WO2008075376A8 - Formes polymorphes du bortézomibe et leur procédé de préparation - Google Patents

Formes polymorphes du bortézomibe et leur procédé de préparation Download PDF

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Publication number
WO2008075376A8
WO2008075376A8 PCT/IN2007/000561 IN2007000561W WO2008075376A8 WO 2008075376 A8 WO2008075376 A8 WO 2008075376A8 IN 2007000561 W IN2007000561 W IN 2007000561W WO 2008075376 A8 WO2008075376 A8 WO 2008075376A8
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WO
WIPO (PCT)
Prior art keywords
bortezomib
preparation
polymorphic forms
forms
novel
Prior art date
Application number
PCT/IN2007/000561
Other languages
English (en)
Other versions
WO2008075376A1 (fr
Inventor
Janaki Rama Rao Ravi
Muddasani Pulla Reddy
Bhujanga Rao Adibatla Kali Satya
Nannapaneni Venkaiah Chowdary
Original Assignee
Natco Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Limited filed Critical Natco Pharma Limited
Publication of WO2008075376A1 publication Critical patent/WO2008075376A1/fr
Publication of WO2008075376A8 publication Critical patent/WO2008075376A8/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur deux nouvelles formes polymorphes stables du bortézomibe (formes I et II) et sur leur procédé de préparation. Le bortézomibe (1) est un agent anti-néoplasique utilisé dans le traitement du myélome multiple.
PCT/IN2007/000561 2006-12-18 2007-12-03 Formes polymorphes du bortézomibe et leur procédé de préparation WO2008075376A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2348CH2006 2006-12-18
IN2348/CHE/2006 2006-12-18

Publications (2)

Publication Number Publication Date
WO2008075376A1 WO2008075376A1 (fr) 2008-06-26
WO2008075376A8 true WO2008075376A8 (fr) 2010-04-15

Family

ID=39327992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000561 WO2008075376A1 (fr) 2006-12-18 2007-12-03 Formes polymorphes du bortézomibe et leur procédé de préparation

Country Status (1)

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WO (1) WO2008075376A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010002836A (es) * 2007-09-12 2010-03-31 Reddys Lab Ltd Dr Bortezomib y proceso para la produccion del mismo.
WO2011099018A1 (fr) * 2010-02-15 2011-08-18 Hetero Research Foundation Polymorphes de bortézomib
WO2011107912A1 (fr) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Formes polymorphes de bortézomib
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
US9061037B2 (en) 2010-03-18 2015-06-23 Innopharma, Inc. Stable bortezomib formulations
WO2012047845A1 (fr) 2010-10-05 2012-04-12 App Pharmaceuticals Formulations de bortézomib stabilisées par de l'acide borique
US8497374B2 (en) 2011-05-12 2013-07-30 Scinopharm Taiwan, Ltd. Process for preparing and purifying bortezomib
CA2784240C (fr) 2012-03-27 2014-07-08 Innopharma, Inc. Formulations stables a base de bortezomib
AU2013346322B2 (en) * 2012-11-16 2016-11-10 Shilpa Medicare Limited Crystalline Bortezomib process
WO2014097306A1 (fr) 2012-12-21 2014-06-26 Natco Pharma Limited Forme polymorphe stable et pure du bortézomib
IN2013MU01431A (fr) * 2013-04-16 2015-06-26 Cipla Ltd
WO2015122702A1 (fr) * 2014-02-14 2015-08-20 Kyongbo Pharm. Co., Ltd. Nouvelle forme cristalline de bortézomib et procédé de préparation associé
WO2016085943A1 (fr) 2014-11-25 2016-06-02 Rastelli, Luca Utilisation d'inhibiteurs du système ubiquitine-protéasome pour le traitement de tumeurs associées à la neurofibromatose de type 2
EP3031811A1 (fr) 2014-12-09 2016-06-15 Teva Pharmaceuticals Ltd. Esters d'acide malique de bortézomib
CN110312727A (zh) * 2017-02-17 2019-10-08 费森尤斯卡比肿瘤学有限公司 一种改进的制备硼酸酯的方法
JP7263263B2 (ja) * 2018-02-01 2023-04-24 日本化薬株式会社 ボルテゾミブ結晶の製造方法
CN110642881A (zh) * 2019-10-18 2020-01-03 扬子江药业集团上海海尼药业有限公司 一种硼替佐米晶型m及其制备方法和用途
US11964993B2 (en) 2021-07-03 2024-04-23 Shilpa Pharma Lifesciences Limited Crystalline bortezomib process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65253B1 (sr) * 2004-03-30 2024-03-29 Millennium Pharm Inc Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline
WO2006101535A1 (fr) * 2005-03-23 2006-09-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inhibition de la fonction du proteasome pour renforcer l’activite proapoptotique et antitumorale des cytokines

Also Published As

Publication number Publication date
WO2008075376A1 (fr) 2008-06-26

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