WO2008086400A2 (en
Inventor
John Alfred Doney
Original Assignee
Isp Investments Inc
John Alfred Doney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isp Investments Inc, John Alfred Doney filed Critical Isp Investments Inc
Publication of WO2008086400A2 publication Critical patent/WO2008086400A2/en
Publication of WO2008086400A3 publication Critical patent/WO2008086400A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Abstract

Sirtuin-activating compounds (SACs) of enhanced solubility and bioavailability are described that contain at least one SAC with at least one solubility-enhancing organic material (solubility-enhancing organic material). Described methods to produce the bioenhanced products include dry blending and solvent spray drying. In one embodiment the solubility-enhancing organic material is polymeric. In accordance with certain embodiments of the invention, the method includes the steps of providing a mixture comprising at least one SAC, a solubility-enhancing polymer and a solvent and removing the solvent to form amorphous SAC. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.
PCT/US2008/050588 2007-01-09 2008-01-09 Sirtuin-activating compounds of enhanced bioavailability WO2008086400A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87946407P 2007-01-09 2007-01-09
US60/879,464 2007-01-09

Publications (2)

Publication Number Publication Date
WO2008086400A2 WO2008086400A2 (en) 2008-07-17
WO2008086400A3 true WO2008086400A3 (en) 2008-12-31

Family

ID=39310011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/050588 WO2008086400A2 (en) 2007-01-09 2008-01-09 Sirtuin-activating compounds of enhanced bioavailability

Country Status (1)

Country Link
WO (1) WO2008086400A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010077642A1 (en) 2008-12-08 2010-07-08 Northwestern University Method of modulating hsf-1
WO2010102245A1 (en) * 2009-03-05 2010-09-10 Upsher-Smith Laboratories, Inc. Solid dispersion comprising resveratrol
CN103751156B (en) * 2009-04-03 2015-07-22 森永制果株式会社 Piceatannol-containing composition, and drinking food and cosmetics containing piceatannol-containing composition
WO2010113315A1 (en) 2009-04-03 2010-10-07 森永製菓株式会社 Piceatannol-containing composition and method of producing piceatannol-containing composition
CN102552208B (en) * 2011-12-29 2013-08-21 浙江现代中药与天然药物研究院有限公司 Daidzein solid dispersion micro-pill capsule and preparation method thereof
EP4228600A2 (en) * 2020-10-16 2023-08-23 Humanetics Corporation Solid dispersion genistein compositions and methods of making and using the same
CN114869853A (en) * 2022-05-25 2022-08-09 济宁医学院 Naringenin solid dispersion and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049851A1 (en) * 1998-04-01 1999-10-07 Bioresponse, L.L.C. Compositions and methods of adjusting steroid hormone metabolism through facilitated absorption of hydrophobic dietary compounds
WO2003099040A1 (en) * 2002-05-27 2003-12-04 Advance Holdings Limited Dietary supplements from wine vinasses and relevant production process
WO2006085089A1 (en) * 2005-02-10 2006-08-17 Pharmaterials Limited Solid dispersion of hydrophobic bioactive

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049851A1 (en) * 1998-04-01 1999-10-07 Bioresponse, L.L.C. Compositions and methods of adjusting steroid hormone metabolism through facilitated absorption of hydrophobic dietary compounds
WO2003099040A1 (en) * 2002-05-27 2003-12-04 Advance Holdings Limited Dietary supplements from wine vinasses and relevant production process
WO2006085089A1 (en) * 2005-02-10 2006-08-17 Pharmaterials Limited Solid dispersion of hydrophobic bioactive

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAYAGAM VASANTHA M ET AL: "SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents", JOURNAL OF BIOMOLECULAR SCREENING, LARCHMONT, NY, US, vol. 11, no. 8, 1 December 2006 (2006-12-01), pages 959 - 967, XP009091509, ISSN: 1087-0571 *

Also Published As

Publication number Publication date
WO2008086400A2 (en) 2008-07-17

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