WO2008059521A3 - Nouveau procédé pour la préparation de chlorhydrate de moxifloxacine et nouveau polymorphe de moxifloxacine - Google Patents

Nouveau procédé pour la préparation de chlorhydrate de moxifloxacine et nouveau polymorphe de moxifloxacine Download PDF

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Publication number
WO2008059521A3
WO2008059521A3 PCT/IN2007/000448 IN2007000448W WO2008059521A3 WO 2008059521 A3 WO2008059521 A3 WO 2008059521A3 IN 2007000448 W IN2007000448 W IN 2007000448W WO 2008059521 A3 WO2008059521 A3 WO 2008059521A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
moxifloxacin
preparation
polymorph
hydrochloride
Prior art date
Application number
PCT/IN2007/000448
Other languages
English (en)
Other versions
WO2008059521A2 (fr
Inventor
Reddy Manne Satyanarayana
Chakilam Nagaraju
Rajan Srinivasan Thirumalai
Ramprasad Achampeta Kodanda
Revu Satyanarayana
Original Assignee
Msn Lab Ltd
Reddy Manne Satyanarayana
Chakilam Nagaraju
Rajan Srinivasan Thirumalai
Ramprasad Achampeta Kodanda
Revu Satyanarayana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Lab Ltd, Reddy Manne Satyanarayana, Chakilam Nagaraju, Rajan Srinivasan Thirumalai, Ramprasad Achampeta Kodanda, Revu Satyanarayana filed Critical Msn Lab Ltd
Priority claimed from IN1345CH2007 external-priority patent/IN2007CH01345A/en
Publication of WO2008059521A2 publication Critical patent/WO2008059521A2/fr
Publication of WO2008059521A3 publication Critical patent/WO2008059521A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention porte sur un nouveau procédé de préparation d'un composé de chlorhydrate de moxifloxacine représenté par la formule 1 par l'intermédiaire de nouveaux composés intermédiaires de quinoléine carboxamide représentés par la formule générale 2. La présente invention concerne le procédé de préparation de nouveaux composés intermédiaires de quinoléine carboxamide représentés par la formule générale 2. La présente invention concerne également un nouveau procédé pour la préparation d'une forme anhydre de chlorhydrate de moxifloxacine et une nouvelle forme cristalline de la moxifloxacine.
PCT/IN2007/000448 2006-11-14 2007-09-27 Nouveau procédé pour la préparation de chlorhydrate de moxifloxacine et nouveau polymorphe de moxifloxacine WO2008059521A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2111/CHE/2006 2006-11-14
IN2111CH2006 2006-11-14
IN1345/CHE/2007 2007-06-25
IN1345CH2007 IN2007CH01345A (fr) 2004-10-01 2007-09-27

Publications (2)

Publication Number Publication Date
WO2008059521A2 WO2008059521A2 (fr) 2008-05-22
WO2008059521A3 true WO2008059521A3 (fr) 2008-08-28

Family

ID=39402100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000448 WO2008059521A2 (fr) 2006-11-14 2007-09-27 Nouveau procédé pour la préparation de chlorhydrate de moxifloxacine et nouveau polymorphe de moxifloxacine

Country Status (1)

Country Link
WO (1) WO2008059521A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2154137A1 (fr) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Formule cristalline à base de moxifloxacine
US20110212990A1 (en) * 2008-11-06 2011-09-01 Hetero Research Foundation Novel polymorph of moxifloxacin hydrochloride
CN102030751B (zh) * 2010-12-01 2012-11-21 上虞京新药业有限公司 一种盐酸莫西沙星的结晶工艺
KR101435244B1 (ko) * 2011-04-12 2014-08-29 씨제이헬스케어 주식회사 목시플록사신 수성 제형 및 이의 제조방법
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ
WO2015093669A1 (fr) * 2013-12-20 2015-06-25 씨제이헬스케어 주식회사 Formulation aqueuse de moxifloxacine et sa méthode de préparation
US20220323448A1 (en) * 2017-05-04 2022-10-13 Ocular Science, Inc. Compositions and methods for treating eyes and methods of preparation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443498A1 (fr) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Dérivés d'isoindoline
EP0550903A1 (fr) * 1992-01-10 1993-07-14 Bayer Ag Dérivés d'acides carboxyliques de quinolone- et de naphthyridone comme agents antibactériens
US6323213B1 (en) * 1996-02-23 2001-11-27 Bayer Aktiengesellschaft Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
WO2005012285A1 (fr) * 2003-08-05 2005-02-10 Matrix Laboratories Ltd Procede ameliore permettant de preparer un hydrochlorure de moxifloxacine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443498A1 (fr) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Dérivés d'isoindoline
EP0550903A1 (fr) * 1992-01-10 1993-07-14 Bayer Ag Dérivés d'acides carboxyliques de quinolone- et de naphthyridone comme agents antibactériens
US6323213B1 (en) * 1996-02-23 2001-11-27 Bayer Aktiengesellschaft Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
WO2005012285A1 (fr) * 2003-08-05 2005-02-10 Matrix Laboratories Ltd Procede ameliore permettant de preparer un hydrochlorure de moxifloxacine

Also Published As

Publication number Publication date
WO2008059521A2 (fr) 2008-05-22

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