WO2008065753A1

WO2008065753A1 - Blood purification device

Info

Publication number: WO2008065753A1
Application number: PCT/JP2007/001316
Authority: WO
Inventors: Hiroshi Nimura; Yoshiro Ueda
Original assignee: Nikkiso Company Limited
Priority date: 2006-11-29
Filing date: 2007-11-29
Publication date: 2008-06-05
Also published as: JP5078122B2; JP2008132196A

Abstract

[PROBLEMS] To provide a blood purification device comprising a pressure measurement chamber which can suppress a change in a liquid level to measure the pressure of blood with higher accuracy. [MEANS FOR SOLVING PROBLEMS] A blood purification device comprising a blood circuit (1), a blood pump (3), a dialyzer (2) for purifying blood which flows through the blood circuit (1), a pressure measurement chamber (4) for measuring the pressure of blood which flows through the blood circuit (1), and a drip chamber (5) for removing bubbles from the blood which flows through the blood circuit (1). The pressure measurement chamber (4) is formed on the lower part in a storage space (4a) and comprises a blood introduction part (4b), which is open at a part near the bottom of the storage space (4a), for introducing blood, and a blood lead-out part (4c) for leading out the blood introduced through the blood introduction part (4b). The blood lead-out part (4c) extends toward the blood introduction part (4b) to a position, where the opening of the blood lead-out part (4c) faces the opening of the blood introduction part (4b) while providing a clearance of a very small size t, and the opening of the blood lead-out part (4c) covers substantially the whole area of the opening of the blood introduction part (4b).

Description

Specification

Blood purification equipment

Technical field

TECHNICAL FIELD [0001] The present invention relates to a blood purification apparatus in which a pressure measuring chain is connected in the middle of a blood circuit for circulating a patient's blood extracorporeally.

Background art

In general, in blood purification therapy, for example, dialysis treatment, a hemodialysis apparatus having a blood circuit composed of a flexible tube that circulates the blood of a patient extracorporeally is used. The blood circuit in this hemodialysis apparatus includes an arterial blood circuit in which an arterial puncture needle for collecting blood from a patient is attached to the tip, and a venous blood circuit in which a venous puncture needle for returning blood to the patient is attached to the tip. The dialyzer is interposed between the arterial blood circuit and the venous blood circuit to purify the blood circulating outside the body.

[0003] Further, the blood circuit (at least one of the arterial blood circuit and the venous blood circuit) is formed of a resin molded product having a large inner diameter accommodating space inside the blood circuit. A drip chamber is connected. In this dripping chamber, as disclosed in Patent Document 1, for example, a pressure monitor line is extended from the air layer side formed in the accommodating space, and a pressure measuring means is connected to the extended end. ing. In other words, the blood pressure of the patient who is undergoing dialysis treatment can be monitored by the pressure monitor line together with the defoaming.

[0004] The drip chamber monitors the pressure of the blood while defoaming the blood circulating outside the body. Therefore, the liquid level in the accommodation space (the blood liquid level) by the air supplemented by the defoaming action The position of the surface has changed, making it difficult to accurately measure the pressure of blood circulating outside the body. Therefore, a separate level adjustment line is usually connected to the dripping chamber.

[0005] The level adjustment line is extended from the air layer side of the drip chamber, and a syringe or the like is connected to the front end, and air is sent to the air layer by the syringe. By inserting or removing air from the air layer, the liquid level in the drip chamber can be adjusted, thereby accurately measuring the pressure of blood circulating outside the body. can do.

Patent Document 1: Japanese Patent Laid-Open No. 2 0 06 _ 1 0 2 2 3 7

Disclosure of the invention

Problems to be solved by the invention

However, since the drip chamber in the conventional blood purification apparatus requires a level adjustment line for adjusting the liquid level in addition to the pressure monitor line, a plurality of lines are extended from one chamber. As a result, handling was inconvenient and caused a connection error in each line. However, it is conceivable that the drip chamber is exclusively used for defoaming, and a chamber for measuring blood pressure (pressure measuring chamber) is provided separately from the drip chamber, but in this case, the pressure measuring chamber is circulated. When air bubbles are generated from the blood, the air level changes due to the air, making it difficult to accurately measure the blood pressure.

[0007] The present invention has been made in view of such circumstances, and a blood purification apparatus including a pressure measurement chamber capable of measuring a blood pressure more accurately while suppressing a change in liquid level. Is to provide.

Means for solving the problem

[0008] The invention according to claim 1 includes a blood circuit including an arterial blood circuit and a venous blood circuit for extracorporeally circulating a patient's blood, a blood pump disposed in the arterial blood circuit, and the arterial side. A blood purification unit that is connected between the blood circuit and the venous blood circuit and purifies blood flowing through the blood circuit; and a storage space that is connected in the middle of the blood circuit and has a predetermined capacity; A pressure measuring chamber in which a pressure monitor line for measuring the pressure of blood flowing through the blood circuit is extended, and connected downstream of the connecting portion of the blood measuring circuit in the blood circuit A blood purification apparatus comprising a dripping chamber for removing the blood of a patient flowing through the blood circuit. Is formed in the lower part of the accommodation space, and is opened near the bottom surface of the accommodation space, and introduces blood, and the openings are opposed to the blood introduction part through a micro dimension clearance. And a blood deriving unit for deriving the blood introduced from the blood introduction unit, which covers the entire area of the opening of the blood introduction unit and opens. To do.

[0009] The invention according to claim 2 is the blood purification apparatus according to claim 1, wherein the arterial blood circuit, the blood purification means, and the venous blood circuit are prefilled with a priming solution, and the pressure measurement The working chamber is characterized in that, by driving the blood pump, a liquid layer is formed in which the upper part is composed of a priming liquid and the lower part is composed of blood.

[0010] The invention described in claim 3 is the blood purification apparatus according to claim 1 or 2, wherein the opening of the blood introduction part in the pressure measuring chamber enters into the opening of the blood guiding part. It is characterized by overlapping.

[001 1] The invention according to claim 4 is the blood purification apparatus according to claim 1 or 2, wherein the clearance of a minute dimension between the blood introduction part and the blood lead-out part in the pressure measurement chamber is used. A mesh is formed.

The invention's effect

[0012] According to the invention of claim 1, the pressure measuring chamber is formed in the lower part of the accommodation space, and introduces blood while opening near the bottom surface of the accommodation space, and the blood introduction part. On the other hand, the openings are extended to a position where the openings are opposed to each other through a clearance of a minute dimension, and open over substantially the entire area of the opening of the blood introduction section, and the blood introduced from the blood introduction section is derived. Since it has a blood outlet, the bubbles in the blood introduced from the blood inlet are reliably led out from the blood outlet. Therefore, it is possible to more accurately measure the blood pressure by suppressing the accumulation of bubbles in the storage space and suppressing the change in the liquid level.

[0013] According to the invention of claim 2, the pressure measuring chamber is driven by the blood pump. In the storage space, a liquid layer consisting of priming liquid at the upper part and blood at the lower part is formed. Can be avoided. Moreover, since blood is only slightly accumulated in the lower part of the liquid layer in the accommodation space, the extracorporeal blood volume can be reduced and the burden on the patient can be reduced.

[0014] According to the invention of claim 3, the blood introduction part in the pressure measuring chamber overlaps when the opening enters the opening of the blood outlet part, so that the blood introduction part is introduced from the blood introduction part. Air bubbles in the blood can be more reliably guided to the blood outlet, and the change in the liquid level can be more reliably suppressed to accurately measure the blood pressure.

[0015] According to the invention of claim 4, since the mesh is formed in the minute dimension clearance between the blood introduction part and the blood lead-out part in the pressure measurement chamber, the mesh is mixed in the accommodation space. Foreign matter or the like can be captured with a mesh, and it can be avoided that the foreign matter or the like is derived from the blood outlet and flows into the blood circuit.

BEST MODE FOR CARRYING OUT THE INVENTION

[001 6] Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.

The blood purification apparatus according to the first embodiment is for purifying a patient's blood while circulating it extracorporeally, and is applied to a dialysis apparatus used in dialysis treatment. As shown in FIG. 1, such a dialyzer is mainly composed of a blood circuit 1 connected to a dialer 2 as a blood purification means, and a dialyzer body 6 for removing water while supplying dialysate to the dialyzer 2. ing. As shown in the figure, the blood circuit 1 is mainly composed of an arterial blood circuit 1 a and a venous blood circuit 1 b made of a flexible tube. The arterial blood circuit 1 a and the venous blood Dialer 2 is connected between circuit 1 b.

[001 7] The arterial blood circuit 1 a has an arterial puncture needle a connected to the tip thereof, and an iron-type blood pump 3, a pressure measuring chamber 4, and a defoaming drip chamber along the way 5 (arterial drip chamber) is installed and connected The Further, from the middle of the arterial blood circuit 1a, a physiological saline line 10 having a physiological saline drip chamber 9 is extended in the middle, and a saline bag 8 containing a physiological saline at the tip 8 Is connected. On the other hand, a venous puncture needle b is connected to the distal end of the venous blood circuit 1b, and a drip chamber 12 (venous drip chamber) for removing bubbles and a bubble detector 11 are connected to the venous blood circuit 1b. Has been.

[0018] The pressure measuring chamber 4 is connected between the site of connection with the physiological saline line 10 in the arterial blood circuit 1a and the site of the blood pump 3, and the drip chamber 5 Is connected downstream of the connection part of the pressure measuring chamber 4 and between the connection part of the blood pump 3 and the connection part of the dialyzer 2. The bubble detector 11 is mainly composed of a sensor 1 1a for detecting bubbles and a clamp 1 1b for cutting off the venous blood circuit 1b when bubbles are detected. In FIG. 1, reference numeral 1 2 denotes a syringe pump for administering a drug or the like to the blood flowing through the blood circuit 1.

[001 9] Then, when the blood pump 3 is driven with the patient punctured with the arterial puncture needle a and the venous puncture needle b, the patient's blood passes through the arterial blood circuit 1a and the dialyzer. 2, blood purification is performed by the dialyzer 2, and defoaming is performed in the dripping chamber 4, and then returned to the patient's body through the venous blood circuit 1 b. That is, the blood of the patient is purified by the dialyzer 2 while circulating outside the blood circuit 1.

[0020] Before blood purification treatment, physiological saline (for example, saline / Kug 8) is used as a priming solution in advance in the arterial blood circuit 1a, the blood flow path of the dialyzer 2 and the venous side blood circuit 1b. When the blood pump 3 is driven, the physiological saline flows into the arterial blood circuit. 1a The blood is gradually replaced from the tip.

[0021] The dialyzer 2 is formed with a blood introduction port 2a, a blood outlet port 2b, a dialysate inlet port 2c, and a dialysate outlet port 2d in its casing, Of these, the proximal end of the arterial blood circuit 1a is connected to the blood introduction port 2a, and the proximal end of the venous blood circuit 1b is connected to the blood outlet port 2b. The dialysate introduction port 2 c and the dialysate outlet port 2 d are connected to a dialysate introduction line L 1 and a dialysate discharge line L 2 extending from the dialyzer body 6, respectively.

[0022] A plurality of hollow fibers are accommodated in the dialyzer 2, the inside of the hollow fibers is used as a blood flow path, and dialysis is performed between the outer peripheral surface of the hollow fibers and the inner peripheral surface of the casing. It is a liquid flow path. A hollow fiber membrane is formed in the hollow fiber by forming a number of minute holes (pores) penetrating the outer peripheral surface and the inner peripheral surface, and impurities in the blood and the like are passed through the membrane in the dialysate. It is comprised so that it can permeate | transmit.

[0023] On the other hand, in the dialyzer main body 6, a dual pump, a dewatering pump, etc. (not shown) are arranged, and in addition to the action of the dialyzer 2, the blood circuit 1 is circulated outside the body. Dialysis treatment can be performed. Further, a pressure gauge 7 is formed in the dialyzer body 6, and the pressure gauge 7 is connected to a pressure monitor line L 3 extending from the pressure measurement chamber 4 via a filter (not shown). Yes.

Here, the pressure measuring chamber 4 is connected in the middle of the arterial blood circuit 1 a (blood circuit 1) and has a predetermined capacity of the accommodating space 4 a, and the arterial side from the accommodating space 4 a The pressure monitor line L 3 for measuring the pressure of the blood flowing through the blood circuit 1 a is extended. Specifically, as shown in FIG. 2, the pressure measuring chamber 4 has a housing space 4a formed in the case C, and a blood introduction part 4b formed in the lower part thereof, and a side surface. And a blood lead-out portion 4 c extending from the head.

[0025] The blood introduction part 4b is a part where blood flowing through the arterial blood circuit 1a can be introduced upward from below while opening upward in the vicinity of the bottom surface of the accommodation space 4a. The blood outlet 4c extends to the position where the openings (4ba, 4be) face each other through the clearance of the minute dimension t with respect to the blood inlet 4b. The blood introduction part 4 b opening 4 b Covers the entire area of a (see Fig. 3), and guides the blood introduced from the blood introduction part 4b out of the accommodation space 4a (that is, downstream of the arterial blood circuit 1a). .

That is, the opening 4 ca of the blood outlet 4 c is set to be larger than the opening 4 ba of the blood introduction part 4 b, and the opening 4 ca passes above the opening 4 ba through a minute clearance. Covering (a state where the projected area of the opening 4 ba is entirely within the opening of the opening 4 ca), the blood led from the blood introduction part 4 b or physiological saline as a priming solution is not cleared. Most of the space is filled from the blood outlet 4c while being filled into the accommodation space 4a.

Next, the operation of the above embodiment will be described.

Before blood purification treatment, the arterial blood circuit 1 a, the blood flow path of the dialyzer 2 and the venous blood circuit 1 b are filled with physiological saline as a brimming solution, and then the arterial puncture needle a and the venous side are filled. The patient is punctured with the puncture needle b and the blood pump 3 is driven. As a result, the physiological saline is guided from the blood introduction part 4 b in the pressure measurement chamber 4, and as shown in FIG. 4, a single layer of physiological saline (a physiological saline layer) is contained in the accommodation space 4 a. ) Will be formed.

[0028] Thereafter, when the physiological saline in the blood circuit 1 is sequentially replaced with blood as the blood pump 3 is driven, blood is guided from the blood introduction part 4b in the pressure measurement chamber 4. Thus, as shown in FIG. 5, a double liquid layer is formed in the accommodation space 4a, the upper part being physiological saline (saline layer) and the lower part being blood (blood layer). . At this time, since the clearance between the opening 4 ba of the blood introduction part 4 b and the opening 4 ca of the blood outlet part 4 c is in the vicinity of the bottom surface of the accommodation space 4 a, the blood in the blood layer; It only accumulates slightly in the lower part of the accommodation space 4a.

[0029] Therefore, since blood in the blood layer; S can be suppressed to a small amount, the extracorporeal blood volume can be reduced and the burden on the patient can be reduced. In addition, the blood layer in the accommodation space 4a; S is the lower part of the physiological saline layer, so it is in direct contact with the air layer. It will not be. Therefore, it is possible to prevent blood in the blood layer; S from coming into contact with the air in the air layer, thereby preventing thrombus from being promoted or foaming.

[0030] In addition, the pressure measuring chamber 4 includes a blood introduction part 4b that introduces blood while opening in the vicinity of the bottom surface of the accommodation space 4a, and a clearance of a minute dimension t with respect to the blood introduction part 4b. Through which the openings of the blood introduction part 4 b are covered and substantially the whole area of the opening of the blood introduction part 4 b is covered (the projected area of the opening of the blood introduction part 4 b is the blood outlet part 4 c). And the blood deriving unit 4 c for deriving the blood introduced from the blood introducing unit 4 b, so that bubbles in the blood introduced from the blood introducing unit 4 b It is surely derived from the blood outlet 4c.

[0031] That is, the bubbles contained in the blood introduced from the blood introduction part 4b have a property of flowing upward because the specific gravity is lighter than that of the blood, and move along the blood flow, so that the clearance It is avoided that the blood reaches the S side through the blood and is smoothly led out from the blood outlet 4c. Therefore, it is possible to suppress the accumulation of bubbles in the storage space 4a, and to suppress the change in the liquid level in the storage space 4a.

In this state, the air layer 4 a side and the pressure gauge 7 communicate with each other via the pressure monitor line L 3, and the value measured by the pressure gauge 7 is the arterial blood circuit 1 a ( This indicates the pressure of blood flowing through the upstream side of blood pump 3). Thus, in the present embodiment, as described above, since the change in the liquid level in the accommodation space 4a is suppressed, the blood pressure can be measured more accurately.

[0033] It should be noted that the bubbles contained in the blood derived from the blood deriving unit 4c reach the downstream dripping chamber 5, where the bubbles are removed. Thus, in the present embodiment, the pressure measuring chamber 4 exclusively measures the blood pressure on the artery side, and bubbles contained in the flowing blood are removed by the downstream drip chamber 5. Therefore, bubbles will reach the dialyzer 2 Can be avoided.

[0034] Next, a second embodiment of the present invention will be described.

As in the previous embodiment, the blood purification apparatus according to this embodiment is for purifying a patient's blood while circulating externally, and is applied to a dialysis apparatus used in dialysis treatment. Such a dialysis apparatus is substantially the same as that shown in FIG. 1, and only the pressure measuring chamber connected to the arterial blood circuit 1a is different. The same components as those in the previous embodiment are denoted by the same reference numerals, and detailed description thereof is omitted.

As shown in FIG. 6, the pressure measuring chamber 4 ′ according to the present embodiment has an accommodation space 4 a formed in the case C, and the blood introduction part 4 formed in the lower part thereof. b 'and a blood outlet 4c' extending downward from the upper surface. The blood introduction part 4 b ′ is a part where blood flowing through the arterial blood circuit 1 a can be introduced upward from below while opening upward near the bottom surface of the accommodation space 4 a.

[0036] Further, the blood outlet 4c 'extends to a position where the openings of the blood inlet 4c' face each other through a clearance of a minute dimension t with respect to the blood inlet 4b '(the suspension of the present embodiment is drooping) The blood introduction part 4 b ′ covers the entire opening (the diameter of the blood introduction part 4 b ′ is larger than the opening of the blood introduction part 4 c ′), and the blood introduction part 4 The blood introduced from b ′ is led out of the accommodation space 4a (that is, downstream of the arterial blood circuit 1a). Here, the opening of the blood introduction part 4 b ′ is configured to enter into the opening of the blood outlet part 4 c ′, and overlaps.

[0037] As in the previous embodiment, the pressure measuring chamber 4 'is driven by the blood pump 3, so that the upper part is physiological saline (saline layer) and the lower part is blood (blood layer; S). A double liquid layer consisting of the blood layer; the blood of S; only slightly accumulates in the lower part of the accommodation space 4a. The bubbles contained in the blood derived from the blood deriving portion 4 c ′ reach the downstream drip chamber 5 (see FIG. 1), where the bubbles are removed. [0038] According to the present embodiment, the openings of the blood introduction part 4b 'and the blood lead-out part 4c' in the pressure measurement chamber 4 'are overlapped, so that they are introduced from the blood introduction part 4b'. The air bubbles in the blood can be more reliably guided to the blood outlet 4 c ′, and the change in the liquid level can be more reliably suppressed to accurately measure the blood pressure.

[0039] Next, a third embodiment of the present invention will be described.

[0040] As shown in Fig. 7, the pressure measuring chamber 4 "according to the present embodiment has an accommodation space 4a formed in the case C, and the blood introduction part 4 formed in the lower part thereof. b "and a blood outlet 4c" extending downward from the upper surface. The blood inlet 4b "opens upward near the bottom surface of the accommodating space 4a and In the site where blood flowing through the side blood circuit 1a can be introduced from below to above

[0041] In addition, the blood outlet 4c "extends to a position where the openings of the blood inlet 4c" face each other through a clearance of a minute dimension t with respect to the blood inlet 4b "(in this embodiment, it is drooping) At the same time, the whole area of the opening of the blood introduction part 4 b "is covered (both openings have substantially the same diameter and are substantially concentric), and the blood introduced from the blood introduction part 4 b" is stored outside the accommodation space 4 a. (Ie, downstream of the arterial blood circuit 1a). Here, a mesh 4 d is formed in the clearance between the opening of the blood introduction part 4 b ″ and the opening of the blood outlet part 4 c ″.

[0042] As in the previous embodiment, the pressure measuring chamber 4 "is driven by the blood pump 3, so that the upper part is physiological saline (saline layer) and the lower part is blood (blood layer; S). A double liquid layer consisting of the blood layer; the blood of S It only accumulates slightly in the lower part of 4a. The bubbles contained in the blood derived from the blood deriving section 4 c ″ reach the drip chamber 5 on the downstream side (see FIG. 1), where the bubbles are removed.

[0043] According to the present embodiment, the mesh 4d is formed in the clearance of the minute dimension t between the blood introduction part 4b "and the blood outlet part 4c" in the pressure measurement chamber 4 ". Therefore, foreign matter mixed in the accommodation space 4a can be captured by the mesh 4d, and the foreign matter is prevented from being led out from the blood outlet 4c "and flowing into the blood circuit 1. can do.

Although the present embodiment has been described above, the present invention is not limited to the above, and for example, the pressure measuring chamber to be connected to the blood circuit is shown in FIG. Is not extended into the storage space 4a, but only the blood outlet 4c is extended in the storage space 4a and the openings are opposed to each other, or as shown in FIG. The clearance between 4 b and blood outlet 4 c may be formed by slit 4 e. A single hole (such as a round hole) may be formed instead of the slit 4a.

[0045] Further, the blood introduction part 4b and the blood lead-out part 4c are not limited to those in which the respective axes coincide with each other as in the above embodiment. For example, as shown in FIG. The axis of 4b and the axis of blood outlet 4c may be displaced substantially in parallel, or as shown in FIG. 11, either one (in this figure, blood introduction part 4b) is the other ( It may be extended with a predetermined angle with respect to the axis of the blood outlet 4c). However, even in this case, the blood outlet 4c is opened so as to cover substantially the entire opening of the blood inlet 4b (the projected area of the opening of the blood inlet 4b is equal to that of the blood outlet 4c). It is necessary to form so that the blood introduced from the blood introduction part 4 b is led out.

Furthermore, as shown in FIG. 12, both the blood introduction part 4 b and the blood lead-out part 4 c may be configured to extend at a predetermined angle from the axis of the case C. Further, as shown in FIG. 13, the blood outlet 4 c is extended in an inverted U shape in the accommodation space 4 a so that the opening faces the opening of the blood introduction part 4 b. Good. In any case, the openings of each other face each other with a minute dimension clearance, the position of the clearance is set near the bottom surface of the accommodation space, and the blood outlet 4c It is necessary to cover almost the entire opening of part 4b.

[0047] However, in this embodiment, the dialysis machine body 6 is applied to either a dialysis monitoring device that does not include a dialysate supply mechanism, or a personal dialyzer that includes a dialysate supply mechanism. You may do it. Further, the present invention can be applied to other blood purification apparatuses such as hemofiltration therapy and hemofiltration dialysis therapy in addition to hemodialysis therapy as in the embodiment.

Industrial applicability

[0048] A blood introduction part that is formed in the lower part of the accommodation space and introduces blood while opening in the vicinity of the bottom surface of the accommodation space, and the openings face each other with a minute dimension clearance with respect to the blood introduction part A pressure measuring chamber having a blood lead-out part that extends to a position where the blood is introduced, covers substantially the entire opening of the blood introduction part, and leads out the blood introduced from the blood introduction part. As long as the blood purification device is connected to the device, it can also be applied to devices with different external shapes or with other functions added.

Brief Description of Drawings

[0049] FIG. 1 is an overall schematic diagram showing a blood purification apparatus according to a first embodiment of the present invention.

FIG. 2 is a schematic cross-sectional view showing a pressure measurement chamber connected to a blood circuit in the blood purification apparatus.

[Fig.3] I I I— I I I line cross section

FIG. 4 is a schematic diagram showing a state in which physiological saline (priming solution) is accommodated in the same pressure measurement chamber.

FIG. 5 is a schematic diagram showing a state in which blood is stored in addition to physiological saline (priming solution) in the same pressure measurement chamber.

FIG. 6 is a schematic cross-sectional view showing a pressure measuring chamber connected to the blood purification apparatus of the second embodiment of the present invention. FIG. 7 is a schematic cross-sectional view showing a pressure measurement chamber connected to the blood purification apparatus of the third embodiment of the present invention.

FIG. 8 is a schematic cross-sectional view showing a pressure measurement chamber in still another embodiment of the present invention.

FIG. 9 is a schematic cross-sectional view showing a pressure measurement chamber in still another embodiment of the present invention.

FIG. 10 is a schematic cross-sectional view showing a pressure measurement chamber in still another embodiment of the present invention.

FIG. 11 is a schematic cross-sectional view showing a pressure measurement chamber in still another embodiment of the present invention.

FIG. 12 is a schematic cross-sectional view showing a pressure measurement chamber in still another embodiment of the present invention.

FIG. 13 is a schematic cross-sectional view showing a pressure measurement chamber in still another embodiment of the present invention.

Explanation of symbols

1 Blood circuit

1 a Arterial blood circuit

1 b Venous blood circuit

2 Dializer (blood purification means)

3 Blood pump

4 Pressure measurement chamber

4 a Containment space

4 b Blood introduction part

4 c Blood outlet

5 Drip Chan / Ku (Arterial Drip Chan / Ku)

6 Dialysis machine body

7 Pressure gauge

8 Raw food bag Saline drip chamber

Saline line

Bubble detector

Drip Chan / KU (Venous Drip Chan / KU) Pressure monitoring line

Saline (priming solution) layer

Blood layer

Air layer

Claims

The scope of the claims

[1] a blood circuit comprising an arterial blood circuit and a venous blood circuit for extracorporeally circulating the patient's blood;

A blood pump disposed in the arterial blood circuit;

Blood purification means connected between the arterial blood circuit and the venous blood circuit and purifying blood flowing through the blood circuit;

A pressure measuring chamber which is connected in the middle of the blood circuit and has a predetermined volume of a storage space, and a pressure monitor line for measuring the pressure of blood flowing through the blood circuit from the storage space;

A blood purification apparatus comprising: a drip chamber connected to a downstream side of a connection portion of the pressure measurement chamber in the blood circuit and defoaming a patient's blood flowing through the blood circuit;

The pressure measuring chamber includes:

A blood introduction part that is formed in a lower part of the accommodation space and introduces blood while opening near the bottom surface of the accommodation space;

The blood introduction part is extended to a position where the openings are opposed to each other through a minute dimension clearance, covers substantially the entire opening of the blood introduction part, and is introduced from the blood introduction part. A blood purification apparatus comprising: a blood deriving unit for deriving the blood.

[2] The arterial blood circuit, the blood purification means, and the venous blood circuit are prefilled with a priming solution, and the pressure measuring chamber is primed at the top in the accommodation space by driving the blood pump. 2. The blood purification apparatus according to claim 1, wherein a liquid layer is formed in which the liquid and the lower part are blood.

[3] The blood purification according to claim 1 or 2, wherein the blood introduction part in the pressure measuring chamber overlaps with the opening of the blood introduction part entering the opening of the blood lead-out part. apparatus.

[4] Minute dimension between blood introduction part and blood lead-out part in the pressure measuring chamber 3. The blood purification apparatus according to claim 1, wherein a mesh is formed in the legal clearance.