WO2008075207A3 - Anti-infection augmentation foamable compositions and kit and uses thereof - Google Patents

Anti-infection augmentation foamable compositions and kit and uses thereof Download PDF

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Publication number
WO2008075207A3
WO2008075207A3 PCT/IB2007/004459 IB2007004459W WO2008075207A3 WO 2008075207 A3 WO2008075207 A3 WO 2008075207A3 IB 2007004459 W IB2007004459 W IB 2007004459W WO 2008075207 A3 WO2008075207 A3 WO 2008075207A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
infective
foamable
kit
foamable compositions
Prior art date
Application number
PCT/IB2007/004459
Other languages
French (fr)
Other versions
WO2008075207A2 (en
Inventor
Dov Tamarkin
Doron Friedman
Meir Eini
Original Assignee
Foamix Ltd
Dov Tamarkin
Doron Friedman
Meir Eini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/448,490 external-priority patent/US9211259B2/en
Application filed by Foamix Ltd, Dov Tamarkin, Doron Friedman, Meir Eini filed Critical Foamix Ltd
Publication of WO2008075207A2 publication Critical patent/WO2008075207A2/en
Publication of WO2008075207A3 publication Critical patent/WO2008075207A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti- infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
PCT/IB2007/004459 2006-04-04 2007-04-04 Anti-infection augmentation foamable compositions and kit and uses thereof WO2008075207A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US78918606P 2006-04-04 2006-04-04
US60/789,186 2006-04-04
US11/448,490 US9211259B2 (en) 2002-11-29 2006-06-07 Antibiotic kit and composition and uses thereof
US11/448,490 2006-06-07
US86162006P 2006-11-29 2006-11-29
US60/861,620 2006-11-29
US88043407P 2007-01-12 2007-01-12
US60/880,434 2007-01-12

Publications (2)

Publication Number Publication Date
WO2008075207A2 WO2008075207A2 (en) 2008-06-26
WO2008075207A3 true WO2008075207A3 (en) 2009-01-29

Family

ID=39536804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004459 WO2008075207A2 (en) 2006-04-04 2007-04-04 Anti-infection augmentation foamable compositions and kit and uses thereof

Country Status (1)

Country Link
WO (1) WO2008075207A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams

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US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US7399790B2 (en) 2001-02-28 2008-07-15 Konowalchuk Thomas W Virucidal compositions
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
WO2004064833A1 (en) 2003-01-24 2004-08-05 Connetics Australia Pty Ltd. Clindamycin phosphate foam
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
PL2005958T3 (en) 2006-03-08 2013-11-29 Nihon Nohyaku Co Ltd External pharmaceutical composition
AU2006339841B2 (en) 2006-03-08 2012-08-30 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
AU2007355106A1 (en) * 2006-11-29 2008-12-18 Foamix Ltd. Foamable waterless compositions with modulating agents
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
EP2191827B1 (en) 2007-09-05 2013-10-30 Pola Pharma Inc. Antifungal composition
KR20100068271A (en) 2007-09-05 2010-06-22 가부시키가이샤 폴라 파마 Antifungal pharmaceutical composition
DE102007044582A1 (en) * 2007-09-19 2009-04-09 Deckner, Peter G., Dr. med. Composition for wound treatment in the human area
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2010041141A2 (en) 2008-10-07 2010-04-15 Foamix Ltd. Oil-based foamable carriers and formulations
WO2009090495A2 (en) 2007-12-07 2009-07-23 Foamix Ltd. Oil and liquid silicone foamable carriers and formulations
US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
DK2400951T3 (en) 2009-02-25 2018-12-03 Mayne Pharma Llc TOPICAL FOAM COMPOSITION
CN102387785B (en) 2009-04-09 2017-08-25 宝丽制药股份有限公司 Antifungal medicine composition
US9050271B2 (en) 2009-04-09 2015-06-09 Pola Pharma Inc. Antimycotic pharmaceutical composition
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
CN102481286B (en) 2009-08-25 2014-02-26 宝丽制药股份有限公司 Antimycotic pharmaceutical composition
EP2482788B1 (en) 2009-10-02 2022-12-14 Journey Medical Corporation Topical tetracycline compositions
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
EP2371350B1 (en) 2010-03-04 2013-04-24 Neubourg Skin Care GmbH & Co. KG Foam formulas for treating animal skin illnesses
CN101926776B (en) * 2010-08-13 2012-07-18 清远容大生物工程有限公司 Salinomycin sodium suspension as well as preparation method and application thereof
GB2496656B (en) * 2011-11-18 2015-12-09 Lrc Products Film-Forming Formulation
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
WO2014121342A1 (en) * 2013-02-08 2014-08-14 Luoda Pharma Pty Limited Methods of treating topical microbial infections
EP2893929A1 (en) 2013-03-15 2015-07-15 Cubist Pharmaceuticals, Inc. Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140275000A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US9895311B2 (en) * 2014-09-25 2018-02-20 Pharmiva Ab Foam-forming compositions and methods for delivering an active to a body cavity
CA3035814A1 (en) * 2015-09-03 2017-03-09 Topical Remedy, Llc Topical antiviral compositions
MX2017011630A (en) 2016-09-08 2018-09-25 Foamix Pharmaceuticals Ltd Compositions and methods for treating rosacea and acne.
AU2018272880B2 (en) 2017-05-23 2024-02-29 Pharmiva Ab Foam-forming compositions for delivering an active to a body cavity
US11331288B2 (en) 2017-09-14 2022-05-17 The Board Of Trustees Of The Leland Stanford Junior University Conditioning irradiated tissue for increasing vascularity
US10993890B2 (en) 2018-03-15 2021-05-04 Pelli Skin Co., Llc Antifungal solution and foot wipe
WO2019232129A1 (en) * 2018-05-30 2019-12-05 The Board Of Regents Of The University Of Texas System Treatment of viral infections and virally associated lesions with sequiterpene lactones
WO2020089682A1 (en) * 2018-11-02 2020-05-07 Shunmugaperumal Tamilvanan An oil-less topical macroemulsion composition and process of preparation thereof
CN111494692B (en) * 2020-04-16 2021-07-20 北京机械设备研究所 Chlorine dioxide slow-release air purification device
US11547657B2 (en) * 2021-02-05 2023-01-10 Jo Ann Feltman Natural shampoo with buchu
CN114404566B (en) * 2022-02-17 2023-10-20 浙江省农业科学院 Application of trichoderma
CN114632075B (en) * 2022-05-19 2022-07-15 奥信阳光(北京)药业科技有限公司 Voriconazole aerosol inhalation and application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064833A1 (en) * 2003-01-24 2004-08-05 Connetics Australia Pty Ltd. Clindamycin phosphate foam
WO2005018530A2 (en) * 2003-08-25 2005-03-03 Foamix Ltd. Penetrating pharmaceutical foam
WO2007099396A2 (en) * 2005-06-07 2007-09-07 Foamix Ltd. Antibiotic kit and composition and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064833A1 (en) * 2003-01-24 2004-08-05 Connetics Australia Pty Ltd. Clindamycin phosphate foam
WO2005018530A2 (en) * 2003-08-25 2005-03-03 Foamix Ltd. Penetrating pharmaceutical foam
WO2007099396A2 (en) * 2005-06-07 2007-09-07 Foamix Ltd. Antibiotic kit and composition and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses

Also Published As

Publication number Publication date
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