CN103751156B - Piceatannol-containing composition, and drinking food and cosmetics containing piceatannol-containing composition - Google Patents
Piceatannol-containing composition, and drinking food and cosmetics containing piceatannol-containing composition Download PDFInfo
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Abstract
A purpose of the present invention is to provide a high piceatannol content piceatannol-containing composition derived from natural materials, and a preparation method thereof. According to the present invention, the piceatannol-containing composition containing 0.0001-99.9% by mass of piceatannol is extracted from passion fruit seeds; and during extraction of the piceatannol, after the passion fruit seeds are crushed, at least a solvent selected from a water-containing alcohol solvent or a water-containing ketone solvent is added to stir, the piceatannol is extracted from the passion fruit seeds contained in the solvent, and stage extraction is performed by preferentially using the two solvents such as the water-containing alcohol solvent and the water-containing ketone solvent.
Description
Technical field
The present invention relates to a kind of containing piceatannol compositions and containing the drink foods and cosmetics of piceatannol compositions containing this containing piceatannol from passionfruit (passion fruit) seed.
Background technology
In following non-patent literature 1, describe and from the polyphenol compound resveratrol (Resveratrol) of Fructus Vitis viniferae and piceatannol (Piceatannol), there is check melanin cellulation and generate melanic effect.But the validation test of its action effect uses commercially available reagent, and the compositions obtained containing piceatannol etc. from the natural goodses such as Fructus Vitis viniferae is not recorded.
In addition, the concentration and recovery carrying out selective and effective resveratrol from the extract of Rhizoma Polygoni Cuspidati (Reynoutria japonicaHoutt.var.japnica) root is at an easy rate described in following patent documentation 1; The Pericarpium Citri tangerinae extract containing resveratrol is described in following patent documentation 2; Describe the extract of the peel of the extract, particularly passionfruit of passionfruit (Passifloraceae, passiflora sp.) in following patent documentation 3,4, and describe its extract in food, dietary supplement and use medically.
But the technology of above-mentioned document is all the compositions obtained from natural goods, the material containing higher piceatannol can not be provided.
Look-ahead technique document
Patent documentation
Patent documentation 1: Japanese Unexamined Patent Publication 2005 ?No. 281179 publications
Patent documentation 2: Japanese Unexamined Patent Publication 2009 ?No. 13159 publications
Patent documentation 3: Japanese Unexamined Patent Publication 2007 ?No. 302659 publications
Patent documentation 4: Japanese Patent announce 2007 ?No. 531734 publications
Non-patent literature
Non-patent literature 1:Takako Yokozawa and You Jung Kim, PiceatannolInhibits Melanogenesis by Its Antioxidative Actions, Biological & PharmaceuticaI Bulletin Vol.30 (2007) No.11p2007 ?2011
From the general concept of related food safety, be added on the piceatannol in the diet such as functional food and health food product, preferably from natural goods.But, to live the natural goods that we do not find to contain abundant piceatannol, in addition, from the natural goodses such as Fructus Vitis viniferae, the low-down compositions of amount only can be obtained.
Therefore, the object of the invention is to, provide a kind of from natural goods, containing higher piceatannol containing piceatannol compositions and containing this drink foods and cosmetics containing piceatannol compositions.
Summary of the invention
The present inventor, for achieving the above object, through studying with keen determination, finding containing abundant piceatannol in the past in the passionfruit seed gone out of use because having no purposes, thus completing the present invention.
That is, of the present invention is obtain from passionfruit seed containing piceatannol compositions, and the amount that it is characterized in that being greater than 10 to 99.9 quality % contains piceatannol.
By of the present invention containing piceatannol compositions, can provide from natural goods, the compositions that contains piceatannol with higher amount.And, owing to being the compositions from natural goods, thus can use it in the diet product of cosmetics, pharmaceuticals and functional food, health food etc.
In addition, the feature of the preparation method containing piceatannol compositions of the present invention is, after passionfruit seed is pulverized, add at least one solvent selected from aqueous alcohol system solvent and moisture ketone system solvent and stir, from the passionfruit seed that this solvent contains, extract piceatannol.
By the preparation method containing piceatannol compositions of the present invention, when extracting piceatannol from passionfruit seed, owing to using aqueous alcohol system solvent or moisture ketone system solvent, thus can with the preparation of higher production rate from natural goods, the compositions that contains piceatannol with higher amount.
Of the present invention containing in the preparation method of piceatannol compositions, after passionfruit seed is pulverized, any one solvent added in aqueous alcohol system solvent and moisture ketone system solvent stirs, from the passionfruit seed that this solvent contains, extract piceatannol obtain the 1st extract, again in the residue do not reclaimed as described extract, the above-mentioned unselected solvent added in aqueous alcohol system solvent and moisture ketone system solvent stirs, from the passionfruit seed that this solvent contains, extract piceatannol obtain the 2nd extract, subsequently by described 1st extract and the mixing of the 2nd extract.In this way, use multiple solvent to carry out interim extraction, thus can with the preparation of higher production rate containing a large amount of piceatannol containing piceatannol compositions.
In the preparation method containing piceatannol compositions of the present invention, described passionfruit seed preferably the life of passionfruit seed or by the seed after the seed drying of the life of passionfruit.
In addition, of the present invention containing in the preparation method of piceatannol compositions, described aqueous alcohol system solvent is preferably aquiferous ethanol, or described moisture ketone system solvent is preferably aqueous acetone.About its moisture content, aquiferous ethanol is preferably the ethanol containing 20 ~ 99.9 volume %; Aqueous acetone is preferably the acetone containing 20 ~ 99.9 volume %.By such form, the extraction efficiency of piceatannol can be improved.
Of the present invention containing in the preparation method of piceatannol compositions, described stirring in each solvent, preferably carries out with ultrasound wave vibration or vibration.By this form, the extraction efficiency of piceatannol can be improved.
In addition, of the present invention containing in the preparation method of piceatannol compositions, after extraction, preferably by distilling under reduced pressure, solvent is removed.
In addition, the invention still further relates to a kind of diet product, wherein with the addition of obtain from passionfruit seed, to contain piceatannol with the amount of 0.0001 ~ 99.9 quality % containing piceatannol compositions.
In addition, the invention still further relates to a kind of cosmetics, wherein with the addition of obtain from passionfruit seed, to contain piceatannol with the amount being greater than 10 to 99.9 quality % containing piceatannol compositions.
By of the present invention containing piceatannol compositions, can provide from natural goods, the compositions that contains piceatannol with higher amount.And, owing to being the compositions from natural goods, thus can be applied in cosmetics, pharmaceuticals and the diet such as functional food, health food product.In addition, by the preparation method containing piceatannol compositions of the present invention, as the solvent extracting piceatannol from passionfruit seed, use aqueous alcohol system solvent or moisture ketone system solvent, thus can with the preparation of higher production rate from natural goods, compositions containing a large amount of piceatannol.In addition, interim extraction can be carried out by the multiple solvent belonging to aqueous alcohol system solvent or moisture ketone system solvent, thus be prepared with higher production rate.
Accompanying drawing explanation
Fig. 1 is the chart of the HPLC chromatograph representing the extract extracted from seed (A) peel (B) and sarcocarp (C);
Fig. 2 is the MS spectrogram (A) of composition and the chart of UV spectrogram (B) that represent stripping near 41 points in the HPLC of Fig. 1 analyzes;
Fig. 3 represents the MS spectrogram (A) of resveratrol (Resveratrol, molecular weight 228) and the chart of UV spectrogram (B);
Fig. 4 represents the MS spectrogram (A) of piceatannol (Piceatannol, molecular weight 244) and the chart of UV spectrogram (B);
Fig. 5 represents that the moisture content of ethanol (A) or acetone (B) is on the chart of the impact of the extraction efficiency of piceatannol.
Detailed description of the invention
Of the present invention is the compositions obtained from passionfruit seed containing piceatannol compositions, contains piceatannol with the amount of 0.0001 ~ 99.9 quality %.Its shape can be aqueous, solid fraction, half solid fraction, gel etc., and in addition, passionfruit seed can be the seeds processing thing of this seed itself and the pastel after being pulverized by seed or the powder after seed lyophilizing being pulverized etc.The solid-state conversion amount of piceatannol, can be 0.0001 ~ 99.9 quality %, more preferably 0.01 ~ 50 quality %, it would be desirable 0.1 ~ 10 quality %.
Piceatannol (Piceatannol) is expressed with following chemical formula (1).
[changing 1]
The piceatannol that upper art chemical formula is expressed, it is the structure that 2 phenyl connect with trans thiazolinyl, it is trans piceatannol, but in the present invention, the concept of piceatannol (Piceatannol) is the cis piceatannol also comprising the structure that 2 phenyl connect with the thiazolinyl of cis in above-mentioned chemical formula.
Passionfruit is the plant of Passifloraceae Passiflora, another name: Passiflora edulis sims, and fruit sweet and sour taste, can be used as fruit and directly eat, and also its squeezing juice can be drunk, or is added in the diet such as fruit jelly, cake product and increases taste.The seed of passionfruit is comparatively hard, needs it to remove from fruit when squeezing juice etc., even if together added in diet by the seed of fruit, also can be difficult to digestion because its crust is really up to the mark and directly be drained.The present invention is finding the invention on the basis containing abundant piceatannol in the past in the passionfruit seed gone out of use because having no purposes.In addition, the passionfruit seed used in the present invention, can be proved by the experience of edible passionfruit in the past, even if be added in the diet such as functional food and health food product, also can not there is the problem of safety.
Of the present invention containing piceatannol compositions, preferably by after such as life or dried passionfruit seed pulverizing, the method using Different solution to carry out extracting obtains.In order to improve extraction efficiency, extract again after also suitably can implementing acid or the chemical treatment such as caustic digestion, enzyme decomposition to passionfruit seed.In addition, by the preparation method containing piceatannol compositions of the present invention of following explanation, can obtain with higher production rate the compositions containing a large amount of piceatannol, therefore preferably use the method to obtain.
Below the preparation method containing piceatannol compositions of the present invention is described.
Of the present invention containing in the preparation method of piceatannol compositions, first passionfruit seed is pulverized.Passionfruit seed can use raw or dried passionfruit seed, in order to improve extraction efficiency, extracts after also suitably can implementing acid or the chemical treatment such as caustic digestion, enzyme decomposition to passionfruit seed again.Pulverization process can use general pulverizer to carry out.In addition, because in passionfruit seed, oil content is more, may be in the pasty state after pulverizing.
Subsequently, add at least one solvent selected from aqueous alcohol system solvent and moisture ketone system solvent in passionfruit seed after being pulverized and stir, from this solvent, extract piceatannol.
Aqueous alcohol system solvent can use the aqueous vehicle such as ethanol, methanol, propanol, wherein preferably uses aquiferous ethanol.In addition, moisture ketone system solvent can use the aqueous vehicle such as acetone, butanone, diethyl ketone, chlroacetone, wherein preferably uses aqueous acetone.
About its moisture content, aquiferous ethanol for comprising the ethanol of 20 ~ 99.9 volume %, more preferably can comprise the ethanol of 40 ~ 99.9 volume %, it would be desirable the ethanol comprising 60 ~ 80 volume %; Aqueous acetone for comprising the acetone of 20 ~ 99.9 volume %, more preferably can comprise the acetone of 40 ~ 99.9 volume %, it would be desirable the acetone comprising 60 ~ 80 volume %.If exceed above-mentioned scope, extraction efficiency may be caused to decline.In addition, in order to the statement of the moisture content of aqueous vehicle is simplified, below the 80 volume % ethanol of such as moisture 20 volume % are expressed as " 80% aquiferous ethanol ", the 70 volume % ethanol of such as moisture 30 volume % are expressed as " 70% aquiferous ethanol ", more such as the 70 volume % acetone of moisture 30 volume % are expressed as " 70% aqueous acetone ".
Of the present invention containing in the preparation method of piceatannol compositions, the stirring in above-mentioned each solvent, preferably uses ultrasound wave vibration or vibration to carry out.Can allow like this and to have pulverized and the passionfruit seed contacted with above-mentioned each solvent effectively vibrates, thus the extraction efficiency extracting piceatannol from passionfruit seed to above-mentioned each solvent can be improved.Ultrasound wave vibration can use general ultrasonic unit to carry out.In addition, vibration also can use general oscillation device to carry out.
In addition, of the present invention containing in the preparation method of piceatannol compositions, after extraction, distillation under vacuum is preferably used to remove above-mentioned solvent.Would not organic solvent be comprised in such compositions, as the food material added in the diet such as functional food and health food product, the standard etc. of its safety can be met.
Of the present invention containing in the preparation method of piceatannol compositions, interim extraction can be carried out by multiple solvent.Like this can with the preparation of higher production rate containing a large amount of piceatannol containing piceatannol compositions.
Specifically, such as, after being pulverized by passionfruit seed, any one solvent added in described aqueous alcohol system solvent and described moisture ketone system solvent stirs, and extracts piceatannol and obtain the 1st extract from this solvent.By the mode such as centrifugal using extract be not separated by the residue reclaimed as extract, in residue, add non-selected another kind of solvent in described solvent stir, from this solvent, extract piceatannol obtain the 2nd extract.Subsequently by described 1st extract and the mixing of the 2nd extract.Certainly, the 2nd extract also can utilize as the extract of passionfruit seed separately.
In addition, passionfruit seed is owing to receiving the 1st extraction process by described aqueous alcohol system solvent or described moisture ketone system solvent, the characteristic of its structure etc. becomes more suitable because of extraction, so when ensuing 2nd extraction process, no matter use described aqueous alcohol system solvent or described moisture ketone system solvent or use other solvent in addition, all can expect that its extraction efficiency improves.And, as as described in embodiment described later, the extraction efficiency of described aqueous alcohol system solvent or described moisture ketone system solvent is moisture based on it, so after carrying out the 1st extraction process with water or aqueous media to passionfruit seed, when ensuing 2nd extraction process, no matter use described aqueous alcohol system solvent or described moisture ketone system solvent or use other solvent in addition, all can expect that its extraction efficiency improves.
The extract of the passionfruit seed obtained by said method, can directly or the liquid material concentrated as containing piceatannol compositions.Also by lyophilization or spraying dry by its powdered, using pulverous material as containing piceatannol compositions.In addition, the invention is not restricted to these forms.Insoluble matter contained in extract suitably can be removed by modes such as filtrations, also insoluble matter can be pulverized again, form minuteness particle shape.
In addition, for the first extract of the passionfruit seed obtained as stated above, can the methods such as ion exchange, size exclusion chromatography (SEC), HPLC method, gel filtration, membrance separation be passed through, piceatannol is carried out classification by index, refining after, it can be used as containing piceatannol compositions.
Specifically, such as, shown in enforcement described later, the compositions extracted from passionfruit seed is used HPLC method under the following conditions, piceatannol is dissolved near 41 points.In addition, carry out mass spectrum (mass spectrum) to this stripping part by quality analysis apparatus and measure, the signal of negative ion mode is m/z243.
[HPLC condition]
Post: Mightysil RP ?18GP150 ?4.6 footpath 4.6mm, long 150mm(Kanto Kagaku K. K.)
Column temperature: 40 DEG C
Leaching condition: flow velocity 1ml/min, 0% methanol → 30% methanol (60min)
UV detects: 280nm
Like this, in the present invention, with the physical property of the piceatannol of above-mentioned example for index carries out suitable classification, refining, thus can prepare improve the amount of piceatannol, from passionfruit seed containing piceatannol compositions.
Of the present invention containing piceatannol compositions, substrate or carrier that materia medica allows can be added as required, the form forming tablet, granule, powder, liquor, powder, granule, capsule, gluey agent etc. is used for medicine, in addition, the forms such as ointment, cream, gel, facial film, astringent, moisturizer can also be formed for cosmetics.
In addition, of the present invention containing piceatannol compositions, also can be added into specific food for health care, dietary supplement, functional food etc. for picked-up.Such food such as has the pastry food of chocolate, cookies, chewing gum, confection, cookie, fruit jelly, ship biscuit etc.; Cereals; The beverage of powder drink, refreshment drink, milk beverage, nutritious drink, soda pop, gel beverage etc.; The freezing point of ice cream, ice cream etc.In addition, the Noodles of Fagopyrum esculentum Moench, wheaten food, noodles, fine dried noodles etc. is also good example.In addition, specific food for health care and dietary supplement etc. can be the forms of powder, granule, capsule, syrup, tablet, sugar-coat agent etc.
Embodiment
Below by embodiment, the present invention is specifically described, but scope of the present invention is not limited with these embodiments.
< test example 1> [detection of the piceatannol in passionfruit and with fixed]
Passionfruit is divided into peel, sarcocarp, seed 3 positions, carries out lyophilization respectively, after pulverizing with pulverizer (trade name " samplemil pattern SK ?M ", Xie Li science and engineering Co., Ltd.), with 80% aquiferous ethanol, each position is extracted.Get the supernatant after the heart far away, after concentrated with vaporizer, carry out lyophilization and form powder.Extract is by water-soluble for this powder.Subsequently, the concentration that each is solid-state is diluted, and seed extract is diluted to 0.01g/ml, and peel extract or pulp extract are diluted to 0.1g/ml, and respectively gets 5 μ l and carry out HPLC analysis.
The analysis condition of HPLC is as follows:
Post: Mightysil RP ?18GP150 ?4.6 footpath 4.6mm, long 150mm(Kanto Kagaku K. K. system)
Column temperature: 40 DEG C
Leaching condition: flow velocity 1ml/min, 0% methanol → 30% methanol (60min)
UV detects: 280nm
The HPLC chromatograph of what Figure 1A ~ Fig. 1 C represented is above-mentioned each extract.As shown in Figure 1A, seed extract reaches peak to its result near 41 points.In contrast to this, the extract of peel and sarcocarp, although the solid-state concentration injected is 10 times of seed extract, peak unconfirmed near 41 points.
Next, the composition of seed extract stripping near the above-mentioned retention time 41 points is what material carries out following same fixed.
First, HPLC/ quality analysis apparatus (THERMO ELECTRON Co., Ltd. system, device name " Thermo ?LCQ ?MS/MS ") is used to measure its mass spectrum (Fig. 2 A).Confirmed by anode, negative electrode two kinds of ion modes, found good ion at negative electrode, so use its data.Consequently, main signal m/z243 is (M ?H)
?, other peak m/z279 belongs to (M+2H
2o ?H)
?, m/z487 belongs to (M × 2 ?H)
?.Therefore determining molecular weight is 244.In addition, get UV spectrum, as λ max, observe 220nm, 304nm, 322nm(Fig. 2 B).
The result of these mass spectrums and UV spectrum, with the polyphenol contained by peanut skin---resveratrol (Resveratrol, molecular weight 228) similar (with reference to Fig. 3 A, B).In addition, the absorption of the resin polyvinylpyrrolidone (PVPP:polyvinylpolypyrrolidone) to adsorbing polyphenols is also confirmed separately.In addition, the peak near above-mentioned 41 points is compared with the retention time of the resveratrol under identical HPLC condition, and the retention time to reversed-phase column is shorter.In sum, the composition of above-mentioned seed extract stripping near the retention time 41 points, be the hydroxyl of 1 molecular weight larger than resveratrol, the piceatannol (Piceatannol, molecular weight 244) shown in following formula (1).
[changing 2]
Therefore, under condition same as described above, HPLC analysis has been carried out to the pure compound (SIGMA Inc.) of piceatannol, again obtained mass spectrum and UV spectrum (Fig. 4 A, B).Consequently, the retention time of HPLC and the ownership of mass spectrum and UV spectrum completely the same.
Can confirm thus, the peak near in above-mentioned HPLC analyzes 41 points of above-mentioned seed extract is the peak of piceatannol, containing a large amount of piceatannols in the seed of passionfruit.In addition, piceatannol is not detected in the peel of passionfruit and sarcocarp.
< test example 2> [extracting piceatannol 1 from passionfruit seed]
We are studied the method extracting piceatannol from passionfruit seed.Specifically use different solvents, the efficiency extracting piceatannol in the seed from domestic product and the external 2 kinds of passionfruits produced is confirmed.
(1) extraction of 80% aquiferous ethanol is used
In the seed that 5g pulverizes, add 80% aquiferous ethanol 50ml, extract while ultrasound wave vibration in 30 minutes.After reclaiming its supernatant, repeat 2 same operations, carry out 3 times altogether and extract.Subsequently the extracting solution of recovery is concentrated, the extracting solution of acquisition is settled to 200ml with 80% aquiferous ethanol, its 10 μ l is carried out HPLC analysis.Subsequently, by common method, under the peak that HPLC analyzes area, it can be used as the slotted line of standard concentration, thus the amount of piceatannol contained in extract is carried out quantitatively.In addition, in order to carry out reference, quantitative too to resveratrol.
(2) extraction of 70% aqueous acetone is used
In extraction residue after above-mentioned use 80% aquiferous ethanol extracts, add 70% aqueous acetone 50ml, extract while ultrasound wave vibration in 30 minutes.After reclaiming its supernatant, repeat 2 same operations, carry out 3 times altogether and extract.Subsequently the extracting solution of recovery is concentrated, the extracting solution of acquisition is settled to 200ml with 70% aqueous acetone, as described above, the amount of piceatannol contained in extract and resveratrol is carried out quantitatively.
(3) extraction of ethyl acetate is used
Solvent is replaced by ethyl acetate, same with the extraction of above-mentioned use 80% aquiferous ethanol, the seed of passionfruit (above-mentioned outer domestic) is extracted, the amount of the piceatannol extracted from the 5g seed powder after lyophilization and resveratrol is carried out quantitatively.
(4) extraction of dichloromethane (dichloromethane) is used
Solvent is replaced by dichloromethane, same with the extraction of above-mentioned use 80% aquiferous ethanol, the seed of passionfruit (above-mentioned outer domestic) is extracted, the amount of the piceatannol extracted from the 5g seed powder after lyophilization and resveratrol is carried out quantitatively.
After result is arranged as described in Table 1.In addition, in this table 1, the result of extraction efficiency is scaled the amount of piceatannol extracted from the 100g seed powder after lyophilization or the amount of resveratrol carries out representing.
[table 1]
As shown in table 1, even if in the extraction residue after use 80% aquiferous ethanol extracts, compared with the extraction of use 80% aquiferous ethanol, be still extracted more piceatannol.In addition, the extraction efficiency being used alone ethyl acetate is lower, is used alone dichloromethane when extracting, fails to detect piceatannol and resveratrol.It can thus be appreciated that the efficiency that use 70 is carried out extracting containing acetone is best.Can also know in addition, by the extraction of use 80 aquiferous ethanol and the extraction of 70% aqueous acetone and use, better extraction efficiency can be obtained.
< test example 3> [extracting piceatannol 2 from passionfruit seed]
We have carried out further research to the method extracting piceatannol from passionfruit seed.Specifically on as the ethanol of solvent and the moisture content of acetone, the impact on extraction efficiency confirms.
For this reason, we use the ethanol of different water cut or acetone as solvent, same with above-mentioned test example 2, carry out quantitatively the amount of the piceatannol extracted from the 5g seed powder after passionfruit (above-mentioned outer domestic) lyophilization and resveratrol.In addition, the solvent ethyl acetate used in above-mentioned test example 2 and dichloromethane, because the intermiscibility of itself and water is lower, all fail to modulate the solvent of same moisture content.
After result is arranged as described in Table 1.In addition, in Figure 5, the result of piceatannol is organized into chart.In addition, in this table 2 and Fig. 5, the result of extraction efficiency is all be scaled the amount of piceatannol extracted from the every 100g seed powder after lyophilization or the amount of resveratrol carries out representing.
[table 2]
*: countless certificate
As shown in table 2, Fig. 5, when using ethanol, use the extraction of 80% aquiferous ethanol the most effective.In addition, when using acetone, use the extraction of 70% aqueous acetone the most effective.
< test example 4>
Weigh the extract (from above-mentioned outer domestic) remove solvent in above-mentioned test example 2 after, calculate solid-state piceatannol content.Its value is as shown in table 3.
[table 3]
| Extract solvent | 80% aquiferous ethanol | 70% aqueous acetone |
| Piceatannol content (quality %) in the solid portion of extracting solution | 2.6 | 3.7 |
As shown in table 3, when using 80% aquiferous ethanol to extract, the solid portion concentration of piceatannol is 2.6mg/100mg extract (2.6 quality %).In addition, when using 70% aqueous acetone to extract after use 80% aquiferous ethanol extracts, be 3.7mg/100mg extract (3.7 quality %).Therefore, use 70% aqueous acetone to extract and can obtain more piceatannol (as shown in test example 2,3), meanwhile, the purity of piceatannol is also higher.
Claims (4)
1. a purposes for passionfruit seed, is characterized in that:
This passionfruit seed obtains for the manufacture of from passionfruit seed, with the amount of 0.0001 ~ 99.9 quality % contain piceatannol containing piceatannol compositions.
2. a purposes for passionfruit seed, is characterized in that:
This passionfruit seed for the manufacture of containing containing the diet product of piceatannol compositions,
Wherein, the described piceatannol compositions that contains contains piceatannol with the amount of 0.0001 ~ 99.9 quality %.
3. a purposes for passionfruit seed, is characterized in that:
This passionfruit seed for the manufacture of containing containing the cosmetics of piceatannol compositions,
Wherein, the described piceatannol compositions that contains contains piceatannol with the amount of 0.0001 ~ 99.9 quality %.
4. the purposes of passionfruit seed for originating as piceatannol.
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| CN110734361A (en) * | 2019-09-29 | 2020-01-31 | 钟华 | Preparation method and application of piceatannol |
| CN111763141A (en) * | 2020-07-07 | 2020-10-13 | 昆明翔昊科技有限公司 | Method for extracting piceatannol from rhubarb medicinal materials, microcapsule molecule embedding method and application of microcapsule molecule embedding method in food and health care products |
| CN111704530A (en) * | 2020-07-07 | 2020-09-25 | 昆明翔昊科技有限公司 | Method for extracting piceatannol from rheum officinale, microcapsule molecule embedding method and application of piceatannol in cosmetics |
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| WO2008086400A2 (en) * | 2007-01-09 | 2008-07-17 | Isp Investments Inc. | Sirtuin-activating compounds of enhanced bioavailability |
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