WO2008075148A3 - Tricyclic inhibitors of carbonic anhydrase - Google Patents

Tricyclic inhibitors of carbonic anhydrase Download PDF

Info

Publication number
WO2008075148A3
WO2008075148A3 PCT/IB2007/003768 IB2007003768W WO2008075148A3 WO 2008075148 A3 WO2008075148 A3 WO 2008075148A3 IB 2007003768 W IB2007003768 W IB 2007003768W WO 2008075148 A3 WO2008075148 A3 WO 2008075148A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
formula
relates
carbonic anhydrase
methods
Prior art date
Application number
PCT/IB2007/003768
Other languages
French (fr)
Other versions
WO2008075148A2 (en
Inventor
Sajiv Krishnan Nair
Eugene Yuanjin Rui
Original Assignee
Pfizer Prod Inc
Sajiv Krishnan Nair
Eugene Yuanjin Rui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Sajiv Krishnan Nair, Eugene Yuanjin Rui filed Critical Pfizer Prod Inc
Publication of WO2008075148A2 publication Critical patent/WO2008075148A2/en
Publication of WO2008075148A3 publication Critical patent/WO2008075148A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and R3 are as defined herein. The invention also relates to methods of treating glaucoma, ocular hypertension, age-related macular degeneration, diabetic macular edema, diabetic retinopathy, hypertensive retinopathy, retinal vasculopathies and intraocular pressure in mammals by administering the compounds of formula (I), and to pharmaceutical compositions which contain the compounds of formula (I) for such treatments. The invention also relates to methods of preparing the compounds of formula (I).
PCT/IB2007/003768 2006-12-15 2007-11-22 Tricyclic inhibitors of carbonic anhydrase WO2008075148A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87027806P 2006-12-15 2006-12-15
US60/870,278 2006-12-15

Publications (2)

Publication Number Publication Date
WO2008075148A2 WO2008075148A2 (en) 2008-06-26
WO2008075148A3 true WO2008075148A3 (en) 2008-08-21

Family

ID=39495538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003768 WO2008075148A2 (en) 2006-12-15 2007-11-22 Tricyclic inhibitors of carbonic anhydrase

Country Status (1)

Country Link
WO (1) WO2008075148A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101735209B (en) * 2008-11-12 2012-01-11 上海百灵医药科技有限公司 Method for synthesizing chiral dorzolamide hydrochloride
CN107365320B (en) * 2017-08-08 2019-06-04 杭州乐敦科技有限公司 A kind of synthesis technology of dorzolamide hydrochloride intermediate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235059A (en) * 1991-10-15 1993-08-10 Merck & Co., Inc. Tricyclic thienothiopyran carbonic anhydrase inhibitors
WO2004014352A2 (en) * 2002-08-07 2004-02-19 Pharmacia Corporation Methods for treating carbonic anhydrase mediated disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235059A (en) * 1991-10-15 1993-08-10 Merck & Co., Inc. Tricyclic thienothiopyran carbonic anhydrase inhibitors
WO2004014352A2 (en) * 2002-08-07 2004-02-19 Pharmacia Corporation Methods for treating carbonic anhydrase mediated disorders

Also Published As

Publication number Publication date
WO2008075148A2 (en) 2008-06-26

Similar Documents

Publication Publication Date Title
TW200833341A (en) 6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions
WO2006071548A3 (en) Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases
WO2007046083A3 (en) Compositions for treatment of eye diseases
WO2008008701A3 (en) Substituted cyclopentane derivatives as therapeutic agents
WO2008012635A3 (en) Amine derivatives useful as anticancer agents
WO2006067614A3 (en) Heteroaromatic derivatives useful as anticancer agents
WO2007020213A3 (en) Thiazolyl piperidine derivatives useful as h3 receptor modulators
WO2006044425A3 (en) Ophthalmic compositions for treating ocular hypertension
WO2007138472A3 (en) Triazolopyridazine derivatives
TW200621762A (en) Novel compounds
MY159463A (en) Method and composition for treating ocular hypertension and glaucoma
WO2007108968A3 (en) Ophthalmic compositions for treating ocular hypertension
NO20085385L (en) Thiazole compounds such as cannabinoid receptor ligands and uses thereof
WO2008094992A3 (en) 2-aminopyridine derivatives useful as kinase inhibitors
WO2007076360A8 (en) (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)- pyrazines for treating rho kinase-mediated diseases and conditions
HK1146049A1 (en) Isoxazole derivatives as modulators of 11-beta-hydroxysteroid dehydrogenase type 1
WO2006084217A3 (en) Rnai-mediated inhibition of ocular hypertension targets
UA84726C2 (en) Prostaglandin derivatives, process for the preparation thereof, pharmaceutical composition (variants) and method for the treatment of glaucoma and ocular hypertension
NO20076060L (en) Piperidin-4-yl amide derivatives and their use as SST receptor subtype 5 antagonists
WO2006077024A3 (en) 5-aminoindole derivatives
WO2008020032A8 (en) Use of 2,5-dihydroxybenzene derivatives for the treatment of ocular diseases
NZ597866A (en) Therapeutic lactams
WO2008114114A3 (en) Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition
WO2005020917A3 (en) Ophthalmic compositions for treating ocular hypertension
WO2007089673A3 (en) Compositions and methods for treatment of ophthalmic diseases and disorders

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07858949

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 07858949

Country of ref document: EP

Kind code of ref document: A2