WO2008079328A3 - Omega-5-fatty acids useful in lipoxygenase 5 inhibition and in the treatment of cancer - Google Patents

Omega-5-fatty acids useful in lipoxygenase 5 inhibition and in the treatment of cancer Download PDF

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Publication number
WO2008079328A3
WO2008079328A3 PCT/US2007/026152 US2007026152W WO2008079328A3 WO 2008079328 A3 WO2008079328 A3 WO 2008079328A3 US 2007026152 W US2007026152 W US 2007026152W WO 2008079328 A3 WO2008079328 A3 WO 2008079328A3
Authority
WO
WIPO (PCT)
Prior art keywords
cooh
fatty acids
omega
lipoxygenase
inhibition
Prior art date
Application number
PCT/US2007/026152
Other languages
French (fr)
Other versions
WO2008079328A2 (en
Inventor
Thomas E Adrian
Richard F Murphy
Original Assignee
Univ Creighton
Thomas E Adrian
Richard F Murphy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Creighton, Thomas E Adrian, Richard F Murphy filed Critical Univ Creighton
Publication of WO2008079328A2 publication Critical patent/WO2008079328A2/en
Publication of WO2008079328A3 publication Critical patent/WO2008079328A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic

Abstract

Disclosed are omega-5 fatty acids having one of the following formulae: CH3- (CH2) 3-CH=CH- (CH2) 9-COOH, CH3- (CH2) 3-CH=CH- (CH2) 11-COOH, CH3- (CH2) 3-CH=CH- (CH2) 13-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH- (CH2) 6-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH- (CH2) 8-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH- (CH2) 10-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH-CH2-CH=CH- (CH2) 5-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH-CH2-CH=CH- (CH2) 7-COOH, and CH3- (CH2)3-CH=CH-CH2-CH=CH-CH2-CH=CH-CH2-CH=CH- (CH2)4-COOH and pharmaceutically acceptable esters, salts, amides, and solvates thereof, as well as pharmaceutical compositions which include one or more of aforementioned omega-5 fatty acids and pharmaceutically acceptable esters, salts/ amides, and solvates thereof. Also disclosed are methods of inhibiting 5 -lipoxygenase activity; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; and methods of treating adenocarcinoma in a subject using one or more of aforementioned omega-5 fatty acids and pharmaceutically acceptable esters, salts, amides, and solvates thereof.
PCT/US2007/026152 2006-12-22 2007-12-22 Omega-5-fatty acids useful in lipoxygenase 5 inhibition and in the treatment of cancer WO2008079328A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87671206P 2006-12-22 2006-12-22
US60/876,712 2006-12-22

Publications (2)

Publication Number Publication Date
WO2008079328A2 WO2008079328A2 (en) 2008-07-03
WO2008079328A3 true WO2008079328A3 (en) 2008-12-31

Family

ID=39563099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/026152 WO2008079328A2 (en) 2006-12-22 2007-12-22 Omega-5-fatty acids useful in lipoxygenase 5 inhibition and in the treatment of cancer

Country Status (1)

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WO (1) WO2008079328A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017223447A1 (en) 2016-06-23 2017-12-28 The Regents Of The University Of Michigan 12(s)-hydroxyeicosatrienoic acid compounds and their use as therapeutic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186989A1 (en) * 2000-01-31 2003-10-02 Anthony Marfat Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes
US20030235620A1 (en) * 2000-03-22 2003-12-25 Collin Peter D Compositions derived from modiolus modiolus and methods for making and using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186989A1 (en) * 2000-01-31 2003-10-02 Anthony Marfat Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes
US20030235620A1 (en) * 2000-03-22 2003-12-25 Collin Peter D Compositions derived from modiolus modiolus and methods for making and using same

Also Published As

Publication number Publication date
WO2008079328A2 (en) 2008-07-03

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