WO2008053334A3 - An improved process for preparing rosuvastatin calcium - Google Patents

An improved process for preparing rosuvastatin calcium Download PDF

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Publication number
WO2008053334A3
WO2008053334A3 PCT/IB2007/003312 IB2007003312W WO2008053334A3 WO 2008053334 A3 WO2008053334 A3 WO 2008053334A3 IB 2007003312 W IB2007003312 W IB 2007003312W WO 2008053334 A3 WO2008053334 A3 WO 2008053334A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved process
rosuvastatin calcium
preparing rosuvastatin
preparing
calcium
Prior art date
Application number
PCT/IB2007/003312
Other languages
French (fr)
Other versions
WO2008053334A2 (en
Inventor
Ramesh Dandala
Sambhu Prasad Sarma Mallela
Narayan K A S S Garimella
Sukumar Nandi
Sunil Kumar Buridipad
Gangadhar Bhima Shankar Nangi
Sivakumaran Meenakshisunderam
Original Assignee
Aurobindo Pharma Ltd
Ramesh Dandala
Sambhu Prasad Sarma Mallela
Narayan K A S S Garimella
Sukumar Nandi
Sunil Kumar Buridipad
Gangadhar Bhima Shankar Nangi
Sivakumaran Meenakshisunderam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd, Ramesh Dandala, Sambhu Prasad Sarma Mallela, Narayan K A S S Garimella, Sukumar Nandi, Sunil Kumar Buridipad, Gangadhar Bhima Shankar Nangi, Sivakumaran Meenakshisunderam filed Critical Aurobindo Pharma Ltd
Priority to US12/312,100 priority Critical patent/US8318933B2/en
Priority to EP07825564A priority patent/EP2079712A2/en
Publication of WO2008053334A2 publication Critical patent/WO2008053334A2/en
Publication of WO2008053334A3 publication Critical patent/WO2008053334A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to an improved process for preparing Rosuvastatin calcium of Formula I.
PCT/IB2007/003312 2006-10-31 2007-10-29 An improved process for preparing rosuvastatin calcium WO2008053334A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/312,100 US8318933B2 (en) 2006-10-31 2007-10-29 Process for preparing rosuvastatin calcium
EP07825564A EP2079712A2 (en) 2006-10-31 2007-10-29 An improved process for preparing rosuvastatin calcium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1994/CHE/2006 2006-10-31
IN1994CH2006 2006-10-31

Publications (2)

Publication Number Publication Date
WO2008053334A2 WO2008053334A2 (en) 2008-05-08
WO2008053334A3 true WO2008053334A3 (en) 2008-07-03

Family

ID=39309141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003312 WO2008053334A2 (en) 2006-10-31 2007-10-29 An improved process for preparing rosuvastatin calcium

Country Status (3)

Country Link
US (1) US8318933B2 (en)
EP (1) EP2079712A2 (en)
WO (1) WO2008053334A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20080161560A1 (en) * 2005-04-04 2008-07-03 Pandurang Balwant Deshpande Process for Preparation of Calcium Salt of Rosuvastatin
PL2172471T3 (en) 2007-04-18 2013-08-30 Teva Pharma A process for preparing intermediates of HMG-CoA reductase inhibitors
EP2350025A1 (en) * 2008-09-30 2011-08-03 Aurobindo Pharma Limited An improved process for preparing pyrimidine propenaldehyde
EP2473515A4 (en) 2009-09-04 2013-11-27 Univ Toledo Processes for producing optically pure -lactones from aldehydes and compositions produced thereby
EP2423195A1 (en) 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
CN104744377B (en) * 2015-02-12 2017-04-26 上海弈柯莱生物医药科技有限公司 Preparation method of (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino) pyrimidine-5-yl] acrolein
CN104744378B (en) * 2015-02-12 2017-10-13 上海弈柯莱生物医药科技有限公司 A kind of synthetic method of (E) 3 [base of 4 (4 fluorophenyl) 6 isopropyl 2 (N methyl N methylsulfonyls amido) pyrimidine 5] methacrylaldehyde
KR20160126700A (en) 2015-04-24 2016-11-02 미래파인켐 주식회사 New Statin intermediate, the preparation of the same and the preparation of Rosuvastatin using the same
KR101953575B1 (en) 2016-10-24 2019-05-24 한양대학교 에리카산학협력단 Synthesis of new statin intermediates for hyperlipidemia therapy and synthetic process development for rosuvastatin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100689A1 (en) * 2005-03-22 2006-09-28 Unichem Laboratories Limited Process for preparation of rosuvastatin

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JP2648897B2 (en) * 1991-07-01 1997-09-03 塩野義製薬株式会社 Pyrimidine derivatives
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
GB0204129D0 (en) * 2002-02-21 2002-04-10 Novartis Ag Process for the manufacture of organic compounds
AU2003228010A1 (en) 2002-05-21 2003-12-02 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
SI1578733T1 (en) 2002-12-10 2011-07-29 Ranbaxy Lab Ltd Process for the preparation of rosuvastatin
CA2657076A1 (en) * 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for the preparation of rosuvastatin calcium
CN1886383A (en) * 2003-10-22 2006-12-27 兰贝克赛实验室有限公司 Process for the preparation of amorphous rosuvastatin calcium
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2546701C (en) * 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
WO2006035277A2 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium
CN100351240C (en) 2005-01-19 2007-11-28 安徽省庆云医药化工有限公司 Rosuvastatin calcium synthesis method
JP4713574B2 (en) * 2005-02-22 2011-06-29 テバ ファーマシューティカル インダストリーズ リミティド Rosuvastatin free from rosuvastatin alkyl ether and salts thereof and method for producing them
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
US20080161560A1 (en) 2005-04-04 2008-07-03 Pandurang Balwant Deshpande Process for Preparation of Calcium Salt of Rosuvastatin
WO2006136407A1 (en) * 2005-06-24 2006-12-28 Lek Pharmaceuticals D.D. Process for preparing amorphous rosuvastatin calcium free of impurities
US8207333B2 (en) * 2005-06-24 2012-06-26 Lek Pharmaceuticals D. D. Process for preparing pure amorphous rosuvastatin calcuim
CZ299215B6 (en) 2005-06-29 2008-05-21 Zentiva, A. S. Process for preparing hemi-calcium salt of rosuvastatin, i.e. (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid
GB0514078D0 (en) 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
WO2007017117A1 (en) * 2005-07-28 2007-02-15 Lek Pharmaceuticals D.D. Process for the synthesis of rosuvastatin calcium
MX2007004423A (en) * 2005-08-16 2007-06-14 Teva Pharma Rosuvastatin calcium with a low salt content.
TW200804305A (en) * 2005-10-03 2008-01-16 Teva Pharma Diastereomeric purification of rosuvastatin
WO2007099561A1 (en) 2006-02-27 2007-09-07 Cadila Healthcare Limited Process for preparing rosuvastatin calcium
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
EP2022784A1 (en) 2007-08-08 2009-02-11 LEK Pharmaceuticals D.D. Process for the preparation of methyl ester of rosuvastatin
HU230637B1 (en) 2007-10-12 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Process for producing intermediates of rosuvastatin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100689A1 (en) * 2005-03-22 2006-09-28 Unichem Laboratories Limited Process for preparation of rosuvastatin

Also Published As

Publication number Publication date
US8318933B2 (en) 2012-11-27
EP2079712A2 (en) 2009-07-22
US20100048899A1 (en) 2010-02-25
WO2008053334A2 (en) 2008-05-08

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